FitoterapiaThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Pages: 1 2 3 4

169 records returned

Supramolecular phospholipids-polyphenolics interactions: The PHYTOSOME(R) strategy to improve the bioavailability of phytochemicals.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the preparation and characterization of PHYTOSOME((R)) complexes and their activity in various medicinal (cardiovascular, anti-inflammatory, hepatoprotective, anticancer) and cosmetic (skin aging) realms of application. PMID: 19919847 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - November 14, 2009 Category: Biochemistry Authors: Semalty A, Semalty M, Rawat MS, Franceschi F Tags: Fitoterapia Source Type: journals

A new cytotoxic flavonoid from the fruit of Sinopodophyllum hexandrum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Constituents of the fruit of Sinopodophyllum hexandrum (Royle) Ying (Sinopodophylli Fructus) were investigated. A new flavonoid, 8,2'-diprenylquercetin 3-methyl ether along with 9 known compounds were isolated and identified. Among them, the new compound 8,2'-diprenylquercetin 3-methyl ether exhibited cytotoxic activity against MDA-231 and T47D breast cancer cell lines, quercetin, kaempferol and rutin were isolated from Sinopodophylli Fructus for the first time. PMID: 19909799 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - November 9, 2009 Category: Biochemistry Authors: Kong Y, Xiao JJ, Meng SC, Dong XM, Ge YW, Wang RF, Shang MY, Cai SQ Tags: Fitoterapia Source Type: journals

Steroidal saponins from the leaves of Agave macroacantha.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new monodesmosidic spirostanol saponin, along with three known saponins were isolated from Agave macroacantha Zucc leaves. The structure of the new saponin was established as hecogenin-3-O-alpha-L-rhamnopyranosyl (1-->4) beta-D-xylopyranosyl (1-->3)[ beta-D-glucopyranosyl (1-->2)] beta-D-glucopyranosyl (1-->4) beta-D-galactopyranoside. The (1)H and (13)C resonances of the four compounds were assigned using a combination of 1D and 2D NMR techniques including (1)H, (13)C, COSY, TOCSY, ROESY, HSQC and HMBC NMR and confirmed by mass spectrometry. PMID: 19909800 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - November 9, 2009 Category: Biochemistry Authors: Eskander J, Lavaud C, Harakat D Tags: Fitoterapia Source Type: journals

Vasorelaxant and antihypertensive effects of methanolic extract from roots of Laelia anceps are mediated by calcium channel antagonism.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
RMELanc induced relaxation in aortic rings pre-contracted with NE, 5-HT and KCl. Also reduced NE-induced transient contraction in Ca(2+)-free solution and inhibited contraction induced by increasing external calcium. Nevertheless, the vasorelaxant effect of RMELanc was not reduced by ODQ, 1-alprenolol, TEA, glibenclamide, and 2-AP. Oral administration of 100mg/kg of RMELanc exhibited a significant decrease in systolic and diastolic blood pressure in SHR rats. HPLC analysis allowed us to detect the presence of 2,7-dihydroxy-3,4,9-trimethoxyphenantrene (1), which induced a significant relaxation effect. Therefore, our re...
Source: Fitoterapia - October 29, 2009 Category: Biochemistry Authors: Vergara-Galicia J, Ortiz-Andrade R, Rivera-Leyva J, Castillo-España P, Villalobos-Molina R, Ibarra-Barajas M, Gallardo-Ortiz I, Estrada-Soto S Tags: Fitoterapia Source Type: journals

Chemical composition of the Lippia origanoides essential oils and their antigenotoxicity against bleomycin-induced DNA damage.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The present work evaluated chemical composition of the essential oils (EO) from Lippia origanoides and their DNA protective effect against bleomycin-induced genotoxicity. L. origanoides EO chemical composition was determined by gas chromatography - mass spectrometry (GC-MS). The major compounds of the L. origanoides EOs were thymol (34 - 58%) and carvacrol (26%). The antigenotoxicity of the EOs and their major compounds was assayed in co-incubation procedures using the SOS Chromotest in Escherichia coli. Both EOs and their major compounds protected bacterial cells against bleomycin-induced genotoxicity indicating that ...
Source: Fitoterapia - October 26, 2009 Category: Biochemistry Authors: Vicuña GC, Stashenko EE, Fuentes JL Tags: Fitoterapia Source Type: journals

Berberine inhibits adipogenesis in high-fat diet-induced obesity mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the effects of berberine on the adipogenesis of high-fat diet-induced obesity (FD) or normal diet (ND) mice and possible transcriptional impact are investigated. The results demonstrated that in FD mice, berberine reduced mouse weight gain and food intake and serum glucose, triglyceride, and total cholesterol levels accompanied with a down-regulation of PPARgamma expression and an up-regulation of GATA-3 expression. Berberine had no adverse effects on ND mice. These encouraging findings suggest that berberine has excellent pharmacological potential to prevent obesity. PMID: 19861153 [PubMed - as supplied...
Source: Fitoterapia - October 24, 2009 Category: Biochemistry Authors: Hu YS, Davies GE Tags: Fitoterapia Source Type: journals

Evaluation of a new eastern blotting technique for the analysis of ginsenoside Re in American ginseng berry pulp extracts.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new eastern blotting technique has been established for ginsenoside Re (G-Re) contained in American ginseng berry pulp extracts. G-Re in American ginseng berry pulp was extracted using 100% methanol, 100% ethanol, 50% aqueous methanol, and 50% aqueous ethanol. The combined crude extracts were applied onto a polyethersulfone membrane and developed using the methanol-water-acetic acid solvent system (45:55:1 v/v). Separated components were immunostained using anti-G-Re monoclonal antibody. G-Re was first specifically detected and then quantitatively analyzed using NIH Imaging software. We also confirmed that the most s...
Source: Fitoterapia - October 19, 2009 Category: Biochemistry Authors: Morinaga O, Uto T, Yuan CS, Tanaka H, Shoyama Y Tags: Fitoterapia Source Type: journals

In vitro antifungal activity of phenylheptatriyne from Bidens Cernua L. against yeasts.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In vitro antifungal activity of phenylheptatriyne from Bidens cernua L. (Asteraceae) was studied using broth macrodilution method against 125 strains of yeasts including 104 clinical and other isolates of Candida spp. (C. albicans, C. krusei, C. tropicalis, C. guilliermondii, C. parapsilosis, C. glabrata, C. inconspicua), 16 strains of basidiomycetous yeasts (Cryptococcus neoformans, C. albidus, Trichosporon cutaneum, Rhodotorula glutinis) and five standard reference strains of Candida species. Phenylheptatriyne has shown significant activity against investigated strains, the Minimal Inhibitory Concentrations for Candi...
Source: Fitoterapia - October 14, 2009 Category: Biochemistry Authors: Rybalchenko NP, Prykhodko VA, Nagorna SS, Volynets NN, Ostapchuk AN, Klochko VV, Rybalchenko TV, Avdeeva LV Tags: Fitoterapia Source Type: journals

Two new compounds from transgenic Panax quinquefolium.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new ceramide and a new poly-hydroxyl octadecenoic acid were isolated from transgenic crown galls of Panax quinquefolium. Their structures were elucidated as (2S, 3S, 4R, 20E)-2-[(2'R)-2'-hydroxyl l-palmitoyl -amino]-20-hexacosene-1, 3, 4-triol (1) and 12, 13, 15-trihydroxy-9-octadecenoic acid (2) respectively on the basis of spectroscopic and chemical methods. PMID: 19836436 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - October 13, 2009 Category: Biochemistry Authors: Zhu JH, Yu RM, Yang L, Li WM Tags: Fitoterapia Source Type: journals

Coffee and liver diseases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Coffee consumption is worldwide spread with few side effects. Interestingly, coffee intake has been inversely related to the serum enzyme activities gamma-glutamyltransferase, and alanine aminotransferase in studies performed in various countries. In addition, epidemiological results, taken together, indicate that coffee consumption is inversely related with hepatic cirrhosis; however, they cannot demonstrate a causative role of coffee with prevention of liver injury. Animal models and cell culture studies indicate that kahweol, diterpenes and cafestol (some coffee compounds) can function as blocking agents by modulati...
Source: Fitoterapia - October 9, 2009 Category: Biochemistry Authors: Muriel P, Arauz J Tags: Fitoterapia Source Type: journals

Ocotea quixos Lam. essential oil: In vitro and in vivo investigation on its anti-inflammatory properties.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion we provide the first evidence of a significant anti-inflammatory gastro-sparing activity of Ocotea quixos essential oil. PMID: 19825398 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - October 9, 2009 Category: Biochemistry Authors: Ballabeni V, Tognolini M, Giorgio C, Bertoni S, Bruni R, Barocelli E Tags: Fitoterapia Source Type: journals

Reproductive and Developmental Toxicity Evaluation of a Purified Arabinogalactan-Protein (AGP) Composition in Wistar Rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A purified Arabinogalactan-Protein composition (LL-4218) was prepared from the leaves of Argemone mexicana to treat psoriasis. The effect of (LL-4218) was evaluated on reproductive (male and female fertility) and developmental toxicity in rats. LL-4218 was administered orally at the doses of 250, 500 and 1000mg kg(-1). The results showed that LL-4218 did not produce any significant dose related changes in reproductive and developmental toxicity studies. Therefore, it is concluded that LL-4218 did not produce any significant toxic effect on reproduction and developmental parameters of rats and NOAEL for reproductive and...
Source: Fitoterapia - October 9, 2009 Category: Biochemistry Authors: Tamboli S, Arora S, Bhatnagar U, Vishwase G, Singh M Tags: Fitoterapia Source Type: journals

Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
StAPs are potato aspartic proteases with cytotoxic activity against plant pathogens and spermatozoa. StAPs cytotoxic activity is selective, since these proteins do not exert toxic effect on plant cells and erythrocytes. In this work, we investigated the capacity of StAPs to exert cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on Jurkat T cells after short time of incubation in a dose dependent manner. However, not significative effect on the T lymphocytes viability was observed at all StAPs incubation times and concentrations tested. These results suggest that StAPs can be conc...
Source: Fitoterapia - October 9, 2009 Category: Biochemistry Authors: Mendieta JR, Fimognari C, Daleo GR, Hrelia P, Guevara MG Tags: Fitoterapia Source Type: journals

Crocin and geniposide profiles and radical scavenging activity of gardenia fruits (Gardenia jasminoides Ellis.) from different cultivars and at the various stages of maturation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigate crocins and geniposide profiles of gardenia fruits from different cultivars and at the various stages of maturation. DPPH scavenging activity of gardenia fruits from different cultivars and at the various stages of fruit maturation was also assayed. Quantitative determination of crocins in the gardenia at the various stages of maturation revealed a significant increase when ripening. However, geniposide content was negatively correlated with ripening stages. A significant difference was observed when comparing crocin content of different gardenia from various cultivars and geniposide content a...
Source: Fitoterapia - October 4, 2009 Category: Biochemistry Authors: Chen Y, Zhang H, Li YX, Cai L, Huang J, Zhao C, Jia L, Buchanan R, Yang T, Jiang LJ Tags: Fitoterapia Source Type: journals

A new flavonol glycoside from Millettia speciosa.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new flavonol triglycoside, millettiaspecoside D, was isolated from the caulis of Millettia speciosa Champ. Its structure was elucidated on the basis of spectroscopic analysis. PMID: 19808081 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - October 2, 2009 Category: Biochemistry Authors: Yin T, Liang H, Wang B, Zhao Y Tags: Fitoterapia Source Type: journals

Inhibitory effect and transcriptional impact of berberine and evodiamine on human white preadipocyte differentiation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It has been reported that the botanical alkaloids, berberine and evodiamine inhibit mouse preadipocyte 3T3-L1 differentiation. The aim of this study was to investigate the effect and transcriptional impact of berberine and evodiamine individually and in combination on human white preadipocyte (HWP) differentiation. We have shown that treatment with 8 microM berberine or 4 microM evodiamine resulted in a major inhibition of HWP differentiation accompanied by up-regulation of both GATA binding protein 2 and 3 (GATA-2 and GATA-3) mRNA and protein expression, suggesting that both compounds may have excellent potential as a...
Source: Fitoterapia - September 28, 2009 Category: Biochemistry Authors: Hu YS, Fahmy H, Zjawiony JK, Davies GE Tags: Fitoterapia Source Type: journals

Cassia occidentalis L.: A review on its ethnobotany, phytochemical and pharmacological profile.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cassia occidentalis L. is an annual or perennial Ayurvedic plant which is used in several traditional medicines to cure various diseases. This weed has been known to possess antibacterial, antifungal, antidiabetic, anti-inflammatory, anticancerous, antimutagenic and hepatoprotective activity. A wide range of chemical compounds including achrosin, aloe-emodin, emodin, anthraquinones, anthrones, apigenin, aurantiobtusin, campesterol, cassiollin, chryso-obtusin, chrysophanic acid, chrysarobin, chrysophanol, chrysoeriol etc. have been isolated from this plant. The presented review summarizes the information concerning the ...
Source: Fitoterapia - September 27, 2009 Category: Biochemistry Authors: Yadav JP, Arya V, Yadav S, Panghal M, Kumar S, Dhankhar S Tags: Fitoterapia Source Type: journals

Evaluation of variation in Podophyllum hexandrum by chemical and RAPD markers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Detailed chemical profiles and RAPD analysis was done in different populations of Podophyllum hexandrum collected from high altitude regions of North Western Himalayas. Random amplified polymorphic DNA (RAPD) analysis revealed a high degree of genetic diversity among the 12 collected populations, attributed to its varied geographical and climatic conditions. HPLC analysis also revealed variation in the concentration of two major marker compounds which lead to the identification of a chemotype. The study demonstrated that RAPD and chemical markers are very useful tools to compare the genetic relationship and pattern of ...
Source: Fitoterapia - September 25, 2009 Category: Biochemistry Authors: Sultan P, Shawl AS, Suriya R, Ahmed SF, Ramteke PW Tags: Fitoterapia Source Type: journals

Dammarane-type Glycosides and Long chain Sesquiterpene Glycosides from Gynostemma yixingense.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new dammarane-type glycoside and a new long chain sesquiterpene glycoside, along with nine known compounds 20(S)-ginsenoside Rh1 (3), 20(R)-ginsenoside Rh1 (4), ginsenoside F1 (5), amarantholidoside IV (6), ginsenoside Rc (7), 20(S)-ginsenoside Rg2 (8), 20(R)-ginsenoside Rg2 (9), ginsenoside Rd (10) and gypenoside XLVI (11) were isolated from Gynostemma yixingense. The structures of the new compounds were determined on the basis of spectroscopic analysis, including 1D-, 2D-NMR and ESI-MS techniques as well as by comparison of the spectral data with those of related compounds as 2alpha,3beta,20(S)-trihydroxydammar-24-...
Source: Fitoterapia - September 21, 2009 Category: Biochemistry Authors: Xiang WJ, Guo CY, Ma L, Hu LH Tags: Fitoterapia Source Type: journals

Antituberculosis activity of alkylated mulinane diterpenoids.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Natural azorellane and mulinane diterpenoids show antituberculosis activity, which is increased by methylation of their free carboxyl group. We have systematically investigated the effect of alkylation in this class of diterpenoids and found that the profile of bioactivity is relatively unaffected by the introduction of short alkyl groups, both linear and branched. In this investigation, three semisynthetic diterpenoids, 13 hydroxy-mulin-11-en-20-oic acid n-propyl ester (3) and the n-propyl (19) and n-butyl (20) esters of isomulinic acid, showed the strongest antituberculosis activity (MIC=6.25mug/mL) against a drug-re...
Source: Fitoterapia - September 21, 2009 Category: Biochemistry Authors: Molina-Salinas GM, Bórquez J, Said-Fernández S, Loyola LA, Yam-Puc A, Becerril-Montes P, Escalante-Erosa F, Peña-Rodríguez LM Tags: Fitoterapia Source Type: journals

Bioactive flavones and biflavones from Selaginella moellendorffii Hieron.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Three new flavones named 5-carboxymethyl-4',7-dihydroxyflavone (1), its ethyl ester (2) and butyl ester (3) were isolated from the herb of Selaginella moellendorffii Hieron., together with ten known compounds. Their structures were elucidated on the basis of spectroscopic and chemical analysis. Selected compounds were evaluated for their anti-HBV and cytotoxic activity. Among them, compound 2 and 3 displayed inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC(50) values of 0.17mg/ml and 0.46mg/ml, and on HBV e antigen (HBeAg) secretion with IC(5...
Source: Fitoterapia - September 19, 2009 Category: Biochemistry Authors: Cao Y, Tan NH, Chen JJ, Zeng GZ, Ma YB, Wu YP, Yan H, Yang J, Lu LF, Wang Q Tags: Fitoterapia Source Type: journals

A HPTLC densitometric method for the determination of aloeverose in Aloe vera gel.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aloe vera gel is a familiar ingredient in a range of widely available and advertisement healthcare and cosmetic products. As till date there are no documented reports on the standardization of A. vera gel the following study is an attempt in this direction. A. vera gel was evaluated for its aloeverose content for the first time. Aloeverose, was separated on a thin- layer of silica gel by isocratic gradient elution technique was determined by using HPTLC-photodensitometry. The proposed method is simple and sensitive and can be used for the routine assay of aloeverose in phytomedicines containing A. vera gel. PMID: 1...
Source: Fitoterapia - September 13, 2009 Category: Biochemistry Authors: Lobo R, Prabhu KS, Shirwaikar A, Ballal M, Balachandran C, Shirwaikar A Tags: Fitoterapia Source Type: journals

Anti-inflammatory and analgesic properties of cis-mulberroside A from Ramulus mori.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined the analgesic and anti-inflammatory actions of cis-mulberroside A isolated from Ramulus mori in several models of inflammatory pain in mice. Cis-mulberroside A (25 and 50mg/kg) given by p.o. route 30min before challenge produced a dose-dependent inhibition of the acetic acid-induced pain and Evans blue leakage in mice. In addition, this compound exhibited significant systemic anti-inflammatory activity in carrageenan-induced mouse paw edema in a concentration-related manner (33.1-68.5% inhibition), and similar results were achieved in formalin test. Suppressive effects of cis-mulberroside A on the produ...
Source: Fitoterapia - September 11, 2009 Category: Biochemistry Authors: Zhang Z, Shi L Tags: Fitoterapia Source Type: journals

Reactive oxygen species scavenging activities and inhibition on DNA oxidative damage of dimeric compounds from the oxidation of (-)-epigallocatechin-3-O-gallate.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The dimeric catechins dehydrotheasinensin A (2) and theacitrin C (3) were pre-pared from the oxidation of (-)-epigallocatechin-3-O-gallate (EGCG, 1),and their antioxidant activity was investigated using a chemiluminescence (CL) method in vitro. Both compounds showed significant inhibitory effects on reactive oxygen species (O(2)(.-), H(2)O(2) and *OH) and DNA oxidative damage, with 2 being more pot- ent than 3 and EGCG itself. PMID: 19751808 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - September 10, 2009 Category: Biochemistry Authors: Qi X Tags: Fitoterapia Source Type: journals

A new steroidal saponin from the dried stems of Asparagus officinalis L.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Yamogenin II (1), A new steroidal saponin with a unique aglycone moiety, together with a known steroidal saponin, (25S)-spirostan-5-ene-3beta-ol-3-O-alpha-L- rhamnopyranosyl-(1,2)-[alpha-L-rhamnopyranosyl-(1,4)]-beta-D-glucopyranoside (2), were isolated from the dried stems of Asparagus officinalis L. On the basis of 1D and 2D NMR and HRESI-MS, the structure of 1 were determined as (25S)-spirostan-5-ene- 3beta,21-diol-3-O-alpha-L-rhamnopyranosyl-(1,2)-[alpha-L-rhamnopyranosyl-(1,4)]-beta-D-glucopyranoside. PMID: 19751809 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - September 10, 2009 Category: Biochemistry Authors: Sun Z, Huang X, Kong L Tags: Fitoterapia Source Type: journals

Antioxidant flavonoid glycosides from Evolvulus alsinoides.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oxidative damage is an established outcome of chronic stress. Thus, present study was designed to investigate the modulatory role of ethanolic extract of Evolvulus alsinoides(EA) in terms of oxidative alterations at peripheral and central level in rats subjected to chronic unpredictable stress (CUS). CUS exposure for 7days reduced Cu, Zn superoxide dismutase and catalase activity with increase in glutathione peroxidase activity and lipid peroxidation, while decrease in reduced glutathione level in blood plasma, frontal cortex and hippocampus regions of brain. Oral administration of EA extract at 200mg/kg p.o. normalize...
Source: Fitoterapia - September 9, 2009 Category: Biochemistry Authors: Kumar M, Ahmad A, Rawat P, Rasheed N, Gupta P, B S, Bhatia G, Palit G, Maurya R Tags: Fitoterapia Source Type: journals

Study of anti-inflammatory, analgesic and antipyretic activities of seeds of hyoscyamus niger and isolation of a new coumarinolignans.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hyoscyamus niger is a traditionally used anti-inflammatory drug. The methanolic extract of H. niger (MHN) produced significant analgesic activity in hot plate as well as acetic acid induced writhing models. It was also found as an effective anti-inflammatory drug in carrageenin-induced paw oedema and cotton-pellet granuloma methods. Additionally, it exhibited antipyretic activity in yeast-induced pyrexia model. Furthermore, from bioactive MHN, a new coumarinolignan, cleomiscosin A methyl ether and four known coumarinolignans were isolated and characterized by spectroscopic and comparative HPLC analysis. Cleomiscosin A ...
Source: Fitoterapia - August 27, 2009 Category: Biochemistry Authors: Begum S, Saxena B, Goyal M, Ranjan R, Joshi VB, Rao CV, Krishnamurthy S, Sahai M Tags: Fitoterapia Source Type: journals

Two new cerebrosides from the pollen of Typha angustifolia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two new cerebrosides, 1-O-(beta-D-glucopyranosyloxy)-(2S,3S,4R,8Z)-2- [(2'R)-2'-hydroxytricosanoylamino]-8-nonadecene-3,4-diol (1) and 1-O-(beta-D- glucopyranosyloxy)-(2S,3R,4E,8Z)-2-[(2'R)-2'-hydroxynonadecanoylamino]-4,13-nonadecene-3-diol (2), were isolated from the Pollen of Typha angustifolia. Their structures were elucidates by chemical and spectral means. This is the first report on the occurrence of cerebroside in the Typha (typhaceae). Compounds 1 and 2 exhibited effect on the proliferation of cultured vascular smooth muscle cell (VSMCs) induced by fatal bovine serum (FBS). PMID: 19720118 [PubMed - as supp...
Source: Fitoterapia - August 27, 2009 Category: Biochemistry Authors: Tao WW, Yang NY, Liu L, Duan JA, Wu DK, Qian DW, Tang YP Tags: Fitoterapia Source Type: journals

Leiyemudanosides A-C, Three New Bidesmosidic Triterpenoid Saponins from the Roots of Caulophyllum robustum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Three new oleanane bidesmosidic triterpenoid saponins, named leiyemudanosides A-C (1-3) were isolated from the roots of Caulophyllum robustum Maxim. Their structures were established by chemical and detailed spectroscopic analysis as 3-O-alpha-L-arabinopyranosyl-caulophyllogenin-28-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl ester (1), 3-O-beta-D-glucopyranosyl-(1-->3)-alpha-L-arabinopyranosyl-caulophyllogenin-28-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl ester (2), and 3-O-beta-D-glucopyranosyl-(1-->3)-alpha-L-arabinopyranosyl-echinocystic acid-28-O-a...
Source: Fitoterapia - August 27, 2009 Category: Biochemistry Authors: Li G, Zhang Y, Yang B, Xia Y, Zhang Y, Lü S, Kuang H Tags: Fitoterapia Source Type: journals

Cerebrosides with antiproliferative activity from Euphorbia peplis L.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two new cerebrosides have been isolated from the whole plants of Euphorbia peplis L. The structures were established by FT-IR spectroscopy, FAB-MS, EI-MS, ESI-MS, 1D and 2D NMR spectroscopy. The structures of the cerebrosides were characterized as 1-O-beta-D-glycosides of phytosphingosines, which comprised a common long-chain base, (2S, 3S, 4R, 8Z)-2-amino-8 (Z)-octadecene-1,3,4-triol with 2-hydroxy fatty acids of varying chain lengths (C25, C22) linked to the amino group. The isolated compounds were shown to possess significant antiproliferative properties against cultured human tumor cell lines KB and IMR-32. PMI...
Source: Fitoterapia - August 20, 2009 Category: Biochemistry Authors: Cateni F, Zilic J, Zacchigna M, Procida G Tags: Fitoterapia Source Type: journals

Ayurvedic processed seeds of nux-vomica: Neuropharmacological & chemical evaluation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ayurvedic processed seeds of nux-vomica: Neuropharmacological & chemical evaluation. Fitoterapia. 2009 Aug 20; Authors: Katiyar C, Kumar A, Bhattacharya LS, Singh LR The effect of detoxification on Strychnos nux-vomica seeds by traditional processing with aloe and ginger juices (B), by frying in cow ghee (C), and by boiling in cow milk (D) was investigated. The ethanolic extract was analyzed for spontaneous motor activity (SMA), pentobarbitone-induced hypnosis, PTZ induced convulsions, diazepam-assisted protection, and morphine induced catalepsy. All samples could reduce SMA and inhibited catalepsy. The see...
Source: Fitoterapia - August 19, 2009 Category: Biochemistry Authors: Katiyar C, Kumar A, Bhattacharya LS, Singh LR Tags: Fitoterapia Source Type: journals

Chemical constituents of Baeckea frutescens leaves inhibit copper-induced low-density lipoprotein oxidation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study focused on the effects of the leaves of Baeckea frutescens in the prevention of arteriosclerosis. The leaves of B. frutescens have afforded, besides known flavonoid and chromone glycosides, a novel biflavonoid glycoside, characterized as 3-O-alpha-L-rhamnopyranosylmyricetinyl-(I-2",II-2")-3-O-alpha-L-rhamnopyranosylmyricetin on the basis of chemical and spectral evidence. This compound exhibited marked inhibition of copper-induced LDL oxidation. PMID: 19699785 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - August 19, 2009 Category: Biochemistry Authors: Kamiya K, Satake T Tags: Fitoterapia Source Type: journals

Anti-diabetic effects of emodin involved in the activation of PPARgamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rheum palmatum Linn has been widely applied in the clinical treatment of diabetes mellitus. It has been found that emodin as the major bioactive component of R. palmatum L exhibits the competency to activate peroxisomal proliferator-activated receptor-gamma (PPARgamma) in vitro. So the aim of this study was to evaluate the anti-diabetic effects of emodin through the activation of PPARgamma on high-fat diet-fed and low dose of streptozotocin (STZ)-induced diabetic mice. The diabetic mice were intraperitoneally injected with emodin for three weeks. No changes of food consumption and the body weight in emodin-treated mice...
Source: Fitoterapia - August 18, 2009 Category: Biochemistry Authors: Xue J, Ding W, Liu Y Tags: Fitoterapia Source Type: journals

Antioxidant and enzyme inhibition activities and chemical profiles of Polygonum sachalinensis F.Schmidt ex Maxim (Polygonaceae).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Polygonum sachalinensis is a wide spread invasive plant in Europe. Chemical profiles of its different organs were studied by HPLC-UV-ESI/MS. Seven major constituents quercetin-3-O-beta-D-galactopyranoside, quercetin-3-O-arabinopyranoside, lapathoside D, N-trans-feruloyltyramine, lapathoside C, hydropiperoside, and vanicoside B were isolated and identified. The free radical-scavenging, alpha/beta-glucosidase, and acetylcholinesterase inhibitory activities of crude MeOH extracts and isolated compounds were studied. The structure-activity relationships were discussed. The chemical profiles revealed flavonoids and phenylpr...
Source: Fitoterapia - August 17, 2009 Category: Biochemistry Authors: Fan P, Terrier L, Hay AE, Marston A, Hostettmann K Tags: Fitoterapia Source Type: journals

Promising Candidates in clinical trials against multidrug-resistant tuberculosis (MDR-TB) based on natural products.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the twenty first century the interest in new anti-tuberculosis drugs based on natural products, specially against MDR (multidrug-resistant) and XDR (extensively drug resistant) tuberculosis (TB) is growing, as indicated by the increasing number of publications in this field. Some natural products, semisynthetic or synthetic compounds based on nature are in clinical studies and are the subject of this article. PMID: 19698768 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - August 17, 2009 Category: Biochemistry Authors: de Souza MV Tags: Fitoterapia Source Type: journals

Antinociceptive and anti-inflammatory activities of iridoid glycosides extract of Lamiophlomis rotata (Benth.) Kudo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the antinociceptive and anti-inflammatory activities of iridoid glycosides extract of L. rotata (IGLR) in mice. Our results showed that the iridoid glycosides extract could decrease acetic-acid-induced writhings times and formalin-induced lickings times, inhibit carrageenan-induced hind paw edema and xylene-induced ear swelling, and suppress peritoneal capillary permeability and leukocyte infiltration also induced by acetic acid in mice. All of these results suggested that the iridoid glycosides extract possesses the significant antinociceptive and anti-inflammatory activities. PMID: 1969...
Source: Fitoterapia - August 17, 2009 Category: Biochemistry Authors: Li M, Shang X, Zhang R, Jia Z, Fan P, Ying Q, Wei L Tags: Fitoterapia Source Type: journals

Proanthocyanidins and a phlorogucinol derivative from Rumex acetosa L.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
From the ethyl acetate soluble fraction of an acetone-water extract of the aerial parts of Rumex acetosa L. (Polygonaceae), a variety of monomeric flavan-3-ols (catechin, epicatechin, epicatechin-3-O-gallate), A- and B-type procyanidins and propelargonidins (15 dimers, 7 trimers, 2 tetramers) were isolated with 5 so far unknown natural products. Dimers: procyanidin B1, B2, B3, B4, B5, B7, A2, epiafzelechin-(4beta-->8)-epicatechin, epiafzelechin-(4beta-->8)-epicatechin-3-O-gallate (new natural product), epiafzelechin-(4beta-->6)-epicatechin-3-O-gallate (new natural product), epiafzelechin-3-O-gallate-(4beta--&g...
Source: Fitoterapia - August 16, 2009 Category: Biochemistry Authors: Bicker J, Petereit F, Hensel A Tags: Fitoterapia Source Type: journals

Two 22S-solanidine-type steroidal alkaloids from Fritillaria anhuiensis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Phytochemical investigation of the fresh bulbs of Fritillaria anhuiensis S. C. Chen et S. E. Yin. resulted in the isolation of a known steroidal alkaloid solanidine of (22S,25 S)-solanid-5-en-3beta-ol (1), which has never yet been found as a natural substance, and of a new steroidal alkaloid (22 S,25 S)-solanid-5,20(21)-dien-3beta-ol. Compound 1 and 2 were the first solanidine-type alkaloids with 22-S configuration discovered from nature. Their structures were elucidated based on spectroscopic analysis, including 1D and 2D NMR experiments. PMID: 19695313 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - August 16, 2009 Category: Biochemistry Authors: Shou QY, Tan Q, Shen ZW Tags: Fitoterapia Source Type: journals

Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The bioassay guided fractionation of the n-hexane extract of the seeds of Murraya koenigii Spreng (Rutaceae) resulted in the isolation of three bioactive carbazole alkaloids, Kurryam (I), Koenimbine (II) and Koenine (III). The structures of the compounds were confirmed from their (1)H-, (13)C-, and 2D-NMR spectral data. Of the three compounds (I) and (II) exhibited significant inhibitory activity against castor oil-induced diarrhoea and PGE(2)-induced enterpooling in rats. The compounds also produced a significant reduction in gastro-intestinal motility in the charcoal meal test in Wister rats. PMID: 19695314 [PubM...
Source: Fitoterapia - August 16, 2009 Category: Biochemistry Authors: Mandal S, Nayak A, Kar M, Banerjee SK, Das A, Upadhyay SN, Singh RK, Banerji A, Banerji J Tags: Fitoterapia Source Type: journals

Study of dynamic accumulation of secondary metabolites in three subspecies of Hypericum perforatum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
St. John's Wort extracts are used for the treatment of mild to moderately severe depression, and their composition and standardization have been thoroughly investigated. Standardization of St. John's Wort extracts has to cope with several factors that affect the phytochemical profile of the plant, with geographic location, seasonal variations and subspecies being all important. To address this issue, three different subspecies of Hypericum perforatum L. were profiled in relation to different maturation phases, evaluating the variations in the context of the major secondary metabolites from this plant. HPLC analysis ind...
Source: Fitoterapia - August 13, 2009 Category: Biochemistry Authors: Filippini R, Piovan A, Borsarini A, Caniato R Tags: Fitoterapia Source Type: journals

Structure analysis of water-soluble polysaccharide CPPS(3) isolated from Codonopsis pilosula.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Codonopsis pilosula is a perennial species of flowering plant propagate in Northeast Asia. A water-soluble polysaccharide, CPPS(3), was extracted from the root of Codonopsis pilosula by boiled water extraction and ethanol precipitation. The molecular weight was estimate to be 7.4x10(4)Da determined by using Gel permeation chromatography. Monosaccharide composition and the structure of the polysaccharide were determined by gas spectroscopy Fourier transform IR(FT-IR)spectroscopy NMR spectroscopy mass spectroscopy and some chemical method analysis was made. The components were galactosearabinose and rhamnose in the molar...
Source: Fitoterapia - August 13, 2009 Category: Biochemistry Authors: Zhang YJ, Zhang LX, Yang JF, Liang ZY Tags: Fitoterapia Source Type: journals

Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
alpha(2)beta(1) and alpha(IIb)beta(3) integrins, that support platelet adhesion to collagen and fibrinogen, respectively, share common signaling molecules. The effect of quercetin on platelet static adhesion to collagen and fibrinogen was assessed and correlated with its kinase inhibitory activity. Quercetin strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin or the combined use of adenosine diphosphate and thromboxane A(2) inhibitors abrogated platelet spreading on these surfaces to a similar extent. We suggest that the inhibitory effect of quercetin o...
Source: Fitoterapia - August 13, 2009 Category: Biochemistry Authors: Navarro-Núñez L, Lozano ML, Martínez C, Vicente V, Rivera J Tags: Fitoterapia Source Type: journals

Quercetin-3-O-beta-D-glucuronopyranoside (QGC)-induced HO-1 expression through ERK and PI3K activation in cultured feline esophageal epithelial cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heme oxygenase-1 (HO-1) is one of the antioxidant enzymes which help protect against celluar damage. The present study examined the ability of Quercetin-3-O-beta-D-glucuronopyranoside (QGC), flavonoid glucoside extracted from Rumex Aquaticus Herba, to induce expression of HO-1 and analyzed its signaling mechanism in cultured feline esophageal epithelial cells (EEC). Culture of the esophageal epithelial cells from cat was prepared. The data suggested that QGC could result in enhanced antioxidant enzyme defense system via HO-1 expression and Nrf2 translocation involving both the ERK and PI3K-Akt pathways as well as partl...
Source: Fitoterapia - August 13, 2009 Category: Biochemistry Authors: Kim JS, Song HJ, Ko SK, Whang WK, Sohn UD Tags: Fitoterapia Source Type: journals

Bakkenolides from Petasites tatewakianus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new bakkenolide and a known one were isolated from Petasites tatewakianus. The structure of new compound was elucidated on the basis of spectroscopic methods including IR, EIMS, HRESIMS, 1D and 2D NMR, and the known compound was established by single crystal X-ray structural analysis. The in vitro cytotoxic activity of these two compounds against cultured Human cervical carcinoma (HeLa), human breast cancer (MCF-7) and murine Lewis lung carcinoma (LLC) cell lines was also evaluated. PMID: 19686812 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - August 13, 2009 Category: Biochemistry Authors: Xie WD, Li RJ, Gao X, Row KH Tags: Fitoterapia Source Type: journals

A novel antifungal anthraquinone from seeds of Aegle marmelos Correa (family Rutaceae).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new anthraquinone, 1-methyl-2-(3'-methyl-but-2'-enyloxy)-anthraquinone (1) has been isolated from seeds of Aegle marmelos Correa and was characterized on the basis of spectral analysis (UV, IR, (1)H NMR, (13)C NMR, 2D NMR and mass spectroscopy). The compound exhibited significant antifungal activity against pathogenic strains of Aspergillus species and Candida albicans in disc diffusion assay (MIC value of 6.25mug/disc), microbroth dilution and percent spore germination inhibition assays (MIC value of 31.25-62.5mug/ml). PMID: 19686813 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - August 13, 2009 Category: Biochemistry Authors: Mishra BB, Kishore N, Tiwari VK, Singh DD, Tripathi V Tags: Fitoterapia Source Type: journals

Puqienine E: An angiotensin converting enzyme inhibitory steroidal alkaloid from Fritillaria puqiensis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eight steroidal alkaloids, puqienine A , puqienine B , puqienine C , puqienine D , puqienine E , puqietinone , puqiedine and peimisine were isolated from Fritillaria puqiensis G. D. Yu et. G. Y. Chen, and their anti-hypertensive effect were assessed in vitro based on the inhibition of the purified angiotensin converting enzyme (ACE) using high-performance liquid chromatography assay. The results showed that puqienine E, puqienine B and puqienine A exhibited better inhibitory activity against ACE than others, with inhibition ratios of 70.2+/-0.5%, 24.7+/-0.5% and 20.4+/-2.8%, respectively at the concentration of 200 muM...
Source: Fitoterapia - August 13, 2009 Category: Biochemistry Authors: An JJ, Zhou JL, Li HJ, Jiang Y, Li P Tags: Fitoterapia Source Type: journals

NMR characterization for polysaccharide moiety of a glycopeptide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ganoderma lucidum is a traditional medicinal herbal used to treat various diseases in Chinese and southeast Asian for thousand years. An aqueous glycopeptide, LZ-B-1, was prepared by a successive chromatography and exhibiting an immunostimulating potential. To better understand the mechanism of bioactivity for this compound, the polysaccharide moiety of glycopeptide LZ-B-1 was studied by NMR spectroscopy. The results indicated that polysaccharide moiety had a backbone of 1,6-disubstituted-alpha-galactopyranosyl, 1,2,6-trisubstituted-alpha-galactopyranosyl, 1,3-disubstituted-beta-glucopyranosyl and 1,4,6-trisubstituted-...
Source: Fitoterapia - August 13, 2009 Category: Biochemistry Authors: Ye L, Li J, Zhang J Tags: Fitoterapia Source Type: journals

Immunomodulatory effects of proanthocyanidin A-1 derived in vitro from Rhododendron spiciferum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to evaluate the immunomodulatory effects of Proanthocyanidin A-1 (PAA-1) from leaves of Rhododendron spiciferum (Ericaceae). In vitro tests showed that PAA-1 stimulated cell proliferation of splenocytes and peritoneal macrophages significantly enhanced the cytotoxicity of natural killer (NK) cells and increased CD4(+) and CD8(+) cell populations. PAA-1 also regulated the expression of Th1- and Th2-related cytokines. Moreover, this study showed that PAA-1 exhibited a significant effect on NBT dye reduction and lysosomal enzyme activity responses in macrophages, indicating effective phagocytic...
Source: Fitoterapia - August 13, 2009 Category: Biochemistry Authors: Liu YZ, Cao YG, Ye JQ, Wang WG, Song KJ, Wang XL, Wang CH, Li RT, Deng XM Tags: Fitoterapia Source Type: journals

Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rohitukine, a chromane alkaloid, is a precursor of flavopiridol, a promising anti-cancer compound. Currently in Phase III clinical trials, flavopiridol is a potent inhibitor of several cyclin-dependent kinases (CDKs). Rohitukine was first reported from Amoora rohituka (0.083 % dry weight) followed by that in Dysoxylum binectariferum (0.9 % dry weight), both belonging to the family Meliaceae. Here, we report incredibly high yields of rohitukine (7% dry weight) in trees of D. binectariferum from the Western Ghats, India. Crude extracts of the tree were found to be highly effective against ovarian and breast cancer lines ...
Source: Fitoterapia - August 13, 2009 Category: Biochemistry Authors: Patel MK, Nambiar S, Vaidyanathan P, Thimmappa RB, Gudasalamani R, Narayanagowda GK, Ramesh V, John M, Retnabai ST, Dutt MP, Viswakarma R, Ramanan US Tags: Fitoterapia Source Type: journals

Constituents from fruits of Cupressus sempervirens.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two new phenolic glycosides (1, 2), along with fourteen known compounds (3-16) have been isolated from the fruit of Cupressus sempervirens. The structures of these compounds were determined by spectroscopic analysis and were evaluated for their inhibitory activity against glycogen phosphorylase and glucose-6-phosphatase enzymes. Compounds 14 showed a moderate inhibition against glucose-6-phosphatase and 15 against glycogen phosphorylase enzymes. PMID: 19686818 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - August 13, 2009 Category: Biochemistry Authors: Rawat P, Khan MF, Kumar M, Tamarkar AK, Srivastava AK, Arya KR, Maurya R Tags: Fitoterapia Source Type: journals