Interleukin-33 as a biomarker affected intrathecal synthesis of immunoglobulin in NMOSD and MOGAD
Conclusions: Thus, we concluded that IL-33 may induce dysfunction of the blood brain barrier and lead to intrathecal synthesis of immunoglobulin in the AQP4+NMOSD and MOGAD, especially in MOGAD. It maybe as a biomarker, at least in part, was involved in the demyelinating diseases of the central nervous system. (Source: European Neurology)
Source: European Neurology - April 26, 2023 Category: Neurology Source Type: research

Close your eyes and see – stroke sequelae versus functional neurological disorder in a physician
The first author was a left-handed, 51-year-old nephrologist who experienced a neurologic event. She underwent neurosurgery complicated by hemorrhage. Post-operatively, she developed persistent vertigo and unilateral tongue pain which persisted for over five years. Early neuroimaging revealed expected encephalomalacia but no neuroanatomical basis for my symptoms. A functional neurological disorder was suspected, and she was seen by several psychiatrists and psychotherapists. However, she suspected a neuroanatomical lesion would better explain her unrelenting symptoms. After seeing many neurologists, a neuroanatomical diagn...
Source: European Neurology - April 20, 2023 Category: Neurology Source Type: research

Efficacy and safety of ticagrelor versus aspirin and clopidogrel for stroke prevention in patients with vascular disease: a systematic review and meta-analysis
Introduction: Currently, it is still controversial to treat stroke with ticagrelor alone. The purpose of our study was to systematically review and analyze the efficacy and safety of ticagrelor on cerebrovascular outcomes in patients with vascular risk factors. Methods: The PubMed, Cochrane Library, and EMBASE databases were systematically searched using the keywords stroke, ticagrelor, clopidogrel, and aspirin to identify randomized controlled trials (RCT). Primary outcomes included reported stroke, ischemic stroke and complex events; the secondary outcome was hemorrhagic stroke. The safety outcomes included major bleedi...
Source: European Neurology - April 17, 2023 Category: Neurology Source Type: research

Association between respiratory function and motor function in different stages of Parkinson ’s disease
Conclusion: Our findings revealed that respiratory impairment is present in moderate and advanced PD patients, and directly related to the severity of the disease. It is important to conduct respiratory function test in the clinic al practice. (Source: European Neurology)
Source: European Neurology - April 17, 2023 Category: Neurology Source Type: research

Popeye Sign: Look at the Heart (and the Nerves)
(Source: European Neurology)
Source: European Neurology - March 31, 2023 Category: Neurology Source Type: research

Neurologic Images Popeye sign: look at the heart (and the nerves)
Abstract is not required for Neurologic Images (Source: European Neurology)
Source: European Neurology - March 31, 2023 Category: Neurology Source Type: research

Relationship between peripheral blood inflammatory factors and prognosis of subarachnoid hemorrhage: A meta-analysis
Background: Subarachnoid hemorrhage (SAH) is a severe cerebrovascular event with high mortality and disability rate. Neuroinflammation is involved in the brain injury after SAH, but the exact association between SAH progression and peripheral blood inflammatory factors is unknown. Therefore, to determine the relationship between inflammatory factors and the prognosis of SAH, we performed a meta-analysis. Method: A systematic literature review was conducted in PubMed, EMBASE, and Cochrane Library. Studies comparing the relationship between inflammatory factors (C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-10...
Source: European Neurology - March 27, 2023 Category: Neurology Source Type: research

Delirium and dementia in the elderly: sometimes associated or always together?
Background – In the elderly, the association of delirium and dementia can cause diagnostic problems because they share the same symptom of confusion. Delirium is often misdiagnosed as dementia and treated inappropriately, ignoring that it could be successfully addressed, which can lead to increased health ri sks up to death. Summary – Confusion indicates that functional reserve fails to compensate for the action of stressors. The decline in reserve is linked to aging-related changes in blood flow, mitochondria, cerebrospinal fluid, and immune function, as well as the appearance of structural precursor s of disease. It ...
Source: European Neurology - March 23, 2023 Category: Neurology Source Type: research

Berlin Bowel Bothers: Might Adolf Hitler ’s Gut Problems Have Been Parkinson-Related?
It has been argued that Adolf Hitler (1889 – 1945) had Parkinson’s disease. He also experienced several gastrointestinal symptoms, for which various explanations have been sought, both contemporaneously and by later authors. In this Historical Note, a possible relationship between Hitler’s Parkinson’s disease and his gastrointestinal symptoms is explored. Specifically, we posit the hypothesis that Hitler may have suffered from small-intestinal bacterial overgrowth (SIBO), thus providing an early example of SIBO occurring as a prodromal Parkinson’s disease symptom. (Source: European Neurology)
Source: European Neurology - March 15, 2023 Category: Neurology Source Type: research

Summary of safety and efficacy of COVID-19 vaccination in patients with multiple sclerosis
The objective of this article is to summarize the current knowledge on immune responses to the COVID-19 vaccines and their safety in MS patients and to provide practical guidance based on the data available to date. Key Messages: Although MS is not associated with a higher risk of COVID-19, this infection can trigger relapses or pseudo-relapses. Vaccines against SARS-CoV-2 are recommended for all MS patients who are not in the active phase of the disease, despite the fact that there is still a lack of long-term reliable data on the effectiveness and safety of vaccines against COVID-19. Some DMTs can reduce vaccine humoral...
Source: European Neurology - March 4, 2023 Category: Neurology Source Type: research

A simplified clinical prediction rule for prognosticating dependent daily living in patients with thoracic spinal cord injury: A multicenter nationwide Japan registry study
Conclusions   We developed a simplified, moderately accurate CPR for predicting whether patients with thoracic SCI achieve independent living at hospital discharge. (Source: European Neurology)
Source: European Neurology - March 3, 2023 Category: Neurology Source Type: research

Development of Acute Transverse Myelitis following COVID-19 Infection: A Review on the Potential Pathways
Background: Acute transverse myelitis (ATM) is a rare neurological disorder in adults characterized by localized inflammation of gray and white matter in one or more contiguous spinal cord segments in the absence of a compressive injury. Several reports have connected the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to the pathophysiology of ATM. Summary: Direct invasion of the spinal cord, cytokine storm, or an autoimmune response are the possible pathways by which the SARS-CoV-2 virus can affect the spinal cord and lead to ATM. Direct invasion is facilitated by the presence of angiotensin-converting enzym...
Source: European Neurology - March 1, 2023 Category: Neurology Source Type: research

Minor salivary gland biopsy for the diagnosis of neurosarcoidosis
Conclusion: Considering the low sensitivity of MSGB for the diagnosis of NS, MSGB should be per formed in selected indications, including a suspicion of spinal cord sarcoidosis, or when there is a strong clinical, laboratory and radiological suspicion of NS. MSGB should rather not be performed when the chest CT-scan does not show signs of pulmonary or lymph node sarcoidosis. (Source: European Neurology)
Source: European Neurology - March 1, 2023 Category: Neurology Source Type: research

Long-Lasting COVID-Associated Brain Fog: A Follow-Up Study
Conclusion: We may conclude that a minority of the hospitalized patients with COVID-19 may suffer from long-lasting post-COVID brain fog, at least for more than 1 year after their initial illness. Long-lasting post-COVID brain fog has a significant association with the severity of the initial illness. (Source: European Neurology)
Source: European Neurology - February 24, 2023 Category: Neurology Source Type: research

Long-lasting COVID-associated brain fog; a follow-up study
Conclusion: We may conclude that a minority of the hospitalized patients with COVID-19 may suffer from long-lasting post-COVID brain fog, at least for more than one year after their initial illness. Long-lasting post-COVID brain fog has a significant association with the severity of the initial illness. (Source: European Neurology)
Source: European Neurology - February 24, 2023 Category: Neurology Source Type: research