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Erratum to: HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memoryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00228-009-0752-2Authors Antonio Drago, University of Bologna Institute of Psychiatry Viale Carlo Pepoli 5 40123 Bologna ItalySilvia Alboni, University of Modena and Reggio Emilia Department of Biomedical Sciences Modena ItalyNicoletta Brunello, University of Modena and Reggio Emilia Department of Biomedical Sciences Modena ItalyDiana De Ronchi, University of Bologna Institute of Psychiatry Viale Carlo Pepoli 5 40123 Bologna ItalyAlessandro Serretti, University of Bologna Institute of Psychiatry Viale Carlo Pepoli 5 40123 Bologna Italy Journal European Jour...
Source: European Journal of Clinical Pharmacology - November 18, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Prescriptions as a proxy for asthma in children: a good choice?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions When additional validation studies were taken into account, asthma medications were found to be prescribed not only for asthma but also for other respiratory diseases. In addition, not all children with current asthma had prescriptions. We therefore conclude that asthma medications are therefore not a good proxy for the disease. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionDOI 10.1007/s00228-009-0755-zAuthors Falk Hoffmann, University of Bremen Division Health Economics, Health Policy and Outcomes Research, Center for Social Policy Research Bremen GermanyGerd G...
Source: European Journal of Clinical Pharmacology - November 18, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

The pharmacokinetic profile of fesoterodine 8 mg with daytime or nighttime dosingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The AUC values for daytime and nighttime administration of fesoterodine were equivalent. The 21% reduction in the Cmax for nighttime dosing is unlikely to be clinically relevant. No safety issues were apparent. These results support both daytime and nighttime administration of fesoterodine for OAB treatment. Content Type Journal ArticleCategory Pharmacokinetics and DispositionDOI 10.1007/s00228-009-0748-yAuthors Bimal K. Malhotra, Pfizer Inc New York NY USAPenelope H. Crownover, Pfizer Inc New York NY USARobert LaBadie, Pfizer Inc New York NY USAPaul Glue, University of Otago Department of ...
Source: European Journal of Clinical Pharmacology - November 13, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Racecadotril is more effective than loperamide−probably due to drug interaction with loperamide−and it is not related to pharmacogenetic susceptibility. Racecadotril is also more cost effective than loperamide. Content Type Journal ArticleCategory Clinical TrialDOI 10.1007/s00228-009-0751-3Authors Luca Gallelli, University Magna Graecia of Catanzaro, Mater Domini University Hospital Chair of Pharmacology, School of Medicine and Surgery, Department of Experimental and Clinical Medicine Catanzaro ItalyManuela Colosimo, Geriatric Nursing Home “Madonna di Porto” Catanzaro ItalyGrazia A....
Source: European Journal of Clinical Pharmacology - November 9, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Prescription of anti-osteoporosis drugs during 2004–2007—a nationwide register study in NorwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion There was an increasing prevalence and a decreasing incidence of AOD use over this limited time period. There was substantial geographical variation in the prevalence of anti-osteoporosis drugs. We also observed a high minimum refill rate. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionDOI 10.1007/s00228-009-0746-0Authors Helene M. Devold, Norwegian Institute of Public Health Department of Chronic Diseases P.b. 4404 Nydalen 0403 Oslo NorwayGia Man Doung, Norwegian Institute of Public Health Department of Chronic Diseases P.b. 4404 Nydalen 0403 Oslo NorwayAage Tverd...
Source: European Journal of Clinical Pharmacology - November 6, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

The pharmacokinetics and pharmacodynamics of prasugrel in healthy Chinese, Japanese, and Korean subjects compared with healthy Caucasian subjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Mean exposure to the prasugrel active metabolite following prasugrel 60-mg LD and during daily 10-mg or 5-mg MD was higher in each of the Asian groups than in the Caucasian group, which resulted in greater platelet inhibition. Content Type Journal ArticleCategory Clinical TrialDOI 10.1007/s00228-009-0737-1Authors David S. Small, Eli Lilly and Company Lilly Research Laboratories Lilly Corporate Center Indianapolis IN 46285 USAPrajakti Kothare, Eli Lilly and Company Lilly Research Laboratories Lilly Corporate Center Indianapolis IN 46285 USAEunice Yuen, Eli Lilly and Company Lilly Research La...
Source: European Journal of Clinical Pharmacology - November 3, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

The effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of glipizide in Chinese subjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These results suggest that CYP2C9 polymorphism significantly influences the pharmacokinetics and pharmacodynamics of glipizide, which needs to be considered in clinical practice. CYP2C19 polymorphism exhibits a tendency to influence the effects of glipizide, to a certain extent similarly to CYP2C9 polymorphism. Content Type Journal ArticleCategory PharmacogeneticsDOI 10.1007/s00228-009-0736-2Authors Bo Tan, Chinese Academy of Sciences Shanghai Institute of Materia Medica Shanghai 201203 ChinaYi-Fan Zhang, Chinese Academy of Sciences Shanghai Institute of Materia Medica Shanghai 201203 China...
Source: European Journal of Clinical Pharmacology - October 21, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Perception of risk regarding the use of medications and other exposures during pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Women overestimate the risk of drug use and other exposures during pregnancy. Therefore, it is important for health care providers to use evidence-based information, to reduce unnecessary anxiety, and to ensure safe and appropriate treatment during pregnancy. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionDOI 10.1007/s00228-009-0744-2Authors Hedvig Nordeng, University of Oslo Department of Pharmacy, School of Pharmacy P. O. Box 1065 Blindern Oslo N-0316 NorwayEivind Ystrøm, Norwegian Institute of Public Health Division of Mental Health Oslo NorwayAdrienne Einarso...
Source: European Journal of Clinical Pharmacology - October 20, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Ontogeny of midazolam glucuronidation in preterm infantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The glucuronidation of OHM appears immature in preterm infants less than 2 weeks of age. The observed increase in urinary excretion of OHMG with postconceptional age likely reflects the combined maturation of glucuronidation and renal function. Content Type Journal ArticleCategory Pharmacokinetics and DispositionDOI 10.1007/s00228-009-0741-5Authors Saskia N. de Wildt, Erasmus MC Sophia Children’s Hospital Departments of Paediatrics and Paediatric Surgery, Intensive Care Dr Molewaterplein 60, Sk3140 3015 GJ Rotterdam The NetherlandsGreg L. Kearns, Children’s Mercy Hospitals and Clini...
Source: European Journal of Clinical Pharmacology - October 16, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Stronger association of drug-induced progressive multifocal leukoencephalopathy (PML) with biological immunomodulating agentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We found a strong relationship between PML and MAbs, especially when used in autoimmune diseases. PML is becoming a crucial issue of MAbs, since they can cause severe ADRs through the imbalance of the immune system. Based on these results, patients treated with MAbs should be carefully monitored for early signs and symptoms of PML. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionDOI 10.1007/s00228-009-0739-zAuthors Carlo Piccinni, University of Bologna Department of Pharmacology Via Irnerio, 48 40126 Bologna ItalyChiara Sacripanti, University of Bologna Department...
Source: European Journal of Clinical Pharmacology - October 16, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Novel therapeutic strategies in Parkinson’s diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s00228-009-0742-4Authors Peter Klivenyi, University of Szeged Department of Neurology, Albert Szent-Gyorgyi Clinical Centre Semmelweis u. 6. 6725 Szeged HungaryLaszlo Vecsei, University of Szeged Department of Neurology, Albert Szent-Gyorgyi Clinical Centre Semmelweis u. 6. 6725 Szeged Hungary Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 15, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

The effects of pummelo juice on pharmacokinetics of sildenafil in healthy adult male Jordanian volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Patients should be advised not to drink pummelo juice before or immediately after taking sildenafil. Content Type Journal ArticleCategory Pharmacokinetics and DispositionDOI 10.1007/s00228-009-0738-0Authors Mutasim A. Al-Ghazawi, University of Jordan Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy Amman JordanMaha S. Tutunji, University of Jordan Department of Chemistry, Faculty of Science Amman JordanSalah M. AbuRuz, University of Jordan Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy Amman Jordan Journal European Journal of Clinical...
Source: European Journal of Clinical Pharmacology - October 14, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Regional variation and adherence to guidelines for drug treatment of asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion There are large regional variations in the utilization of antiasthmatics between Swedish regions, with substantial room for improvement in the adherence to guidelines. New methods of influencing physician behavior may be needed in the future to enhance adherence. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionDOI 10.1007/s00228-009-0731-7Authors Marianne Heibert Arnlind, Karolinska Institutet Centre for Allergy Research SE-171 77 Stockholm SwedenBjörn Wettermark, Karolinska University Hospital Centre for Pharmacoepidemiology, Karolinska Institutet SE-171 76 Stock...
Source: European Journal of Clinical Pharmacology - October 13, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Is cyclosporine A transport inhibited by pravastatin via multidrug resistant protein 2?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Based on these results, we suggest that CyA transport may be competitively inhibited by pravastatin via MRP2. Content Type Journal ArticleCategory Pharmacokinetics and DispositionDOI 10.1007/s00228-009-0740-6Authors Ryuji Kato, Osaka University of Pharmaceutical Sciences Laboratory of Clinical Pharmacy & Clinical Pharmacokinetics 4-20-1 Nasahara Takastuki Osaka 569-1094 JapanMami Nishide, Osaka University of Pharmaceutical Sciences Laboratory of Clinical Pharmacy & Clinical Pharmacokinetics 4-20-1 Nasahara Takastuki Osaka 569-1094 JapanChihiro Kozu, Osaka University of Pharmaceutical Science...
Source: European Journal of Clinical Pharmacology - October 13, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Dosage and formulation issues: oral vitamin E therapy in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The differences in dosing recommendations in children may be due to lack of systematic studies. Existing published data on oral vitamin E do not provide a basis for evaluation of dosage recommendations in children. Comparative clinical studies are required for scientific evaluation of pharmacokinetics, dosage regimens, and efficacy/ADR assessments in children. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s00228-009-0729-1Authors Tone Westergren, Oslo University Hospital, Rikshospitalet RELIS, Regional Medicines Information Center Oslo NorwayBetty Kalikstad, University of ...
Source: European Journal of Clinical Pharmacology - October 13, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Uptake of anthracyclines in vitro and in vivo in acute myeloid leukemia cells in relation to apoptosis and clinical responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results indicate that intracellular anthracycline levels in vivo are suboptimal and that protocols should be used that increase intracellular anthracycline levels. Content Type Journal ArticleCategory PharmacodynamicsDOI 10.1007/s00228-009-0734-4Authors Alex Bogason, Karolinska Institute/Karolinska University Hospital Department of Medicine, Division of Clinical Pharmacology Solna Stockholm 171 76 SwedenHasanuzzaman Bhuiyan, Karolinska Institute/Karolinska University Hospital Department of Medicine, Division of Clinical Pharmacology Solna Stockholm 171 76 SwedenMichèle Masquelier, Karo...
Source: European Journal of Clinical Pharmacology - October 10, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Outpatient utilization of drugs acting on nervous system: a study from the Republic of Srpska, Bosnia & HerzegovinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The observed tendency toward increased total drug utilization observed in our study is comparable to worldwide trends. Implementation of new clinical guidelines for nervous diseases and updating of the list of reimbursable drugs with the addition of new ones contributed to the observed improvement in prescribing patterns in primary healthcare during the study period. The DU90% is shown to be a simple rough method for assessing prescribing quality. More stratified analyses should be performed on a routine basis to ensure a rational use of medicines and a cost-efficient use of limited healthcare re...
Source: European Journal of Clinical Pharmacology - October 9, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Investigations of inter- and intraindividual relationships between exposure to oral salmon calcitonin and a surrogate marker of pharmacodynamic efficacyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Increased bioavailability of orally administered 0.8 mg sCT was highly correlated with increased suppression of the bone resorption marker serum CTX-I irrespective of the time of day. However, the high inter- and intraindividual variability in sCT exposure demonstrates the importance of determining the optimum conditions for ensuring the most beneficial sCT uptake. Content Type Journal ArticleCategory Clinical TrialDOI 10.1007/s00228-009-0735-3Authors Morten A. Karsdal, Nordic Bioscience A/S, CCBR Herlev/Ballerup Hovedgade 207 DK-2730 Herlev DenmarkInger Byrjalsen, Nordic Bioscience A/...
Source: European Journal of Clinical Pharmacology - October 8, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memoryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The possible reasons for the contrast between the prime relevance of HTR1B in regulating memory and motivation and the limited evidence brought by genetic association studies in humans are discussed, and some suggestions for possible future directions are provided. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s00228-009-0724-6Authors Antonio Drago, University of Bologna Institute of Psychiatry Viale Carlo Pepoli 5 40123 Bologna ItalySilvia Alboni, University of Modena and Reggio Emilia Department of Biomedical Sciences Modena ItalyBrunello Nicoletta, University of Modena ...
Source: European Journal of Clinical Pharmacology - October 7, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

A fenugreek seed extract selectively reduces spontaneous fat consumption in healthy volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The repeated administration of a fenugreek seed extract specifically decreases dietary fat consumption in humans which, given the traditional use of the plant, constitutes a novel result. Content Type Journal ArticleCategory Clinical TrialDOI 10.1007/s00228-009-0733-5Authors Hugues Chevassus, CHRU Montpellier, Centre d’Investigation Clinique Montpellier FranceNathalie Molinier, CHRU Montpellier, Centre d’Investigation Clinique Montpellier FranceFrançoise Costa, CHRU Montpellier, Centre d’Investigation Clinique Montpellier FranceFlorence Galtier, CHRU Montpellier, Centre d’Investiga...
Source: European Journal of Clinical Pharmacology - October 7, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Population pharmacokinetics of intravenous ondansetron in oncology and surgical patients aged 1−48 monthsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The population pharmacokinetic analysis of ondansetron allows for characterization of individual patients based on body weight and age. It is recommended that patients younger than 4 months receiving ondansetron be closely monitored. Content Type Journal ArticleCategory Pharmacokinetics and DispositionDOI 10.1007/s00228-009-0730-8Authors John T. Mondick, Metrum Institute 2 Tunxis Road, Suite 112 Tariffville CT 06081 USABrendan M. Johnson, GlaxoSmithKline Clinical Pharmacokinetics/Modeling and Simulation Research Triangle Park NC 27709 USALynda J. Haberer, GlaxoSmithKline Clinical Pharm...
Source: European Journal of Clinical Pharmacology - October 1, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Nurse-led medication reviews and the quality of drug treatment of elderly hospitalized patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Nurses are able to detect a high proportion of clinically relevant DRPs not detected by the usual care and thereby increase the quality of the drug treatment in elderly hospitalized patients. Our study showed no effect on re-hospitalization or IDU. By using a SYM nurses can find DRPs that computer-based decision support systems miss. Content Type Journal ArticleCategory Clinical TrialDOI 10.1007/s00228-009-0728-2Authors Monica Bergqvist, Karolinska Institutet, Södersjukhuset Department of Clinical Science and Education Stockholm SwedenJohanna Ulfvarson, Karolinska Institutet Department of...
Source: European Journal of Clinical Pharmacology - October 1, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

CYP3A4*1G genetic polymorphism influences CYP3A activity and response to fentanyl in Chinese gynecologic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions CYP3A4*1G genetic polymorphism decreases CYP3A activity and fentanyl consumption for postoperative pain control. Content Type Journal ArticleCategory PharmacogeneticsDOI 10.1007/s00228-009-0726-4Authors Wei Zhang, Zhengzhou University Department of Anesthesiology, First Affiliated Hospital No.1 East-JianShe Road Zhengzhou 450052 ChinaYan-Zi Chang, Zhengzhou University Department of Anesthesiology, First Affiliated Hospital No.1 East-JianShe Road Zhengzhou 450052 ChinaQuan-Cheng Kan, Zhengzhou University Department of Anesthesiology, First Affiliated Hospital No.1 East-JianShe Road Zhengzho...
Source: European Journal of Clinical Pharmacology - September 28, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Oral cyclosporin A inhibits CD4 T cell P-glycoprotein activity in HIV-infected adults initiating treatment with nucleoside reverse transcriptase inhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Oral cyclosporin A can inhibit peripheral blood CD4 T cell P-glycoprotein activity. Targeted P-glycoprotein inhibition may enhance the delivery of ART to T cells. Content Type Journal ArticleCategory Clinical TrialDOI 10.1007/s00228-009-0725-5Authors Todd Hulgan, Vanderbilt University School of Medicine Department of Medicine, Division of Infectious Diseases 345 24th Ave N, Suite 105 Nashville TN 37203 USAJohn P. Donahue, Vanderbilt University School of Medicine Department of Medicine, Division of Infectious Diseases 345 24th Ave N, Suite 105 Nashville TN 37203 USALaura Smeaton, Harvard Uni...
Source: European Journal of Clinical Pharmacology - September 24, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Adverse interaction of warfarin and paracetamol: evidence from a post-mortem studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This study supports the clinical evidence suggesting that warfarin-paracetamol interactions may create significant life-threatening conditions. It also accentuates the significant role post-mortem database research can have in improving drug safety. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionDOI 10.1007/s00228-009-0727-3Authors Terhi Launiainen, University of Helsinki Department of Forensic Medicine P.O. Box 40 00014 Helsinki FinlandAntti Sajantila, University of Helsinki Department of Forensic Medicine P.O. Box 40 00014 Helsinki FinlandIlpo Rasanen, Univers...
Source: European Journal of Clinical Pharmacology - September 24, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

No impact of age on dose-adjusted pharmacokinetics of tacrolimus, mycophenolic acid and prednisolone 1 month after renal transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The aging process itself may have a small effect on the pharmacokinetics of tacrolimus, MPA, or prednisolone. However, a larger number of subjects need to be studied to confirm the impact of age on the CYP3A5 pharmacogenetics of tacrolimus in the elderly. Content Type Journal ArticleCategory PharmacoeconomicsDOI 10.1007/s00228-009-0721-9Authors Masatomo Miura, Akita University Hospital Department of Pharmacy Akita JapanShigeru Satoh, Akita University School of Medicine Department of Urology Akita JapanHideaki Kagaya, Akita University Hospital Department of Pharmacy Akita JapanMitsuru Saito, ...
Source: European Journal of Clinical Pharmacology - September 16, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Eltrombopag, an oral thrombopoietin receptor agonist, has no impact on the pharmacokinetic profile of probe drugs for cytochrome P450 isoenzymes CYP3A4, CYP1A2, CYP2C9 and CYP2C19 in healthy men: a cocktail analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Once-daily administration of eltrombopag 75 mg for 7 days did not alter CYP3A4, CYP1A2, CYP2C9 or CYP2C19 activity in healthy volunteers. Content Type Journal ArticleCategory Pharmacokinetics and DispositionDOI 10.1007/s00228-009-0716-6Authors Julian Jenkins, GlaxoSmithKline Research & Development Oncology Medicine Development Center 1250 Collegeville Road Collegeville PA 19426 USADaphne Williams, GlaxoSmithKline Research Triangle Park Durham NC USAYanli Deng, GlaxoSmithKline Research & Development Oncology Medicine Development Center 1250 Collegeville Road Collegeville PA 19426 US...
Source: European Journal of Clinical Pharmacology - September 16, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Drug utilisation on a preterm and neonatal intensive care unit in Germany: a prospective, cohort-based analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Treatment strategies on a preterm intensive care unit are complex and little information is available for the drugs used. Analgesics and cardiovascular drugs are of major concern. Efforts will have to be made to conduct well-designed and powered studies in this vulnerable population. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionDOI 10.1007/s00228-009-0722-8Authors Antje Neubert, University of London Centre for Paediatric Pharmacy Research, The School of Pharmacy and Institute of Child Health 29–39 Brunswick Square London WC1N 1AX UKKristin Lukas, Friedrich-Al...
Source: European Journal of Clinical Pharmacology - September 16, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients: nonlinear mixed-effect modelingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The CYP2C19 and CYP2C9 genotypes significantly influenced the PK variability of VPA, as quantified by NONMEM software. Content Type Journal ArticleCategory PharmacogeneticsDOI 10.1007/s00228-009-0712-xAuthors Dechun Jiang, Xuanwu Hospital of Capital Medical University Department of Pharmacy Beijing 100053 ChinaXiangrong Bai, Xuanwu Hospital of Capital Medical University Department of Pharmacy Beijing 100053 ChinaQingxia Zhang, Xuanwu Hospital of Capital Medical University Department of Pharmacy Beijing 100053 ChinaWei Lu, Peking University School of Pharmaceutical Science Beijing 100083 China...
Source: European Journal of Clinical Pharmacology - September 16, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Statins and total (not LDL) cholesterol concentration and outcome of myocardial infarction: results from a meta-analysis and an observational studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Total cholesterol measurements can be used with confidence in the absence of LDL measurements to make decisions about statin drug introduction or titration. Randomised trials of statin therapy had good external validity and cholesterol changes and outcomes in trials were comparable to those observed in the setting of usual care. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s00228-009-0720-xAuthors Xia Sheng, University of Dundee Medicines Monitoring Unit, Division of Medical Sciences Dundee UKLi Wei, University of Dundee Medicines Monitoring Unit, Division of Medical Scie...
Source: European Journal of Clinical Pharmacology - September 16, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Rhabdomyolysis associated with fibrate therapy: review of 76 published cases and a new case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Chronic renal failure may be a risk factor for rhabdomyolysis associated with fibrates. Although rhabdomyolysis usually occurred when fibrates were combined with statins, a well-known class of agents that potentially induce rhabdomyolysis, precautions against serious adverse effects should also be taken with fibrate monotherapy. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s00228-009-0723-7Authors Jianyong Wu, Zhejiang University Kidney Disease Center, First Affiliated Hospital, College of Medicine 79 Qingchun Road Hanghzou 310003 Zhejiang People’s Republic of ChinaYan ...
Source: European Journal of Clinical Pharmacology - September 16, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Population pharmacokinetic analysis of infliximab in patients with ulcerative colitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The disposition of infliximab in patients with moderately to severely active ulcerative colitis, unlike in rheumatoid arthritis, was not affected by coadministration of immunomodulators and corticosteroids but was related to formation of antibodies to infliximab and, notably, to serum albumin levels. Content Type Journal ArticleCategory Pharmacokinetics and DispositionDOI 10.1007/s00228-009-0718-4Authors Adedigbo A. Fasanmade, Centocor Research and Development, Inc Malvern PA USAOmoniyi J. Adedokun, Centocor Research and Development, Inc Malvern PA USAJoyce Ford, Centocor Research and Deve...
Source: European Journal of Clinical Pharmacology - September 16, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Blood−brain barrier transporters and response to CNS-active drugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Drug transporters play a fundamental role in protecting the brain from exposure to drugs and other potential toxicants. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s00228-009-0714-8Authors Bradley L. Urquhart, Division of Clinical Pharmacology, Department of Medicine, The University of Western Ontario London ON CanadaRichard B. Kim, Division of Clinical Pharmacology, Department of Medicine, The University of Western Ontario London ON Canada Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - September 3, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Exacerbation of inflammatory bowel diseases associated with the use of nonsteroidal anti-inflammatory drugs: myth or reality?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Further randomized, double-blind, controlled trials should be performed to address this issue, and more in vitro studies to identify the pathways involved are required. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s00228-009-0719-3Authors Helenie Kefalakes, University of Crete Clinical Pharmacology, Faculty of Medicine Crete GreeceTheodoros J. Stylianides, University of Crete Clinical Pharmacology, Faculty of Medicine Crete GreeceGeorge Amanakis, University of Crete Clinical Pharmacology, Faculty of Medicine Crete GreeceGeorge Kolios, Democritus University of Thrace Labora...
Source: European Journal of Clinical Pharmacology - August 27, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Montelukast use during pregnancy: a multicentre, prospective, comparative study of infant outcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Montelukast does not appear to increase the baseline rate of major malformations. The lower birth weight in both asthma groups is most likely associated with the severity of the maternal condition. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionDOI 10.1007/s00228-009-0713-9Authors Moumita Sarkar, The Motherisk Program Toronto CanadaGideon Koren, The Motherisk Program Toronto CanadaSanjog Kalra, The Motherisk Program Toronto CanadaAngela Ying, The Motherisk Program Toronto CanadaCarlo Smorlesi, Servicio di Tossicologica Perinatale Firenze ItalyMarco De Santis, Tele...
Source: European Journal of Clinical Pharmacology - August 25, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Seizures associated with levofloxacin: case presentation and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s00228-009-0717-5Authors Alfredo Bellon, INSERM U894 Laboratoire de Physiopathologie des Maladies Psychiatriques Centre de Psychiatrie et Neurosciences Paris FranceGonzalo Perez-Garcia, Baylor College of Medicine Menninger Department of Psychiatry & Behavioral Sciences Houston TX USAJohn H. Coverdale, Baylor College of Medicine Menninger Department of Psychia...
Source: European Journal of Clinical Pharmacology - August 25, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Paroxetine may cause increase in carcinoebmryonic antigen (CEA)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorsDOI 10.1007/s00228-009-0715-7Authors Mehmet Emin Ceylan, Bakirkoy Research and Training Hospital for Psychiatric and Neurological Diseases Istanbul TurkeyAhmet Turkcan, Bakirkoy Research and Training Hospital for Psychiatric and Neurological Diseases Istanbul TurkeyUrun Ozer, Bakirkoy Research and Training Hospital for Psychiatric and Neurological Diseases Istanbul Turkey Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - August 17, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These preliminary results suggest a possible influence of CYP2C9 genotype on proteinuria and blood pressure in Caucasian CKD patients treated with losartan. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00228-009-0707-7Authors Melanie S. Joy, University of North Carolina Division of Nephrology and Hypertension, School of Medicine, UNC Kidney Center Chapel Hill NC USAKimberly Dornbrook-Lavender, Shire Pharmaceuticals Durham NC USAJoyce Blaisdell, National Institutes of Environmental Health Sciences Pharmacology, Human Metabolism Group Durham NC USATandrea Hilliard, Unive...
Source: European Journal of Clinical Pharmacology - August 10, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Evidence of safety of chloral hydrate for prolonged sedation in PICU in a tertiary teaching hospital in southern BrazilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The study described the clinical practice of sedation with CH in the PICU setting of a tertiary teaching hospital in southern Brazil. Data suggest that CH is an alternative for prolonged sedation in PICU. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionDOI 10.1007/s00228-009-0694-8Authors Jacqueline Kohut Martinbiancho, Universidade Federal do Rio Grande do Sul Post-Graduate Program in Medical Sciences, School of Medicine Rio Grande do Sul RS BrazilPaulo Roberto Antonacci Carvalho, Universidade Federal do Rio Grande do Sul Department of Pediatrics Porto Alegre RS B...
Source: European Journal of Clinical Pharmacology - August 10, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Clinical and pharmacogenetic determinants for the discontinuation of non-ergoline dopamine agonists in Parkinson’s diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This study identified apomorphine use and levodopa dosages between 500 and 1000 mg as non-genetic and the 15× DRD2 CA repeat allele as genetic determinants for the discontinuation of non-ergoline DA treatment in patients with PD. More research is needed to replicate these findings. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionDOI 10.1007/s00228-009-0708-6Authors Maurits E. L. Arbouw, University Medical Center Utrecht Department of Clinical Pharmacy Utrecht The NetherlandsKris L. L. Movig, Medisch Spectrum Twente Department of Clinical Pharmacy Enschede The...
Source: European Journal of Clinical Pharmacology - August 9, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Risk of digoxin intoxication caused by clarithromycin–digoxin interactions in heart failure patients: a population-based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This study provides empirical evidence that digoxin–clarithromycin interactions do increase the risk of hospitalization for digoxin intoxication in HF patients and that this risk could reach as high as 55.4-fold. We strongly recommend that the combined use of digoxin with clarithromycin should be avoided and that digoxin concentrations should be monitored closely in situations where the combination can not be avoided. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionDOI 10.1007/s00228-009-0698-4Authors Agnes L. F. Chan, Chi Mei Medical Center Department of Pharma...
Source: European Journal of Clinical Pharmacology - August 4, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Age dependency of cerebral P-gp function measured with (R)-[11C]verapamil and PETEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Increased VPM DV values in the brains of elderly subjects suggest a decrease in cerebral P-gp function with increasing age. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00228-009-0709-5Authors Martin Bauer, Medical University of Vienna Department of Clinical Pharmacology Vienna AustriaRudolf Karch, Medical University of Vienna Department of Medical Computer Sciences Vienna AustriaFriederike Neumann, Medical University of Vienna Department of Medical Computer Sciences Vienna AustriaAiman Abrahim, Medical University of Vienna Department of Clinical Pharmacology Vienna A...
Source: European Journal of Clinical Pharmacology - August 4, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Delirium, thrombocytopenia, insomnia, and mild liver damage associated with MAOI withdrawalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorsDOI 10.1007/s00228-009-0711-yAuthors Alfredo Bellon, Psychiatry Centre de Psychiatrie et Neurosciences Paris FranceJohn H. Coverdale, Baylor College of Medicine Menninger Department of Psychiatry & Behavioral Sciences Houston TX USA Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - August 4, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Individualised dosing of amikacin in neonatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorsDOI 10.1007/s00228-009-0691-yAuthors Catherine M. T. Sherwin, Cincinnati Children’s Hospital Medical Centre Division of Clinical Pharmacology 3333 Burnet Avenue, MLC 6018 Cincinnati OH 45229-3039 USARoland S. Broadbent, University of Otago Department of Women’s and Children’s Health, Dunedin School of Medicine P.O. Box 913 Dunedin New ZealandNatalie J. Medlicott, University of Otago New Zealand’s National School of Pharmacy Dunedin New ZealandDavid M. Reith, University of Otago Department of Women’s and Children’s Health, Dunedin School of Medicine ...
Source: European Journal of Clinical Pharmacology - August 4, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Therapeutic efficacy of acenocoumarol in a warfarin-resistant patient with deep venous thrombosis: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorsDOI 10.1007/s00228-009-0710-zAuthors Srecko Marusic, University Hospital Dubrava Department of Clinical Pharmacology Av. Gojka Suska 6 10000 Zagreb CroatiaNives Gojo-Tomic, University Hospital Dubrava Department of Clinical Pharmacology Av. Gojka Suska 6 10000 Zagreb CroatiaMiljenko Franic, University Hospital Dubrava Department of Orthopedic Surgery Av. Gojka Suska 6 10000 Zagreb CroatiaNada Bozina, University Institute of Laboratory Diagnosis, University Hospital Center Zagreb and School of Medicine Salata 2 10000 Zagreb Croatia Journal European Journal...
Source: European Journal of Clinical Pharmacology - August 3, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Assessment of inter-individual variability in predicted phenytoin clearanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Mechanistic modelling and simulation allow inter-individual variability in clearance to be considered during in vitro–in vivo extrapolation, and this approach may offer a superior indication of variability and covariates in the clinic than that provided by small pharmacokinetic studies. Content Type Journal ArticleCategory Pharmacokinetics and DispositionDOI 10.1007/s00228-009-0703-yAuthors Thomas M. Polasek, Flinders University and Flinders Medical Centre Department of Clinical Pharmacology Flinders Drive Adelaide South Australia AustraliaSebastian Polak, Simcyp Limited Sheffield UKMatt...
Source: European Journal of Clinical Pharmacology - July 31, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

The use of driving impairing medicines: a European surveyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions During the study period, trends within countries showed slight to no increase in the consumption of selected medicinal drug groups, with the exception of the antidepressants and the selective serotonin reuptake inhibitors: they showed a remarkable increased use during the study time-frame. Our results illustrate that it is still difficult to perform a valid and comprehensive collection of drug utilization data on driving impairing medicines. Therefore, efforts to harmonize data collection techniques are required and recommended. Content Type Journal ArticleCategory Pharmacoepidemiology and...
Source: European Journal of Clinical Pharmacology - July 30, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Association between the use of anticholinergic antiparkinson drugs and safety and receptor drug-binding profiles of antipsychotic agentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The liability of antipsychotic drugs to cause EPS seemed to vary considerably and largely independently of the distinction between typical and atypical antipsychotics. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionDOI 10.1007/s00228-009-0696-6Authors Pål Gjerden, Telemark Hospital Department of Psychiatry N-3710 Skien NorwayLars Slørdal, Norwegian University of Science and Technology Department of Laboratory Medicine, Children`s and Women`s Health Trondheim NorwayJørgen G. Bramness, University of Oslo Norwegian Centre for Addiction Research Oslo Norway ...
Source: European Journal of Clinical Pharmacology - July 30, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Seretide withdrawal increases airway inflammation in moderate COPD patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorsDOI 10.1007/s00228-009-0697-5Authors Zoe Borrill, University of Manchester Medicines Evaluation Unit Manchester UKKay Roy, University of Manchester Medicines Evaluation Unit Manchester UKUmme Kolsum, University of Manchester Medicines Evaluation Unit Manchester UKTom Southworth, University of Manchester Medicines Evaluation Unit Manchester UKJorgen Vestbo, Northwest Lung Centre Wythenshawe Hospital Manchester UKDave Singh, University of Manchester Medicines Evaluation Unit Manchester UK Journal European Journal of Clinical PharmacologyOnline ISSN 1432-104...
Source: European Journal of Clinical Pharmacology - July 30, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Population pharmacokinetics of recombinant factor VIII:C (ReFacto®) in adult HIV-negative and HIV-positive haemophilia patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Both HIV– and HIV+ patients showed 100% success with the 20% threshold at doses >20 IU/kg. HIV– patients receiving >50 IU/kg had a 100% expected chance of success for all thresholds. HIV+ patients for moderate or life-threatening haemorrhage treatment need 10 IU/kg more than the HIV– patient equivalent to have the same probability of success. Content Type Journal ArticleCategory Pharmacokinetics and DispositionDOI 10.1007/s00228-009-0699-3Authors Anastasia Karafoulidou, Laikon General Hospital 2nd Blood Transfusion Center, Haemophilia Center Athens GreeceElena Suarez, Universit...
Source: European Journal of Clinical Pharmacology - July 30, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals