Fibrogenesis and Tissue RepairThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

11 records returned

Reactive oxygen and nitrogen species induce protein and DNA modifications driving arthrofibrosis following total knee arthroplastyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Based on our current findings, we suggest that ROS/RNS initiate and sustain the arthrofibrotic response driving aggressive fibroblast proliferation and subsequent HO. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - November 13, 2009 Category: Biomedical Science Authors: Theresa FreemanJavad ParviziCraig Della ValleMarla Steinbeck Source Type: journals

Hepatic wound repairEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Emerging mechanisms and concepts related to liver fibrogenesis may significantly contribute to clinical management of patients affected by CLDs. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - September 24, 2009 Category: Biomedical Science Authors: Maurizio ParolaMassimo Pinzani Source Type: journals

Regression of fibrosis in paediatric autoimmune hepatitis: morphometric assessment of fibrosis versus semiquantiatative methodsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Significant regression of fibrosis in paediatric AIH could occur with current therapeutic regimens. Morphometric assessment of fibrosis is more sensitive than semi-quantitative methods to identify changes in fibrosis. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - April 2, 2009 Category: Biomedical Science Authors: Ahmed F Abdalla, Khaled R Zalata, Abeer F Ismail, Gamal Shiha, Mohamed Attiya and Ahmed Abo-Alyazeed Source Type: journals

Evaluation of intracellular signalling pathways in response to insulin-like growth factor I in apoptotic-resistant activated human hepatic stellate cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In addition to Bcl-2, several other anti-apoptotic pathways are responsible for human hepatic stellate cell resistance to apoptosis. These features are relevant for the progression and limited reversibility of liver fibrosis in humans. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - January 30, 2009 Category: Biomedical Science Authors: Alessandra Gentilini, Benedetta Lottini, Marco Brogi, Alessandra Caligiuri, Lorenzo Cosmi, Fabio Marra and Massimo Pinzani Source Type: journals

Organotypic modelling as a means of investigating epithelial-stromal interactions during tumourigenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The advent of co-culture approaches has allowed researchers to more accurately model the behaviour of epithelial cells in cell culture studies. The initial work on epidermal modelling allowed the development of reconstituted epidermis, growing keratinocytes on top of fibroblasts seeded in a collagen gel at an air-liquid interface to generate terminally differentiated 'skin equivalents'. In addition to developing ex vivo skin sheets for the treatment of burns victims, such cultures have also been used as a means of investigating both the development and repair of the epidermis, in more relevant conditions than simple two-di...
Source: Fibrogenesis and Tissue Repair - December 11, 2008 Category: Biomedical Science Authors: Athina-Myrto Chioni and Richard Grose Source Type: journals

Transplantation of genetically engineered cardiac fibroblasts producing recombinant human erythropoietin to repair the infarcted myocardiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In situ expression of rhEPO enhances vascularization and reduces cell apoptosis in the infarcted myocardium. However, local EPO therapy is insufficient for functional improvement after MI in rat. (Source: Fibrogenesis and Tissue Repair)
Source: Fibrogenesis and Tissue Repair - November 3, 2008 Category: Biomedical Science Authors: Emil Ruvinov, Orna Sharabani-Yosef, Arnon Nagler, Tom Einbinder, Micha S Feinberg, Radka Holbova, Amos Douvdevani and Jonathan Leor Source Type: journals

Welcome to Fibrogenesis & Tissue RepairEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fibroproliferative diseases affecting different organs and systems constitute the largest burden and challenge of modern medicine. Nearly 45% of all deaths in the developed world are caused by chronic inflammatory and fibrogenic disorders such as cardiovascular disease, pulmonary fibrosis, progressive kidney disease, systemic sclerosis, liver cirrhosis and inflammatory bowel disease. In addition, chronic inflammation and fibrotic tissue remodelling associated with neo-angiogenesis represent key mechanisms leading to the development of cancer, thus accounting for an additional number of deaths. Regardless of the final clini...
Source: Fibrogenesis and Tissue Repair - October 13, 2008 Category: Biomedical Science Authors: Massimo Pinzani Source Type: journals

Viruses as co-factors for the initiation or exacerbation of lung fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Idiopathic pulmonary fibrosis (IPF) remains exactly that. The disease originates from an unknown cause, and little is known about the mechanisms of pathogenesis. While the disease is likely multi-factorial, evidence is accumulating to implicate viruses as co-factors (either as initiating or exacerbating agents) of fibrotic lung disease. This review summarizes the available clinical and experimental observations that form the basis for the hypothesis that viral infections may augment fibrotic responses. We review the data suggesting a link between hepatitis C virus, adenovirus, human cytomegalovirus and, in particular, the ...
Source: Fibrogenesis and Tissue Repair - October 13, 2008 Category: Biomedical Science Authors: Kevin M Vannella and Bethany B Moore Source Type: journals

Connective tissue growth factor promoter activity in normal and wounded skinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we use transgenic knock-in mice in which the Pacific jellyfish Aequorea victoria enhanced green fluorescent protein (E-GFP) gene has been inserted between the endogenous CTGF promoter and gene. Unwounded (day 0) and wounded (days 3 and 7) skin was examined for GFP to detect cells in which the CTGF promoter was active, α-smooth muscle actin (α-SMA) to detect myofibroblasts, and NG2 expression to detect pericytes. In unwounded mice, CTGF expression was absent in epidermis and was present in a few cells in the dermis. Upon wounding, CTGF expression was induced in the dermis. Double immunolabeling revealed th...
Source: Fibrogenesis and Tissue Repair - October 13, 2008 Category: Biomedical Science Authors: Mohit Kapoor, Shangxi Liu, Kun Huh, Sunil Parapuram, Laura Kennedy and Andrew Leask Source Type: journals

Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new era has begun in the treatment of ischemic disease and heart failure. With the discovery that stem cells from diverse organs and tissues, including bone marrow, adipose tissue, umbilical cord blood, and vessel wall, have the potential to improve cardiac function beyond that of conventional pharmacological therapy comes a new field of research aiming at understanding the precise mechanisms of stem cell-mediated cardiac repair. Not only will it be important to determine the most efficacious cell population for cardiac repair, but also whether overlapping, common mechanisms exist. Increasing evidence suggests that one m...
Source: Fibrogenesis and Tissue Repair - October 13, 2008 Category: Biomedical Science Authors: Jana S Burchfield and Stefanie Dimmeler Source Type: journals

Redox mechanisms in hepatic chronic wound healing and fibrogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reactive oxygen species (ROS) generated within cells or, more generally, in a tissue environment, may easily turn into a source of cell and tissue injury. Aerobic organisms have developed evolutionarily conserved mechanisms and strategies to carefully control the generation of ROS and other oxidative stress-related radical or non-radical reactive intermediates (that is, to maintain redox homeostasis), as well as to 'make use' of these molecules under physiological conditions as tools to modulate signal transduction, gene expression and cellular functional responses (that is, redox signalling). However, a derangement in red...
Source: Fibrogenesis and Tissue Repair - October 13, 2008 Category: Biomedical Science Authors: Erica Novo and Maurizio Parola Source Type: journals