The biology of the cell – insights from mass cytometry
High ‐dimensional profiling of individual cells by mass cytometry allows for simultaneous multimodal analyses of membrane proteins, intracellular proteins, mRNA, and epigenetic traits, all in millions of cells. In single ‐cell biology there is an ongoing push toward more and more comprehensive measurements made in individual cells. By combining measurements of proteins, mRNA, genetic, and epigenetic traits, in contexts of cell stimulation or drug treatment, novel single‐cell analyses will help understand the det erminants of cellular identity, differentiation decisions, and regulatory mechanisms governing cellular fu...
Source: FEBS Journal - November 26, 2018 Category: Research Authors: Petter Brodin Tags: Review Article Source Type: research
The structure of Legionella effector protein LpnE provides insights into its interaction with Oculocerebrorenal syndrome of Lowe (OCRL) protein
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 26, 2018 Category: Research Authors: Kevin Voth,
Ivy Yeuk Wah Chung,
Karin van Straaten,
Lei Li,
Michal T Boniecki,
Miroslaw Cygler Tags: Original Article Source Type: research
The biology of the cell – insights from mass cytometry
High ‐dimensional profiling of individual cells by mass cytometry allows for simultaneous multimodal analyses of membrane proteins, intracellular proteins, mRNA, and epigenetic traits, all in millions of cells. In single ‐cell biology there is an ongoing push toward more and more comprehensive measurements made in individual cells. By combining measurements of proteins, mRNA, genetic, and epigenetic traits, in contexts of cell stimulation or drug treatment, novel single‐cell analyses will help understand the det erminants of cellular identity, differentiation decisions, and regulatory mechanisms governing cellular fu...
Source: FEBS Journal - November 26, 2018 Category: Research Authors: Petter Brodin Tags: Review Article Source Type: research
The structure of Legionella effector protein LpnE provides insights into its interaction with Oculocerebrorenal syndrome of Lowe (OCRL) protein
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 26, 2018 Category: Research Authors: Kevin Voth,
Ivy Yeuk Wah Chung,
Karin van Straaten,
Lei Li,
Michal T Boniecki,
Miroslaw Cygler Tags: Original Article Source Type: research
Misdecoding of Rare CGA Codon by Translation Termination Factors, eRF1/eRF3, Suggests Novel Class of Ribosome Rescue Pathway in S. cerevisiae
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 24, 2018 Category: Research Authors: Miki Wada,
Koichi Ito Tags: Original Article Source Type: research
Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 23, 2018 Category: Research Authors: Kifayat Ullah,
Emmanuel Zubia,
Mahesh Narayan,
Jing Yang,
Guoqiang Xu Tags: Non ‐invited Review Source Type: research
Towards development of generic inhibitors against the 3C proteases of picornaviruses
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 21, 2018 Category: Research Authors: Kamalika Banerjee,
Ruchika Bhat,
V. U. Bhaskara Rao,
Anshu Nain,
Kartik Lakshmi Rallapalli,
Sohona Gangopadhyay,
R. P. Singh,
Manidipa Banerjee,
B. Jayaram Tags: Original Article Source Type: research
‘Inside Out’– a dialogue between mitochondria and bacteria
Gut microbiome orchestrates biological processes in the host by communicating with mitochondria, intracellular organelles that originated from bacteria. Reciprocating to environmental challenges, bacteria produce metabolites that can modulate mitochondrial dynamics to adjust intracellular activities. Together, the interplay between microbiome and mitochondria provides new insights into the regulation of host metabolic health and longevity. Mitochondria play crucial roles in regulating metabolism and longevity. A body of recent evidences reveals that the gut microbiome can also exert significant effects on these activities ...
Source: FEBS Journal - November 21, 2018 Category: Research Authors: Bing Han,
Chih ‐Chun Janet Lin,
Guo Hu,
Meng C. Wang Tags: State ‐of‐the‐Art Review Source Type: research
Towards development of generic inhibitors against the 3C proteases of picornaviruses
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 21, 2018 Category: Research Authors: Kamalika Banerjee,
Ruchika Bhat,
V. U. Bhaskara Rao,
Anshu Nain,
Kartik Lakshmi Rallapalli,
Sohona Gangopadhyay,
R. P. Singh,
Manidipa Banerjee,
B. Jayaram Tags: Original Article Source Type: research
‘Inside Out’– a dialogue between mitochondria and bacteria
Gut microbiome orchestrates biological processes in the host by communicating with mitochondria, intracellular organelles that originated from bacteria. Reciprocating to environmental challenges, bacteria produce metabolites that can modulate mitochondrial dynamics to adjust intracellular activities. Together, the interplay between microbiome and mitochondria provides new insights into the regulation of host metabolic health and longevity. Mitochondria play crucial roles in regulating metabolism and longevity. A body of recent evidences reveals that the gut microbiome can also exert significant effects on these activities ...
Source: FEBS Journal - November 21, 2018 Category: Research Authors: Bing Han,
Chih ‐Chun Janet Lin,
Guo Hu,
Meng C. Wang Tags: State ‐of‐the‐Art Review Source Type: research
The Golgi ‘casein kinase’ Fam20C is a genuine ‘phosvitin kinase’ and phosphorylates polyserine stretches devoid of the canonical consensus
Despite its early discovery in 1900, the kinase(s) responsible for the multiphosphorylation of egg yolk phosvitin remained a mystery until now. Here, we providein vitro andin vivo evidence that the atypical kinase Fam20C, responsible for the generation of many secreted proteins, fulfills all criteria for being considered a genuine phosvitin kinase although many clusters of phosvitin phosphoserines lack their canonical priming consensus SSEE. Egg yolk phosvitins, generated through the fragmentation of vitellogenins (VTGs), are among the most heavily phosphorylated proteins ever described. Despite the early discovery in ...
Source: FEBS Journal - November 20, 2018 Category: Research Authors: Giorgio Cozza,
Enrico Moro,
Miles Black,
Oriano Marin,
Mauro Salvi,
Andrea Venerando,
Vincent S. Tagliabracci,
Lorenzo A. Pinna Tags: Original Article Source Type: research
Cryo ‐EM is uncovering the mechanism of eukaryotic protein N‐glycosylation
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 19, 2018 Category: Research Authors: Lin Bai,
Huilin Li Tags: Structural Snapshot Source Type: research
