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AnnouncementsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Source Type: journals

CalendarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Source Type: journals

Intramammary lymph node metastasis of breast cancer after sentinel node biopsy: Two cases and a review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with interest the paper from Bats et al., published in the March 2009 issue of this journal. Our letter has two goals: (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: C. Araújo, J.L. Fougo Tags: Correspondence Source Type: journals

Clinicopathologic risk factors for distant metastases from head and neck squamous cell carcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The number of levels with pathologic lymph node, the site of primary tumor and the level of tumor invasion are decisive risk factors in determining the development of DM in head and neck SCC patients. Patients with multilevel nodal involvement in neck, with laryngeal and hypopharyngeal carcinomas, and patients with primary tumor invasion into muscular, bone or cartilage have the highest risk of developing DM. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: X. Li, B. Di, Y. Shang, Y. Zhou, J. Cheng, Z. He Tags: Original Articles Source Type: journals

Outcome of intralesional curettage for low-grade chondrosarcoma of long bonesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Intralesional curettage is an effective treatment strategy for low-grade intramedullary chondrosarcoma of long bones, with excellent oncological and functional results. Careful case selection with stringent clinical and radiographic follow-up is recommended. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: S.A. Hanna, P. Whittingham-Jones, M.D. Sewell, R.C. Pollock, J.A. Skinner, A. Saifuddin, A. Flanagan, S.R. Cannon, T.W.R. Briggs Tags: Original Articles Source Type: journals

Tumor stage and resection margins not the mandibular invasion determines the survival in patients with cancers of oro-mandibular regionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In absence of randomized controlled trial which are difficult to design and conduct, the results of present study shows that mandibular conservation may be carried out, even in presence of involved mandible if negative resection margins could be achieved. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: M. Pandey, L.P. Rao, S.R. Das, M. Shukla Tags: Original Articles Source Type: journals

An audit of nephroureterectomy for upper tract urothelial carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This is the only study in recent 2 decades to evaluate the necessity of synchronous adrenalectomy in treating localized upper tract urothelial carcinoma. Adrenal-sparing nephroureterectomy seems justified for clinically localized upper tract urothelial carcinoma. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: C.-Y. Huang, S.-D. Chung, S.-M. Wang, C.-H. Liao, M.-K. Lai, K.-H. Huang, Y.-S. Pu, S.-C. Chueh, H.-J. Yu Tags: Original Articles Source Type: journals

Improved diagnosis and treatment of soft tissue sarcoma patients after implementation of national guidelines: A population-based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study evaluates the compliance with the guidelines over time.Patients: Population-based series of 119 operated patients with a soft tissue sarcoma (STS) diagnosed in 1998–1999 (79 before implementation of new guidelines) and in 2006 (40 after implementation).Methods: Coded information regarding patient and tumour characteristics as well as (the results of) pathology review was collected from the medical patient file by two experienced data-managers.Results: Diagnostic imaging of the tumour was performed according to the guidelines in 75–100% depending on the site of the tumour (abdominal versus non-abdominal) as w...
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: M.L.E.A. Jansen-Landheer, P. Krijnen, M.J. Oostindiër, W.M. Kloosterman-Boele, E.M. Noordijk, M.A. Nooij, W.H. Steup, A.H.M. Taminiau, R. Vree, P.C.W. Hogendoorn, R.A.E.M. Tollenaar, H. Gelderblom Tags: Original Articles Source Type: journals

Limb-salvage reconstruction with MUTARS® hemipelvic endoprosthesis: A prospective multicenter studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Periacetabular endoprosthetic replacement showed an acceptable functional and oncological outcome but had a high complication rate owing, predominantly, to infection. The indication for hemipelvic prosthesis in patients with a metastatic disease must be considered seriously. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: D. Witte, L. Bernd, J. Bruns, G. Gosheger, J. Hardes, E. Hartwig, B. Lehner, I. Melcher, W. Mutschler, M. Schulte, P.-U. Tunn, W. Wozniak, A. Zahlten-Hinguranage, F. Zeifang Tags: Original Articles Source Type: journals

Age disparities in referrals to specialist surgical care for papillary thyroid cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Despite their better prognosis, younger patients with papillary thyroid cancer were referred to specialist care across significantly greater distances, regardless of their lymph node status, than older patients who have a worse prognosis. The causes underlying these age disparities in referrals to specialist care warrant further research. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: A. Machens, H. Dralle Tags: Original Articles Source Type: journals

Neoadjuvant chemoradiation and pancreaticoduodenectomy for initially locally advanced head pancreatic adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PD after CRT was safe and resected patients had interesting survival rates. However, resected patients developed metastatic disease and new neoadjuvant regimens are needed to improve the survival of these patients. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: O. Turrini, F. Viret, L. Moureau-Zabotto, J. Guiramand, V. Moutardier, B. Lelong, M. Giovannini, J.R. Delpero Tags: Original Articles Source Type: journals

Peritoneal carcinomatosis and liver metastases from colorectal cancer treated with cytoreductive surgery perioperative intraperitoneal chemotherapy and liver resectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: An aggressive therapy comprising of cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) and liver resection/ablation is generally not offered to patients with both colorectal peritoneal carcinomatosis (CRPC) and liver metastases (LM) as it no longer represents a loco-regional disease. We review the outcomes of patients who underwent an aggressive treatment with a curative intent for both CRPC and LM as a prelude towards determining the suitability of this treatment.Methods: Patients with CRPC were treated with cytoreductive surgery and perioperative intraperitoneal chemoth...
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: T.C. Chua, T.D. Yan, J. Zhao, D.L. Morris Tags: Original Articles Source Type: journals

Inflammatory pseudotumours of the liver: A spectrum of presentation and management optionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Purpose: To review the current management options in inflammatory pseudotumours via analysis of ten cases from this unit the largest experience of this pathology in a Western series. To assess the medical and operative options available for this condition and the varying outcomes and the lessons learned in this unit over the time period.Results: Data from the ten cases were analysed and a comprehensive review of the published literature to date has detailed 128 case reports with 215 cases of inflammatory pseudotumour of the liver. Data analysed included patient demographics, diagnostic modalities, details of trea...
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: P.J. Goldsmith, A. Loganathan, M. Jacob, N. Ahmad, G.J. Toogood, J.P.A. Lodge, K.R. Prasad Tags: Original Articles Source Type: journals

Expression patterns of hypoxic markers at the invasive margin of colorectal cancers and liver metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aim: To understand the role of hypoxia in cancer progression of primary colorectal cancer and colorectal liver metastases. To look at associations of hypoxia with more aggressive phenotypes.Methods: Archival tissue was retrieved from 55 patients and tissue micro arrays were constructed using tissue from the margin and the centre of the tumour. Hypoxia markers Hif-1α, Vegf, CA-9, VHL and Glut-1 were visualised using immunohistochemical detection and quantified using semi-quantitative analysis of the digitised images. Clinical details and outcome data were retrieved by case note review and collated with hypoxia m...
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: R. Rajaganeshan, R. Prasad, P.J. Guillou, N. Scott, G. Poston, D.G. Jayne Tags: Original Articles Source Type: journals

Transanal endoscopic microsurgery versus total mesorectal excision of T1 rectal adenocarcinomas with curative intentionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Purpose: After total mesorectal excision (TME) for rectal cancer, pathology is standardized with margin status as a predictor for recurrence. This has yet to be implemented after transanal endoscopic microsurgery (TEM) and was investigated prospectively for T1 rectal adenocarcinomas.Patients and methods: Eighty patients after TEM were compared to 75 patients after TME. The study protocol included standardized pathology. TEM patients were eligible when excision margins were negative.Results: TEM was safer than TME as reflected by operating time, blood loss, hospital stay, morbidity, re-operation rate and stoma for...
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: E.J.R. De Graaf, P.G. Doornebosch, R.A.E.M. Tollenaar, E. Meershoek-Klein Kranenbarg, A.C. de Boer, F.C. Bekkering, C.J.H. van de Velde Tags: Original Articles Source Type: journals

Conversion from laparoscopic to open colonic cancer resection – Associated factors and their influence on long-term oncological outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Conversion of laparoscopic colon cancer resection worsens DFS in locally advanced stage II carcinoma. There is a need to reduce the conversion rate by adequate patient selection for laparoscopic resection by experienced surgeons. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: H. Ptok, R. Kube, U. Schmidt, F. Köckerling, I. Gastinger, H. Lippert, the “Colon/Rectum Carcinoma (Primary Tumor)” Study Group Tags: Original Articles Source Type: journals

Influence of neoadjuvant radio-chemotherapy on tumor-infiltrating lymphocytes in squamous esophageal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Neoadjuvant RCT reduced the number of TILs in esophageal SCC. This was primarily seen in the centre of tumors and suggests that the effect of RCT on immunological response is located in the centre of tumors. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: U. Zingg, M. Montani, D.M. Frey, S. Dirnhofer, P. Went, D. Oertli Tags: Original Articles Source Type: journals

Body mass index and breast cancer survival in relation to the introduction of mammographic screeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Overweight and obese women may be a group that profit from mammographic screening to more than normal weight women. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: Å. Olsson, J.P. Garne, I. Tengrup, S. Zackrisson, J. Manjer Tags: Original Articles Source Type: journals

The significance of immunohistochemistry positivity in sentinel nodes which are negative on haematoxylin and eosin in breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Introduction: Sentinel lymph node (SLN) biopsy allows a more detailed examination of a smaller number of lymph nodes in patients with clinically node negative breast cancer. Immunohistochemistry detects small tumour burden not routinely seen on haematoxylin and eosin (H&E). The significance of such findings remains to be fully elucidated.Aim: To assess the axillary disease burden of patients in whom the sentinel lymph node biopsy was positive on immunohistochemistry and negative on H and E.Methods: An analysis of patients who underwent SLN mapping for breast cancer at St Vincent's University Hospital from January...
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: S. Mac Giobuin, D.O. Kavanagh, E. Myers, A.O. Doherty, C.M. Quinn, T. Crotty, D. Evoy, E. McDermott Tags: Original Articles Source Type: journals

Sentinel node imaging in breast cancer using superficial injections: Technical details and observationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The NEW START recommended, combined superficial injection techniques, have high localisation rates. Pre-operative sentinel node imaging is recommended and a template for reporting is provided. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: S.K. Somasundaram, D.W. Chicken, W.A. Waddington, J. Bomanji, P.J. Ell, M.R.S. Keshtgar Tags: Original Articles Source Type: journals

Factors predicting the sentinel node metastases in T1 breast cancer tumor:An analysis of 1416 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aim: To determine the factors associated with the metastatic involvement of sentinel lymph node (SLN) biopsy in patients with early breast cancer.Study design: This was a retrospective study of patients with T1 invasive breast cancer who underwent SLN biopsy at Claudius Regaud Institute between January 2001 and September 2008.Results: 1416 patients were recruited into this study. SLN metastases were detected in 368 patients (26%). Younger age, tumor size and location, histological type, nuclear grade, and lymphovascular invasion appear to be significant risk factors of SNL involvement. In multivariate analysis, t...
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: J. Capdet, P. Martel, H. Charitansky, Y.K.T. Lim, G. Ferron, L. Battle, A. Landier, E. Mery, S. Zerdoub, H. Roche, D. Querleu Tags: Original Articles Source Type: journals

The State of the EJSO 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I am delighted to be able to report at the end of 2009 and symbolically at the end of the first decade of the 21st century that the EJSO is in excellent shape. Since its origins in the mid-1970s, the journal has progressed from a small regional subspeciality journal with a negligible Impact Factor to an Internet enabled, broadly based multi-disciplinary journal with an IF of around 2.5; a manuscript flow of around 600 per annum; an increase in publication frequency from 6 to 12 per year; a healthy rejection rate and list of manuscripts awaiting publication; and a logged full article download of some 300,000 items annually...
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: David Rew Tags: Editorial Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Source Type: journals

AnnouncementsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Source Type: journals

CalendarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Source Type: journals

A joint specialist breast cancer and menopause symptoms (BCMS) clinic: Service development using a clinical governance approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objectives: To ensure safe, evidence based, patient care delivery Methods: Working in close liaison with the Trust's breast team, a monthly BCMS clinic was established in late 2006. Referrals are for patients with personal or family history of breast cancer seeking specialist menopause management advice. A clinical governance approach has informed service development. Multi-disciplinary menopause team patient case conferences operate at the end of each clinic. Depending on available staffing resources, a specialist breast care nurse attends each clinic. Quarterly MDT meetings with the Breast Unit team have been particular...
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Nuttan Tanna, J. Woyka, K. Abernathy, R. Reichart, J. Pitkin Tags: Abstracts Source Type: journals

The role of suppressors of cytokine signaling in human breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined the expression of SOCS 1-7 genes in normal and breast cancer tissue and correlated this with several clinico-pathological and prognostic factors. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Walid Sasi, W. Jiang, A. Sharma, K. Mokbel Tags: Abstracts Source Type: journals

Surgery for nipple discharge: rich harvest or poor yield?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Nipple discharge (ND) constitutes around 5% of breast clinic presentations with surgical intervention being reserved for pathological or suspicious ND. The aim of this study was to determine the malignant yield from surgery for ND and to assess the association between malignancy and pre-operative findings. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Matthew Stephenson, E. Shah Tags: Abstracts Source Type: journals

Mastectomy for C5 cytology- is it safe practice?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: To evaluate the accuracy of cytological diagnosis of breast cancers greater than 11mm in detecting invasive cancers and therefore the ability to use fine needle aspiration (FNA) as the sole diagnostic parameter. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Hazem Khout, R. Frame, J. McCaslin, K. Clark Tags: Abstracts Source Type: journals

Immunohistochemical expression of mammaglobin in breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aims to examine the relationship between mammaglobin A expression in breast cancer specimens with pathological grades/markers. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Liz Baker, L. Hall, J. France, D. Whetter, P. Bhaskar Tags: Abstracts Source Type: journals

Has sentinel node biopsy increased frequency of completion clearances and affected how we should counsel patients?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In our unit, new breast cancer patients are counselled on the probability of nodal metastases using a Kaufman axillary treatment (KAT) scale derived from our own unit's data. This equates to the likelihood of needing a second operation to clear, if opting for initial nodal sampling. We were concerned that following more detailed nodal pathological analysis as part of the new sentinel node procedure, stage migration would alter this probability. We aimed to determine whether our scale needed recalibrating to take account of this. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Joseph Maalo, S. Thomson Tags: Abstracts Source Type: journals

To dilute or not to dilute? A study of the effect of dilution of patent blue dye on the identification rate of sentinel lymph nodes in breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study compares the efficacy of injection of 2mls of undiluted blue dye with 2mls of blue dye diluted in a further 3mls of saline. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Katie Eyre, T. Oakley, J. Gill, R. Cutress, R. Nicol, A. Agrawal, C. Yiangou, M. Wise Tags: Abstracts Source Type: journals

Use of multiple drains after mastectomy is associated with more discomfort and longer post-operative hospital stayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Seromas constitute a common complication following surgery for breast cancer and closed drainage is used routinely to reduce its incidence. The aim of this study was to evaluate the influence of number of drains on patient discomfort, seroma formation, and hospital stay after mastectomy for breast cancer. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Soni Soumian, A. Saratzis, R. Willetts, P. Stonelake Tags: Abstracts Source Type: journals

Use of sentinel lymph node biopsy halves the Lymphoedema rate overallEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Lymphoedema following breast cancer treatment is a chronic, disabling condition. Following introduction of sentinel lymph node biopsy (SLNB) for axillary staging only the patients with positive axilla have completion clearance. How much has SLNB reduced the morbidity of lymphoedema in our DGH? (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Tahira Aslam, B. Chandrasekaran, R. Cochrane Tags: Abstracts Source Type: journals

Validation of Van Nuys classification in 183 patients with screen detected DCIS, a retrospective analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: The Van Nuys Prognostic Index (VNPI) is a numerical index designed to guide treatment following Breast Conserving Surgery for DCIS. It combines size, margin and grade and separates patients into low risk group suitable for treatment with excision only, moderate risk group suitable for excision with radiotherapy and high-risk group where mastectomy is recommended. The authors tested the validity of VNPI and the proposed benefit of adjuvant radiotherapy. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Lona Jalini, G. Mazdai, I. Mokadem, H. Lucraft, D. Hemming, D. Browell Tags: Abstracts Source Type: journals

BORIS (Brother of Regulator of Imprinting Sites) as a possible new blood marker for breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: The CTCF- paralogous transcriptional factor, BORIS, is a member of the Cancer- Testis gene family specifically expressed in the testis, but abnormally expressed in various malignancies including breast cancer. The aim of the study was to investigate the expression of BORIS in the leukocyte fractions from Breast cancer patients and healthy donors. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Sankaran ChandraSekharan, N. Pore, E. Klenova Tags: Abstracts Source Type: journals

Single dose radiotherapy during surgery for breast cancer patients where external beam radiation was not feasible - results after 3 years of follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Intra-operative radiotherapy (IORT) with Intrabeam® (Carl Zeiss, Germany) has been used since 2000 in the international randomised TARGIT Trial to determine if there is equivalence between the novel IORT technique and conventional external beam radiotherapy (EBRT) in women with early breast cancer. Some patients were unsuitable for inclusion in our trial for a number of reasons and were given IORT as a single treatment off-trial. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Mohammed Keshtgar, J. Vaidya, C. Stacey, J. Tobias, N. Williams, M. Baum Tags: Abstracts Source Type: journals

Audit of Blue dye guided axillary surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aim: The aim of the audit was to look at the accuracy of using blue dye alone for identifying Sentinel nodes and to look at false negative rates. Background: We are currently in the audit phase of the Almanac study. All patients having axillary surgery (who are not in the Almanac study) will have blue dye injected at time of operation. The MDT prior to operation will have decided whether patients are having a sample or full dissection. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Sankaran ChandraSekharan, S. Marsh, I. Anwar Tags: Abstracts Source Type: journals

Tumour suppressor function of CHIP & LOX in human breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, mRNA expression of CHIP and LOX were assessed in a cohort of breast cancers and correlated to clinico-pathological parameters over a 10 year follow-up period. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Neill Patani, W. Jiang, K. Mokbel Tags: Abstracts Source Type: journals

Sentinel Lymph node biopsy in breast cancer: How many nodes should we remove?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigates whether there is a maximum number of sentinel lymph nodes (SLN) that need to be excised without compromising the false negative (FN) rate of this procedure. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Roslyn Pursell, J. Gill, R. Lovegrove, K. Naessens, T. Cominos, C. McCormick Tags: Abstracts Source Type: journals

Assessment of symptomatic patients in the NHS Breast Screening Programme (NHSBSP) - Is It worthwhile?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Within the NHSBSP the majority of patients attending for screening are asymptomatic. Significant breast symptoms or signs can be noted at the time of screening and are an indication for recall to an assessment clinic (NHSBSP publication no.49). The aim of this study was to review the outcome of patients recalled to an assessment clinic due to breast symptoms. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Amanda Taylor, K. Chin, A. Havard, P. Evans, G. Komodikis Tags: Abstracts Source Type: journals

Review of 22 cases of breast Phyllodes tumour presented and treated at Doncaster Bassetlaw Hospitals NHS TrustEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Phyllodes Tumor accounts for 0.5% to 1.0% of all breast tumors, difficulty in diagnosis arise from similarity to a more common fibroadenomas, potentially to recur locally and/or metastasize, diagnostic and therapeutic procedures remaining a challenge. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Ali Siala, J. Psaila, M. Kolar, N. Kazzazi, A. Verchese Tags: Abstracts Source Type: journals

Ultrasound of axilla - does size of the lymph node metastasis matter in breast cancer?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Lymph node status (LN) is the most important prognostic indicator in breast cancer. Preoperative assessment of axilla with ultrasound with or without cytology helps us to advise patients' appropriate surgery to the axilla. This is a recommendation in the latest NICE guidelines. A proportion of patients with normal ultrasound of the axillae do still have metastasis in the lymph nodes on histological assessment post excision. We feel the size of the metastasis may have an influence in such assessment. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Rathinasabapathy Rathinaezhil, K. Allen, M. Taylor, A. Berresford, A. Yelland, C. Zammit Tags: Abstracts Source Type: journals

Survivorship experience of West Midlands breast cancer patients who died in 2005-07Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study takes a cohort of female patients with invasive breast cancer who died in 2005-07 and looks backwards in time giving a different perspective on breast cancer survival. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Gill Lawrence, J. Walton, E. O'Sullivan, M. Porter, C. Mellors, O. Kearins Tags: Abstracts Source Type: journals

PR status of invasive breast cancer in relation to Src kinase expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Recently it has been published that high cytoplasmic total Src kinase and activated (Y419) Src kinase expression is associated with worse clinical outcome in breast cancer patients. This observation is potentiated in ER negative patients. It's also known that ER/PR positive patients with acquired tamoxifen resistance have a better outcome than ER/PR negative when total Src is highly expressed in the nucleus. Aim of this study was to establish the significance and correlation of PR status to clinical and Src kinase expression data of our cohort. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Beatrix Elsberger, S. Brown, T. Mitchell, J. Edwards Tags: Abstracts Source Type: journals

High expression of Src kinase family members (SKFMs) in breast cancer specimens and their association to patients' clinical outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Pilot results, investigating mRNA expression levels of SKFMs, have shown that Src and Lyn were highest expressed in invasive breast cancer tissue, and that Lck and Lyn were higher expressed in ER negative compared to ER positive tumours. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Beatrix Elsberger, R. Fullerton, B. Tan, T. Mitchell, J. Edwards Tags: Abstracts Source Type: journals

The role of pre-operative lymphoscintigraphy before sentinel lymph node biopsy (SLNB) for breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Pre-operative lymphoscintigram for axillary SLNB requires on-site nuclear medicine facilities which are not available at district general hospitals and may not be required for successful SLNB. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Abraham Mathew, A. Saha, T. Saleem, N. Saddozai, I. Hutchinson, A. Nejim Tags: Abstracts Source Type: journals

The causes of immediate implant-based breast reconstruction failure and its sequelaeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Implant-based breast reconstruction, whether expander or prosthesis, is currently the most common technique for immediate breast reconstruction (IBR) after mastectomy for cancer. Whilst loss of the reconstruction, due to infection or cutaneous necrosis and extrusion, is rare, it is a devastating complication and almost 70% undergo no further reconstructive attempts. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: M.G. Berry, H. Charitansky, F. Petitperrin, V. Mosseri, R. Salmon, A. Fitoussi Tags: Abstracts Source Type: journals

Oncoplastic breast surgery for cancer: the first 20 yearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: For large tumours and those in less favourable locations, standard breast conserving therapy (BCT) is being replaced by more imaginative oncoplastic breast surgery (OBS) techniques that draw on plastic surgery principles to both anticipate and avoid poor aesthetic outcomes and further reduce the rate of mastectomy. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: M.G. Berry, A. Fitoussi, F. Fama, B. Couturaud, R. Salmon Tags: Abstracts Source Type: journals

Coding and revenue: impact on Portsmouth Breast UnitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: The Department of Health has introduced Payment by Results whereby Hospital Trusts charge Primary Care Trusts (PCTs) for work undertaken. This relies on accurate completion of spell summaries (TTOs) and coding to determine levels of reimbursement. This audit reviewed the breast surgery undertaken within the Portsmouth Breast Unit to assess whether tariffs charged were in line with actual work undertaken. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Iain Edgar, J. Gill, A. Agrawal, M. Wise, C. Yiangou, R. Cutress Tags: Abstracts Source Type: journals