Letter to the editor: 5-year follow-up results of a JCOG1104 (OPAS-1) phase III non-inferiority trial to compare 4 courses and 8 courses of S-1 adjuvant chemotherapy for pathological stage II gastric cancer
(Source: Gastric Cancer)
Source: Gastric Cancer - April 11, 2024 Category: Gastroenterology Source Type: research
Genome-wide 5-hydroxymethylcytosines in circulating cell-free DNA as noninvasive diagnostic markers for gastric cancer
ConclusionsThe characteristics of 5-hydroxymethylcytosine in cell free DNA are specific to gastric cancer patients, and the diagnostic model constructed by five genes ’ 5-hydroxymethylcytosine features could effectively identify gastric cancer patients. (Source: Gastric Cancer)
Source: Gastric Cancer - April 7, 2024 Category: Gastroenterology Source Type: research
Precise highlighting of the pancreas by semantic segmentation during robot-assisted gastrectomy: visual assistance with artificial intelligence for surgeons
ConclusionsOur surgical AI system precisely highlighted the pancreas during robot-assisted gastrectomy at a level that was convincing to surgeons. This technology may prevent misrecognition of the pancreas by surgeons, thus leading to fewer POPFs. (Source: Gastric Cancer)
Source: Gastric Cancer - April 4, 2024 Category: Gastroenterology Source Type: research
Global burden of young-onset gastric cancer: a systematic trend analysis of the global burden of disease study 2019
ConclusionsThe global incidence and mortality rates of both young- and late-onset gastric cancer have decreased since 1990. However, the incidence rate of young-onset cancer has demonstrated a small but significant upward trend since 2015. There was disparity in the decline in young-onset gastric cancer among male and high SDI countries. These findings could help to inform future strategies in preventing gastric cancer in younger individuals. (Source: Gastric Cancer)
Source: Gastric Cancer - April 3, 2024 Category: Gastroenterology Source Type: research
Risk prediction model for gastric cancer within 5 years in healthy Korean adults
ConclusionOur prediction model, including young adults, showed good discrimination and calibration. Furthermore, this model considered a fixed time interval of 5 years to predict the risk of developing gastric cancer, considering endoscopic results. Thus, it could be clinically useful, especially for adults with endoscopic results. (Source: Gastric Cancer)
Source: Gastric Cancer - April 1, 2024 Category: Gastroenterology Source Type: research
Prognostic value of mismatch repair deficiency in patients receiving first-line fluoropyrimidine plus platinum for metastatic, recurrent, or unresectable gastric cancer
ConclusionsEfficacy of first-line FP was not different by MMR status in mGC patients. (Source: Gastric Cancer)
Source: Gastric Cancer - March 31, 2024 Category: Gastroenterology Source Type: research
Correction: Ubiquitous mitochondrial creatine kinase promotes the progression of gastric cancer through a JNK-MAPK/JUN/HK2 axis regulated glycolysis
(Source: Gastric Cancer)
Source: Gastric Cancer - March 22, 2024 Category: Gastroenterology Source Type: research
Correction: Resistance to FGFR1-targeted therapy leads to autophagy via TAK1/AMPK activation in gastric cancer
(Source: Gastric Cancer)
Source: Gastric Cancer - March 21, 2024 Category: Gastroenterology Source Type: research
Superior lymph node harvest by fluorescent lymphography during minimally invasive gastrectomy for gastric cancer patients with high body mass index
ConclusionFL resulted in more LN retrieval, even in high BMI patients. FL ensures accurate staging by maintaining the appropriate retrieved LN number in high BMI gastric cancer patients. (Source: Gastric Cancer)
Source: Gastric Cancer - March 19, 2024 Category: Gastroenterology Source Type: research
Ethnic ‑specific associations between body mass index and gastric cancer: a Mendelian randomization study in European and Korean populations
(Source: Gastric Cancer)
Source: Gastric Cancer - March 18, 2024 Category: Gastroenterology Source Type: research
Adjuvant treatment for locally advanced gastric cancer: an Asian perspective
AbstractStandard adjuvant treatment for locally advanced gastric cancer (LAGC) is regionally different. Whereas perioperative chemotherapy is the standard in Western populations, D2 gastrectomy followed by adjuvant chemotherapy has been the standard in East Asia. Recently, the pivotal phase 3 PRODIGY and RESOLVE studies have demonstrated survival benefits of adding neoadjuvant chemotherapy to surgery followed by adjuvant chemotherapy over up-front surgery followed by adjuvant chemotherapy in Asian patients. Based on these results, neoadjuvant chemotherapy is considered one of the viable options for patients with LAGC. In t...
Source: Gastric Cancer - March 15, 2024 Category: Gastroenterology Source Type: research
Specific lineage transition of tumor-associated macrophages elicits immune evasion of ascitic tumor cells in gastric cancer with peritoneal metastasis
ConclusionsFor the first time, we identified an immunosuppressive macrophage transition from CTShigh to C1Qhigh TAM in ascites from patients with PM-GC. This may contribute to developing potential TAM-targeted immunotherapies for PM-GC.Graphical AbstractSchematic of the immune TME of ascites and the crosstalk with aDTCs in patients with PM-GC. In ascites with TAM-dominant TME, the ascitic TAMs undergo CTS-to-C1Q transition to support multiple phases of aDTC dissemination, including aDTC homing, proliferation, immune escape, and therapeutic resistance. While in ascites with T-cell-dominant TME, enriched T cells do not imply...
Source: Gastric Cancer - March 9, 2024 Category: Gastroenterology Source Type: research
Perioperative chemotherapy with docetaxel plus oxaliplatin and S-1 (DOS) versus oxaliplatin plus S-1 (SOX) for the treatment of locally advanced gastric or gastro-esophageal junction adenocarcinoma (MATCH): an open-label, randomized, phase 2 clinical trial
ConclusionsPerioperative DOS improved MPR significantly and tended to produce longer PFS compared to SOX in LAG/GEJ cancer in Asia, and might be considered as a preferred option for perioperative chemotherapy and worth further investigation. (Source: Gastric Cancer)
Source: Gastric Cancer - March 8, 2024 Category: Gastroenterology Source Type: research
Clinicopathological significance of microsatellite instability and immune escape mechanism in patients with gastric solid-type poorly differentiated adenocarcinoma
ConclusionsdMMR status can be a useful prognostic predictor, and CXCR2 and MDSCs can be novel therapeutic targets in patients with solid-type PDA. (Source: Gastric Cancer)
Source: Gastric Cancer - March 5, 2024 Category: Gastroenterology Source Type: research
Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project
ConclusionsThe findings of our pooled study suggest that vitamin C is inversely associated with GC, with a potentially beneficial effect also for intakes above the currently recommended daily intake (90 mg for men and 75 mg for women). (Source: Gastric Cancer)
Source: Gastric Cancer - March 4, 2024 Category: Gastroenterology Source Type: research
