European Journal of Pharmaceutical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Current uncertainties and challenges of publicly available pharmaceutical environmental risk assessment data
Eur J Pharm Sci. 2024 Apr 15:106769. doi: 10.1016/j.ejps.2024.106769. Online ahead of print.ABSTRACTPharmaceutical residues are widely detected in aquatic environment worldwide mainly arising from human excretions in sewage systems. Presently, publicly available, high quality environmental risk assessment (ERA) data for pharmaceuticals are limited. However, databases like the Swedish Fass offer valuable resources aiding healthcare professionals and environmental scientists in identifying substances of significant concern. In this review, we provide a concise overview of the regulatory ERA process for medicinal products int...
Source: European Journal of Pharmaceutical Sciences - April 17, 2024 Category: Drugs & Pharmacology Authors: H Ahkola L Äystö T Sikanen S Riikonen T Pihlaja S Kauppi Source Type: research

Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: a promising therapeutic and prophylactic treatment for viral respiratory infections
Eur J Pharm Sci. 2024 Apr 12:106766. doi: 10.1016/j.ejps.2024.106766. Online ahead of print.ABSTRACTOne of the most frequent causes of respiratory infections are viruses. Viruses reaching the airways can be absorbed by the human body through the respiratory mucosa and mainly infect lung cells. Several viral infections are not yet curable, such as coronavirus-2 (SARS-CoV-2). Furthermore, the side effect of synthetic antiviral drugs and reduced efficacy against resistant variants have reinforced the search for alternative and effective treatment options, such as plant-derived antiviral molecules. Curcumin (CUR) and quercetin...
Source: European Journal of Pharmaceutical Sciences - April 14, 2024 Category: Drugs & Pharmacology Authors: Daniela Pastorim Vaiss Jamile Lima Rodrigues Virginia Campello Yurgel Frank do Carmo Guedes Lauanda Larissa Mendon ça da Matta Paula Alice Bezerra Barros Gustavo Richter Vaz Ra íssa Nunes Dos Santos Bibiana Franzen Matte Larine Kupski Jaqueline Garda-Bu Source Type: research

Cubic liquid crystals containing propolis flavonoids as in situ thermo-sensitive hydrogel depots for periodontitis treatment: Preparation, pharmacodynamics and therapeutic mechanisms
In this study, we constructed an in situ thermosensitive depot systems using total flavonoids from propolis-loaded cubic liquid crystals (TFP-CLC) hydrogel for periodontal delivery. TFP-CLC inhibited inflammatory cell infiltration, reactive oxygen species and the expression of inflammatory cytokines of NF-κB and IL-1β. In addition, alveolar bone and collagen were significantly regenerated after TFP-CLC administration according to micro-CT and immunohistochemistry. Mechanism studies suggested that TFP-CLC alleviated inflammation and promoted alveolar bone repair via regulating TLR4/MyD88/NF-κB p65 and RANK/NF-κB signali...
Source: European Journal of Pharmaceutical Sciences - April 13, 2024 Category: Drugs & Pharmacology Authors: Maomao Tang Jiaxin Li Guichun Wang Yuxiao Wang Chengjun Peng Xiangwei Chang Yaotian Tao Jian Guo Shuangying Gui Source Type: research

Cubic liquid crystals containing propolis flavonoids as in situ thermo-sensitive hydrogel depots for periodontitis treatment: preparation, pharmacodynamics and therapeutic mechanisms
In this study, we constructed an in situ thermosensitive depot systems using total flavonoids from propolis-loaded cubic liquid crystals (TFP-CLC) hydrogel for periodontal delivery. TFP-CLC inhibited inflammatory cell infiltration, reactive oxygen species and the expression of inflammatory cytokines of NF-κB and IL-1β. In addition, alveolar bone and collagen were significantly regenerated after TFP-CLC administration according to micro-CT and immunohistochemistry. Mechanism studies suggested that TFP-CLC alleviated inflammation and promoted alveolar bone repair via regulating TLR4/MyD88/NF-κB p65 and RANK/NF-κB signali...
Source: European Journal of Pharmaceutical Sciences - April 13, 2024 Category: Drugs & Pharmacology Authors: Maomao Tang Jiaxin Li Guichun Wang Yuxiao Wang Chengjun Peng Xiangwei Chang Yaotian Tao Jian Guo Shuangying Gui Source Type: research

Absorption of Cinnarizine from Type II Lipid-Based Formulations: Impact of Lipid Chain Length, Supersaturation, Digestion, and Precipitation Inhibition
Eur J Pharm Sci. 2024 Apr 10:106765. doi: 10.1016/j.ejps.2024.106765. Online ahead of print.ABSTRACTLipid-based formulations (LBFs) are an enabling-formulation approach for lipophilic poorly water-soluble compounds. In LBFs, drugs are commonly pre-dissolved in lipids, and/or surfactants/cosolvents, hereby avoiding the rate-limiting dissolution step. According to the Lipid formulation classification system, proposed by Pouton in 2006, in type II LBFs a surfactant with an HLB-value lower than 12 is added to the lipids. If high drug doses are required, e.g. for preclinical toxicity studies, supersaturated LBFs prepared at ele...
Source: European Journal of Pharmaceutical Sciences - April 12, 2024 Category: Drugs & Pharmacology Authors: Felix Paulus Ren é Holm Jef Stappaerts Annette Bauer-Brandl Source Type: research

Model informed drug development: HSK21542 PBPK model supporting dose decisions in specific populations
Eur J Pharm Sci. 2024 Apr 8;196:106763. doi: 10.1016/j.ejps.2024.106763. Online ahead of print.ABSTRACTHKS21542, a highly selective activator of peripheral kappa opioid receptor agonists, plays a critical role in antinociception and itch inhibition during clinical development. Due to its indication population and elimination characteristics, it is imperative to evaluate the potential HSK21542 systemic exposure in individuals with renal impairment, hepatic impairment, the elderly, and the geriatric population. Here, a physiologically-based pharmacokinetic (PBPK) model for HSK21542 was developed based on in vitro metabolism ...
Source: European Journal of Pharmaceutical Sciences - April 10, 2024 Category: Drugs & Pharmacology Authors: Miao Zhang Zihan Lei Xueting Yao Lei Zhang Pangke Yan Nan Wu Meixia Chen Fengyi Zhang Dongyang Liu Source Type: research

First-In-Human Study on Pharmacokinetics, Safety, and Tolerability of Single and Multiple Escalating Doses of PA9159 Nasal Spray, a Highly Potent Glucocorticoid in Healthy Chinese Volunteers
CONCLUSIONS: The PA9159 nasal spray was generally safe and well tolerated, and the effects of PA9159 on serum cortisol levels were limited. The plasma concentration and systemic exposure to PA9159 were very low. These findings support the necessity for further clinical studies on PA9159 nasal spray in patients suffering from allergic rhinitis.PMID:38599506 | DOI:10.1016/j.ejps.2024.106764 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - April 10, 2024 Category: Drugs & Pharmacology Authors: Shaojie Guo Yingchun Hu Chengshuo Wang Yuan Zhang Feng Wu Siyang Ni Yuyang Dai Ying Han Minwan Hu Chunping Lu Zhijian Xi Laichun Lu Xiuli Zhao Luo Zhang Source Type: research

Model informed drug development: HSK21542 PBPK model supporting dose decisions in specific populations
Eur J Pharm Sci. 2024 Apr 8:106763. doi: 10.1016/j.ejps.2024.106763. Online ahead of print.ABSTRACTHKS21542, a highly selective activator of peripheral kappa opioid receptor agonists, plays a critical role in antinociception and itch inhibition during clinical development. Due to its indication population and elimination characteristics, it is imperative to evaluate the potential HSK21542 systemic exposure in individuals with renal impairment, hepatic impairment, the elderly, and the geriatric population. Here, a physiologically-based pharmacokinetic (PBPK) model for HSK21542 was developed based on in vitro metabolism and ...
Source: European Journal of Pharmaceutical Sciences - April 10, 2024 Category: Drugs & Pharmacology Authors: Miao Zhang Zihan Lei Xueting Yao Lei Zhang Pangke Yan Nan Wu Meixia Chen Fengyi Zhang Dongyang Liu Source Type: research

Unveiling the potential of biomaterials and their synergistic fusion in tissue engineering
Eur J Pharm Sci. 2024 Apr 3;196:106761. doi: 10.1016/j.ejps.2024.106761. Online ahead of print.ABSTRACTInspired by nature, tissue engineering aims to employ intricate mechanisms for advanced clinical interventions, unlocking inherent biological potential and propelling medical breakthroughs. Therefore, medical, and pharmaceutical fields are growing interest in tissue and organ replacement, repair, and regeneration by this technology. Three primary mechanisms are currently used in tissue engineering: transplantation of cells (I), injection of growth factors (II) and cellular seeding in scaffolds (III). However, to develop s...
Source: European Journal of Pharmaceutical Sciences - April 5, 2024 Category: Drugs & Pharmacology Authors: Eva Sanchez Armengol Nathalie Hock Sila Saribal Dennis To Simona Summonte Florina Veider Gergely Kali Andreas Bernkop-Schn ürch Flavia Laffleur Source Type: research