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The emerging role of liquid biopsy in oral squamous cell carcinoma detection: advantages and challenges
Expert Rev Mol Diagn. 2024 Apr 12:1-21. doi: 10.1080/14737159.2024.2340997. Online ahead of print.ABSTRACTINTRODUCTION: Oral Squamous Cell Carcinoma (OSCC), the sixth most widespread malignancy in the world, accounts for 90% of all cases of oral cancer. The primary risk factors are tobacco chewing, alcohol consumption, viral infection, and genetic modifications. OSCC has a high morbidity rate due to the lack of early diagnostic methods. Nowadays, liquid biopsy plays a vital role in the initial diagnosis of oral cancer. ctNAs extracted from saliva and serum/plasma offer meaningful insights into tumor genetics and dynamics. ...
Source: Expert Review of Molecular Diagnostics - April 12, 2024 Category: Laboratory Medicine Authors: Sudha Gupta Brijesh Singh Rajul Abhishek Sameer Gupta Manisha Sachan Source Type: research

Body fluid markers for multiple sclerosis and differential diagnosis from atypical demyelinating disorders
Expert Rev Mol Diagn. 2024 Mar 27:1-15. doi: 10.1080/14737159.2024.2334849. Online ahead of print.ABSTRACTINTRODUCTION: Body fluid markers could be helpful to predict the conversion into clinically definite multiple sclerosis (MS) in people with a first demyelinating event of the central nervous system (CNS). Consequently, biomarkers such as oligoclonal bands, which are integrated in the current MS diagnostic criteria, could assist early MS diagnosis.AREAS COVERED: This review examines existing knowledge on a broad spectrum of body fluid markers in people with a first CNS demyelinating event, explores their potential to pr...
Source: Expert Review of Molecular Diagnostics - March 27, 2024 Category: Laboratory Medicine Authors: Angelika Bauer Harald Hegen Markus Reindl Source Type: research