Determination of Δ9-tetrahydrocannabinol, 11-nor-carboxy-Δ9-tetrahydrocannabinol and cannabidiol in human plasma and urine after a commercial cannabidiol oil product intake
ConclusionThe results showed that Δ9-THC is likely to be found in plasma although at low concentrations. In addition, the detection of 11-nor-carboxy- Δ9-THC in both urine and plasma samples raises questions and concerns for the proper interpretation of toxicological results, especially considering Greece ’s zero tolerance law applied in DUID and workplace cases. (Source: Forensic Toxicology)
Source: Forensic Toxicology - April 9, 2024 Category: Forensic Medicine Source Type: research
Development of an LC –MS/MS method for the determination of five psychoactive drugs in postmortem urine by optimization of enzymatic hydrolysis of glucuronide conjugates
ConclusionsWe have established an LC –MS/MS method for five psychoactive drugs in urine after enzymatic hydrolysis of glucuronide conjugates directly on extraction columns. The method was successfully applied to forensic autopsy samples. The established method will have broad applications, including forensic and clinical toxicologica l investigations. (Source: Forensic Toxicology)
Source: Forensic Toxicology - April 1, 2024 Category: Forensic Medicine Source Type: research
Short- and long-term stability of synthetic cathinones and dihydro-metabolites in human urine samples
ConclusionsIrrespective of parent analytes, dihydro-metabolites had improved stability at each tested temperature, which highlights their importance as appropriate urine biomarkers when retesting is required after a long period of storage. (Source: Forensic Toxicology)
Source: Forensic Toxicology - March 30, 2024 Category: Forensic Medicine Source Type: research
Development of a simple screening method for analyzing cereulide toxin in fried rice using liquid chromatography-tandem mass spectrometry
ConclusionsThe QuEChERS extraction procedure described herein showed substantial promise as a reliable screening tool for cereulide in fried rice sample. (Source: Forensic Toxicology)
Source: Forensic Toxicology - March 22, 2024 Category: Forensic Medicine Source Type: research
Kerosene condenses in the trachea following inhalation
ConclusionHigh-boiling point components are retained in the trachea, whereas relatively lower-boiling point components are detected predominantly in the tracheal gas phase and blood. (Source: Forensic Toxicology)
Source: Forensic Toxicology - March 4, 2024 Category: Forensic Medicine Source Type: research
Rapid screening of riot control agents using DART-TD-HRMS
ConclusionDART-TD-HRMS enables rapid and simple screening of RCAs on fabric samples enabling a high sample throughput. (Source: Forensic Toxicology)
Source: Forensic Toxicology - February 22, 2024 Category: Forensic Medicine Source Type: research
Intracerebral hemorrhage in methanol toxicity patients during COVID-19 pandemic: case report and review of literature
ConclusionMethanol intoxication, causing bilateral putaminal involvement and a 50% mortality rate in intracerebral hemorrhage patients, warrants urgent toxicological analysis due to potential putaminal hemorrhage. (Source: Forensic Toxicology)
Source: Forensic Toxicology - February 9, 2024 Category: Forensic Medicine Source Type: research
The biological effects and thermal degradation of NPB-22, a synthetic cannabinoid
ConclusionIt was estimated that the biological effects of NPB-22 on the inhalation exposure test weakened because it underwent thermal degradation by combustion, and the resultant degradation compounds did not have any CB1 activity in vitro. (Source: Forensic Toxicology)
Source: Forensic Toxicology - January 31, 2024 Category: Forensic Medicine Source Type: research
Detection and quantification of etomidate and metomidate in human hairs by ultraperformance liquid chromatography with triple quadrupole mass spectrometry (UPLC −MS/MS)
ConclusionsIn this study, a simple and reliable analytical method for etomidate and metomidate in the human hair has been established. To the best of our knowledge, this is the first report to establish a method for the simultaneous detection and quantification of etomidate and metomidate in the human hair, and to apply it to authentic samples seized in authentic cases. (Source: Forensic Toxicology)
Source: Forensic Toxicology - January 19, 2024 Category: Forensic Medicine Source Type: research
Determination of 3- and 4-chloromethcathinone interactions with plasma proteins: study involving analytical and theoretical methods
ConclusionsAlthough many studies describe pharmacological and toxicological properties of synthetic cathinones (SC), the data taking SCs binding in plasma into consideration are scarce. To our knowledge, this is the first report presenting comprehensive experimental and theoretical characterization of 3- and 4-CMC binding with plasma proteins. (Source: Forensic Toxicology)
Source: Forensic Toxicology - December 18, 2023 Category: Forensic Medicine Source Type: research
Acute and subacute toxic effects of CUMYL-4CN-BINACA on male albino rats
ConclusionThis study showed for the first time that CUMYL-4CN-BINACA adversely affects healthy male albino rats. It can be estimated that the abuse of the cannabinoid may harm human health in the same way. (Source: Forensic Toxicology)
Source: Forensic Toxicology - December 15, 2023 Category: Forensic Medicine Source Type: research
Effects of temperature, humidity, light, and soil on drug stability in hair: a preliminary study for estimating personal profiles using micro-segmental analysis of corpse hair
ConclusionsAlthough the exposure to sunlight and storage in soil for long times made drug-distribution analysis difficult, MSA could be applied even to hair strands collected from corpses left in severe environments. (Source: Forensic Toxicology)
Source: Forensic Toxicology - December 6, 2023 Category: Forensic Medicine Source Type: research
Alcohol spiked with zolpidem and midazolam potentiates inflammation, oxidative stress and organ damage in a mouse model
ConclusionExposure to alcohol spiked with midazolam or zolpidem appears to exacerbate neurological deficits, inflammation, oxidative stress, and organ damage. (Source: Forensic Toxicology)
Source: Forensic Toxicology - October 9, 2023 Category: Forensic Medicine Source Type: research
Cannabigerol (CBG) signal enhancement in its analysis by gas chromatography coupled with tandem mass spectrometry
ConclusionsThe presented results shows that although the signal increase of CBG can be obtained through its derivatization by silylation and/or acylation, the greatest increase is observed in the case of its cyclization to the pyranic CBG form during the sample preparation process. The CBG cyclization procedure is very simple and workable in estimating this cannabinoid in blood/plasma samples.Graphical abstract (Source: Forensic Toxicology)
Source: Forensic Toxicology - September 27, 2023 Category: Forensic Medicine Source Type: research
Identifying a suspect powder as a cannabis concentrate through chemical analysis and DNA testing
ConclusionsThe seized powder was found to be a processed product made from a finely pulverized resin-like cannabis concentrate. Our results indicate that combined chemical and DNA analysis should help identify cannabis-related samples in various forms. (Source: Forensic Toxicology)
Source: Forensic Toxicology - August 21, 2023 Category: Forensic Medicine Source Type: research
