A nationwide study on immunosenescence biomarkers profile in older adults: ELSI-Brazil
Exp Gerontol. 2024 Apr 13:112433. doi: 10.1016/j.exger.2024.112433. Online ahead of print.ABSTRACTImmunosenescence is a phenomenon caused by changes in the immune system, and part of these changes involves an increase in circulating immunological biomarkers, a process known as "Inflammaging." Inflammaging can be associated with many diseases related to older people. As the older population continues to grow, understanding changes in the immune system becomes essential. While prior studies assessing these alterations have been conducted in countries with Caucasian populations, this investigation marks a pioneering effort. T...
Source: Experimental Gerontology - April 15, 2024 Category: Geriatrics Authors: Maria Luiza Lima-Silva Karen Cec ília Lima Torres Juliana Vaz de Melo Mambrini Nathalia Coimbra de Brot Sara de Oliveira Santos Olindo Assis Martins-Filho Andr éa Teixeira-Carvalho Maria Fernanda Lima-Costa S érgio Viana Peixoto Source Type: research
A nationwide study on immunosenescence biomarkers profile in older adults: ELSI-Brazil
Exp Gerontol. 2024 Apr 13:112433. doi: 10.1016/j.exger.2024.112433. Online ahead of print.ABSTRACTImmunosenescence is a phenomenon caused by changes in the immune system, and part of these changes involves an increase in circulating immunological biomarkers, a process known as "Inflammaging." Inflammaging can be associated with many diseases related to older people. As the older population continues to grow, understanding changes in the immune system becomes essential. While prior studies assessing these alterations have been conducted in countries with Caucasian populations, this investigation marks a pioneering effort. T...
Source: Experimental Gerontology - April 15, 2024 Category: Geriatrics Authors: Maria Luiza Lima-Silva Karen Cec ília Lima Torres Juliana Vaz de Melo Mambrini Nathalia Coimbra de Brot Sara de Oliveira Santos Olindo Assis Martins-Filho Andr éa Teixeira-Carvalho Maria Fernanda Lima-Costa S érgio Viana Peixoto Source Type: research
The oxytocin receptor is essential for the protective effect of pair housing on post-stroke depression in mice
In conclusion, pair housing protects against the development of PSD depending on OXT and OXTR in the brain, with no significant divergence based on sex. These findings provide valuable insights into the potential of social interaction and oxytocin as therapeutic targets for PSD. Further research into the underlying mechanisms of these effects may contribute to the development of novel treatments for PSD.PMID:38614224 | DOI:10.1016/j.exger.2024.112432 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Su-Ting Jiang Shu-Ying Lian Yao-Huan Sun Mei-Bo Pan Bin Wang Hui Wang Jun Hua Yi-Chen Wang Qiu-Ling Wang Yin-Feng Dong Source Type: research
Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease
CONCLUSION: These findings suggested that LY96 might be a novel potential biomarker for PD, and offer insights into its immunoregulatory role.PMID:38614225 | DOI:10.1016/j.exger.2024.112415 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Haoran Peng Longyu Wu Siyuan Chen Shaopu Wu Xiaoxue Shi Jianjun Ma Hongqi Yang Xue Li Source Type: research
The oxytocin receptor is essential for the protective effect of pair housing on post-stroke depression in mice
In conclusion, pair housing protects against the development of PSD depending on OXT and OXTR in the brain, with no significant divergence based on sex. These findings provide valuable insights into the potential of social interaction and oxytocin as therapeutic targets for PSD. Further research into the underlying mechanisms of these effects may contribute to the development of novel treatments for PSD.PMID:38614224 | DOI:10.1016/j.exger.2024.112432 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Su-Ting Jiang Shu-Ying Lian Yao-Huan Sun Mei-Bo Pan Bin Wang Hui Wang Jun Hua Yi-Chen Wang Qiu-Ling Wang Yin-Feng Dong Source Type: research
Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease
CONCLUSION: These findings suggested that LY96 might be a novel potential biomarker for PD, and offer insights into its immunoregulatory role.PMID:38614225 | DOI:10.1016/j.exger.2024.112415 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Haoran Peng Longyu Wu Siyuan Chen Shaopu Wu Xiaoxue Shi Jianjun Ma Hongqi Yang Xue Li Source Type: research
The oxytocin receptor is essential for the protective effect of pair housing on post-stroke depression in mice
In conclusion, pair housing protects against the development of PSD depending on OXT and OXTR in the brain, with no significant divergence based on sex. These findings provide valuable insights into the potential of social interaction and oxytocin as therapeutic targets for PSD. Further research into the underlying mechanisms of these effects may contribute to the development of novel treatments for PSD.PMID:38614224 | DOI:10.1016/j.exger.2024.112432 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Su-Ting Jiang Shu-Ying Lian Yao-Huan Sun Mei-Bo Pan Bin Wang Hui Wang Jun Hua Yi-Chen Wang Qiu-Ling Wang Yin-Feng Dong Source Type: research
Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease
CONCLUSION: These findings suggested that LY96 might be a novel potential biomarker for PD, and offer insights into its immunoregulatory role.PMID:38614225 | DOI:10.1016/j.exger.2024.112415 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Haoran Peng Longyu Wu Siyuan Chen Shaopu Wu Xiaoxue Shi Jianjun Ma Hongqi Yang Xue Li Source Type: research
Stretch-shortening cycles protect against the age-related loss of power generation in rat single muscle fibres
Exp Gerontol. 2024 Apr 10:112423. doi: 10.1016/j.exger.2024.112423. Online ahead of print.ABSTRACTAging is associated with impaired strength and power during isometric and shortening contractions, however, during lengthening (i.e., eccentric) contractions, strength is maintained. During daily movements, muscles undergo stretch-shortening cycles (SSCs). It is unclear whether the age-related maintenance of eccentric strength offsets age-related impairments in power generation during SSCs owing to the utilization of elastic energy or other cross-bridge based mechanisms. Here we investigated how aging influences SSC performanc...
Source: Experimental Gerontology - April 12, 2024 Category: Geriatrics Authors: Makenna A Patterson Avery Hinks Binta S Njai Benjamin E Dalton Emma F Hubbard Geoffrey A Power Source Type: research
Cardiorespiratory fitness mediates the relationship between depressive symptomatology and cognition in older but not younger adults
Exp Gerontol. 2024 Apr 10:112429. doi: 10.1016/j.exger.2024.112429. Online ahead of print.ABSTRACTAging is commonly associated with emotional, physical, and cognitive changes, with the latter, particularly affecting executive functioning. Further, such changes may interact. For instance, depressive symptomatology is a known risk factor for developing cognitive deficits, especially at older ages. In contrast, an active lifestyle, reflected in high cardiorespiratory fitness (CRF) levels, has proven to protect against adverse effects on cognition across the adult lifespan. Hence, this study aimed to investigate the relationsh...
Source: Experimental Gerontology - April 12, 2024 Category: Geriatrics Authors: Catarina Barros Adriana Sampaio Diego Pinal Source Type: research
The effect of tamoxifen on estradiol, SHBG, IGF-1, and CRP in women with breast cancer or at risk of developing breast cancer: a meta-analysis of randomized controlled trials
CONCLUSION: Tamoxifen administration seems to increase estradiol and SHBG levels and reduce CRP and IGF-1 levels in women with breast cancer or at risk of developing breast cancer. Further studies are needed to determine whether these changes have any clinical relevance.PMID:38608792 | DOI:10.1016/j.exger.2024.112431 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 12, 2024 Category: Geriatrics Authors: XingDa Li XueJiao Hou Benjamin Hern ández-Wolters Kousalya Prabahar Hamed Kord-Varkaneh Bo Mei Source Type: research
Home-based resistance training performed at either fast or slow speeds improves power output in older adults
CONCLUSIONS: Unsupervised, body mass- and home-based resistance training performed at either fast or slow speeds can improve muscle power in older adults, while fast-speed exercise may be preferable over slow-speed owing to the relatively greater improvement of muscle-power, -volume, -architecture, and better time efficiency.PMID:38608793 | DOI:10.1016/j.exger.2024.112430 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 12, 2024 Category: Geriatrics Authors: Kosuke Hirata Mari Ito Yuta Nomura Chiho Kawashima Tsukasa Yoshida Yosuke Yamada Neale A Tillin Geoffrey A Power Ryota Akagi Source Type: research
The associations of daytime napping and motoric cognitive risk syndrome: Findings from the China Health and Retirement Longitudinal Study
CONCLUSION: A moderate nap of 30-89 min could lower the odds of MCR, especially for older adults with a night sleep duration of ≤8 h.PMID:38604250 | DOI:10.1016/j.exger.2024.112426 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 11, 2024 Category: Geriatrics Authors: Lixing Zhou Yan Zhang Meiling Ge Gongchang Zhang Rui Cheng Yixin Liu Xiaoli Chen Xiaolei Liu Birong Dong Source Type: research
The effect of age and sex on peak oxygen uptake during upper and lower body exercise: A systematic review
CONCLUSIONS: These responses suggest that upper body VO2peak decreases in line with that of the lower body but, due to the lower peak values achieved during ACE, decreases in VO2peak may have more profound functional impact compared to that for the lower body. Using absolute and relative measures of VO2peak results in different age-related profiles when considered below 50 years of age. To further our understanding of whole body ageing more data is required for participants in mid and later life. The association between VO2peak and underlying physiological factors with age needs to be studied further, particularly in conju...
Source: Experimental Gerontology - April 11, 2024 Category: Geriatrics Authors: M J Price P M Smith L M Bottoms M W Hill Source Type: research
Age-related changes in muscle coordination patterns of stepping responses to recover from loss of balance
CONCLUSION: Although synergy structure was not affected by age, the delayed step onsets and the enhanced early synergy recruitment point at a relative bias towards non-stepping behavior in older adults. They may need more time for accumulating information on the direction of perturbation and making the corresponding sensorimotor transformations before initiating the step. Future work may investigate whether perturbation-based training improves these age-related deficits.PMID:38604252 | DOI:10.1016/j.exger.2024.112424 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 11, 2024 Category: Geriatrics Authors: Wouter Staring Sarah Zandvliet Digna de Kam Teodoro Solis-Escalante Alexander Geurts Vivian Weerdesteyn Source Type: research
