Strides Pharma gets USFDA nod for antidepressant medication
As per IMS, Fluoxetine tablets have a market size of USD 23.9 million. This approval further strengthens the company's presence in the Fluoxetine portfolio, complementing the existing approval of Fluoxetine capsules, which has a market size of USD106 million, the Bengaluru based firm said. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 9, 2024 Category: Pharmaceuticals Source Type: news
Pressure grows to ditch controversial forced swim test in rodent studies of depression
For the past few decades, scientists studying candidate antidepressant drugs have had a convenient animal test: how long a rodent dropped in water keeps swimming.
Invented in 1977
, the forced swim test (FST) hinged on the idea that a depressed animal would give up quickly. It seemed to work: Antidepressants and electroconvulsive therapy often made the animal try harder. The test remains popular,
appearing in about 600 papers per year
.
But researchers have recently begun to question the assumption that the test really gauges depression and is a good predictor of human responses to drugs. Oppositi...
Source: ScienceNOW - March 20, 2024 Category: Science Source Type: news
What are Some Causes of Acute Onset of Loss of Speech Abilities?
Discussion
Acute mental status changes are worrisome in the least and scary at their worst. Seizures, cerebrovascular problems and central nervous system tumor swirl in professionals’ heads as they take in the history, physical examination and start to evaluate and manage the problem. Usually respiratory distress is recognized by family members and treatment is also sought.
Another cause of loss of speech is selective (or elective) mutism (SM). The child does not speak at all or minimally. When speaking it is usually within a close group of individuals or in certain circumstances such as only speaking to a parent o...
Source: PediatricEducation.org - February 19, 2024 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Antidepressants taken by 400,000 US pregnant women each year can damage a baby's brain in the womb and increase their risk of mental health problems in the future, study suggests
Prozac, also known as fluoxetine, increases levels of mood-boosting serotonin in the brain - but scientists discovered this can affect a child's developing prefrontal cortex. (Source: the Mail online | Health)
Source: the Mail online | Health - February 16, 2024 Category: Consumer Health News Source Type: news
Long COVID Research Is In Its ‘ Most Hopeful ’ Phase Yet
A phenomenal amount of research on Long COVID—the name for chronic symptoms following a case of COVID-19—has been published over the past three years. But scientific advances have yet to bring relief to people who are already sick, a group estimated to include about 5% of U.S. adults but hard to precisely quantify due to the difficulty of diagnosing people correctly.
Researchers are optimistic that breakthroughs are coming. The U.S. National Institutes of Health (NIH) has launched multiple clinical trials focused on potential therapies, and several recent studies have pointed to biomarkers that may help doct...
Source: TIME: Health - October 23, 2023 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news
Low serotonin levels might explain some Long Covid symptoms, study proposes
Although theories abound, there is still no clear explanation for how infection with SARS-CoV-2 leads to lingering difficulty concentrating, problems with attention and memory, and other, often-debilitating symptoms associated with Long Covid.
Now, researchers studying people who reported these and other symptoms months postinfection propose a new possibility: That
inflammation in response to SARS-CoV-2 causes a drop in serotonin
—a chemical messenger involved in regulating mood and digestion, among myriad other functions—which in turn causes cognitive problems.
The propos...
Source: ScienceNOW - October 16, 2023 Category: Science Source Type: news
Fluoxetine restrains allergic inflammation by targeting an Fc ɛRI-ATP positive feedback loop in mast cells | Science Signaling
Fluoxetine inhibits IgE- and ATP-driven driven mast cell function in allergic inflammation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 12, 2023 Category: Science Source Type: news
Millions of Brits are prescribed antidepressants for pain every year, study claims
Around 10 million prescriptions for drugs including amitriptyline and fluoxetine, more commonly known as Prozac, were dished out in the last 12 months for long term pain management. (Source: the Mail online | Health)
Source: the Mail online | Health - May 9, 2023 Category: Consumer Health News Source Type: news
Most antidepressants prescribed for chronic pain lack reliable evidence of efficacy or safety, scientists warn
Largest ever investigation into antidepressants used for chronic pain shows insufficient evidence to determine how effective or harmful they may be.Study reviewed commonly prescribed medications including amitriptyline, duloxetine, fluoxetine, citalopram, paroxetine, and sertraline.One third of people globally are living with long-term pain with many prescribed antidepressants to relieve symptoms.Most antidepressants used for chronic pain are being prescribed with “insufficient” evidence of their effectiveness, scientists have warned.A major investigation into medications used to manage long-term pain found that harms ...
Source: Cochrane News and Events - May 9, 2023 Category: Information Technology Authors: Muriah Umoquit Source Type: news
'The side effects of Prozac made me think I was going mad - but here's why I'm still taking it'
EVE SIMMONS: My meltdown was caused by the pills I was taking to help me cope with stress. It happened two weeks after I'd started on the antidepressant Prozac, also known as fluoxetine. (Source: the Mail online | Health)
Source: the Mail online | Health - March 19, 2023 Category: Consumer Health News Source Type: news
Serotonin transporter availability in physically aggressive personality disordered patients: associations with trait and state aggression, and response to fluoxetine - Rosell DR, Slifstein M, Thompson J, Xu X, Perez-Rodriguez MM, McClure MM, Hazlett EA, New AS, Nabulsi N, Huang Y, Carson RE, Siever LS, Abi-Dargham A, Koenigsberg HW.
RATIONALE: Characterizing the neuroanatomical basis of serotonergic abnormalities in severe, chronic, impulsive aggression will allow for rational treatment selection, development of novel therapeutics, and biomarkers to identify at-risk individuals. ... (Source: SafetyLit)
Source: SafetyLit - January 18, 2023 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Can fluoxetine combined with cognitive behavioral therapy reduce the suicide and non-suicidal self-injury incidence and recurrence rate in depressed adolescents compared with fluoxetine alone? A meta-analysis - Liu W, Li G, Wang C, Yu M, Zhu MY, Yang L.
OBJECTIVE: The efficacy of medication and psychotherapy for adolescent depression is controversial, so we conducted a meta-analysis to evaluate the efficacy of combination therapy. METHODS: We followed the PRISMA checklist in completing the meta-an... (Source: SafetyLit)
Source: SafetyLit - November 14, 2022 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Early Promise With Fluoxetine for Refractory Nocturnal Enuresis in Children
(MedPage Today) -- Children with refractory primary monosymptomatic nocturnal enuresis (PMNE) obtained significant short-term symptom relief with the selective serotonin reuptake inhibitor (SSRI) fluoxetine, a small placebo-controlled trial showed... (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - November 1, 2022 Category: Psychiatry Source Type: news
Repurposing drugs to treat age-related macular degeneration
Researchers found that the antidepressant fluoxetine blocks the inflammation that leads to dry age-related macular degeneration, or AMD, a common cause of vision loss. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - November 9, 2021 Category: Consumer Health News Source Type: news
Patient and clinical factors associated with response to medications for posttraumatic stress disorder - Shiner BR, Gui J, Rozema L, Cornelius SL, Dufort V, Schnurr PP, Watts BV.
OBJECTIVE: Fluoxetine, paroxetine, sertraline, topiramate, and venlafaxine have previously shown efficacy for posttraumatic stress disorder (PTSD) in randomized clinical trials. Two prior studies using Department of Veterans Affairs (VA) medical records da... (Source: SafetyLit)
Source: SafetyLit - October 11, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
