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(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - November 2, 2009 Category: Psychiatry & Psychology Source Type: journals

ECNP Calendar of EventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - November 2, 2009 Category: Psychiatry & Psychology Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - November 2, 2009 Category: Psychiatry & Psychology Source Type: journals

Antipsychotic effects on auditory sensory gating in schizophrenia patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: P50 sensory gating deficit has repeatedly been demonstrated in schizophrenia. Studies have produced inconsistent findings with respect to normalization of P50 gating in patients with schizophrenia receiving treatment with different antipsychotics. The current study was designed to determine whether there is a difference in P50 gating in schizophrenia patients treated with first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs), including clozapine. P50 evoked potential recordings were obtained from 160 patients with schizophrenia and 77 healthy comparison subjects. Forty-three patients ...
Source: European Neuropsychopharmacology - October 15, 2009 Category: Psychiatry & Psychology Authors: Eva María Sánchez-Morla, José Luis Santos, Ana Aparicio, María Ángeles García-Jiménez, Clara Villanueva, Vicente Martínez-Vizcaíno, Celso Arango Tags: Research papers Source Type: journals

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(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - October 5, 2009 Category: Psychiatry & Psychology Source Type: journals

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(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - October 5, 2009 Category: Psychiatry & Psychology Source Type: journals

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(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - October 5, 2009 Category: Psychiatry & Psychology Source Type: journals

BL-1020, a novel antipsychotic candidate with GABA-enhancing effects: D2 receptor occupancy study in humansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: BL-1020 is a potentially novel antipsychotic, which comprises the typical antipsychotic perphenazine linked by an ester bound to γ-aminobutyric acid (GABA), intending a simultaneous dopamine-2 (D2) receptor blockade and GABA facilitation in the brain. This positron emission tomography (PET) study, using [11C]raclopride, assessed the extent and duration of D2 receptor occupancy (D2 RO) and safety for single doses of BL-1020 in healthy male subjects. Overall, this study did not raise any safety concern. Single doses of 16–32 mg BL-1020 caused a dose dependent striatal D2 RO. The 32 mg dose of BL-1020 resulted ...
Source: European Neuropsychopharmacology - September 1, 2009 Category: Psychiatry & Psychology Authors: Lieuwe Appel, Yona Geffen, Kerstin Heurling, Catarina Eriksson, Gunnar Antoni, Shitij Kapur Tags: Research papers Source Type: journals

Brain structural changes associated with chronicity and antipsychotic treatment in schizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Accumulating evidence suggest a life-long impact of disease related mechanisms on brain structure in schizophrenia which may be modified by antipsychotic treatment. The aim of the present study was to investigate in a large sample of patients with schizophrenia the effect of illness duration and antipsychotic treatment on brain structure. Seventy-one schizophrenic patients and 79 age and gender matched healthy participants underwent brain magnetic resonance imaging (MRI). All images were processed with voxel based morphometry, using SPM5. Compared to healthy participants, patients showed decrements in gray matter...
Source: European Neuropsychopharmacology - September 1, 2009 Category: Psychiatry & Psychology Authors: Luisa Tomelleri, Jigar Jogia, Cinzia Perlini, Marcella Bellani, Adele Ferro, Gianluca Rambaldelli, Michele Tansella, Sophia Frangou, Paolo Brambilla, The Neuroimaging Network of the ECNP networks initiative Tags: Research papers Source Type: journals

Atomoxetine hydrochloride in the treatment of children and adolescents with attention-deficit/hyperactivity disorder and comorbid oppositional defiant disorder: A placebo-controlled Italian studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objective: The primary aim of this study was to assess the efficacy of atomoxetine in improving ADHD and ODD symptoms in paediatric patients with ADHD and comorbid oppositional defiant disorder (ODD), non-responders to previous psychological intervention with parent support.Methods: This was a multicentre, randomised, placebo-controlled trial conducted in patients aged 6–15 years, with ADHD and ODD diagnosed according to the DSM-IV criteria by a structured clinical interview (K-SADS-PL). Only subjects who are non-responders to a 6-week standardized parent training were randomised to atomoxetine (up to 1.2 mg/...
Source: European Neuropsychopharmacology - August 31, 2009 Category: Psychiatry & Psychology Authors: Grazia Dell'Agnello, Dino Maschietto, Carmela Bravaccio, Filippo Calamoneri, Gabriele Masi, Paolo Curatolo, Dante Besana, Francesca Mancini, Andrea Rossi, Lynne Poole, Rodrigo Escobar, Alessandro Zuddas, for the LYCY Study Group Tags: Research papers Source Type: journals

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(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - August 31, 2009 Category: Psychiatry & Psychology Source Type: journals

ECNP Announcement: ECNP 2010 Awards for Outstanding ScientistsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - August 31, 2009 Category: Psychiatry & Psychology Source Type: journals

ECNP Calendar of EventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - August 31, 2009 Category: Psychiatry & Psychology Source Type: journals

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(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - August 31, 2009 Category: Psychiatry & Psychology Source Type: journals

Rejuvenation of antioxidant and cholinergic systems contributes to the effect of procyanidins extracted from the lotus seedpod ameliorating memory impairment in cognitively impaired aged ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The major purpose of this study was to determine the effect of procyanidins extracted from the lotus seedpod (LSPC) on the learning and memory impairments in cognitively impaired aged rats. Based on Morris water maze performance compared with young female rats, aged unimpaired (AU) and aged impaired (AI) rats were chosen from aged female rats. LSPC supplementation (50, 100 mg/kg BW, p.o.) for 7 weeks significantly improved learning and memory impairments in AI animals in the Morris water maze test, as evaluated by shortened escape latency and swimming distance. Aged rats had significantly declined antioxidant d...
Source: European Neuropsychopharmacology - August 28, 2009 Category: Psychiatry & Psychology Authors: Jiqu Xu, Shuang Rong, Bijun Xie, Zhida Sun, Li Zhang, Hailei Wu, Ping Yao, Xiping Zhang, Yunjian Zhang, Liegang Liu Tags: Research papers Source Type: journals

Antidepressive behaviors induced byenriched environment might be modulated by glucocorticoid levelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Exposure to enriched environment (EE) can influence expression of depression symptoms, however, the underlying mechanism has not been established, although neurogenesis was probably involved. It has been reported that EE stimulates glucocorticoids release. However, the role of corticosterone (CORT) in effects of EE is still unknown. To address these issues, we examined depression-like behaviors of the animals exposed to EE with low dose CORT supplement following bilateral adrenalectomy (ADX+CORT). Two months after housing, tail suspension test and forced swim test were used to assess depression-related behavior o...
Source: European Neuropsychopharmacology - August 7, 2009 Category: Psychiatry & Psychology Authors: Zhiwei Xu, Bing Hou, Youzhi Zhang, Yan Gao, Yonghong Wu, Shifu Zhao, Chenggang Zhang Tags: Research papers Source Type: journals

Effects of quetiapine on phencyclidine-induced cognitive deficits in mice: A possible role of α1-adrenoceptorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Accumulating evidence suggests that α1-adrenoceptors may be involved in the mechanisms of action of some antipsychotic drugs. The present study was undertaken to examine the effects of quetiapine, an atypical antipsychotic drug with α1-adrenoceptor antagonism, on cognitive deficits in mice after repeated administration of the NMDA receptor antagonist phencyclidine (PCP). Subsequent subchronic (14 days) administration of quetiapine (1.0, 10, or 30 mg/kg, p.o.) attenuated PCP (10 mg/kg/day for 10 days)-induced cognitive deficits in mice, in a dose dependent manner. Furthermore, PCP (10 mg/kg)-induced cogniti...
Source: European Neuropsychopharmacology - August 5, 2009 Category: Psychiatry & Psychology Authors: Yuko Tanibuchi, Yuko Fujita, Mami Kohno, Tamaki Ishima, Yuto Takatsu, Masaomi Iyo, Kenji Hashimoto Tags: Research papers Source Type: journals

Chronic treatment with 13-cis-retinoic acid changes aggressive behaviours in the resident–intruder paradigm in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Retinoids, vitamin A related compounds, have an established role in the development of the nervous system and are increasingly recognized to play a role in adult brain function. The synthetic retinoid, 13-cis-retinoic acid (13-cis-RA, Roaccutane) is widely used to treat severe acne but has been linked to an increased risk of neuropsychiatric side effects, including depression. Here we report that chronic administration with 13-cis-RA (1mg/kg i.p. daily, 7–14days) in adult rats reduced aggression- and increased flight-related behaviours in the resident–intruder paradigm. However, in the forced swim, sucrose co...
Source: European Neuropsychopharmacology - August 3, 2009 Category: Psychiatry & Psychology Authors: Simon Trent, Cheney J.G. Drew, Paul J. Mitchell, Sarah J. Bailey Tags: Research papers Source Type: journals

Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Suggestive associations have been reported between trace amines and heat shock proteins, and a disrupted pathophysiology that enhances the risk of psychosis and that modifies responses to antipsychotic treatments. Our group previously reported genetic studies on TAAR6 and HSP-70 separately in patients with schizophrenia. In the current study, we investigated possible epistasis between the same set of variations in a sample of 281 patients diagnosed with schizophrenia and 288 healthy controls. We applied the generalized multifactor dimensionality reduction (MDR) method and controlled covariates significantly assoc...
Source: European Neuropsychopharmacology - July 29, 2009 Category: Psychiatry & Psychology Authors: Chi-Un Pae, Antonio Drago, Ashwin A. Patkar, Tae-Youn Jun, Alessandro Serretti Tags: Research papers Source Type: journals

Stress-mediated decreases in brain-derived neurotrophic factor as potential confounding factor for acute tryptophan depletion-induced neurochemical effectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Acute tryptophan depletion (ATD) is extensively used to investigate the implication of serotonin (5-hydroxytryptamine; 5-HT) in the onset and treatment of depression and cognitive disorders. Brain-derived neurotrophic factor (BDNF) is strongly linked to the 5-HT system and plays an essential role in mood and memory processes. The present study investigated the effects of ATD upon BDNF in serum, hippocampus and prefrontal cortex in the rat to further explore the underlying mechanism of ATD.ATD significantly decreased peripheral tryptophan (TRP) levels and moderately interrupted 5-HT metabolism 4h after administrat...
Source: European Neuropsychopharmacology - July 28, 2009 Category: Psychiatry & Psychology Authors: Eva L. van Donkelaar, Daniël L.A. van den Hove, Arjan Blokland, Harry W.M. Steinbusch, Jos Prickaerts Tags: Research papers Source Type: journals

Proapoptotic and chemosensitizing effects of selective serotonin reuptake inhibitors on T cell lymphoma/leukemia (Jurkat) in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: While selective serotonin reuptake inhibitors (SSRIs) are commonly used for psychiatric indications, evidence implies them to possess anti-cancerous properties as well. We evaluated such in vitro effects in malignant T cells (Jurkat), finding that exposure to high concentrations of sertraline (IC50=9.5µM) or paroxetine (IC50=18µM) yielded a considerable reduction in cellular viability, exceeding equimolar doses of the chemotherapeutics vincristine and cyclophosphamide (P (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - July 26, 2009 Category: Psychiatry & Psychology Authors: Ben Hayman Amit, Irit Gil-Ad, Michal Taler, Meytal Bar, Amichai Zolokov, Abraham Weizman Tags: Research papers Source Type: journals

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(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - July 25, 2009 Category: Psychiatry & Psychology Source Type: journals

ECNP Announcement: 2010 ECNP WorkshopEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - July 25, 2009 Category: Psychiatry & Psychology Source Type: journals

ECNP Calendar of EventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - July 25, 2009 Category: Psychiatry & Psychology Source Type: journals

Guide for AuthorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - July 25, 2009 Category: Psychiatry & Psychology Source Type: journals

Welcome message from the new editorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dear colleagues, Traditionally, the foundations of medical education and progress have been paths of knowledge transfer — from master to trainee/apprentice, from colleague to colleague, and through the medical press, whose all-important task it is to gather the most recent and relevant scientific information, screen it for accuracy, and distribute it to the medical community. Over the last three decades, interrelated technological and social developments have changed the nature of medical education and the medical press, making the exchange of information virtually unlimited. European Neuropsychopharmacology is included...
Source: European Neuropsychopharmacology - July 25, 2009 Category: Psychiatry & Psychology Authors: Michael Davidson Tags: Editorials Source Type: journals

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(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - July 25, 2009 Category: Psychiatry & Psychology Source Type: journals

Clomipramine treatment reversed the glial pathology in a chronic unpredictable stress-induced rat model of depressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Growing evidence indicates that glia pathology contributes to the pathophysiology and possibly the etiology of depression. The study investigates changes in behaviors and glial fibrillary associated protein (GFAP) in the rat hippocampus after chronic unpredictable stress (CUS), a rat model of depression. Furthermore, we studied the effects of clomipramine, one of tricyclic antidepressants (TCAs), known to modulate serotonin and norepinephrine uptake, on CUS-induced depressive-like behaviors and GFAP levels. Rats exposed to CUS showed behavioral deficits in physical state, open field test and forced swimming test ...
Source: European Neuropsychopharmacology - July 20, 2009 Category: Psychiatry & Psychology Authors: Qiong Liu, Bing Li, Hai-Yan Zhu, Yan-Qing Wang, Jin Yu, Gen-Cheng Wu Tags: Research papers Source Type: journals

Differential influence of selective 5-HT5A vs 5-HT1A, 5-HT1B, or 5-HT2C receptor blockade upon light-induced phase shifts in circadian activity rhythms: Interaction studies with citalopramEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this is the first in vivo evidence for an influence of 5-HT5A receptors upon circadian rhythms, but no single class of 5-HT receptor mediates their control by citalopram. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - July 15, 2009 Category: Psychiatry & Psychology Authors: Robert L. Gannon, Jean-Louis Peglion, Mark J. Millan Tags: Research papers Source Type: journals

Farewell message from the Founding EditorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Twenty years have passed since the European College of Neuropsychopharmacology made the decision to found the College's journal; a bold and forward looking decision for an association that was very young at the time. Two editors were selected in order to focus on the publication of basic and of clinical research. We were honoured to be given the opportunity to watch over the birth of the journal and to contribute to its development. The members of ECNP represent a body of serious researchers working in a broad spectrum of disciplines and deserve a scientific journal of the first rank. Our editorial aims were clear: the jou...
Source: European Neuropsychopharmacology - July 14, 2009 Category: Psychiatry & Psychology Authors: Stuart A. Montgomery, Jan M. van Ree Tags: Editorials Source Type: journals

Brain opioid receptor binding in early abstinence from alcohol dependence and relationship to craving: An [11C]diprenorphine PET studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The importance of the opioid receptor system in substance dependence is increasingly recognised. We used PET with the non-selective tracer [11C]diprenorphine to examine opioid receptor binding in early abstinence from alcohol dependence and the relationship to craving. We recruited 11 alcohol dependent patients and 13 controls. Subjects underwent one [11C]diprenorphine PET scan in early abstinence from dependent alcohol use (∼2weeks) and 2months later if continuously abstinent. Global and regional [11C]diprenorphine volumes of distribution (VD) were increased in alcohol dependent patients compared with controls...
Source: European Neuropsychopharmacology - July 12, 2009 Category: Psychiatry & Psychology Authors: Tim M. Williams, Simon J.C. Davies, Lindsay G. Taylor, Mark R.C. Daglish, Alexander Hammers, David J. Brooks, David J. Nutt, Anne Lingford-Hughes Tags: Research papers Source Type: journals

Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Social isolation from weaning in rats produces behavioural and hippocampal structural changes at adulthood. Here, rats were group or isolation reared for eight-weeks. Following the initial four-week period of rearing, fluoxetine (10mg/kg i.p.) was administered for 28days. Changes in recognition memory, hippocampal monoamines, and cytoskeletal microtubules were investigated. Isolation-rearing for four- or eight-weeks produced recognition memory deficits that were not reversed by fluoxetine. Eight-weeks of isolation decreased α-tubulin acetylation (Acet-Tub) and the tyrosinated/detyrosinated α-tubulin ratio (Tyr/...
Source: European Neuropsychopharmacology - July 7, 2009 Category: Psychiatry & Psychology Authors: Massimiliano Bianchi, Kevin C.F. Fone, Ajit J. Shah, Alan R. Atkins, Lee A. Dawson, Christian A. Heidbreder, Jim J. Hagan, Charles A. Marsden Tags: Research papers Source Type: journals

The antinociceptive properties of reboxetine in acute painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The antinociceptive effects of the selective noradrenaline reuptake inhibitor antidepressant reboxetine and its interaction with various opioid and noradrenaline receptor subtypes were evaluated. Reboxetine (i.p.) induced a weak dose-dependent antinociceptive effect in acute pain, using the hotplate model. The reboxetine-induced antinociception was significantly inhibited by the opioid receptor antagonists naloxone, nor-BNI, naltrindole and b-FNA, implying a non-selective role for the opioid receptors in the reboxetine's antinociceptive effect. The adrenergic antagonists yohimbine and phentolamine attenuated to s...
Source: European Neuropsychopharmacology - July 7, 2009 Category: Psychiatry & Psychology Authors: Shaul Schreiber, Ruthi Frishtick, Ina Volis, Vardit Rubovitch, Chaim G. Pick, Ronit Weizman Tags: Research papers Source Type: journals

Effect of basic fibroblast growth factor (FGF2) gene polymorphisms on SSRIs treatment response and side effectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this is the first study investigating the association of antidepressant response and intolerance with FGF2 variants. This finding adds an important piece of information for the pathway of detecting the genetics of antidepressant response. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - July 7, 2009 Category: Psychiatry & Psychology Authors: Masaki Kato, Gaku Okugawa, Masataka Wakeno, Yoshiteru Takekita, Shinpei Nonen, Shinji Tetsuo, Keiichiro Nishida, Junichi Azuma, Toshihiko Kinoshita, Alessandro Serretti Tags: Research papers Source Type: journals

Altered expression and modulation of activity-regulated cytoskeletal associated protein (Arc) in serotonin transporter knockout ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A gene variant in the human serotonin transporter (SERT) can increase the vulnerability to mood disorders. SERT knockout animals show similarities to the human condition and represent an important tool to investigate the mechanisms underlying the pathologic condition in humans. Along this line of thinking, we used SERT KO rats (SERT+/− and SERT−/−) to investigate abnormalities in the expression and function of the activity-regulated gene Arc (Activity-regulated cytoskeletal associated protein) and the early inducible gene Zif-268, (zinc finger binding protein clone 268), which are important players in neuro...
Source: European Neuropsychopharmacology - July 6, 2009 Category: Psychiatry & Psychology Authors: Raffaella Molteni, Francesca Calabrese, Paola F. Maj, Jocelien D.A. Olivier, Giorgio Racagni, Bart A. Ellenbroek, Marco A. Riva Tags: Research papers Source Type: journals

Response to prophylactic lithium in bipolar disorder may be associated with a preservation of executive cognitive functionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We assessed performance on the Wisconsin Card Sorting Test (WCST), measuring executive functions, in 30 patients showing different prophylactic effect of lithium (excellent lithium responders—ER, partial responders—PR and non-responders—NR), and in fifty persons of their offspring (12 of ER, 26 of PR, and 12 of NR). Age- and gender head-to-head matched population consisted of 30 subjects for lithium group and 50 subjects for the offspring of lithium patients. In lithium patients, NR had significantly worse results compared to the remaining groups and to control subjects on perseverative errors (WCST-P) and ...
Source: European Neuropsychopharmacology - July 5, 2009 Category: Psychiatry & Psychology Authors: Janusz K. Rybakowski, Agnieszka Permoda-Osip, Alina Borkowska Tags: Research papers Source Type: journals

A novel compound N1,N5-(Z)-N10-(E)-tri-p-coumaroylspermidine isolated from Carthamus tinctorius L. and acting by serotonin transporter inhibitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Safflower, the dry flower of Carthamus tinctorius L., has long been applied for empirically treating cerebral ischemia and depression in traditional Chinese medicine. Pathogenesis of major depression involves monoaminergic transmission. The present study assessed whether safflower or its isolate would be effective in functionally regulating monoamine transporter using in vitro screening cell lines. We discovered that safflower insoluble fraction significantly inhibited serotonin uptake in Chinese hamster ovary cells stably expressing serotonin transporter (i.e. S6 cells). This fraction went through an activity-gu...
Source: European Neuropsychopharmacology - July 5, 2009 Category: Psychiatry & Psychology Authors: Gang Zhao, Yue Gai, Wen-Jing Chu, Guo-Wei Qin, Li-He Guo Tags: Research papers Source Type: journals

Frontal EEG predictors of treatment outcome in major depressive disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Using automated analysis of frontal EEG collected during the first week of antidepressant treatment it may be possible to facilitate prediction of SSRI or venlafaxine efficacy in MDD. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - July 2, 2009 Category: Psychiatry & Psychology Authors: Dan V. Iosifescu, Scott Greenwald, Philip Devlin, David Mischoulon, John W. Denninger, Jonathan E. Alpert, Maurizio Fava Tags: Research papers Source Type: journals

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(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - June 26, 2009 Category: Psychiatry & Psychology Tags: Research papers Source Type: journals

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(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - June 26, 2009 Category: Psychiatry & Psychology Tags: Research papers Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - June 26, 2009 Category: Psychiatry & Psychology Source Type: journals

SSRIs, bone mineral density, and risk of fractures — a reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A possibility for selective serotonin reuptake inhibitors (SSRIs) to increase the risk of bone fracture has been debated during recent years. Proposed causes include an ability for the drugs to reduce bone mineral density (BMD). Experimental data have identified a functional 5-HT system in bone, although its role is unclear. Results from numerous epidemiological studies are heterogeneous and several different associations have been suggested; between depression and low BMD, SSRIs and low BMD, depression and falls, SSRIs and falls, depression and fractures, and SSRIs and fractures. In this paper, we review the ava...
Source: European Neuropsychopharmacology - June 21, 2009 Category: Psychiatry & Psychology Authors: Sofie Schwan, Pär Hallberg Tags: Review Source Type: journals

Prenatal viral infection of mice at E16 causes changes in gene expression in hippocampi of the offspringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The hippocampus governs memory formation and emotional regulation, and there is widespread evidence of hippocampal dysfunction in psychiatric disorders, including schizophrenia and autism. There is abundant evidence that prenatal viral infection may play a role in the development of these two disorders. In the current study, we have examined gene expression and structural changes of the hippocampi of exposed neonates following maternal infection at embryonic day (E) 16 (middle second trimester). We observed significant changes in gene expression in the offspring at postnatal day (P) 0 (birth), P14 (childhood), an...
Source: European Neuropsychopharmacology - June 7, 2009 Category: Psychiatry & Psychology Authors: S. Hossein Fatemi, Timothy D. Folsom, Teri J. Reutiman, Hao Huang, Kenichi Oishi, Susumu Mori Tags: Research papers Source Type: journals

Molecular tools for assessing human depression by positron emission tomographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We review reports published over the past 5 years on positron emission tomography (PET) of neurotransmission in depressive disorders. The molecular tools of PET neuroimaging are compounds labeled with a positron-emitting nuclide. PET radioligands have been used in recent years to study several aspects of monoaminergic and cholinergic neurotransmission in the brain of depressed subjects and healthy controls. The value of kinetic parameters of certain PET radioligands has often been reported to be lower in depressed subjects than in healthy ones, but there is usually no reliable relationship between the binding po...
Source: European Neuropsychopharmacology - June 7, 2009 Category: Psychiatry & Psychology Authors: Donald F. Smith, Steen Jakobsen Tags: Reviews Source Type: journals

Tolerability of outpatient antipsychotic treatment: 36-month results from the European Schizophrenia Outpatient Health Outcomes (SOHO) studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, antipsychotics have different tolerability profiles in terms of the adverse events we monitored. Results should be interpreted conservatively due to the observational study design. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - June 7, 2009 Category: Psychiatry & Psychology Authors: Diego Novick, Josep Maria Haro, Elena Perrin, David Suarez, João Marques Texeira Tags: Research papers Source Type: journals

Association between corneal temperature and mental status of treatment-resistant schizophrenia inpatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study indicates that treatment-resistant overtly psychotic schizophrenia inpatients' mental status (as assessed by the PANSS) correlates with their corneal temperature. The relevance of these phenomena to the pathophysiology of schizophrenia, the biological mechanism underlying corneal temperature alterations and the possible role of temperature-modulating drugs (neuroleptics or non-neuroleptics) on schizophrenic psychosis merits further large-scale investigation in both medicated- and drug-free schizophrenia patients compared to matched controls. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - June 3, 2009 Category: Psychiatry & Psychology Authors: Roni Shiloh, Lior Schapir, Danit Bar-Ziv, Rafael Stryjer, Shai Konas, Rachel Louis, Haggai Hermesh, Hanan Munitz, Abraham Weizman, Avi Valevski Tags: Research papers Source Type: journals

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(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - May 30, 2009 Category: Psychiatry & Psychology Source Type: journals

ECNP Announcement: Deadline Late Registration - 22nd ECNP CongressEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - May 30, 2009 Category: Psychiatry & Psychology Source Type: journals

ECNP Calendar of EventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - May 30, 2009 Category: Psychiatry & Psychology Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - May 30, 2009 Category: Psychiatry & Psychology Source Type: journals