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Home orthostatic training in chronic fatigue syndrome – a randomized, placebo-controlled feasibility studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A placebo-controlled study of HOT in CFS is feasible. HOT is well tolerated and generally complied with. A likely physiological rationale for HOT in CFS is related to reductions in orthostatic intolerance. An adequately powered study including strategies to enhance compliance is warranted. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 13, 2009 Category: Journals (General) Authors: K. Sutcliffe, J. Gray, M. P. Tan, J. Pairman, K. Wilton, S. W. Parry, J. L. Newton Source Type: journals

The acute effect of smoking in healthy and asthmatic smokersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Acute smoking has more deleterious effects in well-controlled properly treated asthmatic smokers compared with matched normal smokers. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 12, 2009 Category: Journals (General) Authors: A. I. Papaioannou, A. Koutsokera, K. Tanou, T. S. Kiropoulos, I. Tsilioni, S. Oikonomidi, K. Liadaki, S. Pournaras, K. I. Gourgoulianis, K. Kostikas Source Type: journals

Fluvastatin/fenofibrate vs. simvastatin/ezetimibe in patients with metabolic syndrome: different effects on LDL-profilesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 12, 2009 Category: Journals (General) Authors: J. Westerink, F. L. J. Visseren Source Type: journals

15-Lipoxygenase-2 is expressed in macrophages in human carotid plaques and regulated by hypoxia-inducible factor-1αEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These results demonstrate that 15-LOX-2 is highly expressed in human plaques and is correlated with the presence of macrophages and HIF-1[alpha]. 15-LOX-2 enzyme activity can be modulated by HIF-1[alpha]. Thus, increased expression of 15-LOX-2 in macrophages in hypoxic atherosclerotic plaque may enhance inflammation and the recruitment of inflammatory cells. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 12, 2009 Category: Journals (General) Authors: L. M. Hultén, F. J. Olson, H. Åberg, J. Carlsson, L. Karlström, J. Borén, B. Fagerberg, O. Wiklund Source Type: journals

Urinary L-FABP and anaemia: distinct roles of urinary markers in type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Different urinary biomarkers may reflect distinct pathophysiological mechanisms of tubulointerstitial damage in early diabetic nephropathy: Urinary L-FABP could be a novel biomarker for chronic intrarenal ischaemia. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 11, 2009 Category: Journals (General) Authors: M. von Eynatten, M. Baumann, U. Heemann, D. Zdunek, G. Hess, P. P. Nawroth, A. Bierhaus, P. M. Humpert Source Type: journals

Saliva DHEA and cortisol responses following short-term corticosteroid intakeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These data are consistent with previous studies on blood samples and suggest that non-invasive saliva samples may offer a practical approach to assessing pituitary-adrenal function continuously during and after short-term corticosteroid therapy. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - October 29, 2009 Category: Journals (General) Authors: L. Jollin, R. Thomasson, B. Le Panse, A. Baillot, N. Vibarel-Rebot, A. M. Lecoq, V. Amiot, J. De Ceaurriz, K. Collomp Source Type: journals

Cardiovascular risk factors and collateral artery formationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eur J Clin Invest 2009 Arterial lumen narrowing and vascular occlusion is the actual cause of morbidity and mortality in atherosclerotic disease. Collateral artery formation (arteriogenesis) refers to an active remodelling of non-functional vascular anastomoses to functional collateral arteries, capable to bypass the site of obstruction and preserve the tissue that is jeopardized by ischaemia. Hemodynamic forces such as shear stress and wall stress play a pivotal role in collateral artery formation, accompanied by the expression of various cytokines and invasion of circulating leucocytes. Arteriogenesis hence represents an...
Source: European Journal of Clinical Investigation - October 21, 2009 Category: Journals (General) Authors: D. de Groot, G. Pasterkamp, I. E. Hoefer Source Type: journals

Outcome after device implantation in chronic heart failure is dependent on concomitant medical treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our data stress the importance of professional monitoring and titration of pharmacotherapy not only in medically treated CHF patients but also in patients under device therapy by a heart failure unit or a specialized cardiologist. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - October 15, 2009 Category: Journals (General) Authors: C. Adlbrecht, M. Hülsmann, M. Gwechenberger, G. Strunk, C. Khazen, F. Wiesbauer, M. Elhenicky, S. Neuhold, T. Binder, G. Maurer, I. M. Lang, R. Pacher Source Type: journals

Activated complement is more extensively present in diseased aortic valves than naturally occurring complement inhibitors: a sign of ongoing inflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our study indicates that anti-complement mediators (C1-inh and clusterin) are deposited in diseased aortic valves together with activated complement, indicating an existing counter response against complement locally in the valve. However, deposition of activated complement is significantly more widespread than that of its inhibitors, which could explain ongoing inflammation in those diseased aortic valves. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - October 14, 2009 Category: Journals (General) Authors: M. ter Weeme, A. B. A. Vonk, K. Kupreishvili, M. van Ham, S. Zeerleeder, D. Wouters, W. Stooker, L. Eijsman, V. W. M. Van Hinsbergh, P. A. J. Krijnen, H. W. M. Niessen Source Type: journals

MMP/ TIMP balance is modulated in vitro by 15dPGJ2 in fetuses and placentas from diabetic ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This study demonstrates that 15dPGJ2 is a potent modulator of the balance between MMP activities and TIMP levels, which is needed in the correct formation and function of the placenta and foetal organs. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - October 6, 2009 Category: Journals (General) Authors: M. C. Pustovrh, E. Capobianco, N. Martínez, R. Higa, V. White, A. Jawerbaum Source Type: journals

High plasma levels of the soluble receptor for advanced glycation endproducts in patients with symptomatic carotid atherosclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eur J Clin Invest 2009Background Advanced glycation endproducts (AGEs), particularly carboxymethyl(lysine)-adducts (CML), exert part of their cellular effects by binding to a receptor, named receptor for AGEs (RAGE). The soluble form of this receptor (sRAGE) has been shown to have an athero-protective role. We hypothesized the existence of a relationship between the AGE[ndash]RAGE axis and the occurrence of symptoms related to carotid atherosclerosis in nondiabetic conditions.Materials and methods We evaluated plasma levels of CML and sRAGE (by ELISA), and tissue levels (tAGEs and tRAGE, semiquantitatively, by immunohistoc...
Source: European Journal of Clinical Investigation - October 6, 2009 Category: Journals (General) Authors: G. Basta, M. Castagnini, S. Del Turco, M. C. Epistolato, P. Righini, G. M. Sangiorgi, R. De Caterina, P. Tanganelli Source Type: journals

Antegrade flow and peripheral resistance determine the level of endogenous arteriogenesis in patients with superficial femoral artery occlusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Ankle-brachial index, grade of symptoms and daily walking capacity could be used to predict collateral density. Importantly, a good antegrade flow and peripheral runoff seem to have a significant effect on collateral density, implying an impact on the activation of arteriogenesis. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - October 5, 2009 Category: Journals (General) Authors: I. Vajanto, P. Korpisalo, J. Karjalainen, T. Hakala, K. Mäkinen, S. Ylä-Herttuala Source Type: journals

Fat distribution influences the cardio-metabolic profile in a clinically healthy European populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Adjustment of waist circumference for its determinants permits the detection of early impairment of cardiovascular function and of glucose and lipid metabolism in a clinically healthy population, in particular in normal body weight subjects. Enlarged hip adjusted values are associated with greater insulin sensitivity. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - October 5, 2009 Category: Journals (General) Authors: E. Bobbioni-Harsch, Z. Pataky, V. Makoundou, M. Kozakova, J. Dekker, A. Golay Source Type: journals

Spontaneous and bleomycin-induced chromosome damage in non cancer thyroid patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We report that hypothyroid patients exhibit a moderate increase in the level of spontaneous genome damage, and that AI thyroid patients resulted to be less sensitive than NAI patients to the mutagen sensitivity test. In prospective, it may be of interest to reinvestigate hypothyroid patients when correction of their dysfunction is achieved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - October 5, 2009 Category: Journals (General) Authors: R. Scarpato, I. Tusa, A. Antonelli, P. Fallhai, I. Sbrana Source Type: journals

Age determines vascular reactivity as measured by optical rhinometryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Age is an important predictor of endonasal perfusion. Evaluation of optical rhinometry needs to take age-dependency of results into account. Studies in patients with cardiovascular disease are needed to show if optical rhinometry can provide information about vascular responsiveness as a predictor of cardiovascular morbidity. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - October 5, 2009 Category: Journals (General) Authors: H. C. Tillmann, A. Laske, C. Bernasconi, B. A. Stuck Source Type: journals

Improvement of a dendritic cell-based tumour vaccine by an influenza virusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The pro-inflammatory capacity of influenza NS1 deletion vaccine viruses could serve as an adjuvant-like agent to improve preparations of MODC-based anti-cancer vaccines. The complete NS1 deletion virus appears to be more potent as adjuvant when used for production of tumour lysates. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - October 5, 2009 Category: Journals (General) Authors: M. Sachet, J. Friedl, M. Hassler, M. Ploder, G. Stary, A. Stift, M. Bergmann Source Type: journals

Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg dailyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Dasatinib acts not only anti-neoplastic in CML but may also act as an immunosuppressive agent when applied at 140 mg daily, and produces frequent pleural effusions and weight loss in advanced CML. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - September 8, 2009 Category: Journals (General) Authors: C. Sillaber, H. Herrmann, K. Bennett, U. Rix, C. Baumgartner, A. Böhm, S. Herndlhofer, E. Tschachler, G. Superti-Furga, U. Jäger, P. Valent Source Type: journals

CDKs as therapeutic targets for the human genetic disease tuberous sclerosis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eur J Clin Invest 2009 The tuberous sclerosis gene 2 product tuberin is an important regulator of the mammalian target of rapamycin (mTOR). In addition, tuberin is known to bind to the cyclin-dependent kinase (CDK) inhibitor p27Kip1 (p27) and to regulate its stability and localization via mTOR-independent mechanisms. Recently, evidence has been provided that tuberin also affects p27 localization via regulating mTOR's potential to activate the serum- and glucocorticoid-inducible kinase (SGK1) to phosphorylate p27. Taken together, these findings strengthen the argument that besides mTOR-inhibitors, such as rapamycin analogue...
Source: European Journal of Clinical Investigation - September 8, 2009 Category: Journals (General) Authors: M. Rosner, H. Dolznig, C. Fuchs, N. Siegel, A. Valli, M. Hengstschläger Source Type: journals

Erosion of telomeric single-stranded overhang in patients with aplastic anaemia carrying telomerase complex mutationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Telomeric overhang erosion does not participate in physiological ageing but support a role for eroded telomeric overhangs and abnormal telomere structure in pathological shortening of telomeres, especially caused by loss-of-function telomerase mutations. Disrupted telomere structure caused by short telomeric overhangs may contribute to the mechanisms of abnormal haematopoietic compartment senescence and chromosomal instability in human bone marrow failure. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - August 12, 2009 Category: Journals (General) Authors: R. T. Calado, J. A. Regal, S. Kajigaya, N. S. Young Source Type: journals

CXCL16 in HIV infection – a link between inflammation and viral replicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our findings suggest a complex interaction between CXCL16 and HIV, promoting both inflammatory and anti-inflammatory effects as well as HIV replication, partly dependent on accompanying HIV replication. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - August 10, 2009 Category: Journals (General) Authors: L. Landrø, J. K. Damås, B. Halvorsen, B. Fevang, T. Ueland, K. Otterdal, L. Heggelund, S. S. Frøland, P. Aukrust Source Type: journals

Intensive insulin therapy decreases urinary MCP-1 and ICAM-1 excretions in incipient diabetic nephropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Intensive insulin treatment may protect against renal injury in early DN by reducing the urinary MCP-1 and ICAM-1 excretions. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - August 4, 2009 Category: Journals (General) Authors: S. D. Ye, M. Zheng, L. L. Zhao, Y. Qian, X. M. Yao, A. Ren, S. M. Li, C. Y. Jing Source Type: journals

Biliary proteins and their redox status changes in gallstone patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Biles with cholesterol stones show high CSI and total protein concentration, and rapid COT, which is even faster in patients with multiple stones and high protein concentration. Low PSH levels in cholesterol stone patients point to a biochemical shift, potentially able to affect cholesterol crystallization. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - July 28, 2009 Category: Journals (General) Authors: I. Grattagliano, D. Q-H Wang, A. Di Ciaula, C.V. Diogo, G. Palasciano, P. Portincasa Source Type: journals

The role of matrix metalloproteinases in the pathogenesis of abdominal wall herniasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eur J Clin Invest 2009 Surgical treatment of abdominal wall hernia has been based for many decades on observational evidence, as the disease physiopathology was ambiguous. The long-standing hypothesis of abnormal collagen metabolism as a causative factor of hernia disease seems to become substantiated by modern investigations, demonstrating a link between abnormal matrix metalloproteinase (MMP) expression and abdominal wall hernia. Current evidence suggests a strong correlation between MMP-2 and direct inguinal hernia, while the role of this MMP in indirect, incisional and recurrent hernias has not been completely elucidat...
Source: European Journal of Clinical Investigation - July 26, 2009 Category: Journals (General) Authors: S. A. Antoniou, G. A. Antoniou, F. A. Granderath, C. Simopoulos Source Type: journals

PPARγ2 protects against obesity by means of a mechanism that mediates insulin resistanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These data show that PPAR[gamma]2 mRNA is expressed differently in the two types of MO patients and is associated with IR. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - July 23, 2009 Category: Journals (General) Authors: M. Macias-Gonzalez, I. Moreno-Santos, J. M. García-Almeida, F. J. Tinahones, E. Garcia-Fuentes Source Type: journals

Sex differences in the association between albumin and all-cause and vascular mortalityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This study demonstrates a strong inverse association between serum albumin and mortality in a large patient cohort. The predictive value of low albumin was remarkably higher in men than in women. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - July 22, 2009 Category: Journals (General) Authors: G. Grimm, H. Haslacher, T. Kampitsch, G. Endler, C. Marsik, T. Schickbauer, O. Wagner, B. Jilma Source Type: journals

Four different NCF2 mutations in six families from Turkey and an overview of NCF2 gene mutationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The prevalence of NCF2 mutant families is approximately 15% in our series of 40 CGD families. This high incidence of A67 CGD in Turkey is undoubtedly caused by the high incidence of consanguineous marriages. We found three new mutations in NCF2 and one previously described. These are presented together with an overview of all NCF2 mutations now known. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - July 17, 2009 Category: Journals (General) Authors: M. Y. Köker, Ö. Sanal, K. van Leeuwen, M. de Boer, A. Metin, T. Patıroğlu, T. T. Özgür, I. Tezcan, D. Roos Source Type: journals

Amoxicillin resistance with β-lactamase production in Helicobacter pyloriEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions High-level amoxicillin resistance is associated with [beta]-lactamase production in H. pylori. Low-level amoxicillin resistance is linked to a point mutation on pbp1A. Because H. pylori can exchange DNA through natural transformation, spreading of blaTEM-1 amoxicillin resistance gene among H. pylori is a potential threat when treating H. pylori infection. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - July 16, 2009 Category: Journals (General) Authors: Y.-S. Tseng, D.-C. Wu, C.-Y. Chang, C.-H. Kuo, Y.-C. Yang, C.-M. Jan, Y.-C. Su, F.-C. Kuo, L.-L. Chang Source Type: journals

Chronic erythropoietin treatment affects different molecular pathways of diabetic cardiomyopathy in mouseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Chronic treatment with CERA protects cardiac tissue in diabetic animals, i.e. it inhibits molecular pathways of cardiac fibrosis, and the effects are dose-dependent. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - July 13, 2009 Category: Journals (General) Authors: N. Shushakova, J. K. Park, J. Menne, D. Fliser Source Type: journals

The erythropoietin and regenerative medicine: a lesson from fishEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions All these findings confirm EPO as a new factor involved in regenerative processes, also suggesting a potential, future utility for new therapeutical applications in the field of human regenerative medicine. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - July 13, 2009 Category: Journals (General) Authors: M. Buemi, A. Lacquaniti, D. Bolignano, G. Maricchiolo, A. Favaloro, A. Buemi, G. Grasso, V. Donato, G. Giorgianni, L. Genovese, G. Coppolino, A. Sfacteria Source Type: journals

Comorbidity, iron overload and HFE variants: a new prognostic complex in MDS?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - July 11, 2009 Category: Journals (General) Authors: P. Valent, W. R. Sperr, M. Födinger, M. Kundi Source Type: journals

Regulation of GADD153 induced by mechanical stress in cardiomyocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Mechanical stress enhanced apoptosis and GADD153 expression in cardiomyocytes. Treatment with PBA reversed both GADD153 expression and apoptosis induced by mechanical stress in cardiomyocytes. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - July 9, 2009 Category: Journals (General) Authors: W. P. Cheng, B. W. Wang, K. G. Shyu Source Type: journals

Acquired Glanzmann's thrombasthenia associated with Hairy cell leukaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - July 8, 2009 Category: Journals (General) Authors: M. Kannan, T. Chatterjee, F. Ahmad, R. Kumar, V. P. Choudhry, R. Saxena Source Type: journals

Improvement of fractional flow reserve and collateral flow by treatment with external counterpulsation (Art.Net.-2 Trial)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In this study, we provide direct functional evidence for the stimulation of coronary arteriogenesis via ECP in patients with stable coronary artery disease. These data might open a novel noninvasive and preventive treatment avenue for patients with non-acute vascular stenotic disease. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - July 4, 2009 Category: Journals (General) Authors: E. E. Buschmann, W. Utz, N. Pagonas, J. Schulz-Menger, A. Busjahn, J. Monti, W. Maerz, F. le Noble, L. Thierfelder, R. Dietz, V. Klauss, M. Gross, I.R. Buschmann Source Type: journals

Prevalence of metabolic syndrome and its relationship with leisure time physical activity among Peruvian adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background Metabolic syndrome (MetS) is an important risk factor of cardiovascular disease (CVD) and type 2 diabetes. Previous studies have suggested an inverse relationship between physical activity and MetS. However, these findings were inconsistent, and few investigators have examined these associations among South Americans. We estimated the prevalence of MetS and its association with leisure time physical activity (LTPA) among Peruvian adults.Materials and methods This cross-sectional study of 1675 individuals (619 men and 1056 women) was conducted among residents in Lima and Callao, Peru. Information about LTPA, soci...
Source: European Journal of Clinical Investigation - June 26, 2009 Category: Journals (General) Authors: B. Gelaye, L. R. Tafur, T. Lopez, S. Sanchez, M. A. Williams Source Type: journals

Methods to assess impaired post-prandial metabolism and the impact for early detection of cardiovascular disease riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Post-prandial lipaemia has emerged as a key contributor to cardiovascular disease (CVD) risk and progression. Specifically, delayed clearance of chylomicrons (CM) and their remnants increase the delivery of triglyceride and cholesteryl ester to the vessel wall and can accelerate the progression of atherosclerosis, which may be particularly pertinent to individuals with insulin resistance and/or obesity. As the number of studies linking post-prandial metabolism and chronic disease increases, interest has grown in the use of parameters reflecting CM metabolism as a possible indicator of early CVD risk. This, in turn has rais...
Source: European Journal of Clinical Investigation - June 25, 2009 Category: Journals (General) Authors: J. W. Su, M.-M. U. Nzekwu, M. C. Cabezas, T. Redgrave, S. D. Proctor Source Type: journals

Serum hepcidin concentration in chronic haemodialysis patients: associations and effects of dialysis, iron and erythropoietin therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Hepcidin levels in stable haemodialysis patients appear to reflect systemic iron load, but not inflammation. Due to the negative association between reticulocyte counts and hepcidin, the reduction of circulating hepcidin concentrations by dialysis and/or rhEpo treatment may positively affect erythropoiesis. Eur J Clin Invest 2009 (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 25, 2009 Category: Journals (General) Authors: G. Weiss, I. Theurl, S. Eder, C. Koppelstaetter, K. Kurz, T. Sonnweber, U. Kobold, G. Mayer Source Type: journals

Fatty acids as metabolic mediators in innate immunityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Monocytic activation is differentially regulated by fatty acids and depends on triglyceride levels in T2D. The main finding of the present study shows that eicosapentaenoic acid inhibits the specific binding of LPS to TLR4/MD-2. Eicosapentaenoic acid represents a new anti-inflammatory LPS-antagonist. Eur J Clin Invest 2009 (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 25, 2009 Category: Journals (General) Authors: A. Kopp, P. Gross, W. Falk, M. Bala, J. Weigert, C. Buechler, M. Neumeier, J. Schölmerich, A. Schäffler Source Type: journals

Choline supplementation reduces oxidative stress in mouse model of allergic airway diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Choline administration reduces oxidative stress possibly by modulating the redox status of the cell and inhibits inflammatory response in a mouse model. Eur J Clin Invest 2009 (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 25, 2009 Category: Journals (General) Authors: A. K. Mehta, N. Arora, S. N. Gaur, B. P. Singh Source Type: journals

Neurofibromatosis type 1: should we screen for other genetic syndromes? A case report of co-existence with multiple endocrine neoplasia 2AEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion To our knowledge this is a rare case of co-existence of two pheochromocytoma-related genetic syndromes, and generates the question of whether all patients with these syndromes should undergo a thorough clinical and laboratory investigation for the possibility of another co-existing pheochromocytoma-related genetic syndrome. Eur J Clin Invest 2009; (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 24, 2009 Category: Journals (General) Authors: E. Gkaliagkousi, Z. Erlic, K. Petidis, P. Semertzidis, M. Doumas, C. Zamboulis, H. P. H. Neumann, S. Douma Source Type: journals

The inhibitory effect of resveratrol on leptin secretion from rat adipocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The obtained results revealed the direct ability of resveratrol to reduce leptin secretion from isolated rat adipocytes. Resveratrol is therefore a compound affecting the endocrine function of adipocytes. Eur J Clin Invest 2009 (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 23, 2009 Category: Journals (General) Authors: K. Szkudelska, L. Nogowski, T. Szkudelski Source Type: journals

Hearing impairment in the Sturge-Weber syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 22, 2009 Category: Journals (General) Authors: R. Bovo, A. Castiglione, A. Ciorba, M. Borrelli, A. Martini Source Type: journals

Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated from Celastrus regeliiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our data suggest that celastrol inhibits the production of inflammatory mediators and is a potential target for the treatment of various inflammatory diseases. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 21, 2009 Category: Journals (General) Authors: D. H. Kim, E. K. Shin, Y. H. Kim, B. W. Lee, J.-G. Jun, J. H. Y. Park, J.-K. Kim Source Type: journals

Fenofibrate attenuates endothelial monocyte adhesion in chronic heart failure: an in vitro studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The fenofibrate directly inhibits monocyte binding by TNF-[alpha]-activated HAECs, probably through preventing up-regulation of cell adhesion molecules by endothelial cells in response to inflammatory stimuli. This PPAR[alpha] activator may have the potential to ameliorate vascular inflammation in patients with CHF. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 14, 2009 Category: Journals (General) Authors: W. P. Huang, W. H. Yin, J. W. Chen, H. L. Jen, M. S. Young, S. J. Lin Source Type: journals

Effects of AT1- and β-adrenergic receptor antagonists on TGF-β1-induced fibrosis in transgenic miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The AT1-antagonist TEL reduced myocardial hypertrophy and interstitial fibrosis in TGF-[beta]1-TG mice by normalizing MMP/TIMP ratio. [beta]1-Adrenergic inhibition by MET as well as TGF-[beta]1 antagonism induced antihypertrophic rather than antifibrotic effects. Inhibition of both renin-angiotensin system and [beta]1-adrenergic system may exert different but synergistic effects to reduce myocardial remodelling. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 11, 2009 Category: Journals (General) Authors: U. Seeland, A. Schäffer, S. Selejan, M. Hohl, J.-C. Reil, P. Müller, S. Rosenkranz, M. Böhm Source Type: journals

Mesenchymal cells inhibit expansion but not cytotoxicity exerted by gamma–delta T cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This effect could be relevant in separating graft-vs.-host from the graft-vs.-tumour effect, especially considering the possibility of modulating T-lymphocytes activity by the immunomodulating drugs now available. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 11, 2009 Category: Journals (General) Authors: I. Petrini, S. Pacini, M. Petrini, R. Fazzi, L. Trombi, S. Galimberti Source Type: journals

Vascular hyporesponsiveness to angiotensin II in rats with CCl4-induced liver cirrhosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Vascular hyporesponsiveness to angiotensin II in CCl4 rats is due to enhanced interaction of the AT1 receptor with [beta]-arrestin-2 and consecutively changed receptor function. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 11, 2009 Category: Journals (General) Authors: M. Hennenberg, J. Trebicka, A. Z. Kohistani, J. Heller, T. Sauerbruch Source Type: journals

Renal artery stenosis predicts adverse cardiovascular and renal outcome in patients with peripheral artery diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Severe RAS in patients with symptomatic PAD is an independent predictor of major adverse cardiovascular events, adverse renal outcome and mortality. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 11, 2009 Category: Journals (General) Authors: J. Amighi, O. Schlager, M. Haumer, P. Dick, W. Mlekusch, C. Loewe, G. Böhmig, R. Koppensteiner, E. Minar, M. Schillinger Source Type: journals

Elevated tryptase levels selectively cluster in myeloid neoplasms: a novel diagnostic approach and screen marker in clinical haematologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In summary, tryptase is a new diagnostic marker of myeloid neoplasms and a useful test in clinical haematology. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 11, 2009 Category: Journals (General) Authors: W. R. Sperr, A. El-Samahi, M. Kundi, M. Girschikofsky, S. Winkler, D. Lutz, G. Endler, H. Rumpold, H. Agis, C. Sillaber, U. Jäger, P. Valent Source Type: journals

Quercetin inhibits fatty acid and triacylglycerol synthesis in rat-liver cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In hepatocytes from normal rats, the quercetin-induced decrease in both de novo fatty acid and TAG synthesis, with a consequent reduction in VLDL-TAG formation, may represent a potential mechanism contributing to the reported hypotriacylglycerolemic effect of quercetin. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 7, 2009 Category: Journals (General) Authors: G. V. Gnoni, G. Paglialonga, L. Siculella Source Type: journals

Unbalanced translocation in an adult patient with premature ovarian failure and mental retardation detected by spectral karyotyping and array-comparative genomic hybridizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The phenotype of partial monosomy X and partial trisomy 1q is much attenuated in case of unbalanced translocation (X;1) in adulthood probably owing to skewed X inactivation in derivative X chromosome. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - June 7, 2009 Category: Journals (General) Authors: Q. S. Guo, S. Y. Qin, S. F. Zhou, L. He, D. Ma, Y. P. Zhang, Y. Xiong, T. Peng, Y. Cheng, X. T. Li Source Type: journals