Natural Products in the Modulation of Farnesoid X Receptor Against Nonalcoholic Fatty Liver Disease
Am J Chin Med. 2024 Mar 14:1-24. doi: 10.1142/S0192415X24500137. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is a global health concern with a high prevalence and increasing economic burden, but official medicine remains unavailable. Farnesoid X receptor (FXR), a nuclear receptor member, is one of the most promising drug targets for NAFLD therapy that plays a crucial role in modulating bile acid, glucose, and lipid homeostasis, as well as inhibits hepatic inflammation and fibrosis. However, the rejection of the FXR agonist, obecholic acid, by the Food and Drug Administration for treating hepatic ...
Source: The American Journal of Chinese Medicine - March 14, 2024 Category: Complementary Medicine Authors: Jing Wang Na Yang Yu Xu Source Type: research

Endovascular Strategies for Aortic Arch When US Food and Drug Administration-Approved Devices Are Not Available
Tex Heart Inst J. 2024 Mar 14;51(1):e248391. doi: 10.14503/THIJ-24-8391.NO ABSTRACTPMID:38483472 | DOI:10.14503/THIJ-24-8391 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - March 14, 2024 Category: Cardiology Authors: Gabrielle Sutton Rana Afifi Source Type: research

Pomalidomide Improves Motor Behavioral Deficits and Protects Cerebral Cortex and Striatum Against Neurodegeneration Through a Reduction of Oxidative/Nitrosative Damages and Neuroinflammation After Traumatic Brain Injury
Cell Transplant. 2024 Jan-Dec;33:9636897241237049. doi: 10.1177/09636897241237049.ABSTRACTNeuronal damage resulting from traumatic brain injury (TBI) causes disruption of neuronal projections and neurotransmission that contribute to behavioral deficits. Cellular generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is an early event following TBI. ROS often damage DNA, lipids, proteins, and carbohydrates while RNS attack proteins. The products of lipid peroxidation 4-hydroxynonenal (4-HNE) and protein nitration 3-nitrotyrosine (3-NT) are often used as indicators of oxidative and nitrosative damage...
Source: Cell Transplantation - March 14, 2024 Category: Cytology Authors: Ya-Ni Huang Nigel H Greig Pen-Sen Huang Yung-Hsiao Chiang Alan Hoffer Chih-Hao Yang David Tweedie Ying Chen Ju-Chi Ou Jia-Yi Wang Source Type: research

Endovascular Strategies for Aortic Arch When US Food and Drug Administration-Approved Devices Are Not Available
Tex Heart Inst J. 2024 Mar 14;51(1):e248391. doi: 10.14503/THIJ-24-8391.NO ABSTRACTPMID:38483472 | DOI:10.14503/THIJ-24-8391 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - March 14, 2024 Category: Cardiology Authors: Gabrielle Sutton Rana Afifi Source Type: research

Endovascular Strategies for Aortic Arch When US Food and Drug Administration-Approved Devices Are Not Available
Tex Heart Inst J. 2024 Mar 14;51(1):e248391. doi: 10.14503/THIJ-24-8391.NO ABSTRACTPMID:38483472 | DOI:10.14503/THIJ-24-8391 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - March 14, 2024 Category: Cardiology Authors: Gabrielle Sutton Rana Afifi Source Type: research

A randomized controlled trial of potential tobacco policies prohibiting menthol flavor in cigarettes and e-cigarettes: a study protocol
DISCUSSION: Results will contribute critical information regarding menthol in cigarettes and e-cigarettes to inform regulatory policies that maximize reductions in cigarette smoking and reduce tobacco-related health disparities.TRIAL REGISTRATION: NCT05259566. Yale IRB protocol #2000032211, last approved 12/8/2023.PMID:38475757 | DOI:10.1186/s12888-024-05619-0 (Source: Cancer Control)
Source: Cancer Control - March 13, 2024 Category: Cancer & Oncology Authors: Krysten W Bold Akshika Sharma Angela Haeny Ralitza Gueorguieva Eugenia Buta Stephen Baldassarri Lauren Lempert Suchitra Krishnan-Sarin Stephanie O'Malley Source Type: research

Integrating Full Bayesian Inference and Student's t-Distribution Method for Enhanced Outlier Handling in Caffeine Population Pharmacokinetics: Assessing Drug-Drug Interactions with Enasidenib in Relapsed or Refractory AML and MDS Patients
In this study, a population pharmacokinetic analysis approach was employed to address challenges posed by high, nonzero baseline caffeine concentrations. Moreover, we integrated full Bayesian inference into this approach innovatively for a more detailed understanding of parameter uncertainty and greater modeling flexibility, alongside Student's t-distribution for robust error modeling in handling the abnormal outlier caffeine concentration data observed in this trial. Our analyses demonstrated that multiple doses of enasidenib altered caffeine clearance to a clinically meaningful extent, as evidenced by an approximate 8-fo...
Source: The Journal of Clinical Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Authors: Yiming Cheng Shengnan Du Hongxiang Hu Xiaomin Wang Leon Carayannopoulos Yan Li Source Type: research

Integrating Full Bayesian Inference and Student's t-Distribution Method for Enhanced Outlier Handling in Caffeine Population Pharmacokinetics: Assessing Drug-Drug Interactions with Enasidenib in Relapsed or Refractory AML and MDS Patients
In this study, a population pharmacokinetic analysis approach was employed to address challenges posed by high, nonzero baseline caffeine concentrations. Moreover, we integrated full Bayesian inference into this approach innovatively for a more detailed understanding of parameter uncertainty and greater modeling flexibility, alongside Student's t-distribution for robust error modeling in handling the abnormal outlier caffeine concentration data observed in this trial. Our analyses demonstrated that multiple doses of enasidenib altered caffeine clearance to a clinically meaningful extent, as evidenced by an approximate 8-fo...
Source: The Journal of Clinical Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Authors: Yiming Cheng Shengnan Du Hongxiang Hu Xiaomin Wang Leon Carayannopoulos Yan Li Source Type: research

The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P
Sci Signal. 2024 Mar 12;17(827):eade3643. doi: 10.1126/scisignal.ade3643. Epub 2024 Mar 12.ABSTRACTActivation of the endoplasmic reticulum (ER)-resident adaptor protein STING, a component of a cytosolic DNA-sensing pathway, induces the transcription of genes encoding type I interferons (IFNs) and other proinflammatory factors. Because STING is activated at the Golgi apparatus, control of the localization and activation of STING is important in stimulating antiviral and antitumor immune responses. Through a genome-wide CRISPR interference screen, we found that STING activation required the Golgi-resident protein ACBD3, whic...
Source: Science Signaling - March 12, 2024 Category: Biomedical Science Authors: Rutger D Luteijn Sypke R van Terwisga Jill E Ver Eecke Liberty Onia Shivam A Zaver Joshua J Woodward Richard W Wubbolts David H Raulet Frank J M van Kuppeveld Source Type: research

Emerging drugs for the treatment of hepatic fibrosis on nonalcoholic steatohepatitis
This study reviewed the treatment of NASH with a focus on the effects of existing drugs and new drugs on liver fibrosis.EXPERT OPINION: Considering the complex pathophysiology of fibrosis in NASH, drug therapy may target multiple pathways. The method of assessing fibrosis is important when considering treatment for liver fibrosis in NASH. The Food and Drug Administration considers an important fibrosis endpoint to be histological improvement in at least one fibrosis stage while preventing worsening of fatty hepatitis. To obtain approval as a drug for NASH, efficacy needs to be demonstrated on endpoints such as liver-relate...
Source: Expert Opinion on Emerging Drugs - March 12, 2024 Category: Drugs & Pharmacology Authors: Michihiro Iwaki Masato Yoneda Naohiro Wada Otani Tomohiro Takashi Kobayashi Asako Nogami Satoru Saito Nakajima Atsushi Source Type: research

The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P
Sci Signal. 2024 Mar 12;17(827):eade3643. doi: 10.1126/scisignal.ade3643. Epub 2024 Mar 12.ABSTRACTActivation of the endoplasmic reticulum (ER)-resident adaptor protein STING, a component of a cytosolic DNA-sensing pathway, induces the transcription of genes encoding type I interferons (IFNs) and other proinflammatory factors. Because STING is activated at the Golgi apparatus, control of the localization and activation of STING is important in stimulating antiviral and antitumor immune responses. Through a genome-wide CRISPR interference screen, we found that STING activation required the Golgi-resident protein ACBD3, whic...
Source: Science Signaling - March 12, 2024 Category: Biomedical Science Authors: Rutger D Luteijn Sypke R van Terwisga Jill E Ver Eecke Liberty Onia Shivam A Zaver Joshua J Woodward Richard W Wubbolts David H Raulet Frank J M van Kuppeveld Source Type: research

Emerging drugs for the treatment of hepatic fibrosis on nonalcoholic steatohepatitis
This study reviewed the treatment of NASH with a focus on the effects of existing drugs and new drugs on liver fibrosis.EXPERT OPINION: Considering the complex pathophysiology of fibrosis in NASH, drug therapy may target multiple pathways. The method of assessing fibrosis is important when considering treatment for liver fibrosis in NASH. The Food and Drug Administration considers an important fibrosis endpoint to be histological improvement in at least one fibrosis stage while preventing worsening of fatty hepatitis. To obtain approval as a drug for NASH, efficacy needs to be demonstrated on endpoints such as liver-relate...
Source: Expert Opinion on Emerging Drugs - March 12, 2024 Category: Drugs & Pharmacology Authors: Michihiro Iwaki Masato Yoneda Naohiro Wada Otani Tomohiro Takashi Kobayashi Asako Nogami Satoru Saito Nakajima Atsushi Source Type: research

The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P
Sci Signal. 2024 Mar 12;17(827):eade3643. doi: 10.1126/scisignal.ade3643. Epub 2024 Mar 12.ABSTRACTActivation of the endoplasmic reticulum (ER)-resident adaptor protein STING, a component of a cytosolic DNA-sensing pathway, induces the transcription of genes encoding type I interferons (IFNs) and other proinflammatory factors. Because STING is activated at the Golgi apparatus, control of the localization and activation of STING is important in stimulating antiviral and antitumor immune responses. Through a genome-wide CRISPR interference screen, we found that STING activation required the Golgi-resident protein ACBD3, whic...
Source: Science Signaling - March 12, 2024 Category: Biomedical Science Authors: Rutger D Luteijn Sypke R van Terwisga Jill E Ver Eecke Liberty Onia Shivam A Zaver Joshua J Woodward Richard W Wubbolts David H Raulet Frank J M van Kuppeveld Source Type: research

Emerging drugs for the treatment of hepatic fibrosis on nonalcoholic steatohepatitis
This study reviewed the treatment of NASH with a focus on the effects of existing drugs and new drugs on liver fibrosis.EXPERT OPINION: Considering the complex pathophysiology of fibrosis in NASH, drug therapy may target multiple pathways. The method of assessing fibrosis is important when considering treatment for liver fibrosis in NASH. The Food and Drug Administration considers an important fibrosis endpoint to be histological improvement in at least one fibrosis stage while preventing worsening of fatty hepatitis. To obtain approval as a drug for NASH, efficacy needs to be demonstrated on endpoints such as liver-relate...
Source: Expert Opinion on Emerging Drugs - March 12, 2024 Category: Drugs & Pharmacology Authors: Michihiro Iwaki Masato Yoneda Naohiro Wada Otani Tomohiro Takashi Kobayashi Asako Nogami Satoru Saito Nakajima Atsushi Source Type: research

The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P
Sci Signal. 2024 Mar 12;17(827):eade3643. doi: 10.1126/scisignal.ade3643. Epub 2024 Mar 12.ABSTRACTActivation of the endoplasmic reticulum (ER)-resident adaptor protein STING, a component of a cytosolic DNA-sensing pathway, induces the transcription of genes encoding type I interferons (IFNs) and other proinflammatory factors. Because STING is activated at the Golgi apparatus, control of the localization and activation of STING is important in stimulating antiviral and antitumor immune responses. Through a genome-wide CRISPR interference screen, we found that STING activation required the Golgi-resident protein ACBD3, whic...
Source: Science Signaling - March 12, 2024 Category: Biomedical Science Authors: Rutger D Luteijn Sypke R van Terwisga Jill E Ver Eecke Liberty Onia Shivam A Zaver Joshua J Woodward Richard W Wubbolts David H Raulet Frank J M van Kuppeveld Source Type: research