Expert Review of OphthalmologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Vitreous Substitutes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Modern vitreoretinal surgery is a young science. While tremendous developments have occurred in instrument design and technique since Machemer first described vitrectomy surgery in 1973[1], the application of advanced materials concepts to the development of intra-ocular compounds is a particularly exciting area of research. To date, the development of vitreous substitutes has played a significant role in enabling the dramatic and progressive improvement in surgical outcome, but perhaps no other area of research has the potential to further improve the treatment of retinal detachment and other retinal disorders. While ...
Source: Expert Review of Ophthalmology - April 1, 2008 Category: Opthalmology Authors: Foster WJ Tags: Expert Rev Ophthalmol Source Type: journals

Unfolding the Therapeutic Potential of Chemical Chaperones for Age-related Macular Degeneration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SUMMARYRecent studies suggest that pathological processes involved in age-related macular degeneration (AMD) might induce endoplasmic reticulum (ER) stress. Growing evidence demonstrates the ability of chemical chaperones to decrease ER stress and ameliorate ER stress-related disease phenotypes, suggesting that the field of chaperone therapy might hold novel treatments for AMD. In this review, we examine the evidence suggesting a role for ER stress in AMD. Furthermore, we discuss the use of chaperone therapy for the treatment of ER stress-associated diseases, including other neurodegenerative diseases and retinopathies...
Source: Expert Review of Ophthalmology - February 1, 2008 Category: Opthalmology Authors: Sauer T, Patel M, Chan CC, Tuo J Tags: Expert Rev Ophthalmol Source Type: journals

Ocular toxicity of fludarabine: a purine analog.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purine analogs, fludarabine and cladribine represent an important class of chemotherapy agents used to treat a broad spectrum of lymphoid malignancies. Their toxicity profiles include dose-limiting myelosuppression, immunosuppression, opportunistic infection and severe neurotoxicity. This review summarizes the neurotoxicity of high- and standard-dose fludarabine, focusing on the clinical and pathological manifestations in the eye. The mechanisms of ocular toxicity are probably multifactorial. With increasing clinical use, an awareness of the neurological and ocular vulnerability, particularly to fludarabine, is imp...
Source: Expert Review of Ophthalmology - February 1, 2008 Category: Opthalmology Authors: Ding X, Herzlich AA, Bishop R, Tuo J, Chan CC Tags: Expert Rev Ophthalmol Source Type: journals

Genetic markers and biomarkers for age-related macular degeneration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Age-related macular degeneration (AMD) is the leading cause of visual impairment and blindness in the USA. Although the treatment of AMD has evolved to include laser photocoagulation, photodynamic therapy, surgical macular translocation and antiangiogenesis agents, treatment options for advanced AMD are limited. Furthermore, the dry form of AMD, albeit less devastating than the wet form, has even fewer viable treatment options. This review summarizes the various biomarkers of AMD and analyzes whether or not they may one day be exploited to determine risks of disease onset, measure progression of disease or even assess ...
Source: Expert Review of Ophthalmology - June 1, 2007 Category: Opthalmology Authors: Ross RJ, Verma V, Rosenberg KI, Chan CC, Tuo J Tags: Expert Rev Ophthalmol Source Type: journals