Perioperative maternal fetal outcomes in the setting of minimally invasive fetal therapy for complex monochorionic pregnancies with monitored anesthesia care
Conclusion A low rate of conversion to general anesthesia and no serious adverse maternal events were observed in patients receiving MAC. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - April 24, 2023 Category: Perinatology & Neonatology Source Type: research

Prenatal Rupture of Hydrocolpos in a Cloacal Malformation
Conclusion: In female fetus with a pelvic cyst, one should have a high index of suspicion for cloacal anomaly and consider the possibility of urinary obstruction leading to alteration in amniotic fluid. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - April 21, 2023 Category: Perinatology & Neonatology Source Type: research

Increased risk of retinopathy of prematurity in donors with twin-to-twin transfusion syndrome: a cohort study
Conclusion: Any stage ROP and severe ROP are detected twice as frequently in donors compared to recipients. Increased awareness for ROP is needed in donors, especially those with lower GA at birth and longer duration of mechanical ventilation. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - April 19, 2023 Category: Perinatology & Neonatology Source Type: research

Prenatal diagnosis of G ómez-López-Hernández syndrome
Discussion: As no known genetic causes have been identified and the classical triad is not applicable to prenatal imaging, prenatal diagnosis of GLHS is based on neuro-imaging and the identification of supporting features. In presence of a RES associated with cranio-facial abnormalities in prenatal (brachycephaly, turricephaly, low-set ears, midface retrusion, micrognathia), GLHS should be considered as "possible ” according to postnatal criteria. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - April 14, 2023 Category: Perinatology & Neonatology Source Type: research

Characterization of suboptimal responses to fetoscopic endoluminal tracheal occlusion in congenital diaphragmatic hernia
Introduction: To characterize the changes in fetal lung volume following endoluminal tracheal occlusion (FETO) that are associated with infant survival and need for extracorporeal membrane oxygenation (ECMO) in congenital diaphragmatic hernia (CDH). Methods: Fetuses with CDH who underwent FETO at a single institution were included. CDH cases were reclassified by MRI metrics, [observed-to-expected total lung volume (O/E TLV) and percent liver herniation]. The percent changes of MRI metrics after FETO were calculated. ROC-derived cutoffs of these changes were derived to predict infant survival to discharge. Regression analy...
Source: Fetal Diagnosis and Therapy - April 11, 2023 Category: Perinatology & Neonatology Source Type: research

Quincke versus diamond-tip needles for entry in placental laser surgery for twin-to-twin transfusion syndrome
\ Introduction: Chorioamnion separation (CAS), preterm prelabor rupture of membranes (PPROM), and preterm delivery (PTD) remain major complications of fetoscopic laser photocoagulation (FLP) for twin-to-twin transfusion syndrome (TTTS). We sought to examine whether use of quincke-tip needles for initial entry in FLP reduces the risk of these complications. Methods: This is a secondary analysis of prospectively collected data from patients that had FLP for TTTS at a single tertiary care center (2011 – 2021). We excluded patients for whom direct trocar entry was used. Patients for whom a quincke-tip needle, versus a d...
Source: Fetal Diagnosis and Therapy - April 10, 2023 Category: Perinatology & Neonatology Source Type: research

Role of Fetal MRI in Differentiating Isolated Septal Agenesis from Septo-Optic Dysplasia: Case Study and Review
Conclusion: Differentiating isolated ASP from SOD is imperative for adequate prenatal counseling. Unfortunately, making a prenatal diagnosis of SOD requires visualization and evaluation of the fetal optic nerves, chiasm and pituitary gland, which is very demanding and not always possible using ultrasound. Fetal MRI has the potential of obtaining high-quality images of the fetal brain and therefore this technique can be used for establishing the differential diagnosis in utero. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - April 4, 2023 Category: Perinatology & Neonatology Source Type: research

Prenatal Cystic Fibrosis Transmembrane Conductance Regulator Modulator Therapy: A Promising Way to Change the Impact of Cystic Fibrosis
Conclusion: Prenatal ETI treatment, as well as during breastfeeding, could solve, prevent, and/or delay CF complications. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - March 30, 2023 Category: Perinatology & Neonatology Source Type: research

Prenatal cystic fibrosis transmembrane conductance regulator modulator therapy: A promising way to change the impact of cystic fibrosis
Conclusion: Prenatal ETI treatment, as well as during breastfeeding, could solve, prevent and/or delay CF complications. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - March 30, 2023 Category: Perinatology & Neonatology Source Type: research

Parental psychological distress of missed diagnosis of down syndrome at antenatal screening: a rare, but still real occurrence. a case report and review of literature
Conclusion These programs are considered as routine clinical practice in many countries from last few years, and is necessary to assess the pros and cons of these programs. One of the prime con involves the likeliness of obtaining a false negative result due to lack of 100% sensitivity and specificity. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - March 25, 2023 Category: Perinatology & Neonatology Source Type: research