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Successful umbilical cord blood stem cell transplantation in a child with WHIM syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - November 19, 2009 Category: Hematology Authors: Gergely Kriván, Melinda Erdős, Krisztián Kállay, Gábor Benyó, Ágnes Tóth, János Sinkó, Vera Goda, Beáta Tóth, László Maródi Source Type: journals

Significance of quantitative measurement of heparin-induced platelet antibodiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The measurement of anti-PF4/heparin antibody concentration is a new parameter that may improve the diagnosis of HIT. All samples with extremely strong antibody concentration were positive also by HIPA. For accuracy, antibody concentrations must be in the linear range of the assay and an international standard is needed. (Source: European Journal of Haematology)
Source: European Journal of Haematology - November 12, 2009 Category: Hematology Authors: Kaija Javela, Riitta Kekomäki, Sinikka Koskinen Source Type: journals

Treatment practices in adults with chronic immune thrombocytopenia – a European perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Immune thrombocytopenia (ITP) is characterised by platelet destruction and impaired production leading to isolated thrombocytopenia. The aim of this study, comprising a retrospective longitudinal cohort study complemented by a Delphi panel of 35 physicians, was to describe standard treatment practices and treating physician's perception and preferences for available treatment options in chronic ITP. The medical records of 610 patients were reviewed over 12 months. Mean age at the start of the observational period was 54.6 yr, median platelet count 77 × 109/L with 41% of patients having symptoms of ITP. Treated patients (6...
Source: European Journal of Haematology - November 10, 2009 Category: Hematology Authors: Francesco Rodeghiero, Juan Besalduch, Marc Michel, Drew Provan, Kelly Grotzinger, Gwilym Thompson Source Type: journals

Severe paraneoplastic pemphigus in a patient with follicular lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - November 6, 2009 Category: Hematology Authors: Christian Krogel, Thomas Fischer, Florian Heidel Source Type: journals

Follicular dendritic cells in multicentric Castleman disease present human herpes virus type 8 (HHV8)-latent nuclear antigen 1 (LANA1) in a proportion of cases and is associated with an enhanced T-cell responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Multicentric Castleman disease (MCD) is a rare human herpes virus type 8 (HHV8)-associated lymphoproliferative disorder that occurs more frequently in patients infected with human immunodeficiency virus (HIV). In tissue samples, HHV8-infected plasmablasts localise to the mantle zones of the lymphoid follicles. We revisited the immunohistological features in 25 lymph node (LN) and three spleen samples of MCD. In five (20%) LN and one (33%) spleen sample, HHV8 latent nuclear antigen 1 (LANA1) staining was also noted on the follicular dendritic cells (FDC). The HHV8-positive FDC subgroup of patients had significantly higher n...
Source: European Journal of Haematology - October 30, 2009 Category: Hematology Authors: Hesham El-Daly, Mark Bower, Kikkeri N. Naresh Source Type: journals

Clinical significance of detection of immature platelets: comparison between percentage of reticulated platelets as detected by flow cytometry and immature platelet fraction as detected by automated measurementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - October 28, 2009 Category: Hematology Authors: Yukako Koike, Koji Miyazaki, Masaaki Higashihara, Emiko Kimura, Masahiro Jona, Kinya Uchihashi, Akiko Masuda, Koji Kandabashi, Mineo Kurokawa, Yutaka Yatomi Source Type: journals

Differential expression of HOXB7 gene in multiple myeloma and extramedullary multiple myeloma patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - October 28, 2009 Category: Hematology Authors: Estela M. Novak, Camila Linardi, Martin Metzger, Durvanei A. Maria, Ricardo R. Giorgi, Fernanda Moura, Gracia A. Martinez, Sérgio P. Bydlowski Source Type: journals

Novel immunophenotypic and morphologic presentation in acute myeloid leukemia (AML) with JAK2 V617F mutationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - October 12, 2009 Category: Hematology Authors: Suchitra Swaminathan, Manisha Madkaikar, Kanjaksha Ghosh, Babu Rao Vundinti, Lily Kerketta, Maya Gupta Source Type: journals

Chronic haemolytic anaemia because of pyruvate kinase (PK) deficiency in a child heterozygous for haemoglobin S and no clinical features of sickle cell diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - October 8, 2009 Category: Hematology Authors: Licínio Manco, José Manuel Vagace, Luís Relvas, Umbelina Rebelo, Celeste Bento, Ana Villegas, Maria Letícia Ribeiro Source Type: journals

Effect of combination therapy of hydroxyurea with l-carnitine and magnesium chloride on hematologic parameters and cardiac function of patients with β-thalassemia intermediaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Combination of hydroxyurea with l-carnitine or magnesium could be more effective in improving hematologic parameters and cardiac status in patients with [beta]-thalassemia intermedia than hydroxyurea alone. (Source: European Journal of Haematology)
Source: European Journal of Haematology - October 3, 2009 Category: Hematology Authors: Mehran Karimi, Faranak Mohammadi, Farzane Behmanesh, Soleiman M. Samani, Mohammad Borzouee, Hamid Amoozgar, Sezaneh Haghpanah Source Type: journals

BCR-ABL positive cells and chronic myeloid leukemia in immune suppressed organ transplant recipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The constitutively activated tyrosine kinase activity of the p210bcr-abl fusion protein, generated by a t(9;22)(q34;q11) chromosomal translocation, is pathogenetically associated with chronic myeloid leukemia (CML). However, mechanisms contributing to the expansion of a BCR-ABL positive clone are largely obscure. In the presence of an impaired immune surveillance, cells carrying any of these alterations may become phenotypically relevant. Therefore, immunosuppressed solid organ recipients represent an optimal population to investigate the frequency of mRNA products of this translocation. Blood leukocytes were studied in 20...
Source: European Journal of Haematology - October 3, 2009 Category: Hematology Authors: Philipp le Coutre, Petra Reinke, Ruth Neuhaus, Ralf Trappe, Frauke Ringel, Marc Lalancette, Philipp G. Hemmati, Bernd Dörken, Peter T. Daniel Source Type: journals

No evidence for myocardial iron overload and free iron species in multitransfused patients with sickle/β0-thalassaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Iron overload (IO) in the heart is a life-threatening complication in transfusion-dependent patients with thalassaemia major (TM) and to a lesser extent in sickle cell disease (SCD), while no data are available in patients with sickle/[beta]0-thalassaemia. Iron deposition in the heart, liver and pancreas was assessed using T2* MRI sequences, as well as free iron species assays [ndash] non-transferrin bound iron (NTBI) and labile plasma iron (LPI), in addition to serum ferritin, percentage transferrin saturation and serum hepcidin, in 10 multitransfused patients (>30 yr) with sickle/[beta]0-thalassaemia. None of the patient...
Source: European Journal of Haematology - September 29, 2009 Category: Hematology Authors: Hussam Ghoti, Orly Goitein, Ariel Koren, Carina Levin, Tamar Kushnir, Eliezer Rachmilewitz, Eli Konen Source Type: journals

Haematologic data, iron parameters and molecular findings in two new cases of iron-refractory iron deficiency anaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe two new cases of IRIDA, one patient of Swiss origin and the second of Italian origin. The first case results from a large deletion of 1054 nucleotides corresponding to an in frame deletion of 30 amino acid residues in the low-density lipoprotein receptor-1/-2 (LDLR-1/-2) domains and from a missense mutation in CUB1 (S304L). In the second case, a homozygous G[rarr]C mutation in the last nucleotide of exon 15 and which modified the consensus sequence of the 5' splice donor site of intron 15 (AGgt[rarr]ACgt) was identified. Both patients had a high hepcidin level and low serum iron and transferrin saturation compa...
Source: European Journal of Haematology - September 18, 2009 Category: Hematology Authors: Isabelle Tchou, Myriam Diepold, Pierre-Antonio Pilotto, Dorine Swinkels, Marguerite Neerman-Arbez, Photis Beris Source Type: journals

Optimization of isolation and further characterization of umbilical cord blood-derived very small embryonic/ epiblast-like stem cells (VSELs)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Because of their small size and density, umbilical cord blood (UCB)-derived very small embryonic/epiblast-like stem cells (VSELs) are usually lost at various steps of UCB preparation. Accordingly, we noticed that a significant number of these cells, which are smaller than erythrocytes, are lost during gradient centrifugation over Ficoll-Paque as well as during routine volume depletion of UCB units before freezing. To preserve these cells in final UCB preparations, we propose a relatively short and economical three-step isolation protocol that allows recovery of approximately 60% of the initial number of Lin[minus]/CD45[min...
Source: European Journal of Haematology - September 13, 2009 Category: Hematology Authors: Ewa K. Zuba-Surma, Iza Klich, Nick Greco, Mary J. Laughlin, Janina Ratajczak, Mariusz Z. Ratajczak Source Type: journals

The role of microRNAs in normal and malignant hematopoiesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
MicroRNAs are small non-coding RNAs that act at the post-transcriptional level, regulating protein expression by repressing translation or destabilizing mRNA target. Because of their discovery, microRNAs have been associated with almost every normal cell function, including proliferation, differentiation and apoptosis. Several lines of evidence suggest that they have an important role in normal hematopoiesis as exemplified by the role of mir-155 and mir-150 in the differentiation of B and T lymphocytes, the suppressive role of mir-221 and mir-222 in erythroid differentiation, the inhibitory effect of mir-181 on hematopoiet...
Source: European Journal of Haematology - September 9, 2009 Category: Hematology Authors: Diamantina Vasilatou, Sotirios Papageorgiou, Vassiliki Pappa, Efstathios Papageorgiou, John Dervenoulas Source Type: journals

Elevated serum parathormone levels are associated with myocardial iron overload in patients with β-thalassaemia majorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objectives: Despite advances in conventional treatment, iron-induced cardiomyopathy is still the most frequent cause of death among patients with [beta]-thalassaemia major. Recent studies have correlated increased myocardial iron content to decreased levels of vitamin D in thalassaemic patients. The aim of this study was to measure parathormone (PTH) and metabolites of vitamin D and consequently to investigate whether these parameters predispose to myocardial iron overload in patients with [beta]-thalassaemia major.Methods: In 62 patients (29 M and 33 F, mean age: 22.79 ± 6.18 yr) with [beta]-thalassaemia major levels of ...
Source: European Journal of Haematology - September 9, 2009 Category: Hematology Authors: Meropi Dimitriadou, Athanasios Christoforidis, Marina Economou, Ioanna Tsatra, Efthimia Vlachaki, Liana Fidani, George Katzos, Miranda Athanassiou-Metaxa Source Type: journals

Chronic myeloid leukemia and BCR/ABL signal pathways are not associated with AKT1 pleckstrin homology domain (E17K) mutationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - September 9, 2009 Category: Hematology Authors: Yanli He, Jine Zheng, Yanjie Hu, Hong Xiao, Jun Liu, Xiaoqing Li, Wen Du, Xiangjun Chen, Yu Hu, Shiang Huang Source Type: journals

Hyperhemolysis syndrome in a patient with sickle cell disease with erythrophagocytosis in peripheral bloodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - September 9, 2009 Category: Hematology Authors: Md S. Islam, Lianwea Chia Source Type: journals

Human platelet alloantigens (HPA) 1, HPA2, HPA3, HPA4, and HPA5 polymorphisms in sickle cell anemia patients with vaso-occlusive crisisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This confirms the association of HPA polymorphisms with SCA VOC, of which HPA-3 appears to be independent genetic risk factors for SCA VOC. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 9, 2009 Category: Hematology Authors: Abeer M. Al-Subaie, Najat Mahdi, Iman K. Al-Absi, Khadija Al-Ola, Ghada Ameen, Wassim Y. Almawi Source Type: journals

Intra-atrial thrombosis complicating myocardial relapse of leukaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - September 8, 2009 Category: Hematology Authors: Sarah Kamel, David Ritchie Source Type: journals

Bone marrow blasts level predicts prognosis in patients with refractory cytopenia with multilineage dysplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objectives: Current prognostic models for myelodysplastic syndrome (MDS) do not consider the prognostic value of a bone marrow blast level that is (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 7, 2009 Category: Hematology Authors: Hong Wang, Xiao-Qin Wang, Xiao-Ping Xu, Guo-Wei Lin Source Type: journals

The prolyl-hydroxylase EGLN3 and not EGLN1 is inactivated by methylation in plasma cell neoplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
EGLN1 and EGLN3 are members of the egg-laying-defective 9 (EglN) prolyl-hydroxylases which during normoxia catalyse hydroxylation of the hypoxia-inducible factor (HIF)-1[alpha], thereby promoting its ubiquitination by a complex containing the von Hippel[ndash]Lindau (VHL) tumour suppressor. EGLN3 also has pro-apoptotic activity in some cell types. Analyses of a well-characterised series of cases of plasma cell dyscrasias, including multiple myeloma (MM), Waldenström's macroglobulinaemia (WM) and monoclonal gammopathy of undetermined significance (MGUS) surprisingly demonstrated that the CpG island of EGLN3, and not EGLN1,...
Source: European Journal of Haematology - September 7, 2009 Category: Hematology Authors: Eleftheria Hatzimichael, Aggeliki Dasoula, Reshma Shah, Nelofer Syed, Alexandra Papoudou-Bai, Helen M. Coley, George Dranitsaris, Konstantinos L. Bourantas, Justin Stebbing, Tim Crook Source Type: journals

Absence of cardiac siderosis by MRI T2* despite transfusion burden, hepatic and serum iron overload in Lebanese patients with sickle cell diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our study demonstrates that TR is a stronger predictor of iron overload than TLT. It also confirms cardiac sparing in patients with SCD, even in subjects with significant transfusion burden, systemic and hepatic iron overload. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 7, 2009 Category: Hematology Authors: Adlette Inati, Khaled M. Musallam, John C. Wood, Marwan Sheikh-Taha, Linda Daou, Ali T. Taher Source Type: journals

R-CHOP therapy for MALT lymphoma of the rectumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - September 7, 2009 Category: Hematology Authors: Dai Chihara, Yoshitoyo Kagami, Yasuhiro Oki, Harumi Kato, Hiroshi Onoda, Shouji Ine, Hirofumi Taji, Kazuhito Yamamoto, Yasuo Morishima Source Type: journals

Massive intravascular haemolysis during Clostridium perfrigens sepsis of hepatic originEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - September 3, 2009 Category: Hematology Authors: Anna Merino, Arturo Pereira, Pedro Castro Source Type: journals

Bortezomib: a new therapeutic option for POEMS syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Bortezomib may be an effective and safe therapeutic option for patients with POEMS syndrome. (Source: European Journal of Haematology)
Source: European Journal of Haematology - September 2, 2009 Category: Hematology Authors: Isik Kaygusuz, Hakan Tezcan, Mustafa Cetiner, Ozan Kocakaya, Ant Uzay, Mahmut Bayik Source Type: journals

The impact of cytogenetic abnormalities on the prognosis of primary myelofibrosis: a prospective survey of 202 cases in JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cytogenetic abnormalities were often observed in primary myelofibrosis patients. The presence of specific cytogenetic abnormalities, such as sole abnormalities of chromosome 13q[minus], 20q[minus], or [minus]7/7q[minus], is reported to have the influence on the prognosis of primary myelofibrosis. We analyzed the data from the prospective survey of Japanese primary myelofibrosis patients which was conducted from 1999 to clarify the impact of cytogenetic abnormalities on the prognosis of primary myelofibrosis. A total of 202 primary myelofibrosis patients had the cytogenetic and the prognostic data. Eighty (40%) out of 202 c...
Source: European Journal of Haematology - August 20, 2009 Category: Hematology Authors: Tomonori Hidaka, Kotaro Shide, Haruko Shimoda, Takurou Kameda, Keiko Toyama, Keiko Katayose, Youko Kubuki, Kenji Nagata, Katsuto Takenaka, Koichi Akashi, Takashi Okamura, Yoshiyuki Niho, Hideaki Mizoguchi, Mitsuhiro Omine, Keiya Ozawa, Mine Harada, Kazuya Source Type: journals

Prognostic significance of apoptotic index in multiple myeloma patients treated by conventional therapy and novel agents, thalidomide and bortezomibEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objective: To assess the outcome of the measurement of apoptotic index in myeloma patients treated by conventional chemotherapy and novel drugs with biological mechanism of action, thalidomide and bortezomib.Patients and methods: In a cohort of 189 patients with newly diagnosed multiple myeloma from November 1997 through February 2008, we assessed the prognostic significance of plasma cell apoptotic index (PC-AI) using annexin-V. The whole group was subsequently divided according to treatment approach (conventional chemotherapy only vs. inclusion of novel drugs, thalidomide and bortezomib), and curves of overall survival w...
Source: European Journal of Haematology - August 19, 2009 Category: Hematology Authors: Jiri Minarik, Vlastimil Scudla, Marta Ordeltova, Jaroslav Bacovsky, Tomas Pika, Katerina Langova Source Type: journals

Paroxysmal nocturnal haemoglobinuria: diagnostic tests, advantages, & limitationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Paroxysmal nocturnal haemoglobinuria (PNH) is a rare acquired clonal disorder of haematopoietic stem cells. The molecular defect in PNH is mutation in the phosphotidylinositol glycan complementation class A (PIGA gene) causing defect in glycosylphosphatidylinositol anchored proteins (Cell, 73, 1993, 703). The deficiency of these GPI-anchored proteins on the membranes of haematopoietic cells lead to the various clinical manifestations of PNH. Clinically PNH is classified into classic PNH, PNH in the setting of another specified bone marrow disorder and sub clinical PNH. Size of the PNH clone differs in these different subty...
Source: European Journal of Haematology - August 16, 2009 Category: Hematology Authors: Manisha Madkaikar, Maya Gupta, Farah Jijina, Kanjaksha Ghosh Source Type: journals

Osteopenia and vitamin D deficiency in children with sickle cell diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A slight BMD decrease was found in SCD children, starting before puberty and being more marked in females. The decrease was unrelated to disease severity, vitamin D deficiency, or bone hyperresorption, suggesting abnormal bone formation as the underlying mechanism. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 12, 2009 Category: Hematology Authors: E. Chapelon, M. Garabedian, V. Brousse, J. C. Souberbielle, J. L. Bresson, M. de Montalembert Source Type: journals

Low-power laser to prevent oral mucositis in autologous hematopoietic stem cell transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - August 12, 2009 Category: Hematology Authors: Ana Chor, Sandra R. Torres, Ângelo Maiolino, Marcio Nucci Source Type: journals

Hyperleukocytotic secondary acute myeloid leukemia (AML) with sole monosomy 7 as sequela of Philadelphia-chromosome positive chronic myeloid leukemia (CML)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - August 12, 2009 Category: Hematology Authors: Björn Hackanson, Anja Rückert, Michael Lübbert Source Type: journals

Acute promyelocytic leukemia harboring a STAT5B-RARA fusion gene and a G596V missense mutation in the STAT5B SH2 domain of the STAT5B-RARAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - August 12, 2009 Category: Hematology Authors: Eisaku Iwanaga, Miki Nakamura, Tomoko Nanri, Toshiro Kawakita, Kentaro Horikawa, Hiroaki Mitsuya, Norio Asou Source Type: journals

Demographic and ADAMTS13 biomarker data as predictors of early recurrences of idiopathic thrombotic thrombocytopenic purpuraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: AA is significantly associated with an increased risk for exacerbations of TTP. These data also suggest that decreasing pretreatment ADAMTS13 activity was associated with an increased risk for exacerbation, even after accounting for the effect of race. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 9, 2009 Category: Hematology Authors: Spero R. Cataland, Shang-bin Yang, Leslie Witkoff, Eric H. Kraut, Shili Lin, James N. George, Haifeng M. Wu Source Type: journals

Successful bortezomib-based treatment in POEMS syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - August 5, 2009 Category: Hematology Authors: Xiaowen Tang, Xiaolan Shi, Aining Sun, Huiying Qiu, Bin Gu, Huifen Zhou, Shengli Xue, Yuejun Liu, Changgeng Ruan, Depei Wu Source Type: journals

Contralateral testicular relapse after prophylactic radiation in a patient with primary testicular diffuse large B-cell lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a patient with primary testicular diffuse large B-cell lymphoma, who developed recurrent disease in the contralateral testicle despite receiving prophylactic testicular radiation, central nervous system prophylaxis, and anthracycline-based chemo-immunotherapy. Review of the literature shows that the testicular failure rate after prophylactic radiation may be unexpectedly high at 10% or more. We put forward hypotheses on testicular relapse and discuss potential alternative preventive strategies. (Source: European Journal of Haematology)
Source: European Journal of Haematology - August 3, 2009 Category: Hematology Authors: Amber L. Conrad, Ronald S. Go Source Type: journals

FCRL2 mRNA expression is inversely associated with clinical progression in chronic lymphocytic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fc receptor-like 2 (FCRL2) is highly expressed on B-cell chronic lymphocytic leukemia (B-CLL) cells and could possibly influence disease pathogenesis. Therefore, we investigated FCRL2 mRNA expression in a large cohort with 152 CLL patients in order to assess its role in risk prediction in B-CLL. FCRL2 mRNA expression was found to be expressed at considerably higher levels in peripheral blood mononuclear cells (PBMC) of B-CLL patients compared to controls (range 1.35- to 210-fold upregulation; P < 0.0001) and cells of other hematological diseases. Patients with high FCRL2 expression (according to ROC-analysis) had a signifi...
Source: European Journal of Haematology - August 3, 2009 Category: Hematology Authors: Holger Nückel, Crista H. Collins, Ulrich H. Frey, Ludger Sellmann, Jan Dürig, Winfried Siffert, Ulrich Dührsen Source Type: journals

Differential diagnosis between immune (idiopathic) thrombocytopenic purpura and portal vein thrombosis in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - August 3, 2009 Category: Hematology Authors: Giuseppe Indolfi, Elisa Bartolini, Massimo Resti Source Type: journals

Cold agglutinine diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - August 3, 2009 Category: Hematology Authors: A Röth, A Hüttmann, RP Rother, U Dührsen, T Philipp Source Type: journals

Haematological reference values in Spanish adolescents: the AVENA studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present study provides reference data on the distribution of haematological indices of Spanish adolescents. These data can be useful biomarkers of the nutritional status in adolescents. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 29, 2009 Category: Hematology Authors: Javier Romeo, Julia Wärnberg, Sonia Gómez-Martínez, Ligia E. Díaz, Luis A. Moreno, Manuel J. Castillo, Carlos Redondo, Juan C. Baraza, Ricardo Sola, Salvador Zamora, Ascensión Marcos Source Type: journals

The combined expression of HOXA4 and MEIS1 is an independent prognostic factor in patients with AMLEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our data show that the combination of low HOXA4 and low MEIS1 gene expression is a favourable predictor for outcome in all AML patients and that the expression levels are governed by the methylation state of these genes. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 28, 2009 Category: Hematology Authors: Mike Zangenberg, Lykke Grubach, Anni Aggerholm, Trine Silkjaer, Caroline Juhl-Christensen, Charlotte Guldborg Nyvold, Eigil Kjeldsen, Hans Beier Ommen, Peter Hokland Source Type: journals

PIP4KIIA and β-globin: transcripts differentially expressed in reticulocytes and associated with high levels of Hb H in two siblings with Hb H diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We are reporting here the results of differential gene expression experiments comparing two siblings, a 21-yr-old male and a 19-yr-old female, with the same alpha-thalassemia genotype ([minus][alpha]3.7/[minus][minus]SEA) and quite different levels of Hb H in the peripheral blood (18.7 and 5%, respectively). By using mRNA differential-display reverse-transcription-PCR and suppression subtractive hybridization, two main transcripts were selected in both procedures and validated by qRT-PCR, one corresponding to the phosphatidylinositol phosphate 4-kinase type II-alpha (PIP4KIIA) gene and the other to the [beta]-globin gene, ...
Source: European Journal of Haematology - July 26, 2009 Category: Hematology Authors: Marcia R. S. C. Wenning, Maricilda P. Mello, Tiago G. Andrade, Carolina Lanaro, Dulcineia M. Albuquerque, Sara T. O. Saad, Fernando F. Costa, Maria F. Sonati Source Type: journals

Interphase FISH on TEL/AML1 positive acute lymphoblastic leukemia relapses – analysis of clinical relevance of additional TEL and AML1 copy number changesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, bone marrow samples from 38 children with relapsed TEL/AML1 RT-PCR positive and negative BCP-ALL were analyzed for these mutations by interphase fluorescence in situ hybridization and results were compared with published data.Results: In children with TEL/AML1 positive ALL relapse, additional (a) TEL loss, (b) combined AML1 and der(21) gain, (c) combined TEL loss and AML1 gain as well as (d) the occurrence of a subpopulation with the signal pattern 1T/3A/1TA appear to be related to higher peripheral blast counts (PBCs) at relapse diagnosis (a and d) or a tendency towards the occurrence of a subsequent relaps...
Source: European Journal of Haematology - July 23, 2009 Category: Hematology Authors: Anita Peter, Thomas Heiden, Tillmann Taube, Gabriele Körner, Karl Seeger Source Type: journals

Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A yet homogeneous leukemia entity was further subdivided, based on distinct genetic properties. This approach provided a simplified way to obtain robust and disease-specific gene signatures even in smaller cohorts. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 18, 2009 Category: Hematology Authors: Luca Trentin, Marco Giordan, Theo Dingermann, Giuseppe Basso, Geertruy te Kronnie, Rolf Marschalek Source Type: journals

Transient red blood cells morphological anomalies after acute liver dysfunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - July 17, 2009 Category: Hematology Authors: Jean François Lesesve, Loïc Garçon, Thomas Lecompte Source Type: journals

Addendum to corticosteroid side effects and risk for bleeding in immune thrombocytopenic purpura: patient perspectivesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Haematology)
Source: European Journal of Haematology - July 14, 2009 Category: Hematology Authors: Jacqueline A. Guidry, Shirley Watson, James N. George, Sara K. Vesely, Deirdra R. Terrell Source Type: journals

Detection of renal impairment as one specific comorbidity factor in multiple myeloma: multicenter study in 198 consecutive patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objectives: Comorbidity factors have been reported in cancer patients to predict progression free survival (PFS) and overall survival (OS). Renal impairment (RI) is postulated as one negative prognostic factor in multiple myeloma (MM). The study aim was to detect the best way to define RI and the impact of different RI stages on MM outcome.Methods: In this multicenter analysis, we determined RI [serum creatinine, estimated glomerular filtration rate (eGFR) by modification of diet in renal disease (MDRD) and Cockcroft-Gault] and other prognostic factors in 198 MM patients to ascertain their value on PFS and OS.Results: Medi...
Source: European Journal of Haematology - July 13, 2009 Category: Hematology Authors: Martina Kleber, Gabriele Ihorst, Barbara Deschler, Christian Jakob, Peter Liebisch, Bernd Koch, Orhan Sezer, Monika Engelhardt Source Type: journals

The −509C/T polymorphism of transforming growth factor-β1 is associated with increased risk for development of chronic idiopathic neutropeniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The TGF-[beta]1 [minus]509C/T polymorphism is associated with increased risk for CIN and contributes to the pathophysiology of the disorder by inducing TGF-[beta]1 overproduction. This is the first study providing evidence that genetic factors may predispose to CIN and may have a role in the pathophysiology of the disorder. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 13, 2009 Category: Hematology Authors: Dimitrios G. Eliopoulos, Irene Mavroudi, Charalampos Pontikoglou, Maria Ximeri, Emily Stavroulaki, Katerina Pyrovolaki, Maria Velegraki, Michael Spanoudakis, George Goulielmos, Helen A. Papadaki Source Type: journals

Nodal marginal zone lymphoma: current knowledge and future directions of an heterogeneous diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nodal marginal zone lymphoma (NMZL) is a defined, separate clinicopathological entity. NMZL is a B-cell neoplasm originated in the lymph node, whose histology resembles the nodal infiltration by mucosa-associated lymphoid tissue- or splenic-type marginal zone lymphoma, in the absence of clinical evidence of extranodal or spleen disease. The lack of characteristic phenotypic or molecular diagnostic findings is still hampering the reproducibility of this diagnosis. Herein, we review the main morphological and immunophenotypical markers, discussing the differential with other overlapping entities. We also summarize the clinic...
Source: European Journal of Haematology - July 13, 2009 Category: Hematology Authors: Luca Arcaini, Marco Lucioni, Emanuela Boveri, Marco Paulli Source Type: journals

DV-ICE, intensive induction and early transplantation for adult patients with acute lymphoblastic leukemia: a phase II studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Intensive induction using DV-ICE followed by early transplantation without treatment beyond 4 months failed to improve outcome compared with standard treatment. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 8, 2009 Category: Hematology Authors: Christine Dudler, Mario Bargetzi, André Tichelli, Alois Gratwohl, Jakob R. Passweg, Martin Wernli Source Type: journals