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Incidence of multiple sclerosis in Buenos Aires: a 16-year health maintenance organization–based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The incidence density of 1.76 per 100 000 suggests a low-median risk area for MS. This study constitutes the first of its kind to cover data of MS incidence in Argentina. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 19, 2009 Category: Neurology Authors: E. Cristiano, L. Patrucco, D. Giunta, G. Videla, E. R. Soriano, J. I. Rojas Source Type: journals

The occurrence of mutations in FUS in a Belgian cohort of patients with familial ALSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results show that mutations in FUS are also a significant cause of familial ALS in Belgium. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 18, 2009 Category: Neurology Authors: P. Van Damme, A. Goris, V. Race, N. Hersmus, B. Dubois, L. Van Den Bosch, G. Matthijs, W. Robberecht Source Type: journals

Intravenous thrombolysis for patients with ischaemic stroke on antiplatelet therapy: a blessing in disguise?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - November 18, 2009 Category: Neurology Authors: M. Uyttenboogaart, G.J. Luijckx Source Type: journals

New Vistas on Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - November 18, 2009 Category: Neurology Authors: G. L. Willis, S. M. Armstrong Source Type: journals

Comparison of risk factors and work-up in young and middle-aged patients with TIA and ischaemic strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The risk factor profiles and the work-up results are similar between the TIA and the stroke patients. These findings highlight the etiologic homogeneity of both conditions; therefore, justify their uniform management. In addition, low yield of CT in TIA patients was found, questioning thus the routine use of CT in work-up of TIA. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 18, 2009 Category: Neurology Authors: G. Telman, E. Sprecher, O. Namestnikov, E. Kouperberg Source Type: journals

Restenosis after carotid endarterectomy: significance of newly acquired risk factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: CRFs acquired during long-term follow-up after CEA may independently contribute to progressive ICA stenosis after endarterectomy. Newly acquired CRFs might be more hazardous than CRFs present prior to CEA. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 18, 2009 Category: Neurology Authors: F. Fluri, F. Hatz, B. Voss, P. A. Lyrer, S. T. Engelter Source Type: journals

Addition of cilostazol reduces biological aspirin resistance in aspirin users with ischaemic stroke: a double-blind randomized clinical trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although this was a negative study, our findings disclosed a trend toward enhanced antiplatelet effects when cilostazol was added to aspirin in ischaemic stroke patients. Combination of aspirin and cilostazol might be a treatment option in the ischaemic stroke patients with AR. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 17, 2009 Category: Neurology Authors: J.-H. Lee, J.-K. Cha, S. J. Lee, S.-W. Ha, S. U. Kwon Source Type: journals

Social cognition and Theory of Mind in patients with relapsing-remitting multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: In the absence of marked cognitive decline and disability, patients with ambulatory MS had a deficit interpreting social situations and performing in interpersonal contexts. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 17, 2009 Category: Neurology Authors: M. Banati, J. Sandor, A. Mike, E. Illes, L. Bors, A. Feldmann, R. Herold, Z. Illes Source Type: journals

Transthyretin as a potential CSF biomarker for Alzheimer's disease and dementia with Lewy bodies: effects of treatment with cholinesterase inhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Significant reductions in CSF TTR were found after cholinesterase inhibitor treatment in patients with AD compared to untreated individuals. CSF TTR was unaltered in patients with DLB and had no relationship to depression in the present cohort with dementias. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 17, 2009 Category: Neurology Authors: K. Schultz, K. Nilsson, J. E. Nielsen, S. G. Lindquist, L. E. Hjermind, B. B. Andersen, A. Wallin, C. Nilsson, Å. Petersén Source Type: journals

The broad impact of MSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - November 17, 2009 Category: Neurology Authors: J. Halper Source Type: journals

Changes in regional cerebral blood flow in the right cortex homologous to left language areas are directly affected by left hemispheric damage in aphasic stroke patients: evaluation by Tc-ECD SPECT and novel analytic softwareEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results suggested that the chronic increase in rCBF in the right language-relevant areas is due at least in part to reduction in the trancallosal inhibitory activity of the language-dominant left hemisphere caused by the stroke lesion itself and that these relationships are not always symmetric. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 17, 2009 Category: Neurology Authors: G. Uruma, W. Kakuda, M. Abo Source Type: journals

A novel presenilin1 mutation (Q223R) associated with early onset Alzheimer's disease, dysarthria and spastic paraparesis and decreased Abeta levels in CSFEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Cerebrospinal fluid biomarker analysis might point towards genetic analysis of PSEN1 in patients with positive family history and age of onset below 60 years. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 12, 2009 Category: Neurology Authors: I. Uttner, J. Kirchheiner, H. Tumani, F. M. Mottaghy, E. Lebedeva, E. Özer, A. C. Ludolph, R. Huber, C. A. F. von Arnim Source Type: journals

Assessing autonomic symptoms of Parkinson's disease with the SCOPA-AUT: a new perspective from Rasch analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Suggestions for improving the SCOPA-AUT include a shorter scale with a simpler response scheme and a combination of sexual items for men and women. The resulting SCOPA-AUT is a reliable scale, with good internal construct validity, providing Rasch transformed results on a linear metric scale. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 12, 2009 Category: Neurology Authors: M. J. Forjaz, A. Ayala, C. Rodriguez-Blazquez, B. Frades-Payo, P. Martinez-Martin Source Type: journals

Influence of antiplatelet pre-treatment on the risk of intracranial haemorrhage in acute ischaemic stroke after intravenous thrombolysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Pre-treatment with AP is associated with an increased risk of PH after intravenous thrombolysis in patients with acute ischaemic stroke. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 12, 2009 Category: Neurology Authors: L. Dorado, M. Millán, N. Pérez de la Ossa, C. Guerrero, M. Gomis, E. López-Cancio, A. C. Ricciardi, A. Dávalos Source Type: journals

Outcome of intracerebral haemorrhage patients pre-treated with statinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Statins pre-treatment of patients with intracerebral haemorrhage may provide better functional outcome at 3 months of acute onset. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 12, 2009 Category: Neurology Authors: M. Gomis, A. Ois, A. Rodríguez-Campello, E. Cuadrado-Godia, J. Jiménez-Conde, I. Subirana, A. Dávalos, J. Roquer Source Type: journals

Association of the MAPT locus with Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings show that the H1 haplotype is a significant risk factor for PD. However, one H1-specific SNP (rs242557) previously implicated in PSP did not alter the risk of PD, indicating that distinct H1 sub-haplotypes probably drive the associations with PD and PSP. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 12, 2009 Category: Neurology Authors: C. Wider, C. Vilariño-Güell, B. Jasinska-Myga, M. G. Heckman, A. I. Soto-Ortolaza, S. A. Cobb, J. O. Aasly, J. M. Gibson, T. Lynch, R. J. Uitti, Z. K. Wszolek, M. J. Farrer, O. A. Ross Source Type: journals

Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggest that a peripheral molecular clock, as reflected in the dampened expression of the clock genes BMAL1 in total leukocytes, is altered in PD patients. In addition, the relative BMAL1 levels correlate positively with PD severity, which could provide a molecular basis to help monitor disease progression and response to investigational drugs. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 12, 2009 Category: Neurology Authors: Y. Cai, S. Liu, R. B. Sothern, S. Xu, P. Chan Source Type: journals

A deformation-based morphometry study of patients with early-stage Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results suggest that DBM could be a sensitive method for detecting morphological changes in early-stage PD. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 11, 2009 Category: Neurology Authors: P. Borghammer, K. Østergaard, P. Cumming, A. Gjedde, A. Rodell, N. Hall, M. Mallar Chakravarty Source Type: journals

Refractory generalized seizures and cerebellar ataxia associated with anti-GAD antibodies responsive to immunosuppressive treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - November 10, 2009 Category: Neurology Authors: V. Nociti, G. Frisullo, T. Tartaglione, A. K. Patanella, R. Iorio, P. A. Tonali, A. P. Batocchi Source Type: journals

Autonomic assessment in Parkinson's disease: a measured stride forwardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - November 10, 2009 Category: Neurology Authors: W. P. Cheshire Source Type: journals

Summary of GIGYF2 studies in Parkinson's disease: the burden of proofEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - November 10, 2009 Category: Neurology Authors: E. K. Tan, A. H. Schapira Source Type: journals

Frontal-lobe mediated behavioral dysfunction in amyotrophic lateral sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Frontal-lobe mediated behavioral dysfunction appears to be common in ALS. Cognitively impaired ALS patients had greater behavioral dysfunction. Recognition of behavioral and cognitive dysfunction may assist health-care providers and care-givers recognize changes in decision-making capacity and treatment compliance of patients with ALS. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 29, 2009 Category: Neurology Authors: M. Witgert, A. R. Salamone, A. M. Strutt, A. Jawaid, P. J. Massman, M. Bradshaw, D. Mosnik, S. H. Appel, P. E. Schulz Source Type: journals

Memantine versus donepezil in mild to moderate Alzheimer's disease: a randomized trial with magnetic resonance spectroscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Donepezil and memantine have similar modest clinical and spectroscopic effect on mild to moderate AD. MRS could be useful to monitor progression of the disease. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 28, 2009 Category: Neurology Authors: P. J. Modrego, N. Fayed, J. M. Errea, C. Rios, M. A. Pina, M. Sarasa Source Type: journals

Confabulation Views from Neuroscience, Psychiatry, Psychology and PhilosophyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - October 28, 2009 Category: Neurology Authors: K. A. Jellinger Source Type: journals

Oxford Companion to Emotion and the Affective SciencesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - October 28, 2009 Category: Neurology Authors: K. A. Jellinger Source Type: journals

Understanding Depression A Translational ApproachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - October 28, 2009 Category: Neurology Authors: K. A. Jellinger Source Type: journals

Multiple sclerosis survival: a population-based study in SicilyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present study confirms the higher mortality risk in MS patients with no significant gender difference. Causes of death are related to complications of high disability and to increasing age. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 23, 2009 Category: Neurology Authors: P. Ragonese, P. Aridon, M. A. Mazzola, G. Callari, B. Palmeri, G. Famoso, V. Terruso, G. Salemi, M. D'Amelio, G. Savettieri Source Type: journals

Somatosensory function in asymptomatic Parkin-mutation carriersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Sensory abnormalities of asymptomatic Parkin-mutation carriers as obtained by QST suggest impairment of either small and large peripheral pathways or central somatosensory processing. In contrast to Parkin-associated PD, asymptomatic Parkin-mutation carriers do not show a reduced SNAP. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 22, 2009 Category: Neurology Authors: J. Gierthmühlen, S. Schumacher, G. Deuschl, E. Fritzer, C. Klein, R. Baron, C. Helmchen Source Type: journals

A nationwide retrospective analysis on the effect of immune therapies in patients with chronic inflammatory demyelinating polyradiculoneuropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Switching between traditional therapies increases the number of responder patients. IVIg was confirmed to be a therapy with low SE. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 22, 2009 Category: Neurology Authors: D. Cocito, I. Paolasso, G. Antonini, L. Benedetti, C. Briani, C. Comi, R. Fazio, S. Jann, S. Matà, A. Mazzeo, M. Sabatelli, E. Nobile-Orazio Source Type: journals

The paradox of intracranial hypotension responding well to CSF drainageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - October 22, 2009 Category: Neurology Authors: C. M. Roosendaal, M. H. Coppes, P. C. A. J. Vroomen Source Type: journals

Diffusion-weighted imaging findings differ between stroke attributable to spontaneous cervical artery dissection and patent foramen ovaleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Diffusion-weighted imaging characteristics differ between PFO and dissection, suggesting differences in the pathogenesis of brain infarction between these aetiologies. A single non-territorial infarct seems to favour PFO as stroke aetiology. Whether this or other features are distinctive enough to diagnose PFO or dissection in individual patients requires further testing. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 22, 2009 Category: Neurology Authors: L. H. Bonati, S. G. Wetzel, A. Kessel-Schaefer, P. Buser, P. A. Lyrer, S. T. Engelter Source Type: journals

Effects of intermittent theta burst stimulation on spasticity in patients with multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results show that iTBS, a safe, non-invasive, well-tolerated and feasible protocol, is a promising tool for the treatment of spasticity in MS. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 22, 2009 Category: Neurology Authors: F. Mori, C. Codecà, H. Kusayanagi, F. Monteleone, L. Boffa, A. Rimano, G. Bernardi, G. Koch, D. Centonze Source Type: journals

Growth hormone and ghrelin secretion are associated with clinical severity in Huntington's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings suggest changes in the regulation of GH and ghrelin secretion dynamics in early stage HD patients that could become more prominent in the later stages of the disease. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 20, 2009 Category: Neurology Authors: N. A. Aziz, H. Pijl, M. Frölich, J. P. Schröder-van der Elst, C. van der Bent, F. Roelfsema, R. A. C. Roos Source Type: journals

Another connection between essential tremor and Parkinson's disease?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - October 20, 2009 Category: Neurology Authors: E. D. Louis Source Type: journals

Cerebrospinal fluid biomarkers of white matter lesions – cross-sectional results from the LADIS studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The association of increased CSF-NFL levels with increasing severity of WMLs in non-demented subjects suggests that NFL is a marker for axonal damage in response to small vessel disease in the brain. This manifestation may be distinct from or earlier than the neurodegenerative process seen in AD, as reflected by the lack of association between WMLs and AD biomarkers. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 20, 2009 Category: Neurology Authors: M. Jonsson, H. Zetterberg, E. van Straaten, K. Lind, S. Syversen, Å. Edman, K. Blennow, L. Rosengren, L. Pantoni, D. Inzitari, A. Wallin Source Type: journals

Analysis of the GIGYF2 gene in familial and sporadic Parkinson disease in the Spanish populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings suggest that GIGYF2 mutations are not a frequent cause of PD in the Spanish population, since we found no clearly segregating variants. We propose further analyses in PD subjects from different populations to define the role of GIGYF2. A clear pathogenic mutation in other gene at 2q36-37 in the PARK11-linked PD families would definitively disprove GIGYF2 as the responsible gene. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 20, 2009 Category: Neurology Authors: L. Samaranch, E. Lorenzo, M. A. Pastor, M. Riverol, M. R. Luquin, M. C. Rodríguez-Oroz, J. A. Obeso, P. Pastor Source Type: journals

Free insulin-like growth factor (IGF)-1 and IGF-binding proteins-2 and -3 in serum and cerebrospinal fluid of amyotrophic lateral sclerosis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Though in the serum we did not find significant differences amongst the three groups, IGF-1 bioavailability, represented by the free IGF-1 levels, correlated with disease severity. In the CSF, the significant increment of the free fraction of IGF-1 suggests an up-regulation of the IGF-1 system in the intrathecal compartment of sALS patients. Since IGF-1 is a trophic factor for different tissues, we speculate that high levels of the free IGF-1 in sALS might reflect a physiological defensive mechanism promoted in response to neural degeneration and/or muscle atrophy. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 20, 2009 Category: Neurology Authors: M. Corbo, C. Lunetta, P. Magni, E. Dozio, M. Ruscica, L. Adobbati, V. Silani Source Type: journals

How to Examine the Nervous System. Fourth EditionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - October 20, 2009 Category: Neurology Authors: K. A. Jellinger Source Type: journals

Immune therapy for chronic inflammatory demyelinating polyneuropathy: from clinical trials to real-lifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - October 20, 2009 Category: Neurology Authors: Y. A. Rajabally Source Type: journals

Brain natriuretic peptide as a predictor of delayed atrial fibrillation after ischaemic stroke and transient ischaemic attackEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: High plasma BNP level should be a strong predictor of delayed AF after ischaemic stroke or TIA. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 20, 2009 Category: Neurology Authors: Y. Okada, K. Shibazaki, K. Kimura, Y. Iguchi, T. Miki Source Type: journals

A Queen Square TextbookEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - October 20, 2009 Category: Neurology Authors: K. A. Jellinger Source Type: journals

More than just 'frontal': disentangling behavioural disturbances in amyotrophic lateral sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Neurology)
Source: European Journal of Neurology - October 14, 2009 Category: Neurology Authors: M. Masellis, L. Zinman, S. E. Black Source Type: journals

Pre-hospital notification reduced the door-to-needle time for iv t-PA in acute ischaemic strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The pre-hospital notification system reduced intrahospital processing times which led to increased iv t-PA use after AIS. However, the improvement of clinical outcomes in thrombolysis might require organization of not only intrahospital processes but of outside processes such as the early recognition and rapid dispatch of patients with suspected AIS. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 13, 2009 Category: Neurology Authors: S. K. Kim, S. Y. Lee, H. J. Bae, Y. S. Lee, S. Y. Kim, M. J. Kang, J. K. Cha Source Type: journals

Cystatin C as an index of cerebral small vessel disease: results of a cross-sectional study in community-based Japanese elderlyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present study suggests that there is a close relationship between cystatin C and subclinical cerebral SVD, independently of conventional risk factors, in community-based elderly. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 13, 2009 Category: Neurology Authors: M. Wada, H. Nagasawa, T. Kawanami, K. Kurita, M. Daimon, I. Kubota, T. Kayama, T. Kato Source Type: journals

Should the SCOPA-COG be modified?: a Rasch analysis perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The SCOPA-COG is a unidimensional measure of global cognitive function in PD patients, with good scale targeting and no empirical evidence for use of the subscale scores. Its adequate reliability and internal construct validity were supported. The SCOPA-COG, with the proposed scoring scheme, generates true linear interval scores. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 13, 2009 Category: Neurology Authors: M. J. Forjaz, B. Frades-Payo, C. Rodriguez-Blazquez, A. Ayala, P. Martinez-Martin Source Type: journals

How many dementia cases in France and Europe? Alternative projections and scenarios 2010–2050Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The approach used in our study, integrating both the dementia incidence and the mortality in the calculations, allowed us to refine the projections and stress the great sensitivity of the demographic hypotheses forecasts on the evolution of life expectancy. The likely increase is particularly important and confirms that French and European health systems must take this into account when making future plans. (Source: European Journal of Neurology)
Source: European Journal of Neurology - September 30, 2009 Category: Neurology Authors: T. Mura, J.-F. Dartigues, C. Berr Source Type: journals

Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Increased level of MMPs and TIMP-1 of ALS patients may reflect the degeneration process of motor neurons and skeletal muscles and/or is associated with tissues remodeling. The low level of MMP-9 in CSF may result from impaired balance between MMP-9 and TIMP-1 and/or its increased intrathecal degradation and physical clearance. Although the role of changed MMPs/TIMPs level in the pathogenesis of ALS is not clear their analysis in serum may be used as prognostic factor and a potential marker for monitoring treatment effects. (Source: European Journal of Neurology)
Source: European Journal of Neurology - September 30, 2009 Category: Neurology Authors: I. Niebroj-Dobosz, P. Janik, B. Sokołowska, H. Kwiecinski Source Type: journals

Fatigue and processing speed are related in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The degree of fatigue in MS is related to processing speed impairment and longitudinal studies should clarify their mutual dependency. (Source: European Journal of Neurology)
Source: European Journal of Neurology - September 30, 2009 Category: Neurology Authors: A. K. Andreasen, P. E. Spliid, H. Andersen, J. Jakobsen Source Type: journals

Decision-making in Parkinson's disease patients with and without pathological gamblingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Low performance in decision-making under ambiguity and abnormal social behavior distinguished PD patients with PG from those without this disorder. Dopamine replacement therapy may induce dysfunction of the ventromedial prefrontal cortex and amygdala-ventral striatum system, thus increasing the risk for developing PG. (Source: European Journal of Neurology)
Source: European Journal of Neurology - September 23, 2009 Category: Neurology Authors: M. Rossi, E. R. Gerschcovich, D. de Achaval, S. Perez-Lloret, D. Cerquetti, A. Cammarota, M. Inés Nouzeilles, R. Fahrer, M. Merello, R. Leiguarda Source Type: journals

Autobiographical memory in progressive supranuclear palsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Patients with PSP show mild deficits in autobiographical memory, which is likely to reflect a frontal retrieval deficit. (Source: European Journal of Neurology)
Source: European Journal of Neurology - September 22, 2009 Category: Neurology Authors: M. Zarei, H. R. Pouretemad, T. Bak, J. R. Hodges Source Type: journals