Neurotoxicity of dibutyl phthalate in zebrafish larvae: Decreased energy acquisition by neurons
In conclusion, DBP-induced neurotoxicity may be the combined result of insufficient neuronal energy acquisition, damage to mitochondrial structure, apoptosis and autophagy. These results provide a theoretical basis for understanding the neurotoxic effects of DBP.PMID:38621509 | DOI:10.1016/j.fct.2024.114666 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 15, 2024 Category: Food Science Authors: Yue Tao Xiaodong Yi Yanyan Gu Rongyi Yang Zixu Li Xiangyong Guo Donglin Zhao Ying Zhang Source Type: research
Public views of animal testing and alternatives in chemical risk assessment
This study aimed at investigating public views of animal testing and potential alternatives, namely in vitro and in silico testing. An online survey was conducted (N = 965). The results suggest that people make trade-offs, as they experience negative affect regarding in vivo testing, which partly might explain their openness regarding certain alternatives. In vitro tests were attributed the highest ability to determine harmful effects of chemicals for different endpoints, followed by in vivo and in silico tests. Our results further showed that many people accept chemicals to be only tested with alternatives, with highest a...
Source: Food and Chemical Toxicology - April 14, 2024 Category: Food Science Authors: Angela Bearth Lisa Wiesner Michael Siegrist Source Type: research
Testicular dysfunction and "its recovery effect" after cadmium exposure
In this study, we constructed rat models of cadmium exposure and dis-exposure, and collected relative samples to observe the changes of related indicators. The results showed that cadmium exposure could reduce the fertility, inhibit the hypothalamic-pituitary-testis axis and activate hypothalamic-pituitary-adrenal axis function, the testicular GR/PI3K-AKT/AMPK signal was abnormal, cell proliferation was inhibited and apoptosis was enhanced. Four weeks after the exposure was stopped, the fertility was still decreased, testicular testosterone synthesis and spermatogenesis were inhibited, cell proliferation was inhibited and ...
Source: Food and Chemical Toxicology - April 14, 2024 Category: Food Science Authors: Qi Zhang YanLing Yang Juan Liu YuJiao Wu Yi Liu Jing Zhang Source Type: research
New Insight into Mycotoxins and Bacterial Toxins: Toxicity Assessment, Molecular Mechanism and Food Safety (Preface to the Special Issue of Food and Chemical Toxicology on the Outcomes of Myco & amp; bacterial toxin)
Food Chem Toxicol. 2024 Apr 11:114655. doi: 10.1016/j.fct.2024.114655. Online ahead of print.ABSTRACTThe special issue "New Insight into Mycotoxins and Bacterial Toxins: Toxicity Assessment, Molecular Mechanism and Food Safety" in Food and Chemical Toxicology contains 19 articles on current hot topics in mycotoxins and bacterial toxins. Dietary exposure to mycotoxins and risk assessments are reported in this issue. Molecular mechanisms of multiple mycotoxins and emerging mechanisms of toxicity are especially concerned by researchers. Moreover, mycotoxin-detoxifying substances and antimicrobial agents are also fully investi...
Source: Food and Chemical Toxicology - April 13, 2024 Category: Food Science Authors: Tong Nie Qinghua Wu Miao Long Wenda Wu Kamil Kuca Source Type: research
RIFM fragrance ingredient safety assessment, phenethyl salicylate, CAS Registry Number 87-22-9
Food Chem Toxicol. 2024 Apr 10;189 Suppl 1:114647. doi: 10.1016/j.fct.2024.114647. Online ahead of print.NO ABSTRACTPMID:38608923 | DOI:10.1016/j.fct.2024.114647 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 12, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Deoxynivalenol leads to endoplasmic reticulum stress-mediated apoptosis via the IRE1/JNK/CHOP pathways in porcine embryos
In conclusion, DON exposure impairs the developmental ability of porcine embryos by inducing ER stress-mediated apoptosis via IRE1/JNK/CHOP signaling.PMID:38608924 | DOI:10.1016/j.fct.2024.114633 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 12, 2024 Category: Food Science Authors: Ye-Won Kim Seul-Gi Yang Byoung-Boo Seo Deog-Bon Koo Hyo-Jin Park Source Type: research
RIFM fragrance ingredient safety assessment, benzonitrile, 3,4-dimethyl-, CAS Registry Number 22884-95-3
Food Chem Toxicol. 2024 Apr 10;189 Suppl 1:114648. doi: 10.1016/j.fct.2024.114648. Online ahead of print.NO ABSTRACTPMID:38608925 | DOI:10.1016/j.fct.2024.114648 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 12, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Risk Assessment of Feed Components of Botanical Origin - Approaches taken in the European Union
Food Chem Toxicol. 2024 Apr 10:114654. doi: 10.1016/j.fct.2024.114654. Online ahead of print.ABSTRACTIn view of a continuous trend in replacing synthetic feed additives and especially flavouring compounds by botanical preparations, different aspects of the safety evaluations of plants and plant-derived preparations and components in feed are discussed. This includes risk assessment approaches developed by the European Food Safety Authority (EFSA) for phytotoxins regarding unintentional exposure of target animals and of consumers to animal derived food via carry-over from feed. Relevant regulatory frameworks for feed additi...
Source: Food and Chemical Toxicology - April 12, 2024 Category: Food Science Authors: Birgit Dusemund Gabriele Aquilina Maria de Lourdes Bastos Francesca Marcon Fabiola Pizzo Ruud Woutersen Paola Manini Source Type: research
RIFM fragrance ingredient safety assessment, phenethyl salicylate, CAS Registry Number 87-22-9
Food Chem Toxicol. 2024 Apr 10:114647. doi: 10.1016/j.fct.2024.114647. Online ahead of print.NO ABSTRACTPMID:38608923 | DOI:10.1016/j.fct.2024.114647 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 12, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Deoxynivalenol leads to endoplasmic reticulum stress-mediated apoptosis via the IRE1/JNK/CHOP pathways in porcine embryos
In conclusion, DON exposure impairs the developmental ability of porcine embryos by inducing ER stress-mediated apoptosis via IRE1/JNK/CHOP signaling.PMID:38608924 | DOI:10.1016/j.fct.2024.114633 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 12, 2024 Category: Food Science Authors: Ye-Won Kim Seul-Gi Yang Byoung-Boo Seo Deog-Bon Koo Hyo-Jin Park Source Type: research
RIFM fragrance ingredient safety assessment, benzonitrile, 3,4-dimethyl-, CAS Registry Number 22884-95-3
Food Chem Toxicol. 2024 Apr 10:114648. doi: 10.1016/j.fct.2024.114648. Online ahead of print.NO ABSTRACTPMID:38608925 | DOI:10.1016/j.fct.2024.114648 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 12, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Risk Assessment of Feed Components of Botanical Origin - Approaches taken in the European Union
Food Chem Toxicol. 2024 Apr 10:114654. doi: 10.1016/j.fct.2024.114654. Online ahead of print.ABSTRACTIn view of a continuous trend in replacing synthetic feed additives and especially flavouring compounds by botanical preparations, different aspects of the safety evaluations of plants and plant-derived preparations and components in feed are discussed. This includes risk assessment approaches developed by the European Food Safety Authority (EFSA) for phytotoxins regarding unintentional exposure of target animals and of consumers to animal derived food via carry-over from feed. Relevant regulatory frameworks for feed additi...
Source: Food and Chemical Toxicology - April 12, 2024 Category: Food Science Authors: Birgit Dusemund Gabriele Aquilina Maria de Lourdes Bastos Francesca Marcon Fabiola Pizzo Ruud Woutersen Paola Manini Source Type: research
RIFM fragrance ingredient safety assessment, ethyl 2-methylpentanoate, CAS Registry Number 39255-32-8
Food Chem Toxicol. 2024 Apr 9:114651. doi: 10.1016/j.fct.2024.114651. Online ahead of print.NO ABSTRACTPMID:38604576 | DOI:10.1016/j.fct.2024.114651 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Modulatory interactions of T-2 and deoxynivalenol mycotoxins on murine femoral development and osteological integrity
In this study, we conducted a systematic assessment of the effectsof Deoxynivalenol (DON) and T-2 mycotoxins on the developmental processes and structural integrity of murine femurs, considering both the isolated and synergistic effects of these toxins. To this end, we divided 72 male mice into nine groups, each subjected to varying dosages of T-2, DON, or their combinations. Over a four-week experimental period, meticulous monitoring was undertaken regarding the mice's body weight, biochemical markers of bone formation and resorption, and the activity of relevant cells. To comprehensively evaluate alterations in bone stru...
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: Cong Yao Shuichu Hao Chun Zhang Li Liu Yumeng Jia Peilin Meng Cuiyan Wu Xiong Guo Source Type: research
RIFM fragrance ingredient safety assessment, ethyl 3,5,5-trimethylhexanoate, CAS Registry Number 67707-75-9
Food Chem Toxicol. 2024 Apr 9:114646. doi: 10.1016/j.fct.2024.114646. Online ahead of print.NO ABSTRACTPMID:38604578 | DOI:10.1016/j.fct.2024.114646 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
