Deep learning approaches for seizure video analysis: A review
Epilepsy Behav. 2024 Mar 22;154:109735. doi: 10.1016/j.yebeh.2024.109735. Online ahead of print.ABSTRACTSeizure events can manifest as transient disruptions in the control of movements which may be organized in distinct behavioral sequences, accompanied or not by other observable features such as altered facial expressions. The analysis of these clinical signs, referred to as semiology, is subject to observer variations when specialists evaluate video-recorded events in the clinical setting. To enhance the accuracy and consistency of evaluations, computer-aided video analysis of seizures has emerged as a natural avenue. In...
Source: Epilepsy and Behaviour - March 24, 2024 Category: Neurology Authors: David Ahmedt-Aristizabal Mohammad Ali Armin Zeeshan Hayder Norberto Garcia-Cairasco Lars Petersson Clinton Fookes Simon Denman Aileen McGonigal Source Type: research

Deep learning approaches for seizure video analysis: A review
Epilepsy Behav. 2024 Mar 22;154:109735. doi: 10.1016/j.yebeh.2024.109735. Online ahead of print.ABSTRACTSeizure events can manifest as transient disruptions in the control of movements which may be organized in distinct behavioral sequences, accompanied or not by other observable features such as altered facial expressions. The analysis of these clinical signs, referred to as semiology, is subject to observer variations when specialists evaluate video-recorded events in the clinical setting. To enhance the accuracy and consistency of evaluations, computer-aided video analysis of seizures has emerged as a natural avenue. In...
Source: Epilepsy and Behaviour - March 24, 2024 Category: Neurology Authors: David Ahmedt-Aristizabal Mohammad Ali Armin Zeeshan Hayder Norberto Garcia-Cairasco Lars Petersson Clinton Fookes Simon Denman Aileen McGonigal Source Type: research

Breathing control training for functional seizures: A multi-site, open-label pilot study
Epilepsy Behav. 2024 Mar 22;154:109745. doi: 10.1016/j.yebeh.2024.109745. Online ahead of print.ABSTRACTThere are no well-validated treatments for functional seizures. While specialist psychotherapy is usually recommended, the evidence for its benefit is qualified, and it can be difficult to obtain. Given the association between hyperventilation and functional seizures we explored an alternative modality, breathing control training, in a multi-site open label pilot trial. Participants with functional seizures over the age of 16 received an hour of breathing training from a respiratory physiotherapist, with a half-hour boos...
Source: Epilepsy and Behaviour - March 23, 2024 Category: Neurology Authors: Roderick Duncan David J Berlowitz Saul Mullen Janet Bondarenko Toby T Winton-Brown Terence J O'Brien Sophie Zaloumis Sabine Braat Georgina Oliver Richard A Kanaan Source Type: research

PCDH19-clustering epilepsy, pathophysiology and clinical significance
Epilepsy Behav. 2024 Mar 22;154:109730. doi: 10.1016/j.yebeh.2024.109730. Online ahead of print.ABSTRACTPCDH19 clustering epilepsy (PCDH19-CE) is an X-linked epilepsy disorder associated with intellectual disability (ID) and behavioral disturbances, which is caused by PCDH19 gene variants. PCDH19 pathogenic variant leads to epilepsy in heterozygous females, not in hemizygous males and the inheritance pattern is unusual. The hypothesis of cellular interference was described as a key pathogenic mechanism. According to that, males do not develop the disease because of the uniform expression of PCDH19 (variant or wild type) un...
Source: Epilepsy and Behaviour - March 23, 2024 Category: Neurology Authors: Safoura Kowkabi Majid Yavarian Reza Kaboodkhani Mahmood Mohammadi Reza Shervin Badv Source Type: research

What we have learned from non-human primates as animal models of epilepsy
Epilepsy Behav. 2024 Mar 21;154:109706. doi: 10.1016/j.yebeh.2024.109706. Online ahead of print.ABSTRACTNon-human primates (NHPs) have played a crucial role in our understanding of epilepsy, given their striking similarities with humans. Through their use, we have gained a deeper understanding of the neurophysiology and pathophysiology of epileptic seizures, and they have proven invaluable allies in developing anti-seizure therapies. This review explores the history of NHPs as natural models of epilepsy, discusses the findings obtained after exposure to various chemoconvulsant drugs and focal electrical stimulation protoco...
Source: Epilepsy and Behaviour - March 22, 2024 Category: Neurology Authors: Viviam Sanabria Simone A A Romariz Matheus Braga Jaime Moreira Pires Maria da Gra ça Naffah-Mazzacoratti Luiz Eug ênio Mello Beatriz M Longo Maira Licia Foresti Source Type: research

Utilization of APE2 and RITE2 scores in autoimmune encephalitis patients with seizures
CONCLUSION: APE2 and RITE2 scores had high sensitivities but low specificities to predict seropositivity and seizure responsiveness to immunotherapy in patients with autoimmune encephalitis with seizures.PMID:38518672 | DOI:10.1016/j.yebeh.2024.109737 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - March 22, 2024 Category: Neurology Authors: Trevor Rafferty Anna Koeppen-Babcock Srikanth Muppidi Yi Li Scheherazade Le Source Type: research

The promise of AI Large Language Models for Epilepsy care
Epilepsy Behav. 2024 Mar 21;154:109747. doi: 10.1016/j.yebeh.2024.109747. Online ahead of print.ABSTRACTArtificial intelligence (AI) has been supporting our digital life for decades, but public interest in this has exploded with the recognition of large language models, such as GPT-4. We examine and evaluate the potential uses for generative AI technologies in epilepsy and neurological services. Generative AI could not only improve patient care and safety by refining communication and removing certain barriers to healthcare but may also extend to streamlining a doctor's practice through strategies such as automating paperw...
Source: Epilepsy and Behaviour - March 22, 2024 Category: Neurology Authors: Rapha ëlle Landais Mustafa Sultan Rhys H Thomas Source Type: research

Estimating the active and lifetime prevalence and incidence of epilepsy in Asian Countries: A systematic review and meta-analysis
CONCLUSION: Our findings highlight a high prevalence of active and lifetime epilepsy in West Asia and emphasize the necessity of implementing and formulating specific strategies to tackle the epilepsy burden in this region. Furthermore, high-quality epidemiological studies incorporating economic burdens and comorbidities associated with epilepsy in Asia are still needed.PMID:38518674 | DOI:10.1016/j.yebeh.2024.109739 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - March 22, 2024 Category: Neurology Authors: Mohammed Safeer V S Jitendra Kumar Sahu Priyanka Madaan Sebastian F Winter Gus A Baker Dipika Bansal Source Type: research

What we have learned from non-human primates as animal models of epilepsy
Epilepsy Behav. 2024 Mar 21;154:109706. doi: 10.1016/j.yebeh.2024.109706. Online ahead of print.ABSTRACTNon-human primates (NHPs) have played a crucial role in our understanding of epilepsy, given their striking similarities with humans. Through their use, we have gained a deeper understanding of the neurophysiology and pathophysiology of epileptic seizures, and they have proven invaluable allies in developing anti-seizure therapies. This review explores the history of NHPs as natural models of epilepsy, discusses the findings obtained after exposure to various chemoconvulsant drugs and focal electrical stimulation protoco...
Source: Epilepsy and Behaviour - March 22, 2024 Category: Neurology Authors: Viviam Sanabria Simone A A Romariz Matheus Braga Jaime Moreira Pires Maria da Gra ça Naffah-Mazzacoratti Luiz Eug ênio Mello Beatriz M Longo Maira Licia Foresti Source Type: research

Utilization of APE2 and RITE2 scores in autoimmune encephalitis patients with seizures
CONCLUSION: APE2 and RITE2 scores had high sensitivities but low specificities to predict seropositivity and seizure responsiveness to immunotherapy in patients with autoimmune encephalitis with seizures.PMID:38518672 | DOI:10.1016/j.yebeh.2024.109737 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - March 22, 2024 Category: Neurology Authors: Trevor Rafferty Anna Koeppen-Babcock Srikanth Muppidi Yi Li Scheherazade Le Source Type: research

The promise of AI Large Language Models for Epilepsy care
Epilepsy Behav. 2024 Mar 21;154:109747. doi: 10.1016/j.yebeh.2024.109747. Online ahead of print.ABSTRACTArtificial intelligence (AI) has been supporting our digital life for decades, but public interest in this has exploded with the recognition of large language models, such as GPT-4. We examine and evaluate the potential uses for generative AI technologies in epilepsy and neurological services. Generative AI could not only improve patient care and safety by refining communication and removing certain barriers to healthcare but may also extend to streamlining a doctor's practice through strategies such as automating paperw...
Source: Epilepsy and Behaviour - March 22, 2024 Category: Neurology Authors: Rapha ëlle Landais Mustafa Sultan Rhys H Thomas Source Type: research

Estimating the active and lifetime prevalence and incidence of epilepsy in Asian Countries: A systematic review and meta-analysis
CONCLUSION: Our findings highlight a high prevalence of active and lifetime epilepsy in West Asia and emphasize the necessity of implementing and formulating specific strategies to tackle the epilepsy burden in this region. Furthermore, high-quality epidemiological studies incorporating economic burdens and comorbidities associated with epilepsy in Asia are still needed.PMID:38518674 | DOI:10.1016/j.yebeh.2024.109739 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - March 22, 2024 Category: Neurology Authors: Mohammed Safeer V S Jitendra Kumar Sahu Priyanka Madaan Sebastian F Winter Gus A Baker Dipika Bansal Source Type: research

EEG microstates in epilepsy with and without cognitive dysfunction: Alteration in intrinsic brain activity
CONCLUSION: Our research scrutinizes the disparities observed within EEG microstates among epilepsy patients both with and without comorbid cognitive dysfunction.SIGNIFICANCE: EEG microstate analysis offers a novel metric for assessing neuropsychiatric disorders and supplies evidence for investigating the mechanisms and the dynamic change of epilepsy comorbid cognitive dysfunction.PMID:38513568 | DOI:10.1016/j.yebeh.2024.109729 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - March 21, 2024 Category: Neurology Authors: Shenzhi Fang Chaofeng Zhu Jinying Zhang Luyan Wu Yuying Zhang Huapin Huang Wanhui Lin Source Type: research

eDeeplepsy: An artificial neural framework to reveal different brain states in children with epileptic spasms
In this study, deep learning techniques and, in particular, Convolutional Neural Networks, have been used to develop a model (which we have named eDeeplepsy) for distinguishing different brain states in children with epilepsy.METHODS: A novel EEG database from a homogenous pediatric population with epileptic spasms beyond infancy was constituted by epileptologists, representing a particularly intriguing seizure type and challenging EEG. The analysis was performed on such samples from long-term video-EEG recordings, previously coded as images showing how different parts of the epileptic brain are distinctly activated during...
Source: Epilepsy and Behaviour - March 21, 2024 Category: Neurology Authors: Alberto Nogales Álvaro J García-Tejedor Juan Serrano Vara Arturo Ugalde-Canitrot Source Type: research

Resilience and psychosocial factors in adult with epilepsy: A longitudinal study
CONCLUSIONS: Our study showed that depressive symptoms, anxiety and quality of life were significantly associated with resilience in PwE. Finally, as a novel finding resilience was proved to affect the perception of stigma related to epilepsy more than seizures.PMID:38513570 | DOI:10.1016/j.yebeh.2024.109746 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - March 21, 2024 Category: Neurology Authors: M Tombini F Narducci L Ricci B Sancetta M Boscarino L Quintiliani J Lanzone M Straffi V Di Lazzaro G Assenza Source Type: research