Potential targets for the treatment of MI: GRP75-mediated Ca < sup > 2+ < /sup > transfer in MAM
Eur J Pharmacol. 2024 Mar 23:176530. doi: 10.1016/j.ejphar.2024.176530. Online ahead of print.ABSTRACTAfter myocardial infarction (MI), there is a notable disruption in cellular calcium ion homeostasis and mitochondrial function, which is believed to be intricately linked to endoplasmic reticulum (ER) stress. This research endeavors to elucidate the involvement of glucose regulated protein 75 (GRP75) in post-MI calcium ion homeostasis and mitochondrial function. In MI rats, symptoms of myocardial injury were accompanied by an increase in the activation of ER stress. Moreover, in oxygen-glucose deprivation (OGD)-induced car...
Source: European Journal of Pharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Chenyan Zhang Bowen Liu Jiaxing Sheng Jia Wang Weijie Zhu Chen Xie Xuan Zhou Yuxin Zhang Qinghai Meng Yu Li Source Type: research

Deciphering the dual role of N-methyl-D-Aspartate receptor in postoperative cognitive dysfunction: A comprehensive review
Eur J Pharmacol. 2024 Mar 23:176520. doi: 10.1016/j.ejphar.2024.176520. Online ahead of print.ABSTRACTPostoperative cognitive dysfunction (POCD) is a common complication following surgery, adversely impacting patients' recovery, increasing the risk of negative outcomes, prolonged hospitalization, and higher mortality rates. The N-methyl-D-aspartate (NMDA) receptor, crucial for learning, memory, and synaptic plasticity, plays a significant role in the development of POCD. Various perioperative factors, including age and anesthetic use, can reduce NMDA receptor function, while surgical stress, inflammation, and pain may lead...
Source: European Journal of Pharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Shaodi Guan Yali Li Yueyang Xin Danning Wang Pei Lu Fanglong Han Hui Xu Source Type: research

Potential targets for the treatment of MI: GRP75-mediated Ca < sup > 2+ < /sup > transfer in MAM
Eur J Pharmacol. 2024 Mar 23:176530. doi: 10.1016/j.ejphar.2024.176530. Online ahead of print.ABSTRACTAfter myocardial infarction (MI), there is a notable disruption in cellular calcium ion homeostasis and mitochondrial function, which is believed to be intricately linked to endoplasmic reticulum (ER) stress. This research endeavors to elucidate the involvement of glucose regulated protein 75 (GRP75) in post-MI calcium ion homeostasis and mitochondrial function. In MI rats, symptoms of myocardial injury were accompanied by an increase in the activation of ER stress. Moreover, in oxygen-glucose deprivation (OGD)-induced car...
Source: European Journal of Pharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Chenyan Zhang Bowen Liu Jiaxing Sheng Jia Wang Weijie Zhu Chen Xie Xuan Zhou Yuxin Zhang Qinghai Meng Yu Li Source Type: research

Deciphering the dual role of N-methyl-D-Aspartate receptor in postoperative cognitive dysfunction: A comprehensive review
Eur J Pharmacol. 2024 Mar 23:176520. doi: 10.1016/j.ejphar.2024.176520. Online ahead of print.ABSTRACTPostoperative cognitive dysfunction (POCD) is a common complication following surgery, adversely impacting patients' recovery, increasing the risk of negative outcomes, prolonged hospitalization, and higher mortality rates. The N-methyl-D-aspartate (NMDA) receptor, crucial for learning, memory, and synaptic plasticity, plays a significant role in the development of POCD. Various perioperative factors, including age and anesthetic use, can reduce NMDA receptor function, while surgical stress, inflammation, and pain may lead...
Source: European Journal of Pharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Shaodi Guan Yali Li Yueyang Xin Danning Wang Pei Lu Fanglong Han Hui Xu Source Type: research

FGF17 protects cerebral ischemia reperfusion-induced blood-brain barrier disruption via FGF receptor 3-mediated PI3K/AKT signaling pathway
Eur J Pharmacol. 2024 Mar 22:176521. doi: 10.1016/j.ejphar.2024.176521. Online ahead of print.ABSTRACTMaintaining blood-brain barrier (BBB) integrity is critical components of therapeutic approach for ischemic stroke. Fibroblast growth factor 17 (FGF17), a member of FGF8 superfamily, exhibits the strongest expression throughout the wall of all major arteries during development. However, its molecular action and potential protective role on brain endothelial cells after stroke remains unclear. Here, we observed reduced levels of FGF17 in the serum of patients with ischemic stroke, as well as in the brains of mice subjected ...
Source: European Journal of Pharmacology - March 24, 2024 Category: Drugs & Pharmacology Authors: Wen-Ting Huang Xiong-Jian Chen Yu-Kai Lin Jun-Feng Shi Hong Li Hao-Di Wu Ruo-Lin Jiang Shuai Chen Xue Wang Xian-Xi Tan Ke-Yang Chen Peng Wang Source Type: research

In vitro and vivo anti-tumor activity and mechanisms of the new cryptotanshinone derivative 11 against hepatocellular carcinoma
This study aims to evaluate its in vitro and in vivo antitumor activity against hepatocellular carcinoma. 11 displayed robust anti-proliferative activity against HCC cell lines and promoted apoptosis of HCC cell line through the mitochondrial-mediated apoptotic pathway. In H22 tumor-bearing mice models, 11 exhibited significant in vivo anti-tumor activity with different administration routes. and no obvious toxicity was observed. RNA-seq analysis demonstrated the differential expressed genes and alteration of key pathways associated with immune responses after administration of 11. Up-regulation of anti-tumor cytokines and...
Source: European Journal of Pharmacology - March 24, 2024 Category: Drugs & Pharmacology Authors: Xinni Yang Xianlan She Zhishuang Zhao Jian Ren Peiying Wang Haoqi Dong Qin-Shi Zhao Jiangxin Liu Source Type: research

Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes
In this study, fatostatin effectively suppressed B16 melanoma, MC38 colon cancer, and Lewis lung cancer (LLC) transplanted tumor growth in immunocompetent mice by reducing SREBPs-mediated lipid metabolism, especially cholesterol levels. Mechanistically, fatostatin decreased intracellular cholesterol accumulation and inhibited X-box binding protein 1 (XBP1)-mediated endoplasmic reticulum (ER) stress, reducing Treg cells and alleviating CD8+ T cell exhaustion in the TME, exerting anti-tumor activity. Nevertheless, this effect was impaired in immunodeficient nude mice, suggesting fatostatin's anti-tumor efficacy in transpla...
Source: European Journal of Pharmacology - March 24, 2024 Category: Drugs & Pharmacology Authors: Lei Zhu Yilin Shi Zhelong Feng Dingyi Yuan Shiduo Guo Yuxia Wang Haowen Shen Yan Li Fang Yan Yajing Wang Source Type: research

FGF17 protects cerebral ischemia reperfusion-induced blood-brain barrier disruption via FGF receptor 3-mediated PI3K/AKT signaling pathway
Eur J Pharmacol. 2024 Mar 22:176521. doi: 10.1016/j.ejphar.2024.176521. Online ahead of print.ABSTRACTMaintaining blood-brain barrier (BBB) integrity is critical components of therapeutic approach for ischemic stroke. Fibroblast growth factor 17 (FGF17), a member of FGF8 superfamily, exhibits the strongest expression throughout the wall of all major arteries during development. However, its molecular action and potential protective role on brain endothelial cells after stroke remains unclear. Here, we observed reduced levels of FGF17 in the serum of patients with ischemic stroke, as well as in the brains of mice subjected ...
Source: European Journal of Pharmacology - March 24, 2024 Category: Drugs & Pharmacology Authors: Wen-Ting Huang Xiong-Jian Chen Yu-Kai Lin Jun-Feng Shi Hong Li Hao-Di Wu Ruo-Lin Jiang Shuai Chen Xue Wang Xian-Xi Tan Ke-Yang Chen Peng Wang Source Type: research

In vitro and vivo anti-tumor activity and mechanisms of the new cryptotanshinone derivative 11 against hepatocellular carcinoma
This study aims to evaluate its in vitro and in vivo antitumor activity against hepatocellular carcinoma. 11 displayed robust anti-proliferative activity against HCC cell lines and promoted apoptosis of HCC cell line through the mitochondrial-mediated apoptotic pathway. In H22 tumor-bearing mice models, 11 exhibited significant in vivo anti-tumor activity with different administration routes. and no obvious toxicity was observed. RNA-seq analysis demonstrated the differential expressed genes and alteration of key pathways associated with immune responses after administration of 11. Up-regulation of anti-tumor cytokines and...
Source: European Journal of Pharmacology - March 24, 2024 Category: Drugs & Pharmacology Authors: Xinni Yang Xianlan She Zhishuang Zhao Jian Ren Peiying Wang Haoqi Dong Qin-Shi Zhao Jiangxin Liu Source Type: research

Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes
In this study, fatostatin effectively suppressed B16 melanoma, MC38 colon cancer, and Lewis lung cancer (LLC) transplanted tumor growth in immunocompetent mice by reducing SREBPs-mediated lipid metabolism, especially cholesterol levels. Mechanistically, fatostatin decreased intracellular cholesterol accumulation and inhibited X-box binding protein 1 (XBP1)-mediated endoplasmic reticulum (ER) stress, reducing Treg cells and alleviating CD8+ T cell exhaustion in the TME, exerting anti-tumor activity. Nevertheless, this effect was impaired in immunodeficient nude mice, suggesting fatostatin's anti-tumor efficacy in transpla...
Source: European Journal of Pharmacology - March 24, 2024 Category: Drugs & Pharmacology Authors: Lei Zhu Yilin Shi Zhelong Feng Dingyi Yuan Shiduo Guo Yuxia Wang Haowen Shen Yan Li Fang Yan Yajing Wang Source Type: research

Paeoniflorin ameliorates oxaliplatin-induced peripheral neuropathy via inhibiting neuroinflammation through influence on gut microbiota
This study aimed to investigate the effects of paeoniflorin on OIPN and probe into the underlying mechanisms. The OIPN model was established through oxaliplatin injection in rats. The ameliorative effects of paeoniflorin on OIPN was assessed by nociceptive hypersensitivities through pain behavioral methods. Neuroinflammation were examined by measuring the levels of inflammatory cytokines and immune cells infiltration. The signaling pathway of TLR4/MyD88/NF-κB was evaluated by Western blotting. Gut microbial changes were detected by 16S rDNA sequencing technology. In addition, antibiotics-induced microbiota eradication and...
Source: European Journal of Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Jiayue Xu Langqing Lu Shiqin Jiang Zhiyan Qin Junyuan Huang Min Huang Jing Jin Source Type: research

Paeoniflorin ameliorates oxaliplatin-induced peripheral neuropathy via inhibiting neuroinflammation through influence on gut microbiota
This study aimed to investigate the effects of paeoniflorin on OIPN and probe into the underlying mechanisms. The OIPN model was established through oxaliplatin injection in rats. The ameliorative effects of paeoniflorin on OIPN was assessed by nociceptive hypersensitivities through pain behavioral methods. Neuroinflammation were examined by measuring the levels of inflammatory cytokines and immune cells infiltration. The signaling pathway of TLR4/MyD88/NF-κB was evaluated by Western blotting. Gut microbial changes were detected by 16S rDNA sequencing technology. In addition, antibiotics-induced microbiota eradication and...
Source: European Journal of Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Jiayue Xu Langqing Lu Shiqin Jiang Zhiyan Qin Junyuan Huang Min Huang Jing Jin Source Type: research

Paeoniflorin ameliorates oxaliplatin-induced peripheral neuropathy via inhibiting neuroinflammation through influence on gut microbiota
This study aimed to investigate the effects of paeoniflorin on OIPN and probe into the underlying mechanisms. The OIPN model was established through oxaliplatin injection in rats. The ameliorative effects of paeoniflorin on OIPN was assessed by nociceptive hypersensitivities through pain behavioral methods. Neuroinflammation were examined by measuring the levels of inflammatory cytokines and immune cells infiltration. The signaling pathway of TLR4/MyD88/NF-κB was evaluated by Western blotting. Gut microbial changes were detected by 16S rDNA sequencing technology. In addition, antibiotics-induced microbiota eradication and...
Source: European Journal of Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Jiayue Xu Langqing Lu Shiqin Jiang Zhiyan Qin Junyuan Huang Min Huang Jing Jin Source Type: research

Oxidized DJ-1 activates the p-IKK/NF- κB/Beclin1 pathway by binding PTEN to induce autophagy and exacerbate myocardial ischemia-reperfusion injury
In conclusion, ox-DJ-1 could activate detrimental autophagy through the PTEN/p-IKK/NF-κB/Beclin1 pathway and exacerbate myocardial I/R injury.PMID:38508437 | DOI:10.1016/j.ejphar.2024.176496 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Authors: Huiru Liu Xueying Wang Kang He Zihan Chen Xiaoqi Li Jianmin Ren Xiaoyan Zhao Song Liu Tingting Zhou Heping Chen Source Type: research

Quercetin-3-O-glc-1-3-rham-1-6-glucoside decreases A β production, inhibits Aβ aggregation and neurotoxicity, and prohibits the production of inflammatory cytokines
Eur J Pharmacol. 2024 Mar 17:176491. doi: 10.1016/j.ejphar.2024.176491. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative disease with the hallmark of aggregation of beta-amyloid (Aβ) into extracellular fibrillar deposition. Accumulating evidence suggests that soluble toxic Aβ oligomers exert diverse roles in neuronal cell death, oxidative stress, neuroinflammation, and the eventual pathogenesis of AD. Aβ is derived from the sequential cleavage of amyloid-β precursor protein (APP) by β-secretase (BACE1) and γ-secretase. The current effect of single targeting is not ideal for th...
Source: European Journal of Pharmacology - March 19, 2024 Category: Drugs & Pharmacology Authors: Shuo Tan Linmei Wu Jiayi Liu Zhaoyuan Wu Qiang Cheng Qiuhao Qu Lianghao Zhu Yizhu Yan Hao Wu Tie-Jun Ling Rui-Tian Liu Shigao Yang Source Type: research