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Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Pain)
Source: European Journal of Pain - November 1, 2009 Category: Anesthesiology Source Type: journals

Book critique: “Functional Pain Syndromes: Presentation and Pathophysiology”, Emeran A. Mayer and M. Catherine Bushnell (Editors). IASP Press, Seattle, WA, 2009, 580 pp. ISBN 978-0-931092-75-6. Reviewed by: Christian Maihöfner and Beatrix VillEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Functional pain syndromes can be universally found in the medical disciplines. Diagnosis and treatment are highly demanding. Treatment approaches are often frustrating, both for patients and physicians. Despite the significant clinical problem, the underlying pathophysiology remains elusive. However, over the last years there is accumulating evidence that abnormalities of central neural processing may account for distinct clinical features of this varicoloured group of syndromes. In their most recent book the authors make the most valuable contribution by bringing together current knowledge about this disease group. All au...
Source: European Journal of Pain - October 26, 2009 Category: Anesthesiology Authors: Christian Maihöfner, Beatrix Vill Tags: Bookshelf Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Pain)
Source: European Journal of Pain - September 25, 2009 Category: Anesthesiology Source Type: journals

Numerical rating scale for self-report of pain intensity in children and adolescents: Recent progress and further questionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Until very recently there has been an anomaly in the assessment of the intensity of pediatric pain. The most commonly used self-report scale is the one that, up to now, has had the smallest amount of supportive research. This scale, the numerical rating scale (NRS), is administered by asking patients to say a number, usually from 0 to 10, to express the intensity of their pain. (Source: European Journal of Pain)
Source: European Journal of Pain - September 18, 2009 Category: Anesthesiology Authors: Carl L. von Baeyer Tags: Editorial Source Type: journals

Evidence for the use of a numerical rating scale to assess the intensity of pediatric painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The aim of this work was to evaluate the psychometric properties of the Numerical Rating Scale-11 (NRS-11) when used to assess pediatric pain intensity. We performed two studies: 175 schoolchildren, aged 8–12, participated in Study 1 and 63 children undergoing surgery and aged 6–16, participated in Study 2. The NRS-11 showed (a) adequate convergent construct validity when correlated with the Faces Pain Scale – Revised (FPS-R; r1=0.78, r2=0.93); (b) adequate discriminant validity in relation to measures of pain-related affect (z1=3.55, z2=7.62) and disability (z1=7.62, z2=6.83); and (c) adequate criterion-re...
Source: European Journal of Pain - September 2, 2009 Category: Anesthesiology Authors: Jordi Miró, Elena Castarlenas, Anna Huguet Tags: Psychology & Clinical Interventions Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Pain)
Source: European Journal of Pain - August 7, 2009 Category: Anesthesiology Source Type: journals

Dr. Meissner and colleagues reply to the Letter to the Editor from Andrew Wilcock entitled ‘Prolonged-release naloxone can cause systemic opioid withdrawal’Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dear Editor, Thank you for offering us the opportunity to respond to the letter that addresses our recent publication in the European Journal of Pain (). (Source: European Journal of Pain)
Source: European Journal of Pain - August 2, 2009 Category: Anesthesiology Authors: Winfried Meissner, Müller-Lissner, Joachim Nadstawek, Michael Hopp, Christian Ruckes, Stefan Wirz, Wolfgang Fleischer, Karen Reimer, Petra Leyendecker Tags: Letters to the Editor Source Type: journals

Prolonged-release naloxone can cause systemic opioid withdrawalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite the low oral bio-availability of naloxone, it is well recognized that sufficient amounts can reach the systemic circulation to cause symptoms and signs of opioid withdrawal, e.g. increased sweating, tremor, restlessness, which may or may not be associated with a reversal of analgesia (). Thus, it is surprising that the recent trial of prolonged-release oxycodone and naloxone () did not comment upon this possibility in detail, nor examine for it more specifically, by including, for example, a modified Himmelsbach withdrawal scale, as utilized previously by the lead author (). The study data does not suggest a worsen...
Source: European Journal of Pain - July 16, 2009 Category: Anesthesiology Authors: Andrew Wilcock Tags: Letters to the Editor Source Type: journals

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(Source: European Journal of Pain)
Source: European Journal of Pain - June 29, 2009 Category: Anesthesiology Source Type: journals

In reply to “Is intrathecal lidocaine administration risk-free in rats with neuropathic pain?”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We thank Drs. Umbrain, Smolders, and Poelaert for their interest in our finding that high doses of intrathecal (i.t.) lidocaine have long-lasting therapeutic effects on established hyperalgesia and allodynia (). (Source: European Journal of Pain)
Source: European Journal of Pain - May 17, 2009 Category: Anesthesiology Authors: Jie Tian, Yiwen Gu, Diansan Su, Xiangrui Wang Tags: Letters to the Editor Source Type: journals

Comment on: Chronic pain: Avoidance or endurance? by Petra Karsdorp and Johan VlaeyenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We would like to thank Petra Karsdorp and Johan Vlaeyen for their interest and valuable comments () to our paper published in this issue (), as well as for their appreciation of the avoidance-endurance model (AEM) of pain. However, we would like to note that the aim of the current paper was to report data regarding the development and validation of a new questionnaire, based on AEM hypotheses, and not to outline the AEM itself. A first comprehensive outline, focusing on the theoretical aspects of the AEM will be published shortly (). A number of previous publications () have emphasized some basic assumptions of the AEM: fi...
Source: European Journal of Pain - April 28, 2009 Category: Anesthesiology Authors: Monika I. Hasenbring, Dirk Hallner, Adina C. Rusu Tags: Letters to the Editor Source Type: journals

Chronic pain in women after breast augmentation: Prevalence, predictive factors and quality of lifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic pain is a common complaint after surgery (). Because little is known about chronic pain after cosmetic surgery we investigated the prevalence of chronic pain after breast augmentation, tried to identify possible characteristics of patients developing chronic pain, measured cosmetic satisfaction after surgery and determined quality of life. We performed a retrospective, mono-center study and used a questionnaire which included questions about presence of pain, biometric characteristics, a cosmetic satisfaction VAS, the McGill Pain Questionnaire and the RAND-36 Health Survey and we contacted 494 female patients who u...
Source: European Journal of Pain - April 26, 2009 Category: Anesthesiology Authors: Niek van Elk, Monique A. Steegers, Leo-Peter van der Weij, Andrea W. Evers, Ed H. Hartman, Oliver H. Wilder-Smith Tags: Letters to the Editor Source Type: journals

Fibromyalgia pain and its modulation by hypnotic and non-hypnotic suggestion: An fMRI analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The neuropsychological status of pain conditions such as fibromyalgia, commonly categorized as ‘psychosomatic’ or ‘functional’ disorders, remains controversial. Activation of brain structures dependent upon subjective alterations of fibromyalgia pain experience could provide an insight into the underlying neuropsychological processes. Suggestion following a hypnotic induction can readily modulate the subjective experience of pain. It is unclear whether suggestion without hypnosis is equally effective. To explore these and related questions, suggestions following a hypnotic induction and the same suggestio...
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Stuart W.G. Derbyshire, Matthew G. Whalley, David A. Oakley Tags: Psychology & Clinical Interventions Source Type: journals

Effectiveness of a behaviour graded activity program versus conventional exercise for chronic neck pain patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Chronic neck pain is a common complaint in the Netherlands with a point prevalence of 14.3%. Patients with chronic neck pain are often referred to physiotherapy and, nowadays, are mostly treated with exercise therapy. It is, however, unclear which type of exercise therapy is to be preferred. Therefore, this study evaluates the effectiveness of behaviour graded activity (BGA) compared with conventional exercise (CE) for patients with chronic neck pain.Eligible patients with non-specific chronic neck were randomly allocated to either BGA or CE. Primary treatment outcome is the patient’s global perceived effect co...
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Frieke Vonk, Arianne P. Verhagen, Jos W. Twisk, Albère J.A. Köke, Marlies W.C.T. Luiten, Bart W. Koes Tags: Psychology & Clinical Interventions Source Type: journals

Ultraviolet-B induced inflammation of human skin: Characterisation and comparison with traditional models of hyperlagesiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The effect on human skin of over-exposure to solar ultraviolet radiation (UVR) has been well described. The erythema produced is commonly referred to as ‘sunburn’. Recently UVR induced inflammation has been utilised as a human model of sub-acute pain. Our aim was to characterise the sensory phenotype of UVB inflammation in human volunteers. We delivered UVB to small areas of volar forearm skin in healthy volunteers and found that the degree of inflammation and concomitant increase in sensitivity to cutaneous stimuli were UVB dose and time dependant. We directly compared UVB induced inflammation and the more e...
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Thomas Bishop, Angela Ballard, Helen Holmes, Antony R. Young, Stephen B. McMahon Tags: Psychology & Clinical Interventions Source Type: journals

The fear-avoidance model in whiplash injuriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The aim of this work was to study whether fear of movement, and pain catastrophizing predict pain related-disability and depression in sub-acute whiplash patients. Moreover, we wanted to test if fear of movement is a mediator in the relation between catastrophizing and pain-related disability/depression as has been suggested by the fear-avoidance model [Vlaeyen JWS, Kole-Snijders AMJ, Boeren RGB, van Eek H. Fear of movement/(re)injury in chronic low back pain and its relation to behavioral performance. Pain 1995;62:363–72]. The convenience sample used was of 147 sub-acute whiplash patients (pain duration less t...
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Rubén Nieto, Jordi Miró, Anna Huguet Tags: Psychology & Clinical Interventions Source Type: journals

Spinal cord injury-related pain in rehabilitation: A cross-sectional study of relationships with cognitions, mood and physical functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Although psychological aspects of SCI-related pain have been investigated in those with chronic pain, little data is available regarding these factors in those early in the course of the injury. Using a sample admitted for SCI rehabilitation, this paper describes the relationships between usual pain intensity, mood, disability and both pain and SCI-related psychological factors. The sample were largely similar to other samples of individuals with SCI-related chronic pain in terms of mood, but were noted to be less catastrophic in their thinking about pain than a comparative pain clinic sample. They also reported ...
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Kathryn Nicholson Perry, Michael K. Nicholas, James Middleton Tags: Psychology & Clinical Interventions Source Type: journals

Statistically and clinically important change of pain scores in patients with myogenous temporomandibular disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A within-patient change in pain score after treatment is statistically ‘reliable’ when it exceeds the smallest detectable difference (SDD). The aims of the present study were (i) to determine SDD for scoring pain behavior on a 0–5 point adjectival scale, and (ii) to explore the relationship between SDD, clinically important difference (CID) and effect size (ES) following treatment of known efficacy, and to compare these parameters of pain behavior with those of VAS-scores of pain intensity [van Grootel RJ, van der Bilt A, van der Glas HW. Long-term reliable change of pain scores in individual myogenous TMD ...
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Robert J. van Grootel, Hilbert W. van der Glas Tags: Psychology & Clinical Interventions Source Type: journals

Perioperative ketamine does not prevent chronic pain after thoracotomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Thoracotomy is often responsible for chronic pain, possibly of neuropathic origin. To confirm preclinical studies, the preventive effects of perioperative ketamine were tested in a randomized, double-blind, placebo-controlled clinical trial on persistent neuropathic pain after thoracotomy. Eighty-six patients scheduled for thoracotomy under standardised general anaesthesia were randomised to receive either ketamine (1mgkg−1 at the induction, 1mgkg−1h−1 during surgery, then 1mgkg−1 during 24h; n=42) or normal saline (n=44). Postoperative analgesia included a single dose of intrapleural ropivacaine, intrave...
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Christian Dualé, Fabrice Sibaud, Virginie Guastella, Laurent Vallet, Yves-Alain Gimbert, Hammou Taheri, Marc Filaire, Pierre Schoeffler, Claude Dubray Tags: Therapy & Epidemiology Source Type: journals

Lack of efficacy of alpha-lipoic acid in burning mouth syndrome: A double-blind, randomized, placebo-controlled studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The fairly high placebo effect observed is very similar to data obtained from patients affected by atypical facial pain. This study failed to support a role for ALA in the treatment of BMS, and further investigations are needed to identify the cause of BMS in order to develop efficacious therapies. (Source: European Journal of Pain)
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Mario Carbone, Monica Pentenero, Marco Carrozzo, Alessio Ippolito, Sergio Gandolfo Tags: Therapy & Epidemiology Source Type: journals

Patient led conferences – Who attends, are their expectations met and do they vary in three different countries?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Attendees at national conferences of support groups show considerable disability and their major expectations of improving their knowledge and meeting both expert HCPs and fellow sufferers are fulfilled. (Source: European Journal of Pain)
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Joanna M. Zakrzewska, Teekayu P. Jorns, Amy Spatz Tags: Therapy & Epidemiology Source Type: journals

Chronic pain and other sequelae in long-term breast cancer survivors: Nationwide survey in DenmarkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objectives: To investigate self-reported chronic pain and other sequelae in a nationally representative sample of long-term breast cancer survivors (BCS).Design: Age-stratified random sample of 2,000 female BCS ⩾ 5 years after primary surgery without recurrence drawn from the Danish Breast Cancer Cooperative Group register, which is representative regarding long-term BCS in Denmark.Assessment: Self-administered questionnaire including questions on sociodemography, chronic pain (⩾6 months), health-related quality of life (HRQOL) and other sequelae related to breast cancer. Associations with treatment were inve...
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: V. Peuckmann, O. Ekholm, N.K. Rasmussen, M. Groenvold, P. Christiansen, S. Møller, J. Eriksen, P. Sjøgren Tags: Therapy & Epidemiology Source Type: journals

Cannabinoid-induced effects on the nociceptive system: A neurophysiological study in patients with secondary progressive multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the cannabinoid-induced changes in the RIII reflex threshold and area in patients with MS provide objective neurophysiological evidence that cannabinoids modulate the nociceptive system in patients with MS. (Source: European Journal of Pain)
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Antonella Conte, Chiara Marini Bettolo, Emanuela Onesti, Vittorio Frasca, Elisa Iacovelli, Francesca Gilio, Elena Giacomelli, Maria Gabriele, Massimiliano Aragona, Valentina Tomassini, Patrizia Pantano, Carlo Pozzilli, Maurizio Inghilleri Tags: Therapy & Epidemiology Source Type: journals

An audit of postoperative intravenous patient-controlled analgesia with morphine: Evolution over the last decadeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report reviews the application of postoperative patient-controlled analgesia (PCA) using intravenous morphine in a single institution between 2002 and 2005. More than 5000 patients were evaluated and the results were compared with a similar study performed 10 years ago. Prescription of PCA had increased by more than threefold. Morphine consumption from post-operative day 1 to day 3 (19.1 vs. 26.1, 8.6 vs. 18.1 and 4.5 vs. 19.0μg/kg/h, respectively), demand-to-delivery ratio (1.35–1.76 vs. 2.4–2.8) and the incidence of respiratory depression (0.06% vs. 2%) were significantly reduced (p (Source: European Journal of Pain)
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Chi Wai Cheung, Chee Lun A. Ying, Libby H.Y. Lee, Suk Fung Tsang, Siu Lun Tsui, Michael G. Irwin Tags: Therapy & Epidemiology Source Type: journals

Long-term oral lacosamide in painful diabetic neuropathy: A two-year open-label extension trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The long-term safety profile and sustained efficacy of lacosamide observed in this trial support its continued development for treatment of painful diabetic neuropathy. (Source: European Journal of Pain)
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Aziz Shaibani, Victor Biton, Richard Rauck, Brigitte Koch, Jeffrey Simpson Tags: Clinical & Experimental Neurology Source Type: journals

Differences in the sensitivity of behavioural measures of pain to the selectivity of cyclo-oxygenase inhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Changes in paw pressure threshold seem to best reflect the anti-hyperalgesic properties of COX-inhibitors with enough sensitivity to enable estimation of the dose-exposure-response curve. (Source: European Journal of Pain)
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Dymphy R.H. Huntjens, David J.M. Spalding, Meindert Danhof, Oscar E. Della Pasqua Tags: Neurobiology & Experimental Pharmacology Source Type: journals

The nociceptive mechanism of 5-hydroxytryptamine released into the peripheral tissue in acute inflammatory pain in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The present study examined the contribution of 5-hydroxytryptamine (5-HT) to acute peripheral inflammatory pain in rats. We used formalin test in this study. After formalin injection into the rat hind paw, biphasic pain-related behavior (phases 1 and 2) was observed. A microdialysis study revealed that 5-HT was released into the formalin injection site in a formalin concentration-dependent manner (1.25–5%), and its peak time was 18min after the injection. Previous studies suggest that peripheral 5-HT2 receptors are involved in inflammatory pain. Therefore, we next examined whether 5-HT2A and 5-HT2C receptors ar...
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Kunie Nakajima, Hideaki Obata, Naomi Ito, Fumio Goto, Shigeru Saito Tags: Neurobiology & Experimental Pharmacology Source Type: journals

Toward a definition of pharmacoresistant neuropathic painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pharmacological treatment of neuropathic pain relies currently on evidence from large randomised controlled trials. Systematic reviews and recommendations are available, allowing clinicians to adopt a rational based on available scientific evidence when treating neuropathic pain (). Despite the advances, a considerable number of patients do not get sufficient pain relief and improvement in quality of life (QoL) from available drugs. In evidence-based studies on pain it is customary to consider “responders” to treatment those patients that report a pain relief amounting to 30–50%. Meta-analysis () as well as experienc...
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Authors: Per T. Hansson, Nadine Attal, Ralf Baron, Giorgio Cruccu Tags: Editorial Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Pain)
Source: European Journal of Pain - April 22, 2009 Category: Anesthesiology Source Type: journals

Medication adherence in patients with chronic non-malignant pain: Is there a problem?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kosmidou and colleagues made a constructive contribution to our review (). They added three additional issues to consider, when studying adherence with analgesic treatment. First, how do we define adherence and compliance to treatment? Second, are adherence and compliance numeric or qualitative factors? And finally, there are no studies focusing on neuropathic pain, a common cause of chronic non-malignant pain. (Source: European Journal of Pain)
Source: European Journal of Pain - April 16, 2009 Category: Anesthesiology Authors: Susan Broekmans, Fabienne Dobbels, Koen Milisen, Bart Morlion, Steven Vanderschueren Tags: Letters to the Editor Source Type: journals

Adherence/compliance with the treatment in chronic non-malignant painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with interest the review by concerning the medication adherence in patients with chronic non-malignant pain. The authors concluded that medication non adherence is common in these patients and highlighted important issues in the adherence literature in the management of pain. (Source: European Journal of Pain)
Source: European Journal of Pain - April 8, 2009 Category: Anesthesiology Authors: Maria Kosmidou, Athanassios P. Kyritsis, Sofia Markoula, Sotirios Giannopoulos Tags: Letters to the Editor Source Type: journals

Is Intrathecal lidocaine administration risk-free in rats with neuropathic pain? Reply to [Effects of intrathecal lidocaine on hyperalgesia and allodynia following chronic constriction injury in rats. Eur J Pain 13 (2009) 130–137]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
You demonstrated the protective effect of intrathecal lidocaine in a neuropathic pain model suggesting a 15mg/kg dose of lidocaine as being the best compromise between useful and side effects. Moreover, you showed a dose-dependent relief of mechanical hyperalgesia and allodynia with mild histopathological changes for 2–15mg/kg lidocaine doses. (Source: European Journal of Pain)
Source: European Journal of Pain - March 26, 2009 Category: Anesthesiology Authors: Vincent Umbrain, Ilse Smolders, Jan Poelaert Tags: Letters to the Editor Source Type: journals

Toward a definition of pharmacoresistant neuropathic pain.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19324579 [PubMed - as supplied by publisher] (Source: European Journal of Pain)
Source: European Journal of Pain - March 24, 2009 Category: Anesthesiology Authors: Hansson PT, Attal N, Baron R, Cruccu G Tags: Eur J Pain Source Type: journals

Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Orofacial pain disorders are frequent in the general population and their pharmacological treatment is not always adequately resolved. Cannabinoids have demonstrated their analgesic effect in several pain conditions, both in animal models and in clinical situations. The aim of the present study was to evaluate the cannabinoid-mediated antinociception in two inflammatory models of orofacial pain (orofacial and temporomandibular joint (TMJ) formalin test) and to compare it with a spinal inflammatory model (paw formalin test). WIN 55,212-2 (0.5, 1mg/kg), a synthetic cannabinoid agonist, was intraperitoneally (i.p.) admini...
Source: European Journal of Pain - March 20, 2009 Category: Anesthesiology Authors: Burgos E, Pascual D, Isabel Martín M, Goicoechea C Tags: Eur J Pain Source Type: journals

The inner ear is involved in the aggravation of nociceptive behavior induced by lowering barometric pressure of nerve injured rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients suffering from neuropathic pain often complain of pain aggravation when the weather is changing. The exact mechanism for weather change-induced pain has not been clarified. We have previously demonstrated that experimentally lowering barometric pressure (LP) intensifies pain-related behaviors in rats with chronic constriction injury (CCI). In the present experiment we examined whether this pain aggravating effect of LP exposure in nerve injured rats is still present after lesioning of the inner ear. We used both CCI and spinal nerve ligation (SNL) models for this study. We injected into the middle ear sodium a...
Source: European Journal of Pain - March 20, 2009 Category: Anesthesiology Authors: Funakubo M, Sato J, Honda T, Mizumura K Tags: Eur J Pain Source Type: journals

Chronic pain: Avoidance or endurance?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic musculoskeletal pain poses an important problem in health care and society owing to the large psychological burden and the adverse impact on societal costs. Purely biomedical models seem to be insufficient in explaining the development of chronic pain and disability, and cognitive-behavioural accounts have shown more promising (e.g., ). Basically, individuals who catastrophically (mis)interpret pain are likely to experience fear of pain, which is associated with defensive responses including escape, avoidance, and hypervigilance. Paradoxically, defensive responses may ease fear in the short term, but worsen fear an...
Source: European Journal of Pain - March 16, 2009 Category: Anesthesiology Authors: Petra A. Karsdorp, Johan W.S. Vlaeyen Tags: Editorial Source Type: journals

Chronic pain: Avoidance or endurance?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19285886 [PubMed - as supplied by publisher] (Source: European Journal of Pain)
Source: European Journal of Pain - March 12, 2009 Category: Anesthesiology Authors: Karsdorp PA, Vlaeyen JW Tags: Eur J Pain Source Type: journals

Linguistic validation of the DN4 for use in international studies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The DN4 items were linguistically validated in each of the target languages, thus providing the means for standardising the diagnosis of neuropathic pain and pooling the data collected during clinical research in the different countries involved. PMID: 19282208 [PubMed - as supplied by publisher] (Source: European Journal of Pain)
Source: European Journal of Pain - March 10, 2009 Category: Anesthesiology Authors: Van Seventer R, Vos C, Meerding W, Mear I, Le Gal M, Bouhassira D, Huygen FJ Tags: Eur J Pain Source Type: journals

Long-term follow-up of tailored behavioural treatment and exercise based physical therapy in persistent musculoskeletal pain: A randomized controlled trial in primary careEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined long-term effects of a tailored behavioural treatment protocol (TBT), as compared with an exercise based physical therapy protocol (EBT). One-hundred and twenty-two patients who, due to persistent musculoskeletal pain, consulted physical therapists in primary care were originally randomized to either of the two conditions. Follow-up assessments two-year post-treatment were completed by 65 participants. According to per-protocol analyses, short-term effects were maintained in both groups for the primary outcome, pain-related disability. The TBT-group reported lower disability levels compared with the EBT...
Source: European Journal of Pain - March 6, 2009 Category: Anesthesiology Authors: Pernilla Åsenlöf, Eva Denison, Per Lindberg Tags: Psychology & Clinical Interventions Source Type: journals

Long-term follow-up of tailored behavioural treatment and exercise based physical therapy in persistent musculoskeletal pain: A randomized controlled trial in primary care.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined long-term effects of a tailored behavioural treatment protocol (TBT), as compared with an exercise based physical therapy protocol (EBT). One-hundred and twenty-two patients who, due to persistent musculoskeletal pain, consulted physical therapists in primary care were originally randomized to either of the two conditions. Follow-up assessments two-year post-treatment were completed by 65 participants. According to per-protocol analyses, short-term effects were maintained in both groups for the primary outcome, pain-related disability. The TBT-group reported lower disability levels compared with the EBT...
Source: European Journal of Pain - March 4, 2009 Category: Anesthesiology Authors: Senlöf P, Denison E, Lindberg P Tags: Eur J Pain Source Type: journals

Guidelines on the management of fibromyalgia syndrome - A systematic review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We compared the methodology and the recommendations of evidence-based guidelines for the management of fibromyalgia syndrome (FMS) to give an orientation within the continuously growing number of reviews on the therapy of FMS. Systematic searches up to April 2008 of the US-American National Guideline Clearing House, the Scottish Intercollegiate Guidelines Network, the Association of the Scientific Medical Societies in Germany (AWMF) and Medline were conducted. Three evidence-based guidelines for the management of FMS published by professional organizations were identified: The American Pain Society (APS) (2005), the Eu...
Source: European Journal of Pain - March 3, 2009 Category: Anesthesiology Authors: Häuser W, Thieme K, Turk DC Tags: Eur J Pain Source Type: journals

The effects of the selective and non-peptide CXCR2 receptor antagonist SB225002 on acute and long-lasting models of nociception in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study evaluated the antinociceptive effects of the selective and non-peptide CXCR2 antagonist SB225002 in mouse models of pain. As assessed in different tests of spontaneous nociception, intraperitoneal (i.p.) administration of SB225002 caused consistent and dose-related reduction of acetic acid-induced abdominal constrictions, whereas it did not significantly affect the nociception evoked by formalin, capsaicin, glutamate or phorbol ester acetate (PMA). Systemic treatment with SB225002 strikingly reduced the spontaneous nociception induced by 8-bromo-cAMP (8-Br-cAMP), or mechanical hypernociception induced by prostag...
Source: European Journal of Pain - March 3, 2009 Category: Anesthesiology Authors: Manjavachi MN, Quintão NL, Campos MM, Deschamps IK, Yunes RA, Nunes RJ, Leal PC, Calixto JB Tags: Eur J Pain Source Type: journals

Pain as a stressor: Effects of prior nociceptive stimulation on escape responding of rats to thermal stimulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In our previous studies, psychological stress was shown to enhance operant escape responding of male and female rats. The stressors that produced hyperalgesia were physical restraint and social defeat. Nociceptive input also elicits stress reactions, generating the prediction that pain would facilitate pain under certain circumstances. For example, the usual method of evaluating stress in laboratory animals is to test for effects after termination of the stressor. Accordingly, operant escape performance of male and female rats was evaluated during two successive trials involving nociceptive thermal stimulation. The int...
Source: European Journal of Pain - March 2, 2009 Category: Anesthesiology Authors: Vierck CJ, Green M, Yezierski RP Tags: Eur J Pain Source Type: journals

Nitrous oxide and the inhibitory synaptic transmission in rat dorsal horn neurons.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The analgesic effect of nitrous oxide (N(2)O) is thought to depend on noradrenaline release in the spinal cord following activation of descending inhibitory neurons. In addition to this indirect facilitation of inhibition in the spinal cord, we previously showed direct inhibition of glutamate receptors in dorsal horn neurons by N(2)O. Since general anesthetics could possibly affect excitatory and/or inhibitory components of synaptic transmission, we sought to evaluate the direct effect of N(2)O on inhibitory transmission in spinal cord neurons. Using whole-cell patch-clamp recording from rat transversal spinal cord sli...
Source: European Journal of Pain - March 2, 2009 Category: Anesthesiology Authors: Georgiev SK, Baba H, Kohno T Tags: Eur J Pain Source Type: journals

Quality discrimination for noxious stimuli in secondary somatosensory cortex: A MEG-studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A complex cortical network is believed to encode the multi-dimensionality of the human pain experience. In the present study, we used magnetoencephalography (MEG) to examine whether the cortical processing of noxious stimuli with different psychophysical properties differs in primary (S1) and secondary (S2) somatosensory cortices. Noxious low (condition 1) and high (condition 2) current density stimulations of equal stimulus intensities were applied at the left forearm in 12 subjects in a randomised order. Concomitantly, subjects had to evaluate the corresponding sensory-discriminative and affective-motivational ...
Source: European Journal of Pain - February 24, 2009 Category: Anesthesiology Authors: Christian Maihöfner, Martin Kaltenhäuser Tags: Clinical & Experimental Neurology Source Type: journals

Quality discrimination for noxious stimuli in secondary somatosensory cortex: A MEG-study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A complex cortical network is believed to encode the multi-dimensionality of the human pain experience. In the present study, we used magnetoencephalography (MEG) to examine whether the cortical processing of noxious stimuli with different psychophysical properties differs in primary (S1) and secondary (S2) somatosensory cortices. Noxious low (condition 1) and high (condition 2) current density stimulations of equal stimulus intensities were applied at the left forearm in 12 subjects in a randomised order. Concomitantly, subjects had to evaluate the corresponding sensory-discriminative and affective-motivational pain d...
Source: European Journal of Pain - February 19, 2009 Category: Anesthesiology Authors: Maihöfner C, Kaltenhäuser M Tags: Eur J Pain Source Type: journals

Subgrouping low back pain: A comparison of the STarT Back Tool with the Orebro Musculoskeletal Pain Screening Questionnaire.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The SBT baseline psychometrics performed similarly to the OMPSQ, but the SBT is shorter and easier to score and is an appropriate alternative for identifying high risk LBP patients in primary care. PMID: 19223271 [PubMed - as supplied by publisher] (Source: European Journal of Pain)
Source: European Journal of Pain - February 16, 2009 Category: Anesthesiology Authors: Hill JC, Dunn KM, Main CJ, Hay EM Tags: Eur J Pain Source Type: journals

Menstrual cycle phase does not influence gender differences in experimental pain sensitivity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Influence of menstrual cycle phase on experimental pain sensitivity in women and on gender differences in pain sensitivity was examined in 48 men and 49 women in response to cold pressor, heat, and ischemic pain. Each woman was tested at three points in their menstrual cycle in randomized order, the early follicular, late follicular, and luteal phases, while men were also tested three times, controlling for number of days between test sessions. Cycle phase was confirmed via serum hormone levels. As expected, women were significantly more sensitive to cold pain (p<.01), to heat pain (p<.0001), and to ischemic pain...
Source: European Journal of Pain - February 11, 2009 Category: Anesthesiology Authors: Klatzkin RR, Mechlin B, Girdler SS Tags: Eur J Pain Source Type: journals