New eremophilane-type sesquiterpenes from Synotis solidaginea
Fitoterapia. 2024 Apr 21:105970. doi: 10.1016/j.fitote.2024.105970. Online ahead of print.ABSTRACTEleven new highly oxygenated eremophilane-type sesquiterpenoids were isolated from the whole plant of Synotis solidaginea, including two pairs of C-8 S/R epimers. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis and the absolute configuration of 1 and 9 was confirmed by single-crystal X-ray crystallography using Cu Kα radiation. All the isolates were tested for the inhibition of LPS-stimulated NO production in macrophage-like mouse monocytic leukemia RAW264.7 cells. Compound ...
Source: Fitoterapia - April 23, 2024 Category: Biochemistry Authors: Xin-Yi Wei Hong-Bing Sun Rui-Ying Xi Fan Wu Yi-Lin Liu Zhuo-Lin Jin Da-Le Guo Bing Xia Fei Wang Yan Zhou Source Type: research
Network analysis of microbiome and metabolome to explore the mechanism of raw rhubarb in the protection against ischemic stroke via microbiota-gut-brain axis
In conclusion, our work demonstrated that RR could effectively ameliorate ischemic stroke by modulating the microbiota and metabolic disorders.PMID:38643860 | DOI:10.1016/j.fitote.2024.105969 (Source: Fitoterapia)
Source: Fitoterapia - April 21, 2024 Category: Biochemistry Authors: Minghua Xian Zuqing Ma Sikai Zhan Lin Shen Ting Li Huiting Lin Mingmin Huang Jiale Cai Tao Hu Jiaying Liang Shengwang Liang Shumei Wang Source Type: research
Isolation and characterization of bioactive alkaloids and GC-MS based identification of volatile oil metabolites from fruits of Glycosmis pentaphylla and evaluation of their cytotoxic activity
The objective of this study is to isolate and identify the bioactive compounds found in the fruits of G. pentaphylla and then evaluate their potential for anti-cancer activity in oral cancer CAL 27 cell lines. The extraction of bioactive compounds from fruits was done by maceration, and the isolation of alkaloids and volatile oil fractions (F1-F5) was performed by column chromatography. The alkaloids, such as 3-O-methoxyglycocitrine II, noracronycine, 1-hydroxy-3-methoxy-10-methyl-9-acridone and kokusaginine, were first isolated from the fruits of G. pentaphylla. Additionally, GC-MS analysis identified 78 metabolites. The ...
Source: Fitoterapia - April 19, 2024 Category: Biochemistry Authors: Parusu Kavya Teja Sanjana Kyada Sourav Das Vinal Upadhyay Amit Mandoli Siddheshwar K Chauthe Source Type: research
Ten cyclopentanoid monoterpenes from the whole plant of Rehmannia piasezkii maxim
Fitoterapia. 2024 Apr 16;175:105968. doi: 10.1016/j.fitote.2024.105968. Online ahead of print.ABSTRACTTen new cyclopentanoid monoterpenes (1-10) were isolated from the whole plant of Rehmannia piasezkii. The structures of these compounds were elucidated based on spectroscopic data analysis. In in-vitro assays, compounds 3, 7, and 9 exhibited weak hepatoprotective activities against APAP-induced HepG2 cell damage. Compound 9 exhibited protective effect on hapassocin carbon tetrachloride model.PMID:38636908 | DOI:10.1016/j.fitote.2024.105968 (Source: Fitoterapia)
Source: Fitoterapia - April 18, 2024 Category: Biochemistry Authors: Jie Zhou Guoru Shi Wanqi Zhang Ruoyun Chen Shishan Yu Dequan Yu Yanfei Liu Source Type: research
Four sulfur-containing compounds with effect from marine-derived fungus aspergillus terreus
In this study, four previously undescribed sulfur-containing compounds asperteretals L and M, terreins A and B, together with 17 known compounds were obtained from a culture of marine fungus A. terreus supplemented with inorganic sulfur source Na2SO4. Their planar structures and absolute configurations were elucidated by NMR, HRESIMS, and ECD experiments. The in vitro cytotoxicities of compounds 1-21 against HCT-116 and Caco-2 were evaluated by SRB assay. Asperteretal M (2) exhibited activity against HCT-116 with the IC50 value at 30 μM. The antiproliferative effect of asperteretal M was confirmed by colony formation assa...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Guang-Yu Zhang Bei-Jia Liu Hui-Lin Pan Hou-Jin Li Zi-Feng Huang Taifo Mahmud Wen-Zhe Ma Wen-Jian Lan Source Type: research
Anti-inflammatory monomeric sorbicillinoids from the marine-fish-derived fungus Trichoderma sp. G13
Fitoterapia. 2024 Apr 16;175:105963. doi: 10.1016/j.fitote.2024.105963. Online ahead of print.ABSTRACTFour new monomeric sorbicillinoids, trichillinoids A - D (1-4), along with two known dimeric sorbicillinoids (5 and 6), and five known monomeric sorbicillinoids (7-11), were obtained from the marine-fish-derived fungus Trichoderma sp. G13. They were structurally characterized on the basis of comprehensive spectroscopic investigations (NMR, HRESIMS, and ECD). Compounds 1-4 displayed moderate anti-inflammatory activities, according to inhibiting the production of NO in RAW264.7 cells activated with IC50 values ranging from 1...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Yuhan Zhang Yi Zhang Gang Li Kemin Dong Jialing Wang Shengjia Xiao Hongxiang Lou Xiaoping Peng Source Type: research
Four lathyrane diterpenoids from the seeds of Euphorbia lathyris
Fitoterapia. 2024 Apr 15:105965. doi: 10.1016/j.fitote.2024.105965. Online ahead of print.ABSTRACTFour new diterpenoids, including three secolathyrane diterpenoids (1-3) and one lathyrane diterpenoid (4), together with seven known diterpenoids, were obtained in the shelled seeds of Euphorbia lathyris. In particular, 1-3 possess a rare split ring structure, and currently only one compound with the same skeleton has been identified in E. lathyris. Compound 4 furnishes an unprecedented oxygen bridge structure. The structures were identified using various spectral techniques, including NMR, HR-ESI-MS, single-crystal X-ray diff...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Peng-Xu Chen Lin-Wei Li Shu Xu Guo-Dong Zhang Xu Feng Qi-Zhi Wang Fu-Qin Guan Yu Chen Source Type: research
Isoflavones isolated from the fruits of Ficus altissima and their anti-proliferative activities
In this study, we isolated and identified one new isoflavone (1), three new hydroxycoumaronochromones (2a, 2b and 3a) and 12 known compounds from the fruits of F. altissima. Their chemical structures were determined using spectroscopic analysis methods. We also tested all the isolated compounds for their anti-proliferative activities against eight human tumour cell lines (A-549, AGS, K562, K562/ADR, HepG2, HeLa, SPC-A-1 and CNE2) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Our experiments showed that compound 6 exhibited obvious anti-proliferative activity against the K562 cell line...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Yiliang Liu Yajing Pu Liyuan Shen Dan Li Jingwen Xu Xiangjiu He Yihai Wang Source Type: research
Four sulfur-containing compounds with effect from marine-derived fungus aspergillus terreus
In this study, four previously undescribed sulfur-containing compounds asperteretals L and M, terreins A and B, together with 17 known compounds were obtained from a culture of marine fungus A. terreus supplemented with inorganic sulfur source Na2SO4. Their planar structures and absolute configurations were elucidated by NMR, HRESIMS, and ECD experiments. The in vitro cytotoxicities of compounds 1-21 against HCT-116 and Caco-2 were evaluated by SRB assay. Asperteretal M (2) exhibited activity against HCT-116 with the IC50 value at 30 μM. The antiproliferative effect of asperteretal M was confirmed by colony formation assa...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Guang-Yu Zhang Bei-Jia Liu Hui-Lin Pan Hou-Jin Li Zi-Feng Huang Taifo Mahmud Wen-Zhe Ma Wen-Jian Lan Source Type: research
Anti-inflammatory monomeric sorbicillinoids from the marine-fish- derived fungus Trichoderma sp. G13
Fitoterapia. 2024 Apr 15:105963. doi: 10.1016/j.fitote.2024.105963. Online ahead of print.ABSTRACTFour new monomeric sorbicillinoids, trichillinoids A - D (1-4), along with two known dimeric sorbicillinoids (5 and 6), and five known monomeric sorbicillinoids (7-11), were obtained from the marine-fish-derived fungus Trichoderma sp. G13. They were structurally characterized on the basis of comprehensive spectroscopic investigations (NMR, HRESIMS, and ECD). Compounds 1-4 displayed moderate anti-inflammatory activities, according to inhibiting the production of NO in RAW264.7 cells activated with IC50 values ranging from 14 to...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Yuhan Zhang Yi Zhang Gang Li Kemin Dong Jialing Wang Shengjia Xiao Hongxiang Lou Xiaoping Peng Source Type: research
Four lathyrane diterpenoids from the seeds of Euphorbia lathyris
Fitoterapia. 2024 Apr 15:105965. doi: 10.1016/j.fitote.2024.105965. Online ahead of print.ABSTRACTFour new diterpenoids, including three secolathyrane diterpenoids (1-3) and one lathyrane diterpenoid (4), together with seven known diterpenoids, were obtained in the shelled seeds of Euphorbia lathyris. In particular, 1-3 possess a rare split ring structure, and currently only one compound with the same skeleton has been identified in E. lathyris. Compound 4 furnishes an unprecedented oxygen bridge structure. The structures were identified using various spectral techniques, including NMR, HR-ESI-MS, single-crystal X-ray diff...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Peng-Xu Chen Lin-Wei Li Shu Xu Guo-Dong Zhang Xu Feng Qi-Zhi Wang Fu-Qin Guan Yu Chen Source Type: research
Isoflavones isolated from the fruits of Ficus altissima and their anti-proliferative activities
In this study, we isolated and identified one new isoflavone (1), three new hydroxycoumaronochromones (2a, 2b and 3a) and 12 known compounds from the fruits of F. altissima. Their chemical structures were determined using spectroscopic analysis methods. We also tested all the isolated compounds for their anti-proliferative activities against eight human tumour cell lines (A-549, AGS, K562, K562/ADR, HepG2, HeLa, SPC-A-1 and CNE2) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Our experiments showed that compound 6 exhibited obvious anti-proliferative activity against the K562 cell line...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Yiliang Liu Yajing Pu Liyuan Shen Dan Li Jingwen Xu Xiangjiu He Yihai Wang Source Type: research
Chemical constituents of Rubia tibetica Hook. f. from Tibetan medicine and cytotoxic activity evaluation
Fitoterapia. 2024 Apr 16;175:105961. doi: 10.1016/j.fitote.2024.105961. Online ahead of print.ABSTRACTTwo unprecedented quinone compounds Rubiaxylm A (1) and Rubiaxylm B (2), along with fifteen known anthraquinones (3-17) were isolated and characterized from the roots of Rubia tibetica in Tibetan medicine. Their structures were identified through comprehensive analyses of 1D/2D NMR as well as HR-ESIMS data. Furthermore, all separated compounds were evaluated for their cytotoxic activity on A549, Caco-2, MDA-MB-231 and Skov-3 cell lines. In particular, compound 2 effectively inhibited MDA-MB-231 cells with an IC50 value of ...
Source: Fitoterapia - April 16, 2024 Category: Biochemistry Authors: Min-Min Gu Qing Li Yu Zhang Hong-Wei Wu Yuan-Ling Shao Hong-Ping Han Zhi-Xin Liao Source Type: research
Chemical constituents of Rubia tibetica Hook. f. from Tibetan medicine and cytotoxic activity evaluation
Fitoterapia. 2024 Apr 14:105961. doi: 10.1016/j.fitote.2024.105961. Online ahead of print.ABSTRACTTwo unprecedented quinone compounds Rubiaxylm A (1) and Rubiaxylm B (2), along with fifteen known anthraquinones (3-17) were isolated and characterized from the roots of Rubia tibetica in Tibetan medicine. Their structures were identified through comprehensive analyses of 1D/2D NMR as well as HR-ESIMS data. Furthermore, all separated compounds were evaluated for their cytotoxic activity on A549, Caco-2, MDA-MB-231 and Skov-3 cell lines. In particular, compound 2 effectively inhibited MDA-MB-231 cells with an IC50 value of 8.15...
Source: Fitoterapia - April 16, 2024 Category: Biochemistry Authors: Min-Min Gu Qing Li Yu Zhang Hong-Wei Wu Yuan-Ling Shao Hong-Ping Han Zhi-Xin Liao Source Type: research
Five new eremophilane-type sesquiterpenes from the fresh roots of Rehmannia glutinosa
Fitoterapia. 2024 Apr 13:105960. doi: 10.1016/j.fitote.2024.105960. Online ahead of print.ABSTRACTFive undescribed eremophilane-type sesquiterpenes, remophilanetriols E-I (1-5), along with seven known compounds (6-12) were isolated from the fresh roots of Rehmannia glutinosa. Their structures were characterized by extensive spectroscopic data analysis and their absolute configurations were determined by comparing their calculated electronic circular dichroism (ECD) spectra and experimental ECD spectra. The anti-pulmonary fibrosis activities of all compounds were evaluated in vitro by MTT methods, and compounds 2, 8, 10, an...
Source: Fitoterapia - April 15, 2024 Category: Biochemistry Authors: Xiang-Da Li Yan-Gang Cao Yu-Han Zhang Ying-Jie Ren Meng-Nan Zeng Yan-Ling Liu Xu Chen Xin-Yi Ma Bing-Xian Zhao Xiao-Ke Zheng Wei-Sheng Feng Source Type: research
