Experimental and Clinical Endocrinology and DiabetesThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Influence of Fructose Concentration on Myocardial Infarction in Senile Diabetic and Non-diabetic PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aims to determine the fructose concentration and correlate with antioxidant status in senile diabetic and non-diabetic patients with myocardial infarction.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 19, 2009 Category: Endocrinology Tags: Article Source Type: journals

Comparative Study of Low-dose Pioglitazone or Metformin Treatment in Japanese Diabetic Patients with Metabolic SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 593-599DOI: 10.1055/s-0029-1202792AbstractThe aim of this study was to determine whether a relatively low dose of pioglitazone or metformin was effective in diabetic patients with metabolic syndrome. Fifty diabetic patients with metabolic syndrome were randomly assigned to a low-dose pioglitazone (15 mg/day) treatment group or a low-dose metformin (500 mg/day) treatment group. Drugs were administered for 12 weeks. Systolic and diastolic blood pressure, heart rate, body mass index, triglyceride (TG), HDL and LDL-cholesterol, fasting plasma glucose (FPG), fasting plasma ins...
Source: Experimental and Clinical Endocrinology and Diabetes - November 19, 2009 Category: Endocrinology Tags: Article Source Type: journals

Evaluation of Beta Cell Dysfunction by Mixed Meal Tolerance Test and Oral L-arginine in Patients with Newly Diagnosed Type 2 Diabetes MellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 573-576DOI: 10.1055/s-0029-1234087Abstract Defective insulin secretion is required for the development of frank diabetes mellitus. We evaluated the secretory response of pancreatic beta cells after the ingestion of mixed meal plus oral L-arginine in newly diagnosed type 2 diabetic patients.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 19, 2009 Category: Endocrinology Tags: Article Source Type: journals

Obesity and CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 563-566DOI: 10.1055/s-0029-1241870AbstractEpidemiological studies have suggested that obesity is associated with increased risk of several cancer types including colon, esophagus, breast (in postmenopausal women), endometrium, kidney, liver, gallbladder and pancreas. Suggested mechanisms include increased intake of potentially carcinogenic food ingredients along with excessive amount of calories, loss of cancer protective effects due to reduced physical activity, carcinogenic factors released from increased adipose tissue mass and “secondary” associations via “precu...
Source: Experimental and Clinical Endocrinology and Diabetes - November 19, 2009 Category: Endocrinology Tags: Mini-Review Source Type: journals

Diabetes, Obesity, Insulin Resistance: Different Pathways to Cancer?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 561-562DOI: 10.1055/s-0029-1241797© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 19, 2009 Category: Endocrinology Tags: Editorial Source Type: journals

Medical Antihyperglycaemic Treatment of Type 2 Diabetes Mellitus*Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 522-557DOI: 10.1055/s-0029-1239559© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | FREE: Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 30, 2009 Category: Endocrinology Tags: Guidelines Source Type: journals

Interactions of Thyroid Hormones; Insulin-like Growth Factor-1 (IGF-1), IGF Binding Proteins, and Nutritional Anthropometric Parameters in School Children with Goiter Detected by PalpationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 490-495DOI: 10.1055/s-0029-1237732Abstract In the present study we evaluated anthropometric indices, serum thyroid hormones, insulin-like growth factor-1 (IGF-1) and IGF- binding proteins (IGFBPs) levels, in children who has palpable goiter at endemic population. We aimed to 1) compare children with palpable goiter with healthy peers, 2) detect interaction of anthropometric indices, serum thyroid hormones, IGF-1 and IGFBPs parameters in both groups 3) evaluate the effects of their nutritional status to these parameters.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart ·...
Source: Experimental and Clinical Endocrinology and Diabetes - October 30, 2009 Category: Endocrinology Tags: Article Source Type: journals

Ghrelin Treatment Increases Receptor-bound Leptin in Healthy and Endotoxemic Obese Lewis RatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 473-479DOI: 10.1055/s-0029-1220769AbstractObese patients with sepsis have higher morbidity and mortality rates than normal weight subjects. One crucial factor is the disease-associated disturbed energy balance. Ghrelin is an orexigenic peptide, mainly produced in the stomach. Leptin is an adipose-tissue derived peptide, circulating as free (fl) and receptor-bound protein (bl) acting antagonistically to ghrelin's effects on food intake. In the present study we tested the weight dependent influence of an intravenous (i.v.) ghrelin injection on leptin levels as well as hepatic protein e...
Source: Experimental and Clinical Endocrinology and Diabetes - October 30, 2009 Category: Endocrinology Tags: Article Source Type: journals

A Simple Single Serum Method to Measure Fractional Calcium Absorption using Dual Stable IsotopesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1234088AbstractThe dual stable isotope method with a timed 24-h urine collection is the gold standard approach to measure fractional calcium absorption. However, the need to collect urine for 24 h makes this technique time-consuming and laborious. Our study sought to determine whether a dual isotope method using a single serum sample obtained 4 h after administration of the initial isotope provides a useful approach to measure fractional calcium absorption. Following a metabolic diet with a fixed calcium intake of 30 mmol/day for 10 days, nineteen healthy su...
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2009 Category: Endocrinology Tags: Short Communication Source Type: journals

Obesity: A Complex Growing ChallengeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1233448AbstractThe prevalence of overweight and obesity is increasing worldwide. The physiological mechanisms involved in body weight regulation are complex and incompletely understood. Increasing evidence suggests that obesity is a multifactorial disease where many, if not all, organs of the body are involved. The adipose tissue was considered as a simple fat accumulation for a long period of time. However, nowadays it is fascinating to progressively discover its involvement in hormonal, inflammatory or immune system dysregulation. Adipokines and cytokines are involved in co...
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2009 Category: Endocrinology Tags: Review Source Type: journals

Blockade of the RAS increases Plasma Adiponectin in Subjects with Metabolic Syndrome and Enhances Differentiation and Adiponectin Expression of Human PreadipocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237706Abstract This observational study aimed to investigate the effects of renin-angiotensin system (RAS) blockers on plasma adiponectin in subjects with metabolic syndrome (Mets) and differentiation, adiponectin expression of human omental (OM) and subcutaneous (SC) preadipocytes.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

A Novel Mutation (V101A) of the LHX4 Gene in a Japanese Patient with Combined Pituitary Hormone DeficiencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the study was to clarify the molecular basis of a Japanese patient of CPHD with a small anterior pituitary and an ectopic posterior pituitary.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

Mutational Characterization of Steroid 21-Hydroxylase Gene in Portuguese patients with Congenital Adrenal HyperplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study allow the characterization of the mutational spectrum of CAH patients, mainly non-classical CAH, with 21-hydroxylase deficiency from Portugal showing specific genetic features of this population which reveals differences with worldwide countries.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

Insulin Alters the Permeability of Sheep PleuraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1233452Abstract Insulin promotes ion transportation across epithelia, mainly kidneys, leading to water and electrolyte abnormalities, possibly causing ‘insulin oedema syndrome’, which rarely presents as pleural effusion. Direct stimulation of sheep pleura by insulin and the possible electrophysiology mechanisms involved were investigated.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

A Novel GNAS1 Mutation in a German Family with Albright's Hereditary OsteodystrophyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237708AbstractAlbright's hereditary osteodystrophy (AHO) is an inherited disorder and results from heterozygous mutation within the human Gα gene (GNAS1). AHO appears in two phenotypes, that may occur within the same family. Pseudohypoparathyroidism type Ia (PHP Ia) comprises the clinical features of AHO associated with parathyroid hormone (PTH) resistance while pseudo-pseudohypoparathyroidism (PPHP) includes AHO features without PTH resistance. In the present study we report a mother and a daughter with PPHP and PHP Ia respectively. The 13 exons of GNAS1 were analysed ...
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

Real-time Elastography and Contrast-Enhanced Ultrasound for the Assessment of Thyroid NodulesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237701Abstract Work-up of thyroid nodules remains challenging. Recent technologies enable determination of tissue elasticity and perfusion using ultrasound devices. The aim of the present study was to evaluate real-time elastography (RTE) and contrast-enhanced ultrasound with Sonovue (CEUS) for the differentiation of benign and malignant thyroid nodules.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

Thyroid Remnant Dose: 124I-PET/CT Dosimetric Comparison of rhTSH versus Thyroid Hormone Withholding Before Radioiodine Remnant Ablation in Differentiated Thyroid CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225350Abstract Recombinant human thyroid-stimulating hormone (rhTSH) recently was approved as an alternative to thyroid hormone withholding (THW) to elevate TSH for thyroid remnant ablation in differentiated thyroid carcinoma patients. High ablation success rates are reported with diverse rhTSH-aided I activities. Improved renal function causes ∼50% faster radioiodine clearance under euthyroidism versus hypothyroidism. Knowledge of comparative remnant radioiodine kinetics, particularly the remnant radiation dose in Gy/GBq of administered I activity (RDpA), could assist...
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

The Use of Thyrogen® in the Treatment of Differentiated Thyroid Carcinoma: An Intraindividual Comparison of Clinical Effects and Implications of Daily LifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1234086Abstract Withdrawal of levothyroxine with resultant hypothyroidism is still used in preparation for I-131 diagnostic whole-body scan (DWBS) and thyroglobulin (TG)-measurement in patients afflicted with differentiated thyroid cancer (DTC). Recombinant human thyroid-stimulating hormone (rhTSH) enhances TSH stimulation obviating the clinical and economical consequences of hypothyroidism. Primary aim of this study was an intraindividual comparison of diagnostic follow-up measurements under these two sets of conditions by taking clinical and socio-economic parameters into a...
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

Long Term Follow-up of Patients with Adrenal Incidentalomas- A Single Center Experience and Review of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237704Abstract Adrenal incidentalomas (AIs) constitute an emerging clinical entity due to the increased use of abdominal imaging for diagnostic purposes. Most often it consists of benign-nonfunctioning lesions and an increase in size during follow-up is reported in about 9% (0–26%), whereas their functional evolution is rare.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

Chronic Acetonemia Alters Liver Oxidative Balance and Lipid Content in Rats. A Model of Nash?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the present study was to determine the effects of chronic treatment with acetone in oxidative stress and metabolic parameters in rats. Twenty male Wistar rats were divided into two groups: control (CG) and chronic acetone group (CAG). After 28 days of acetone ingestion in a 5% aqueous solution (CAG) or water (CG) the animals were euthanized and urine, plasma and liver were collected for the determination of acetone, glucose, lipemia, hepatic fat, malondialdehyde (MDA), reduced glutathione (GSH), and vitamin E. As expected, urinary and plasma acetone levels were higher in CAG. There was no difference in hep...
Source: Experimental and Clinical Endocrinology and Diabetes - October 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

Prolonged Culture of Human Islets Induces ER StressEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, isolated human islets may be used for in vitro experiments for up to three weeks. During this time islet function and islet-cell turnover are stable. If islet culture is extended beyond three weeks ER stress may impair islet viability. Studies analyzing the pathophysiology of human T2D at the level of the endocrine pancreas need to confirm results obtained with isolated human islets by analysis of primary human pancreatic tissue.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocr...
Source: Experimental and Clinical Endocrinology and Diabetes - October 18, 2009 Category: Endocrinology Tags: Article Source Type: journals

Achilles tendon volume in type 2 Diabetic Patients with or without Peripheral Neuropathy: MRI StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1224121AbstractThe aim of this study was to evaluate Achilles tendon (AT) in type 2 diabetic patients with vs. without peripheral neuropathy using Magnetic Resonance Imaging (MRI). The study included 19 patients (group A, mean age 63.9±7.4 years) with peripheral neuropathy and 19 patients (group B, mean age 63.6±6.1 years) without peripheral neuropathy, as well as 16 healthy controls (group C, mean age 61.6±8.4 years). Neuropathy was diagnosed by the Diabetic Neuropathy Index (DNI). The maximum AT thickness and AT volume were measured on sagittal T weighted MRI images. AT ...
Source: Experimental and Clinical Endocrinology and Diabetes - October 16, 2009 Category: Endocrinology Tags: Short Communication Source Type: journals

A Polymorphism within the Fructosamine-3-kinase Gene is Associated with HbA1c Levels and the Onset of Type 2 Diabetes MellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1238319Abstract Non-enzymatic glycation is a process, which leads to the formation of advanced glycation endproducts. These compounds are involved in the development of diabetic microvascular complications. Fructosamine-3-kinase (FN3K) is an intracellular enzyme that phosphorylates fructosamines resulting in fructosamine-3-phosphate, which subsequently decomposes to inorganic phosphate, 3-deoxyglucasone and the unmodified amine. Recently, the G900C (rs1056534) single nucleotide polymorpism (SNP) of the FN3K gene was found to be associated with the enzyme activity.[...]© J. A...
Source: Experimental and Clinical Endocrinology and Diabetes - October 16, 2009 Category: Endocrinology Tags: Short Communication Source Type: journals

Pioglitazone Induced Reversible PancytopeniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1234065AbstractPioglitazone is used to improve insulin sensitivity in type 2 diabetes. This group of drugs is usually well tolerated; however, their use may be associated with several adverse effects including edema, weight gain, macular edema and heart failure. Herein we report a patient who developed pancytopenia on the 7th day of oral pioglitazone treatment for the control of diabetes mellitus and fully recovered 6 days after the cessation of this drug. To the best of our knowledge this is the first reported case of pancytopenia induced by pioglitazone therapy.[...]© J. A...
Source: Experimental and Clinical Endocrinology and Diabetes - October 16, 2009 Category: Endocrinology Tags: Short Communication Source Type: journals

Glucose Tolerance in Depressed Inpatients, under Treatment with Mirtazapine and in Healthy ControlsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237361AbstractImpaired glucose tolerance and diabetes have been associated with depression, and antidepressant treatment is assumed to improve impaired glucose tolerance. However, antidepressant treatment is also considered as a risk factor for the development of diabetes. Reports about glucose tolerance under antidepressant treatment frequently lack appropriate control groups. We conducted the oral glucose tolerance test (OGTT) in 10 healthy controls selected from an epidemiological sample with a negative lifetime history of mental Axis I disorder. Controls were carefully m...
Source: Experimental and Clinical Endocrinology and Diabetes - October 16, 2009 Category: Endocrinology Tags: Short Communication Source Type: journals

Increased Ceruloplasmin and Fibrinogen in Type 2 Diabetes Corresponds to Decreased Anti-oxidant Activity in a Preliminary Tertiary South Indian Hospital StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225647AbstractThe relationship between type 2 diabetes, antioxidant-enzyme serum ceruloplasmin, pro-inflammatory blood fibrinogen and antioxidant activity (AOA) was investigated in 40 diabetics and 47 non-diabetics hailing from South India as a preliminary study aspiring to be a crucial stepping stone for a large study. Serum AOA was lower (p<0.01) in diabetics (0.68±0.03 mmol/L) than controls (0.92±0.07 mmol/L) and ceruloplasmin more (p<0.001) in diabetics (983.20±52.18 mg/L) than controls (470.79±39.20 mg/L). Plasma fibrinogen was higher (...
Source: Experimental and Clinical Endocrinology and Diabetes - October 16, 2009 Category: Endocrinology Tags: Short Communication Source Type: journals

Nocturnal Blood Glucose and IGFBP-1 Changes in Type 1 Diabetes: Differences in the Dawn Phenomenon between Insulin RegimensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1239518Abstract Insulin-like growth factor binding protein-1 (IGFBP-1) is known to regulate the bioavailability of insulin-like growth factor (IGF) and the levels of IGFBP-1 are increased in the morning in patients with type 1 diabetes mellitus. We investigated the nocturnal fluctuations of glucose, IGFBP-1, and free IGF-1 levels with three insulin regimens.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 16, 2009 Category: Endocrinology Tags: Article Source Type: journals

Thoracic Epidural Anesthesia and Blood Glucose Levels in Diabetic Patients Undergoing Cardiopulmonary Bypass Under Insulin Infusion According to the Portland ProtocolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237381Abstract We investigated the effect of thoracic epidural anesthesia on perioperative blood glucose levels in diabetic patients undergoing cardiopulmonary bypass by continuous insulin infusion according to the Portland Protocol.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 16, 2009 Category: Endocrinology Tags: Article Source Type: journals

Alcohol Acutely Increases Vascular Reactivity together with Insulin Sensitivity in Type 2 Diabetic MenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1233453AbstractModerate alcohol consumption is associated with increased insulin sensitivity and reduced cardiovascular risk. We hypothesized that this relates to a direct effect of alcohol and therefore investigated whether acute alcohol intake altered insulin sensitivity or endothelial function in patients with type 2 diabetes. In an open-label two period design, the effect of a single oral dose of 40 g of alcohol (168 ml 40% vodka) on an insulin-modified frequently sampled intravenous glucose tolerance test (FSIGT) and on endothelium-dependent (flow mediated, F...
Source: Experimental and Clinical Endocrinology and Diabetes - October 16, 2009 Category: Endocrinology Tags: Article Source Type: journals

In Germany Diabetic Patients with Coronary Artery Disease are Treated More Intensively than Diabetic Patients with Other Manifestations of Atherothrombosis – Results from the REACH RegistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225648Abstract Atherothrombosis can present as coronary artery disease (CAD) cerebrovascular disease (CVD) and peripheral arterial disease (PAD). It is unknown whether diabetics with CAD differ from those with other manifestations of atherothrombosis such as CVD or PAD regarding clinical characteristics, biochemical parameters, or medications.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 16, 2009 Category: Endocrinology Tags: Article Source Type: journals

Visfatin (Nampt) and Ghrelin as Novel Markers of Carotid Atherosclerosis in Patients with Type 2 DiabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1237360Abstract Visfatin (nampt) and ghrelin are the most recently identified adipocytokines, but their role in atherosclerosis is poorly clarified. In our study we investigated their association with advanced carotid atherosclerosis and carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM).[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 16, 2009 Category: Endocrinology Tags: Article Source Type: journals

CD40 Expression and its Association with Low-grade Inflammation in a Greek Population of Type 1 Diabetic Juveniles: Evidence for Differences in CD40 mRNA Isoforms Expressed by Peripheral Blood Mononuclear CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1224151Abstract CD40 signalling has been associated with the pathogenesis of autoimmune diseases and diseases with low-grade chronic inflammation.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 16, 2009 Category: Endocrinology Tags: Article Source Type: journals

Increased Expression of Phosphorylated Smad2 and Smad3 in the Hippocampus of Streptozotocin-induced Diabetic RatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225610AbstractActivation of the Smad signalling pathway has been implicated in the pathological process of diabetic associated complications. The current study was designed to see whether Smad signalling was activated in the hippocampus of streptozotocin-induced diabetic rats. Compared with vehicle-treated controls, immunoblot analysis of hippocampal extracts showed that phosphorylated Smad2 was upregulated at 8 weeks post streptozotocin induction (p<0.01), and phosphorylated Smad3 protein was upregulated at 4 and 8 weeks post streptozotocin induction (p<0.01) in strep...
Source: Experimental and Clinical Endocrinology and Diabetes - October 16, 2009 Category: Endocrinology Tags: Article Source Type: journals

Antiproliferative/Cytotoxic Activity of Molecular Iodine and Iodolactones in Various Human Carcinoma Cell Lines. No Interfering with EGF-signaling, but Evidence for ApoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225615AbstractTwelve human cancer cell lines and one non-malignant cell line were investigated with respect to a potential antiproliferative/cytotoxic activity of molecular iodine and iodolactones. Except CCL221 colon carcinoma cells, the growth of all cancer cell lines decreased if the cells were cultured in the presence of 10 μM molecular iodine (I) for at least two days. δ-iodolactone (IL, 5 μM) was found to have a similar effect. SH-SY5Y neuroblastoma cells turned out to be most susceptible to both iodine compounds (total inhibition), followed ...
Source: Experimental and Clinical Endocrinology and Diabetes - October 3, 2009 Category: Endocrinology Tags: Article Source Type: journals

Testicular Steroid Hormone Secretion in the Boar and Expression of Testicular and Epididymal Steroid Sulphatase and Estrogen Sulphotransferase ActivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1231082Abstract Spermatogenesis and epididymal function depend on testicular steroids with estrogens being important regulatory factors. However, testicular estrogen secretion shows distinct species specificities, with the boar being characterized by the production of high amounts of estrone [E1] and estronesulphate [E1S]. As the boar testis also expresses estrogen sulphatase [StS] and sulphotransferase [EST] the present paper is based on the hypothesis that local availability of biologically active estrogens results from an interplay between estrogen synthesis and local acti...
Source: Experimental and Clinical Endocrinology and Diabetes - October 1, 2009 Category: Endocrinology Tags: Article Source Type: journals

Differentiation between Thyroidal and Ectopic Calcitonin Secretion in patients with Coincidental Thyroid Nodules and Pancreatic Tumors – A Report of Two CasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two patients who presented with excessively elevated calcitonin levels. Diagnostic work-up revealed a single thyroid nodule and a pancreatic tumor with ectopic calcitonin secretion in both of them. On the basis of these case reports, the diagnostic work flow and management in case of clearly elevated calcitonin levels are described and discussed.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - August 19, 2009 Category: Endocrinology Tags: Article Source Type: journals

An Unusual Case of Recurrent Autoimmune HypophysitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225646AbstractAutoimmune hypophysitis (AH) is an inflammatory disease that can present either as empty sella or as pituitary mass. A 16-years-old girl was admitted at our Unit for primary amenorrhea. A pituitary MRI performed 2 years before for severe headache demonstrated a large sellar and suprasellar lesion. As a craniopharyngioma was suspected, the consultant neurosurgeon suggested the removal of the lesion. Two months later, a preoperative MRI showed the disappearance of the lesion and a residual empty sella, figure consistent with AH. When the patient came at our obser...
Source: Experimental and Clinical Endocrinology and Diabetes - August 19, 2009 Category: Endocrinology Tags: Article Source Type: journals

Prevalence of Anterior Pituitary Dysfunction in Patients following Traumatic Brain Injury in a German Multi-centre Screening ProgramEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225611Abstract We determined the prevalence of anterior pituitary dysfunction in a multi-centre screening program across five German endocrine centres in patients rehabilitating from TBI (GCS<13).[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - August 19, 2009 Category: Endocrinology Tags: Article Source Type: journals

Selective Deficiency of Gsα and the Possible Role of Alternative Gene Products of GNAS in Albright Hereditary Osteodystrophy and Pseudohypoparathyroidism Type IaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1215589Abstract Albright hereditary osteodystrophy (AHO) and Pseudohypoparathyroidism type Ia (PHPIa) are caused by an inherited deficiency of Gsα, encoded by the gene. Apart from an exclusive first exon, Gsα shares part of the transcribed regions with NESP55, Exon A/B and XLαs, whose gene products utilize alternative promoter regions of this complex gene locus. However, it is not known, whether the deficiency of all gene products contributes to the AHO and PHPIa phenotype or if they are even causative for some specific symptoms. In these cases, mutations affec...
Source: Experimental and Clinical Endocrinology and Diabetes - August 6, 2009 Category: Endocrinology Tags: Article Source Type: journals

Improved Endothelial Function and Lipid Profile Compensate for Impaired Hemostatic and Inflammatory Status in Iatrogenic Chronic Subclinical Hyperthyroidism of Thyroid Cancer Patients on L-T4 TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1224156Abstract We aimed to compare the changes of endothelial function and haemostatic, inflammatory and metabolic parameters of short-term iatrogenic hypothyroidism to the characteristics of subclinical hyperthyroidism in patients with differentiated thyroid cancer.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - August 6, 2009 Category: Endocrinology Tags: Article Source Type: journals

Benefits of Continuous Subcutaneous Insulin Infusion in Type 1 Diabetes Previously Treated with Multiple Daily Injections with Once-daily Glargine and Pre-meal AnaloguesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225337Abstract There is insufficient information about the use of continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDI) using long-acting insulin analogs in relation to possible metabolic consequences and, as well, on the grade of patient satisfaction. The aim of the study was to evaluate the usefulness of CSII treatment in patients with type 1 diabetes in achieving glycemic objectives using continuous glucose monitoring system (CGMS) and in improving patient's satisfaction with treatment.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG S...
Source: Experimental and Clinical Endocrinology and Diabetes - July 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

Trends in the Management of Type 2 Diabetes and its Prescription Drug Costs in Greece (1998 & 2006)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225338Abstract Aim of the present study is to compare control of hyperglycaemia and other diabetes-related cardiovascular risk factors during the years 1998 and 2006 and to estimate the change in the cost of medications prescribed for this purpose.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

Total and Acylated Ghrelin Levels in Type 2 Diabetic Patients: Similar Levels Observed after Treatment with Metformin, Pioglitazone or Diet TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, total and acylated ghrelin levels after a mixed meal test were similar in type 2 diabetic patients treated with metformin, pioglitazone or diet therapy alone. These results suggest that changes in body weight during metformin and pioglitazone treatment are not associated with plasma ghrelin levels.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

Incidence of Lower-limb Amputations in the Diabetic Compared to the Non-diabetic Population. Findings from Nationwide Insurance Data, Germany, 2005–2007Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225333Abstract One major objective is to reduce the risk of lower limb amputation in diabetes mellitus. Nationwide data to incidences of amputations in the diabetic and non-diabetic populations in Germany as well as relative and attributable risks due to diabetes are lacking so far.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

Reconsideration of Insulin Signals Induced by Improved Laboratory Animal Diets, Japanese and American Diets, in IRS-2 Deficient MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225352AbstractCurrent Japanese and American diets and Japanese diet immediately after the War were converted to laboratory animal diets. As a result, current laboratory animal diet (CA-1, CLEA) unexpectedly resembled the diet of Japanese after the War. This is considered to result in an under-evaluation of diabetes research using laboratory animals at present. Therefore, changes in insulin signals caused by current Japanese and American diets were examined using deficient mice ( mice) and mechanisms of aggravation of type 2 diabetes due to modern diets were examined. mice at...
Source: Experimental and Clinical Endocrinology and Diabetes - July 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

Quantitative Assessment of the Abnormalities of Hyperosmolar Coma when Glucose Excess is Larger than Na DeficitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225354AbstractComputing Na and water deficits of hyperosmolar coma (HC) is important in correcting the derangement, to avoid unwanted iatrogenic electrolyte derangements and brain oedema. This paper derives and applies formulas valid when GA (glucose accumulation) >2·ΔNa (sodium loss), with or without ΔV (water depletion). We built a model system and wrote the equations describing the relationships between volume and concentration of solutes within the body water compartments. HC was simulated on computer experiments by adding GA in different amounts combined w...
Source: Experimental and Clinical Endocrinology and Diabetes - July 24, 2009 Category: Endocrinology Tags: Article Source Type: journals

Preoperative Preparation for Pheochromocytoma Resection: Physician Survey and Clinical PracticeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of this study are to assess the perceptions of endocrinologists regarding sufficient preoperative preparation for resection of pheochromocytoma (PHEO) and to evaluate how patients with PHEO are actually managed preoperatively. A survey on methods of preoperative preparation was sent to all 39 endocrinologists who had privilege at a large academic hospital. The charts of 43 patients who underwent adrenalectomy for PHEO resection at this hospital between 1997 and 2007 were reviewed. Age, tumor size, blood pressure medications, volume assessment and repletion, duration of preparation, preoperative and intraoper...
Source: Experimental and Clinical Endocrinology and Diabetes - July 17, 2009 Category: Endocrinology Tags: Article Source Type: journals

Hair Analysis Provides a Historical Record of Cortisol Levels in Cushing's SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1220771AbstractThe severity of Cushing's Syndrome (CS) depends on the duration and extent of the exposure to excess glucocorticoids. Current measurements of cortisol in serum, saliva and urine reflect systemic cortisol levels at the time of sample collection, but cannot assess past cortisol levels. Hair cortisol levels may be increased in patients with CS, and, as hair grows about 1 cm/month, measurement of hair cortisol may provide historical information on the development of hypercortisolism. We attempted to measure cortisol in hair in relation to clinical course in s...
Source: Experimental and Clinical Endocrinology and Diabetes - July 17, 2009 Category: Endocrinology Tags: Article Source Type: journals

Increased Percentage of Microvessels but Decreased Density of Large Vessels in Papillary Carcinomas as Compared to Hot and Cold Thyroid NodulesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1202795Abstract For thyroid tumors increased as well as decreased vessel densities have been reported. Because of different morphometric methods and specificities of previously used antibodies for small and large vessels our objective was to investigate and compare the density of large vessels and microvessels by different morphometric methods and antibodies in hot nodules(HN), cold nodules (CN), papillary carcinoma (PC) and Graves’ disease (GD) to try to clarify some of these discrepancies.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of conte...
Source: Experimental and Clinical Endocrinology and Diabetes - July 17, 2009 Category: Endocrinology Tags: Article Source Type: journals

Changes in Growth Hormone and Insulin-like Growth Factor-I Levels in the Acute Stage after Open Heart Surgery and at the Time of DischargeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to investigate changes in GH/IGF-I axis in adults undergoing open heart surgery.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - July 17, 2009 Category: Endocrinology Tags: Article Source Type: journals