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Insulin-like growth factor-I and its binding proteins 3 and 1 are differentially associated with metabolic syndrome in older men.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In older men, both lower and higher IGF-I and IGFBP3 levels may be metabolically unfavourable. IGFBP1, as a marker of insulin sensitivity, is relevant in the assessment of metabolic syndrome while the IGF-I/IGFBP3 ratio is less informative. Longitudinal follow-up of this cohort would be needed to determine whether these distributions of IGF-I, IGFBP3 and IGFBP1 predict incidence of cardiovascular events during male ageing. PMID: 19917654 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 16, 2009 Category: Endocrinology Authors: Yeap B, Chubb SA, Ho K, Setoh J, McCaul K, Norman PE, Jamrozik K, Flicker L Tags: Eur J Endocrinol Source Type: journals

Investigation of patients with atypical or severe hyperandrogenaemia including androgen-secreting ovarian teratoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Approximately 7% of women of reproductive age manifest polycystic ovary syndrome (PCOS) and <0.5% have other causes of hyperandrogenism including congenital adrenal hyperplasia, androgen-secreting tumour of an ovary or an adrenal gland, Cushing's syndrome or hyperthecosis. The presence of features atypical of PCOS should prompt more extensive evaluation than typically undertaken. Features atypical of PCOS include the onset of symptoms outside the decade 15-25 years, rapid progression of symptoms, the development of virilization or a serum testosterone concentration in excess of twice the upper limit of the reference...
Source: European Journal of Endocrinology - November 11, 2009 Category: Endocrinology Authors: Dennedy M, Smith D, O'Shea D, McKenna T Tags: Eur J Endocrinol Source Type: journals

Isolated Addison's is unlikely to be caused by mutations in MC2R, MRAP or StAR, three genes responsible for familial glucocorticoid deficiency.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions FGD does not appear be underdiagnosed in the AD population. However, in ~50% of patients with FGD no genetic cause has yet been identified and it is possible that the other, as yet unidentified genes giving rise to FGD maybe implicated in AD. PMID: 19903795 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 10, 2009 Category: Endocrinology Authors: Dias R, Chan L, Metherell L, Pearce S, Clark A Tags: Eur J Endocrinol Source Type: journals

Bevacizumab plus capecitabine as a salvage therapy in advanced adrenocortical carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Bevacizumab plus capecitabine has no activity in patients with very advanced ACC. Hence this regimen can not be recommended as a salvage therapy. PMID: 19903796 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 10, 2009 Category: Endocrinology Authors: Wortmann S, Quinkler M, Ritter C, Kroiss M, Johanssen S, Hahner S, Allolio B, Fassnacht M Tags: Eur J Endocrinol Source Type: journals

Effects of long-term L-thyroxine treatment on endothelial function and arterial distensibility in young adults with congenital hypothyroidism.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Young adults with CH treated with long-term L-T4 replacement therapy may have a significant impairment of both FMD and DC. Our data suggest that high TSH levels, inadequately corrected by L-T4 replacement therapy in CH patients in particular during pubertal period, can exert important effects on the elastic and functional vessel properties. PMID: 19903797 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 10, 2009 Category: Endocrinology Authors: Oliviero U, Cittadini A, Bosso G, Cerbone M, Valvano A, Capalbo D, Apuzzi V, Calabrese F, Lettiero T, Salerno M Tags: Eur J Endocrinol Source Type: journals

Hypothalamic-pituitary-adrenal axis response to the severity of illnessin non- critically ill patients. Does relative corticosteroid insufficiency exist?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Mild alterations of the HPA axis, depending on the severity of illness occurred. However, relative corticosteroid insufficiency in non-critically ill nursed patients did not confirm. PMID: 19903798 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 10, 2009 Category: Endocrinology Authors: Michalaki M, Margeli T, Tsekouras A, Gogos C, Vagenakis A, Kyriazopoulou V Tags: Eur J Endocrinol Source Type: journals

Clinical relevance of thyroid dysfunction on human haematopoiesis - biochemical and molecular studies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: i) TH receptor expression in human haematopoietic cells depends on thyroid hormone status, ii) both hypo- and hyperthyroidism significantly influence clonogenicity and induce apoptosis in CD34+-enriched HPCs, and iii) the molecular mechanism by which THs influence haematopoiesis might provide a basis for designing novel therapeutic interventions in thyroid diseases. PMID: 19903799 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 10, 2009 Category: Endocrinology Authors: Kawa M, Grymula K, Paczkowska E, Baskiewicz-Masiuk M, Dabkowska E, Koziolek M, Tarnowski M, Klos P, Dziedziejko V, Kucia M, Syrenicz A, Machalinski B Tags: Eur J Endocrinol Source Type: journals

Herpes virus type 7 infection may play an important role in individuals with a genetic profile of susceptibility to Graves' disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We suggest that an inherited genetic profile involving TP53 may favor HHV-7 infection and maintenance which, in turn, may initiate and perpetuate GD autoimmune process. PMID: 19903800 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 10, 2009 Category: Endocrinology Authors: Leite J, Bufalo N, Santos R, Romaldini J, Ward L Tags: Eur J Endocrinol Source Type: journals

Trough serum testosterone predicts the development of polycythemia in hypogonadal men treated for up to 21 years with subcutaneous testosterone pellets.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Higher trough serum testosterone concentrations but not duration of treatment predicts the development of polycythemia in men receiving long-acting depot testosterone treatment. PMID: 19903801 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 10, 2009 Category: Endocrinology Authors: Ip F, di Pierro I, Brown R, Cunningham I, Handelsman D, Liu PY Tags: Eur J Endocrinol Source Type: journals

Lower early morning plasma cortisol levels are associated with thyroid autoimmunity in the elderly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Reduced glucocorticoid activity is associated with an increased prevalence of ThAbs positivity in older ambulatory subjects. Subjects without ThAbs in this population sample are relatively older. It is not known if this is related to increasing glucocorticoid activity with age. PMID: 19903802 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 10, 2009 Category: Endocrinology Authors: Terzidis K, Panoutsopoulos A, Mantzou E, Tourli P, Papageorgiou G, Saltiki K, Mara C, Alevizaki M Tags: Eur J Endocrinol Source Type: journals

Autosomal recessive familial neurohypophyseal diabetes insipidus - onset in early infancy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This is the first description of autosomal recessive FNDI presenting in the neonatal period. The unusual early clinical and radiological (MRI) presentation argues against gradual destruction of AVP secreting neurons as the pathophysiologic mechanism. Factors beside allelism of AVP related genes must influence the age of FNDI presentation given the founder effect demonstrated for the P26L mutation. PMID: 19897608 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 6, 2009 Category: Endocrinology Authors: Abu-Libdeh A, Levy-Khademi F, Abdulhadi-Atwan M, Bosin E, Korner M, White P, Zangen D Tags: Eur J Endocrinol Source Type: journals

Serum glucose and insulin are associated with QTc and RR intervals in non-diabetic elderly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We demonstrated in this population-based study that impaired fasting glucose and hyperinsulinemia are associated with a significantly increased QTc-interval and with significant shortening of the RR interval. In addition, we demonstrated that both a prolonged QTc as well as a shortened RR interval are associated with an increased risk of SCD. PMID: 19897609 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 6, 2009 Category: Endocrinology Authors: van Noord C, Sturkenboom M, Straus S, Hofman A, Kors J, Witteman J, Stricker B Tags: Eur J Endocrinol Source Type: journals

No recurrence of sporadic primary hyperparathyroidism when cure is established 6 months after parathyroidectomy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The cure rate of sporadic primary hyperparathyroidism after initial surgery is 93%. When cure is achieved, this is sustained in 100% of patients for up to 24 years post-operatively. Our data suggest that closer early follow-up is advocated in all patients undergoing PTx to definitively establish cure and to provide a safety net for those with residual gland pathology. The data do not support the need for long term follow-up when cure is established 6 months after PTx. PMID: 19884262 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 2, 2009 Category: Endocrinology Authors: Witteveen J, Kievit J, Morreau H, Romijn J, Hamdy N Tags: Eur J Endocrinol Source Type: journals

Increased suppression of serum ghrelin concentration by hyperinsulinemia in women with anorexia nervosa.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Women with AN have an increased suppression of serum ghrelin by hyperinsulinemia. This phenomenon might lead to an increased and more rapid feeling of satiety in AN. PMID: 19884263 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 2, 2009 Category: Endocrinology Authors: Karczewska-Kupczewska M, Straczkowski M, Adamska A, Nikolajuk A, Otziomek E, Gorska M, Kowalska I Tags: Eur J Endocrinol Source Type: journals

Raloxifene and body composition and muscle strength in postmenopausal women: A randomized, double-blind, placebo-controlled trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Raloxifene significantly changed (increased fat-free mass; increased water content) body composition compared with placebo in postmenopausal women. Keywords: Raloxifene; body composition, postmenopausal Trial registration number: NTR: 1232. PMID: 19884264 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 2, 2009 Category: Endocrinology Authors: Jacobsen D, Samson M, Emmelot M, Verhaar H Tags: Eur J Endocrinol Source Type: journals

Cytotoxic T lymphocyte antigen-4 Ala17 polymorphism is a genetic marker of autoimmune adrenal insufficiency: Italian association study and meta-analysis of European studies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The CTLA4 +49 polymorphism is strongly associated with genetic risk for AAD, independentenly from the well known association with HLA class II genes. PMID: 19884265 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 2, 2009 Category: Endocrinology Authors: Brozzetti A, Marzotti S, Tortoioli C, Bini V, Giordano R, Dotta F, Betterle C, De Bellis A, Arnaldi G, Toscano V, Arvat E, Bellastella A, Mantero F, Falorni A Tags: Eur J Endocrinol Source Type: journals

ACROSTUDY: the first 5 years.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the safety data are generally reassuring, while the IGF1 normalisation rate is disappointing, which probably reflects a failure of dose titration. Further effort is needed to understand the reasons for the failure of dose titration. PMID: 19684052 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2009 Category: Endocrinology Authors: Trainer PJ Tags: Eur J Endocrinol Source Type: journals

From isolated GH deficiency to multiple pituitary hormone deficiency: an evolving continuum - a KIMS analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Both AO-IGHD and -MPHD patients have similar baseline clinical presentation and respond equally well to 2 years of GH replacement. Hypopituitarism in adults seems to be a dynamic condition where new deficiencies can appear years after the initial diagnosis, and careful endocrine follow-up of all hypopituitary patients, including those with IGHD, is warranted. PMID: 19684053 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2009 Category: Endocrinology Authors: Klose M, Jonsson B, Abs R, Popovic V, Koltowska-Häggström M, Saller B, Feldt-Rasmussen U, Kourides I Tags: Eur J Endocrinol Source Type: journals

GH replacement in adults: interactions with other pituitary hormone deficiencies and replacement therapies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Severe GH deficiency (GHD) in adults has been described as a clinical entity. However, some of the features associated with GHD could be due to unphysiological and inadequate replacement of other pituitary hormone deficiencies. This may be true for glucocorticoid replacement that lacks a biomarker making dose titration and monitoring difficult. Moreover, oral estrogen replacement therapy decreases IGF1 levels compared with the transdermal route, which attenuates the responsiveness to GH replacement therapy in women. In addition, in untreated female hypogonadism, oral estrogen may augment the features associated with GH...
Source: European Journal of Endocrinology - November 1, 2009 Category: Endocrinology Authors: Filipsson H, Johannsson G Tags: Eur J Endocrinol Source Type: journals

Assessment of quality of life in adult patients with GH deficiency: KIMS contribution to clinical practice and pharmacoeconomic evaluations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Quality of life (QoL) has emerged as an important construct that has found numerous applications across healthcare-related fields, ranging from research and clinical evaluation of treatment effects to pharmacoeconomic evaluations and global healthcare policy. Impairment of QoL is one of the key clinical characteristics in adult GHD and has been extensively studied in the Pfizer International Metabolic Database (KIMS). We provide summarized evidence on GH treatment effects for both clinical and health economic applications based on the KIMS data. The primary focus is on those aspects of QoL research that cannot be inves...
Source: European Journal of Endocrinology - November 1, 2009 Category: Endocrinology Authors: Koltowska-Häggström M, Mattsson AF, Shalet SM Tags: Eur J Endocrinol Source Type: journals

Cardiovascular risk factors in hypopituitary GH-deficient adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Taken together, data from KIMS confirm earlier knowledge about the important benefits of GH replacement therapy, but also on the use of GH in specific subgroups such as isolated GHD, patients above 65 years, and patients after irradiation. No subgroup yet has been identified as not responding well to GH. PMID: 19684057 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2009 Category: Endocrinology Authors: Verhelst J, Abs R Tags: Eur J Endocrinol Source Type: journals

Adult GH deficiency throughout lifetime.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is now accepted that adults with severe GH deficiency (GHD) demonstrate impaired physical and psychological well-being and may benefit from replacement with recombinant human GH. Post-marketing surveillance surveys, such as the Pfizer International Metabolic Database (KIMS), were initially set-up to provide safety data on long-term treatment but have the added benefit of providing ongoing observational data on the effect of GH replacement on body composition, lipid and glucose status, hypertension, bone density and quality of life. These data demonstrate that although GHD has clinical impact at all ages, the individ...
Source: European Journal of Endocrinology - November 1, 2009 Category: Endocrinology Authors: Thomas JD, Monson JP Tags: Eur J Endocrinol Source Type: journals

The value of IGF1 estimation in adults with GH deficiency.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The GH/IGF1 system, like other endocrine systems, is dynamic and its activity changes with age and sexual maturation, and is influenced by body composition and other factors. A normal level of IGF1 does not exclude a diagnosis of GH deficiency (GHD) in adults, and the usefulness of IGF1 in the diagnosis of adult GHD has historically been confusing and contentious. The regulation of IGF1 secretion in adults is complex, and is not solely dependent on GH status with factors recognized to influence IGF1 status in patients with GHD including age, gender, exogenous estrogen therapy, prolactin status, and severity of GHD. The...
Source: European Journal of Endocrinology - November 1, 2009 Category: Endocrinology Authors: Mukherjee A, Shalet SM Tags: Eur J Endocrinol Source Type: journals

Etiology, baseline characteristics, and biochemical diagnosis of GH deficiency in the adult: are there regional variations?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous work has examined potential links between the etiology of GH deficiency (GHD) and the baseline characteristics of the patients including biochemical and psychometric parameters. Using an update of the KIMS pharmaco-epidemiological database (Pfizer International Metabolic Database), we addressed the question how well such results can be generalized and whether regional differences may play a role. From 30 different countries, 13 167 GH-deficient patients were included in KIMS at the data close in December 2008. In order to explore country-specific differences of baseline characteristics documented in KIMS, sepa...
Source: European Journal of Endocrinology - November 1, 2009 Category: Endocrinology Authors: Brabant G, Poll EM, Jönsson P, Polydorou D, Kreitschmann-Andermahr I Tags: Eur J Endocrinol Source Type: journals

Treatment with GH in adults with GH deficiency. Foreword.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19808900 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 1, 2009 Category: Endocrinology Authors: Wilton P Tags: Eur J Endocrinol Source Type: journals

Enhanced insulin sensitivity after acute exercise is not associated with changes in high-molecular weight adiponectin concentration in plasma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Changes in HMW adiponectin concentration are not involved in the acute exercise-induced enhancement of insulin action. PMID: 19864294 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 28, 2009 Category: Endocrinology Authors: Magkos F, Mohammed B, Mittendorfer B Tags: Eur J Endocrinol Source Type: journals

Increased risk of thyroid pathology in patients with thyroid hemiagenesis: results of a large cohort case-control study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results revealed that individuals with THA are more likely to develop thyroid pathology. The observed high incidence of associated pathologies is presumably due to long-lasting TSH overstimulation. Therefore, THA diagnosis should be followed by systematic observation and adequate levothyroxine treatment, in patients with elevated TSH level. PMID: 19846597 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 20, 2009 Category: Endocrinology Authors: Ruchala M, Szczepanek E, Szaflarski W, Moczko J, Czarnywojtek A, Pietz L, Nowicki M, Niedziela M, Zabel M, Köhrle J, Sowinski J Tags: Eur J Endocrinol Source Type: journals

Serum 25 (OH)D3 vitamin status of elderly Finnish women is suboptimal even after summer sunshine but is not associated with bone density or turnover.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Vitamin D status of elderly Finnish women is suboptimal if 25(OH)D3 levels of 50 or 75 nmol/l are used as a threshold. It is moderately increased by supplement intake and summer sunshine. However, 25(OH)D3 concentrations did not determine bone density and in terms of serum PINP bone turnover rate. PMID: 19841043 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 18, 2009 Category: Endocrinology Authors: Pekkarinen T, Turpeinen U, Hämäläinen E, Loyttyniemi E, Alfthan H, Valimaki M Tags: Eur J Endocrinol Source Type: journals

Overweight is associated with impaired beta-cell function during pregnancy: A longitudinal study of 553 normal pregnancies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Beta-cell function adjusted for insulin sensitivity (DIo) deteriorated during pregnancy in both glucose tolerant and glucose intolerant women. The failure to compensate the decrease in insulin sensitivity was accentuated in overweight women. PMID: 19841044 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 18, 2009 Category: Endocrinology Authors: Qvigstad E, Voldner N, Godang K, Henriksen T, Bollerslev J Tags: Eur J Endocrinol Source Type: journals

Metformin :An old medication of new fashion in PCOS.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PCOS is now recognized to be the most common endocrinopathy in women of reproductive age with a prevalence of 6.6 - 6.8%. PCOS a syndrome of unknown aetiology,was initially regarded as a reproductive disorder. However the last fifteen years the role of insulin resistance has been identified as a significant contributor to the pathogenesis of PCOS and the metabolic and cardiovascular sequelae of the syndrome have been increasingly appreciated. The coexistence and interaction of reproductive and cardiometabolic abnormalities in the context of PCOS have created a need for a modified therapeutic management of affected wome...
Source: European Journal of Endocrinology - October 18, 2009 Category: Endocrinology Authors: Diamanti-Kandarakis E, Christakou C, Kandaraki E, Economou F Tags: Eur J Endocrinol Source Type: journals

Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The -11391A ADIPOQ gene variant was associated with increased chance of being born LGA and with higher adiponectin levels in early adult life. PMID: 19841046 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 18, 2009 Category: Endocrinology Authors: Bueno A, Espiñeira A, Fernandes-Rosa F, Souza R, De Castro M, Moreira A, Bettiol H, Barbieri M, Antonini S Tags: Eur J Endocrinol Source Type: journals

Insulin resistance in hyperthyroidism: the role of IL-6 and TNF{alpha}Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In hyperthyroidism: (1) glucose and lipid metabolism are resistant to insulin (2) subcutaneous AT releases IL-6 which could then act as an endocrine mediator of insulin resistance (3) although there is no net secretion of TNFalpha by the subcutaneous AT, increased systemic TNFalpha levels may be related to the development of insulin resistance in lipolysis. PMID: 19837795 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 15, 2009 Category: Endocrinology Authors: Mitrou P, Boutati E, Lambadiari V, Tsegka A, Raptis A, Tountas N, Economopoulos T, Raptis S, Dimitriadis G Tags: Eur J Endocrinol Source Type: journals

Clinical and molecular features of differentiated thyroid cancer diagnosed during pregnancy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: present data indicate that pregnancy has a negative impact on the outcome of thyroid cancer. The presence of ERalpha in the majority of tumors diagnosed during pregnancy indicates that the poorer outcome of these cases could be related to the estrogen-mediated growth stimulus. PMID: 19828692 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 13, 2009 Category: Endocrinology Authors: Vannucchi G, Perrino M, Rossi S, Colombo C, Vicentini L, Dazzi D, Beck-Peccoz P, Fugazzola L Tags: Eur J Endocrinol Source Type: journals

The pituitary-adrenal axis in adult thalassaemic patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Adult thalassaemic patients often present a subtle impairment of adrenocortical function. This may become clinically relevant in case of major stressful events. Thus, we recommend an assessment of adrenocortical function in all adult thalassaemic patients. PMID: 19820036 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 8, 2009 Category: Endocrinology Authors: Scacchi M, Danesi L, Cattaneo A, Valassi E, Pecori Giraldi F, Radaelli P, Ambrogio A, D'Angelo E, Mirra N, Zanaboni L, Cappellini MD, Cavagnini F Tags: Eur J Endocrinol Source Type: journals

Relationships between FSH, inhibin B, anti-Mullerian hormone and testosterone during long-term treatment with the GnRH-agonist Histrelin in patients with prostate cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The secondary increase in FSH following initial suppression with the implant is probably related to impaired inhibin B secretion. The lack of inhibin B response to the secondary increase in FSH suggests that long-term exposure of Sertoli-cells to GnRH-agonist impairs their function. This effect appears to be selective since unlike inhibin B, AMH increased. In the absence of testosterone, FSH has a role in AMH regulation. PMID: 19820037 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 8, 2009 Category: Endocrinology Authors: Eldar-Geva T, Libery G, Chertin B, Fridmans A, Farkas A, Margalioth E, Spitz I Tags: Eur J Endocrinol Source Type: journals

Identification and characterisation of a novel GHR defect disrupting the polypyrimidine tract and resulting in growth hormone insensitivity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Disruption of the GHR polypyrimidine tract causes aberrant mRNA splicing leading to a mutant GHR protein. This is predicted to lack its transmembrane and intracellular domains and, thus, be incapable of transducing a GH signal. PMID: 19812236 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 6, 2009 Category: Endocrinology Authors: David A, Miraki-Moud F, Shaw N, Savage M, Clark A, Metherell L Tags: Eur J Endocrinol Source Type: journals

Severe XIST hypomethylation clearly distinguishes (SRY+) 46,XX-maleness from Klinefelter syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: XIST hypomethylation clearly distinguishes (SRY+) XX-males from Klinefelter men. It does not, however, impair appropriate epigenetic regulation of representative X-linked loci. PMID: 19812237 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 6, 2009 Category: Endocrinology Authors: Poplinski A, Wieacker P, Kliesch S, Gromoll J Tags: Eur J Endocrinol Source Type: journals

Introduction: KIMS and ACROSTUDY Supplement.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
KIMS and ACROSTUDY are two observational surveys (ObS) of treatment with growth hormone in adults with pituitary deficiency and growth hormone receptor blocker in patients with acromegaly respectively. Pro and cons of ObS versus randomized clinical trials are discussed in this paper as well as some introductury remarks of the papers in this supplement of EJE. PMID: 19808900 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 5, 2009 Category: Endocrinology Authors: Wilton P Tags: Eur J Endocrinol Source Type: journals

The PPAR-{gamma} Pro12Ala polymorphism associates with weight gain during GH-treatment in short children born small for gestational age.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The Ala12 variant of the PPARgamma gene is associated with higher weight gain during GH-treatment but not with changes in determinants of metabolic and cardiovascular diseases in Caucasian subjects born SGA. PMID: 19808901 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 5, 2009 Category: Endocrinology Authors: de Kort S, Hokken-Koelega A Tags: Eur J Endocrinol Source Type: journals

Do we need still more trials on T4 and T3 combination therapy in hypothyroidism?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Approximately 10% of hypothyroid patients are dissatisfied with the outcome of levothyroxine replacement. It is unlikely that slight over- or under-treatment with T4 explains remaining complaints. Meta-analysis of randomized clinical trials shows no advantage of T4/T3 combination therapy over T4 monotherapy. However, each of these trials can be criticized, and none is perfect: most of them failed to mimick the physiological ratio of serum FT4 to FT3 concentrations. Development of a sustained-release T3 preparation given as a single night-time dose (together with levothyroxine once daily) might maintain physiological se...
Source: European Journal of Endocrinology - October 5, 2009 Category: Endocrinology Authors: Wiersinga W Tags: Eur J Endocrinol Source Type: journals

A detour guide to The Endocrine Society Clinical Practice Guideline on case detection, diagnosis and treatment of patients with primary aldosteronism.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Endocrine Society USA commissions clinical practice guidelines that address topics of major interest to the Endocrine community and for which international consensus is urgently needed. In this issue of the European Journal of Endocrinology we have reprinted the Clinical Practice Guideline on diagnosis and treatment of primary aldosteronism, which has already appeared in our American partner journal, the Journal of Clinical Endocrinology, Diabetes and Metabolism. PMID: 19797500 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 30, 2009 Category: Endocrinology Authors: Arlt W Tags: Eur J Endocrinol Source Type: journals

Technical details influence the diagnostic accuracy of the 1 mcg ACTH stimulation test.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The high rate of abnormal results, especially in the afternoon, and loss of ACTH through tubing, suggest that morning testing and minimal tubing should be adopted to avoid an inappropriate diagnosis of adrenal insufficiency. Earlier time-points and standardized protocols would facilitate comparison of studies. PMID: 19797501 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 30, 2009 Category: Endocrinology Authors: Wade M, Baid S, Calis K, Raff H, Sinaii N, Nieman L Tags: Eur J Endocrinol Source Type: journals

Validity and reliability of the novel thyroid-specific quality of life questionnaire, ThyPRO.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We found support for the clinical validity of the new thyroid-specific quality of life questionnaire ThyPRO and evidence of good test-retest reliability. The questionnaire is now ready for use in clinical studies of patients with thyroid diseases. PMID: 19797502 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 30, 2009 Category: Endocrinology Authors: Watt T, Hegedus L, Groenvold M, Bjorner J, Rasmussen A, Bonnema S, Feldt-Rasmussen U Tags: Eur J Endocrinol Source Type: journals

Post-surgical hypocortisolism after removal of an adrenal incidentaloma: is it predictable by an accurate endocrinological work-up before surgery?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Post-surgical hypocortisolism cannot be pre-surgically ruled out. A steroid substitutive therapy is indicated after unilateral adrenalectomy for SH or size of the adenoma. PMID: 19797503 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 30, 2009 Category: Endocrinology Authors: Eller-Vainicher C, Morelli V, Salcuni A, Torlontano M, Coletti F, Iorio L, Cuttitta A, Ambrosio A, Vicentini L, Carnevale V, Beck-Peccoz P, Arosio M, Ambrosi B, Scillitani A, Chiodini I Tags: Eur J Endocrinol Source Type: journals

Case detection, diagnosis, and treatment of patients with primary aldosteronism: an Endocrine Society clinical practice guideline.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objective: Our objective was to develop clinical practice guidelines for the diagnosis and treatment of patients with primary aldosteronism. Participants: The Task Force comprised a chair, selected by the Clinical Guidelines Subcommittee (CGS) of The Endocrine Society, six additional experts, one methodologist, and a medical writer. The Task Force received no corporate funding or remuneration. Evidence: Systematic reviews of available evidence were used to formulate the key treatment and prevention recommendations. We used the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) group criteria to...
Source: European Journal of Endocrinology - September 29, 2009 Category: Endocrinology Authors: Funder J, Carey R, Fardella C, Gomez-Sanchez C, Mantero F, Stowasser M, Young W, Montori VM Tags: Eur J Endocrinol Source Type: journals

Nodular disease and parafollicular C-cell distribution: results from a prospective and retrospective clinico-pathological study on thyroid isthmus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. STINs are significantly less likely to be MTC in patients presenting with sporadic disease. Therefore, Ct screening is not warranted in these subjects. Nonetheless, STINs are more likely to be neoplastic and deserve equal attention as those of lateral lobes. PMID: 19793761 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 29, 2009 Category: Endocrinology Authors: Papi G, Rossi G, Corsello S, Corrado S, Fadda G, Di Donato C, Pontecorvi A Tags: Eur J Endocrinol Source Type: journals

Persistent increase of osteoprotegerin levels after cortisol normalization in patients with Cushing's syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In CS we found increased OPG that remained unchanged after recovery. High OPG was also observed in microvascular damage and was associated to an increased cardiovascular mortality. Therefore, high levels of OPG could reflects the persistent damage of the GCs on cardiovascular system. PMID: 19793762 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 29, 2009 Category: Endocrinology Authors: Camozzi V, Sanguin F, Albiger N, Scaroni C, Mantero F, Zaninotto M, Frigo A, Piccolo M, Luisetto G Tags: Eur J Endocrinol Source Type: journals

Geographical correlation between incidence of benign disease and that of cancer of the thyroid among the population of the Rhone-Alpes region of France.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In the Rhône-Alpes population with high rates of thyroid cancer incidence and of thyroid surgery, a number of correlations were found according to gender and tumor size. However, the general incidence of cancer was not directly related to surgical activity. Geographical variability may be related to heterogeneous medical and pathological practices. PMID: 19797258 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 28, 2009 Category: Endocrinology Authors: Sassolas G, Hafdi-Nejjari Z, Schott AM, Bournaud C, Peix JL, Orgiazzi J, Berger-Dutrieux N, Borson-Chazot F Tags: Eur J Endocrinol Source Type: journals

Hypopituitarism following traumatic brain injury: the prevalence is affected by the use of different dynamic tests and different normal values.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The reported variations in the prevalence rates of hypopituitarism after TBI are in part caused by differences in definitions, endocrine assessments of hypopituitarism and confounding factors. These methodological issues prohibit simple generalizations of results of original studies on TBI-associated hypopituitarism in the perspective of meta-analyses or reviews. PMID: 19783619 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 24, 2009 Category: Endocrinology Authors: Kokshoorn N, Wassenaar M, Biermasz N, Roelfsema F, Smit J, Romijn J, Pereira A Tags: Eur J Endocrinol Source Type: journals

Should anterior pituitary function be tested during follow-up of all patients presenting at the emergency department because of traumatic brain injury?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Applying strict diagnostic criteria to an emergency-department-based cohort of TBI patients showed that anterior pituitary dysfunction is rare (<1%). Routine pituitary screening in unselected patients after TBI is unlikely to be cost-effective. PMID: 19783620 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 24, 2009 Category: Endocrinology Authors: van der Eerden A, Twicker M, Sweep F, Beems T, Hendricks H, Hermus A, Vos P Tags: Eur J Endocrinol Source Type: journals