Food and Drug Administration (FDA) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Medical Management of Inflammatory Bowel Disease
This article highlights several key trials and discusses modern treatment paradigms for both UC and CD based on disease severity.PMID:38677828 | DOI:10.1016/j.suc.2023.12.005 (Source: The Surgical Clinics of North America)
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Shahrose Rahman Ranish K Patel Elisa Boden Vassiliki Liana Tsikitis Source Type: research

When Patient Diversity Informs Formulation: Reimagining Treatment for Seborrheic Dermatitis
AbstractSeborrheic dermatitis (SD) impacts a diverse demographic, with treatment effectiveness and suitability varying across hair types and cultural practices. Available shampoo treatments contain surfactants that compromise hair moisture and integrity as well as requiring frequent use, which may not align with the routines of various hair types and cultural hair care practices. Most available topical foams and gels contain high concentrations of drying alcohols that damage hair color and moisture. Newly US Food and Drug Administration (FDA)-approved roflumilast 0.3% foam presents a significant advancement in the treatmen...
Source: Dermatology and Therapy - April 27, 2024 Category: Dermatology Source Type: research

Spinal Stimulators: Review of the Current Evidence
This article discusses the most recent evidence of various indications of SCS to manage pain and improve the quality of life in patients.Recent FindingsThe Food and Drug Administration (FDA) has approved SCS for specific etiologies of chronic pain. The ongoing effort has been dedicated to improving stimulation mechanisms and expanding indications of SCS with promising results. It is essential for providers to be aware of the most current technology and approved and potential indications of SCS to maximize outcomes for each individual patient.SummarySCS can manage chronic pain for patients and improve their function and qua...
Source: Current Physical Medicine and Rehabilitation Reports - April 26, 2024 Category: Rehabilitation Source Type: research

Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer: Unravelling challenges and future directions
World J Gastroenterol. 2024 Apr 7;30(13):1815-1835. doi: 10.3748/wjg.v30.i13.1815.ABSTRACTColorectal cancer (CRC) is a complex disease with diverse etiologies and clinical outcomes. Despite considerable progress in development of CRC therapeutics, challenges remain regarding the diagnosis and management of advanced stage metastatic CRC (mCRC). In particular, the five-year survival rate is very low since mCRC is currently rarely curable. Over the past decade, cancer treatment has significantly improved with the introduction of cancer immunotherapies, specifically immune checkpoint inhibitors. Therapies aimed at blocking imm...
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Samantha Sharma Naresh Singh Anita Ahmed Turk Isabella Wan Akshay Guttikonda Julia Lily Dong Xinna Zhang Mateusz Opyrchal Source Type: research

Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer: Unravelling challenges and future directions
World J Gastroenterol. 2024 Apr 7;30(13):1815-1835. doi: 10.3748/wjg.v30.i13.1815.ABSTRACTColorectal cancer (CRC) is a complex disease with diverse etiologies and clinical outcomes. Despite considerable progress in development of CRC therapeutics, challenges remain regarding the diagnosis and management of advanced stage metastatic CRC (mCRC). In particular, the five-year survival rate is very low since mCRC is currently rarely curable. Over the past decade, cancer treatment has significantly improved with the introduction of cancer immunotherapies, specifically immune checkpoint inhibitors. Therapies aimed at blocking imm...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Samantha Sharma Naresh Singh Anita Ahmed Turk Isabella Wan Akshay Guttikonda Julia Lily Dong Xinna Zhang Mateusz Opyrchal Source Type: research

Radiation Biological Toximetry Using Circulating Cell-Free DNA (cfDNA) for Rapid Radiation/Nuclear Triage
Radiat Res. 2024 Apr 25. doi: 10.1667/RADE-23-00159.1. Online ahead of print.ABSTRACTOptimal triage biodosimetry would include risk stratification within minutes, and it would provide useful triage despite heterogeneous dosimetry, cytokine therapy, mixed radiation quality, race, and age. For regulatory approval, the U.S. Food and Drug Administration (FDA) Biodosimetry Guidance requires suitability for purpose and a validated species-independent mechanism. Circulating cell-free DNA (cfDNA) concentration assays may provide such triage information. To test this hypothesis, cfDNA concentrations were measured in unprocessed mon...
Source: Radiation Research - April 25, 2024 Category: Physics Authors: Paul Okunieff Steven G Swarts Bruce Fenton Stephen B Zhang Zhenhuan Zhang Lori Rice Daohong Zhou France Carrier Lurong Zhang Source Type: research

Clarification of Information in "Navigating Next-Generation Sequencing Laboratory Developed Tests: A Critical Look at Proficiency Testing, US Food and Drug Administration Regulations, and Clinical Laboratory Performance Tests"
Arch Pathol Lab Med. 2024 May 1;148(5):507. doi: 10.5858/arpa.2023-0593-LE.NO ABSTRACTPMID:38662906 | DOI:10.5858/arpa.2023-0593-LE (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 25, 2024 Category: Laboratory Medicine Authors: Christina M Lockwood Source Type: research

Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer: Unravelling challenges and future directions
World J Gastroenterol. 2024 Apr 7;30(13):1815-1835. doi: 10.3748/wjg.v30.i13.1815.ABSTRACTColorectal cancer (CRC) is a complex disease with diverse etiologies and clinical outcomes. Despite considerable progress in development of CRC therapeutics, challenges remain regarding the diagnosis and management of advanced stage metastatic CRC (mCRC). In particular, the five-year survival rate is very low since mCRC is currently rarely curable. Over the past decade, cancer treatment has significantly improved with the introduction of cancer immunotherapies, specifically immune checkpoint inhibitors. Therapies aimed at blocking imm...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Samantha Sharma Naresh Singh Anita Ahmed Turk Isabella Wan Akshay Guttikonda Julia Lily Dong Xinna Zhang Mateusz Opyrchal Source Type: research

Biomedical Approaches and Disparities in HIV Prevention
Human immunodeficiency virus (HIV) remains a significant public concern, with certain groups disproportionately impacted. Pre-exposure prophylaxis (PrEP) for HIV prevention was approved by the Food and Drug Administration in 2012. However, stark disparities persist in PrEP access and uptake, leaving those at highest risk of acquiring HIV without knowledge of, access to, and uptake of PrEP. Nurses play a key role in eliminating the causes of these disparities that occur at the individual, provider, and systemic level. It is imperative that we increase PrEP knowledge, access, and use, especially in groups most at risk for ac...
Source: Nursing Clinics of North America - April 25, 2024 Category: Nursing Authors: Jared Carter-Davis, Ellen Seymour Source Type: research