European Journal of Clinical Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A newly developed algorithm for switching outpatient medications to medications listed in the hospital formulary: a prospective real-word evaluation in patients admitted electively to hospital
ConclusionsDespite comprehensive medication reconciliation, patient- and medication-related information for switching medications to the hospital formulary was often missing. Once all the necessary information was available, standardized switching could be easily carried out according to a newly developed switching algorithm. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 24, 2024 Category: Drugs & Pharmacology Source Type: research

Correction to: Analgesic effect of oral paracetamol 1000 mg/ibuprofen 400 mg, paracetamol 1000 mg/codeine 60 mg, paracetamol 1000 mg/ibuprofen 400 mg/codeine 60 mg, or placebo on acute postoperative pain: a single‑dose, randomized, and double‑blind study
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 24, 2024 Category: Drugs & Pharmacology Source Type: research

Inconclusiveness of psychometric testing of medication adherence questionnaires
ConclusionResults show that assessing the validity and reliability of adherence questionnaires with standard procedures including statistical tests is inconclusive. Refinement of the constructs of non-adherence is needed in pharmacy and medical practice. We suggest a distinction between the (i)extent of missed doses over the past 2 weeks, (ii)modifiable reasons for non-adherence behavior, and (iii)unmodifiable factors of non-adherence. Validation procedures and corresponding statistical methods should be selected according to the specific single constructs. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 22, 2024 Category: Drugs & Pharmacology Source Type: research

Effect of propranolol on pharmacokinetics of clozapine in schizophrenic patients: a meta-analysis
ConclusionThe combination with propranolol could significantly increase systemic exposure and extendedT1/2 of clozapine, and thus need to be considered in prescribing decisions. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 19, 2024 Category: Drugs & Pharmacology Source Type: research

Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
ConclusionWe found that ~ 50% of the pregnant women used medications before and during pregnancy and some took potential teratogenic medications during pregnancy. In birth genomic cohort study, it is expected that investigations into the safety and effectiveness of medications used during pregnancy will advance. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 17, 2024 Category: Drugs & Pharmacology Source Type: research

Albumin: a comprehensive review and practical guideline for clinical use
ConclusionAlbumin administration is most indicated in management of cirrhosis complications. Fluid resuscitation or treatment of severe and refractory edema, especially in patients with hypoalbuminemia and not responding to other treatments, is another rational use for albumin. Implementation of evidence-based guidelines in hospitals can be an effective measure to reduce inappropriate uses of albumin. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 12, 2024 Category: Drugs & Pharmacology Source Type: research

Efficacy and safety of dabigatran and rivaroxaban in atrial fibrillation patients with impaired liver function: a multicenter retrospective cohort study
ConclusionAfter using dabigatran or rivaroxaban, patients with ILF had remarkably increased risk of major bleeding compared with patients with NLF. In AF patients with NLF, dabigatran had the distinct strength of significantly reduced risk of total bleeding compared with rivaroxaban. In patients with AF and ILF, dabigatran use was associated with lower risk for major bleeding compared with rivaroxaban. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 12, 2024 Category: Drugs & Pharmacology Source Type: research

Population pharmacokinetics of cyclosporine A in pediatric patients with thalassemia undergoing allogeneic hematopoietic stem cell transplantation
ConclusionIn the PPK model based on the pediatric cohort on CsA with thalassemia undergoing allogeneic HSCT, WT, POD, FLUC, VORI, POSA, and RBC were found to be the significant factors influencing CL of CsA. The reliability and robustness of the final model were excellent. It is expected that the PPK model can assist in individualizing dosing strategy clinically. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Source Type: research

COVID-19 and pregnancy: A European study on pre- and post-infection medication use
ConclusionOur findings highlight the substantial impact of COVID-19 on primary care medication use among pregnant women, with a marked increase in the use of antithrombotic medications post-COVID-19. These results underscore the need for further research to understand the broader implications of these patterns on maternal and neonatal/fetal health outcomes. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Source Type: research

Serum trough concentration threshold and risk factors of cefoperazone-induced coagulopathy in critically ill patients: A retrospective case-control study
ConclusionCefoperazone-induced coagulopathy usually occurs on the 6th day of cefoperazone use in critically ill patients. The risk will increase in patients with an APACHE II score > 25, hepatic impairment, and cefoperazone Cmin ≥ 87.765 mg/l. Vitamin K1 is effective in preventing this adverse reaction. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Source Type: research

ACD856, a novel positive allosteric modulator of Trk receptors, single ascending doses in healthy subjects: Safety and pharmacokinetics
ConclusionThe prediction proved accurate demonstrating the value of conducting a microdose study prior to ascending dose studies.Trial registrationNCT05783830 March 24, 2023 (microdose study, retrospectively registered) and NCT05077631 October 14, 2021 (single ascending dose study). (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Source Type: research

Understanding hemoglobin contribution to high-dose methotrexate disposition —population pharmacokinetics in pediatric patients with hematological malignancies
ConclusionThe developed population pharmacokinetic model can contribute to the therapy optimization during HDMTX in pediatric patients with ALL and NHL. In addition to renal function and body weight, it describes the influence of hemoglobin on CL, allowing better understanding of its contribution to the disposition of HDMTX. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Source Type: research

The safety and efficacy of dabrafenib and trametinib in patients with glioma: A systematic review and meta-analysis
ConclusionsDabrafenib and trametinib demonstrate promising anti-tumor efficacy in gliomas, particularly low-grade tumors, achieving durable disease stabilization in many patients. However, toxicity significantly limited tolerability. Additional research should further examine efficacy and refine safe administration protocols across glioma subtypes. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Source Type: research