sBridging Clinical Radiotherapy and Space Radiation Therapeutics through Reactive Oxygen Species (ROS)-Triggered Delivery
Free Radic Biol Med. 2024 Apr 15:S0891-5849(24)00390-3. doi: 10.1016/j.freeradbiomed.2024.04.219. Online ahead of print.ABSTRACTThis review explores the convergence of clinical radiotherapy and space radiation therapeutics, focusing on ionizing radiation (IR)-generated reactive oxygen species (ROS). IR, with high-energy particles, induces precise cellular damage, particularly in cancer treatments. The paper discusses parallels between clinical and space IR, highlighting unique characteristics of high-charge and energy particles in space and potential health risks for astronauts. Emphasizing the parallel occurrence of ROS g...
Source: Free Radical Biology and Medicine - April 17, 2024 Category: Biology Authors: Chloe Forenzo Jessica Larsen Source Type: research
RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes
CONCLUSIONS: The findings highlight RNF31's essential role in the regulation of mitochondrial homeostasis in hepatocytes, emphasizing its potential as a therapeutic target for NAFLD.PMID:38615890 | DOI:10.1016/j.freeradbiomed.2024.04.214 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 14, 2024 Category: Biology Authors: Yifei Chen Fuji Yang Yujie Shi Jingyu Sheng Yanjin Wang Liting Zhang Jing Zhou Yi Jin Yongmin Yan Source Type: research
RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes
CONCLUSIONS: The findings highlight RNF31's essential role in the regulation of mitochondrial homeostasis in hepatocytes, emphasizing its potential as a therapeutic target for NAFLD.PMID:38615890 | DOI:10.1016/j.freeradbiomed.2024.04.214 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 14, 2024 Category: Biology Authors: Yifei Chen Fuji Yang Yujie Shi Jingyu Sheng Yanjin Wang Liting Zhang Jing Zhou Yi Jin Yongmin Yan Source Type: research
TRIM47-CDO1 axis dictates hepatocellular carcinoma progression by modulating ferroptotic cell death through the ubiquitin ‒proteasome system
Free Radic Biol Med. 2024 Apr 11:S0891-5849(24)00401-5. doi: 10.1016/j.freeradbiomed.2024.04.222. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the predominant form of liver cancer, characterized by high morbidity and mortality rates, as well as unfavorable treatment outcomes. Tripartite motif-containing protein 47 (TRIM47) has been implicated in various diseases including tumor progression with the activity of E3 ubiquitin ligase. However, the precise regulatory mechanisms underlying the involvement of TRIM47 in HCC remain largely unexplored. Here, we provide evidence that TRIM47 exhibits heightened expr...
Source: Free Radical Biology and Medicine - April 13, 2024 Category: Biology Authors: Jie Zhang Malire Yimamu Ziqi Cheng Jie Ji Liwei Wu Jiao Feng Xuanfu Xu Jianye Wu Chuanyong Guo Source Type: research
TXNIP knockdown protects rats against bupivacaine-induced spinal neurotoxicity via the inhibition of oxidative stress and apoptosis
Free Radic Biol Med. 2024 Apr 14;219:1-16. doi: 10.1016/j.freeradbiomed.2024.04.223. Online ahead of print.ABSTRACTBupivacaine (BUP) is an anesthetic commonly used in clinical practice that when used for spinal anesthesia, might exert neurotoxic effects. Thioredoxin-interacting protein (TXNIP) is a member of the α-arrestin protein superfamily that binds covalently to thioredoxin (TRX) to inhibit its function, leading to increased oxidative stress and activation of apoptosis. The role of TXNIP in BUP-induced oxidative stress and apoptosis remains to be elucidated. In this context, the present study aimed to explore the eff...
Source: Free Radical Biology and Medicine - April 13, 2024 Category: Biology Authors: Yang Zhao Yuanyuan Chen Ziru Liu Lei Zhou Jiao Huang Xi Luo Yunpeng Luo Jia Li Yunan Lin Jian Lai Jingchen Liu Source Type: research
The NEDD8 activating enzyme inhibitor MLN4924 mitigates doxorubicin-induced cardiotoxicity in mice
Free Radic Biol Med. 2024 Apr 11:S0891-5849(24)00400-3. doi: 10.1016/j.freeradbiomed.2024.04.221. Online ahead of print.ABSTRACTDoxorubicin (Dox) is a widely utilized chemotherapeutic agent in clinical oncology for treating various cancers. However, its clinical use is constrained by its significant side effects. Among these, the development of cardiomyopathy, characterized by cardiac remodeling and eventual heart failure, stands as a major concern following Dox chemotherapy.In our current investigation, we have showcased the efficacy of MLN4924 in mitigating doxorubicin-induced cardiotoxicity through direct inhibition of ...
Source: Free Radical Biology and Medicine - April 13, 2024 Category: Biology Authors: KangHui Chen JianMin Sun Li Lin JianWen Liu XinYue Liu GuangDuo Chen Hang Chen ZhaoYang Chen Source Type: research
TRIM47-CDO1 axis dictates hepatocellular carcinoma progression by modulating ferroptotic cell death through the ubiquitin ‒proteasome system
Free Radic Biol Med. 2024 Apr 11:S0891-5849(24)00401-5. doi: 10.1016/j.freeradbiomed.2024.04.222. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the predominant form of liver cancer, characterized by high morbidity and mortality rates, as well as unfavorable treatment outcomes. Tripartite motif-containing protein 47 (TRIM47) has been implicated in various diseases including tumor progression with the activity of E3 ubiquitin ligase. However, the precise regulatory mechanisms underlying the involvement of TRIM47 in HCC remain largely unexplored. Here, we provide evidence that TRIM47 exhibits heightened expr...
Source: Free Radical Biology and Medicine - April 13, 2024 Category: Biology Authors: Jie Zhang Malire Yimamu Ziqi Cheng Jie Ji Liwei Wu Jiao Feng Xuanfu Xu Jianye Wu Chuanyong Guo Source Type: research
TXNIP Knockdown Protects Rats against Bupivacaine-Induced Spinal Neurotoxicity via the Inhibition of Oxidative Stress and Apoptosis
Free Radic Biol Med. 2024 Apr 11:S0891-5849(24)00402-7. doi: 10.1016/j.freeradbiomed.2024.04.223. Online ahead of print.ABSTRACTBupivacaine (BUP) is an anesthetic commonly used in clinical practice that when used for spinal anesthesia, might exert neurotoxic effects. Thioredoxin-interacting protein (TXNIP) is a member of the α-arrestin protein superfamily that binds covalently to thioredoxin (TRX) to inhibit its function, leading to increased oxidative stress and activation of apoptosis. The role of TXNIP in BUP-induced oxidative stress and apoptosis remains to be elucidated. In this context, the present study aimed to ex...
Source: Free Radical Biology and Medicine - April 13, 2024 Category: Biology Authors: Yang Zhao Yuanyuan Chen Ziru Liu Lei Zhou Jiao Huang Xi Luo Yunpeng Luo Jia Li Yunan Lin Jian Lai Jingchen Liu Source Type: research
The NEDD8 activating enzyme inhibitor MLN4924 mitigates doxorubicin-induced cardiotoxicity in mice
Free Radic Biol Med. 2024 Apr 11:S0891-5849(24)00400-3. doi: 10.1016/j.freeradbiomed.2024.04.221. Online ahead of print.ABSTRACTDoxorubicin (Dox) is a widely utilized chemotherapeutic agent in clinical oncology for treating various cancers. However, its clinical use is constrained by its significant side effects. Among these, the development of cardiomyopathy, characterized by cardiac remodeling and eventual heart failure, stands as a major concern following Dox chemotherapy.In our current investigation, we have showcased the efficacy of MLN4924 in mitigating doxorubicin-induced cardiotoxicity through direct inhibition of ...
Source: Free Radical Biology and Medicine - April 13, 2024 Category: Biology Authors: KangHui Chen JianMin Sun Li Lin JianWen Liu XinYue Liu GuangDuo Chen Hang Chen ZhaoYang Chen Source Type: research
The therapeutic potential of thiocyanate and hypothiocyanous acid against pulmonary infections
Free Radic Biol Med. 2024 Apr 10:S0891-5849(24)00388-5. doi: 10.1016/j.freeradbiomed.2024.04.217. Online ahead of print.ABSTRACTHypothiocyanous acid (HOSCN) is an endogenous oxidant produced by peroxidase oxidation of thiocyanate (SCN-), an ubiquitous sulfur-containing pseudohalide synthesized from cyanide. HOSCN serves as a potent microbicidal agent against pathogenic bacteria, viruses, and fungi, functioning through thiol-targeting mechanisms, independent of currently approved antimicrobials. Additionally, SCN- reacts with hypochlorous acid (HOCl), a highly reactive oxidant produced by myeloperoxidase (MPO) at sites of i...
Source: Free Radical Biology and Medicine - April 12, 2024 Category: Biology Authors: Nuha Milad Ashtiwi Susan O Kim Joshua D Chandler Bal ázs Rada Source Type: research
SP2509 functions as a novel ferroptosis inhibitor by reducing intracellular iron level in vascular smooth muscle cells
Free Radic Biol Med. 2024 Apr 10:S0891-5849(24)00399-X. doi: 10.1016/j.freeradbiomed.2024.04.220. Online ahead of print.ABSTRACTPrevious studies have shown that ferroptosis of vascular smooth muscle cells (VSMCs) is involved in the development of aortic dissection (AD) and that histone methylation regulates this process. SP2509 acts as a specific inhibitor of lysine-specific demethylase 1 (LSD1), which governs a variety of biological processes. However, the effect of SP2509 on VSMC ferroptosis and AD remains to be elucidated. This aim of this study was to investigate the role and underlying mechanism of SP2509-mediated his...
Source: Free Radical Biology and Medicine - April 12, 2024 Category: Biology Authors: Yi He Xingbo Wang Siqi Chen Hanshen Luo Bo Huo Xian Guo Rui Li Yue Chen Xin Yi Xiang Wei Ding-Sheng Jiang Source Type: research
Itaconate as a key player in cardiovascular immunometabolism
Free Radic Biol Med. 2024 Apr 9:S0891-5849(24)00389-7. doi: 10.1016/j.freeradbiomed.2024.04.218. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) are the leading cause of death globally, resulting in a major health burden. Thus, an urgent need exists for exploring effective therapeutic targets to block progression of CVDs and improve patient prognoses. Immune and inflammatory responses are involved in the development of atherosclerosis, ischemic myocardial damage responses and repair, calcification, and stenosis of the aortic valve. These responses can involve both large and small blood vessels throughout the b...
Source: Free Radical Biology and Medicine - April 11, 2024 Category: Biology Authors: Wenju Shan Jun Cui Yujie Song Dongxu Yan Linqi Feng Yuhong Jian Wei Yi Yang Sun Source Type: research
MSC-derived small extracellular vesicles mitigate diabetic retinopathy by stabilizing Nrf2 through miR-143-3p-mediated inhibition of neddylation
Free Radic Biol Med. 2024 Apr 9:S0891-5849(24)00387-3. doi: 10.1016/j.freeradbiomed.2024.04.216. Online ahead of print.ABSTRACTDiabetic retinopathy (DR) is a highly hazardous and widespread complication of diabetes mellitus (DM). The accumulated reactive oxygen species (ROS) play a central role in DR development. The aim of this research was to examine the impact and mechanisms of mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEV) on regulating ROS and retinal damage in DR. Intravitreal injection of sEV inhibited Cullin3 neddylation, stabilized Nrf2, decreased ROS, reduced retinal inflammation, suppress...
Source: Free Radical Biology and Medicine - April 11, 2024 Category: Biology Authors: Yueqin Chen Jun Tong Cong Liu Chang He Jinjin Xiang Genhong Yao Huayong Zhang Zhenggao Xie Source Type: research
Itaconate as a key player in cardiovascular immunometabolism
Free Radic Biol Med. 2024 Apr 9:S0891-5849(24)00389-7. doi: 10.1016/j.freeradbiomed.2024.04.218. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) are the leading cause of death globally, resulting in a major health burden. Thus, an urgent need exists for exploring effective therapeutic targets to block progression of CVDs and improve patient prognoses. Immune and inflammatory responses are involved in the development of atherosclerosis, ischemic myocardial damage responses and repair, calcification, and stenosis of the aortic valve. These responses can involve both large and small blood vessels throughout the b...
Source: Free Radical Biology and Medicine - April 11, 2024 Category: Biology Authors: Wenju Shan Jun Cui Yujie Song Dongxu Yan Linqi Feng Yuhong Jian Wei Yi Yang Sun Source Type: research
MSC-derived small extracellular vesicles mitigate diabetic retinopathy by stabilizing Nrf2 through miR-143-3p-mediated inhibition of neddylation
Free Radic Biol Med. 2024 Apr 9:S0891-5849(24)00387-3. doi: 10.1016/j.freeradbiomed.2024.04.216. Online ahead of print.ABSTRACTDiabetic retinopathy (DR) is a highly hazardous and widespread complication of diabetes mellitus (DM). The accumulated reactive oxygen species (ROS) play a central role in DR development. The aim of this research was to examine the impact and mechanisms of mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEV) on regulating ROS and retinal damage in DR. Intravitreal injection of sEV inhibited Cullin3 neddylation, stabilized Nrf2, decreased ROS, reduced retinal inflammation, suppress...
Source: Free Radical Biology and Medicine - April 11, 2024 Category: Biology Authors: Yueqin Chen Jun Tong Cong Liu Chang He Jinjin Xiang Genhong Yao Huayong Zhang Zhenggao Xie Source Type: research
