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Efficacy of sequential methotrexate and 5-fluorouracil (MTX/5FU) in improving oral intake in patients with advanced gastric cancer with severe peritoneal disseminationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion MTX/5FU chemotherapy may be effective in treating peritoneal dissemination of gastric cancer and might improve the patient’s condition in terms of reducing ascites and improving oral intake. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0517-8Authors Masako Imazawa, Shizuoka Cancer Center Division of Gastrointestinal Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanTakashi Kojima, Shizuoka Cancer Center Division of Gastrointestinal Oncology 1007 Shimonagakubo, Nagaizumi-cho Shizuoka 411-8777 JapanNarikazu Boku, Shizuoka Cancer Center Division ...
Source: Gastric Cancer - November 4, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Intraabdominal Roux-en-Y reconstruction with a novel stapling technique after laparoscopic distal gastrectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Laparoscopic gastrectomy is widely used as minimally invasive surgery for gastric carcinoma. Billroth I or Roux-en-Y reconstruction is commonly performed after laparoscopic distal gastrectomy (LDG). Roux-en-Y reconstruction after LDG is one of the best methods for reconstruction of the alimentary tract when Billroth I reconstruction is difficult. There are few reports of intracorporeal Roux-en-Y reconstruction after LDG because of the technical difficulties of such a procedure. In particular, in the case of a very small gastric remnant, gastrojejunostomy using endoscopic linear staplers becomes more...
Source: Gastric Cancer - November 4, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Metastatic gastric tumor from renal cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a rare case of metastatic gastric tumor derived from right renal carcinoma. Gastric endoscopy confirmed a large, polypoid, friable mass (type 1 tumor, about 7 cm in diameter) in the middle part of the stomach body. The mass was surgically excised and pathological examination showed that the gastric tumor was derived from a metastasis from the right kidney, because it was composed of malignant cells that were identical to those from the removed RCC. In addition, the tumor cells were immunoreactive for CD10, CD15, Ecadherin, early membrane antigen (EMA), and vimentin, but no reactivity was observed for cytoker...
Source: Gastric Cancer - November 4, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Pilot study to assess the safety of local lidocaine injections during endoscopic submucosal dissection for early gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Local lidocaine injections into the submucosal layer were safe when administered during ESDs performed on EGC patients under sedation. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0514-yAuthors Shinsuke Kiriyama, National Cancer Center Hospital Endoscopy Division 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045 JapanIchiro Oda, National Cancer Center Hospital Endoscopy Division 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045 JapanFumiya Nishimoto, National Cancer Center Hospital Endoscopy Division 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045 JapanYumi Mashimo, National Cancer Center Hospi...
Source: Gastric Cancer - November 4, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Validation of the pepsinogen test method for gastric cancer screening using a follow-up studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The PG test method alone with a PGI cutoff level of ≤30 ng/ml and PGI/PGII ≤ 2.0 is not appropriate for gastric cancer screening. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0522-yAuthors Shigeto Mizuno, Kobe Pharmaceutical University Department of Medical Pharmaceutics Kobe JapanMasao Kobayashi, Kyoto Second Red Cross Hospital Department of Health Care Kyoto JapanShohken Tomita, Kansai Occupational Health Association Osaka JapanIkuya Miki, Kobe Pharmaceutical University Department of Medical Pharmaceutics Kobe JapanAtsuhiro Masuda, Kobe Pharmaceutical Univ...
Source: Gastric Cancer - November 4, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion UD-type intramucosal EGC 20 mm or less in size without lymphatic-vascular capillary involvement and ulcerative findings presents a negligible risk of lymph node metastasis. We propose that in this circumstance ER could be considered. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0515-xAuthors Toshiaki Hirasawa, Japanese Foundation for Cancer Research Department of Gastroenterology, Cancer Institute Hospital 3-10-6 Ariake, Koto-ku Tokyo 135-8550 JapanTakuji Gotoda, National Cancer Center Hospital Department of Endoscopy Tokyo JapanSatoshi Miyata, Japanese Foundat...
Source: Gastric Cancer - November 4, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

The role of laparoscopy for gastric surgery in the WestEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The only potentially curative treatment available for gastric adenocarcinoma is surgical resection. However, many controversies exist regarding treatment strategy, including whether the laparoscopic approach is appropriate. Many reports of laparoscopic techniques for cancer resection have shown oncologic equivalency to the open technique, with the known benefits of the minimally invasive approach, such as decreased pain, length of hospital stay, blood loss, and complications. The Eastern experience with laparoscopic gastrectomy has been extensive, associated with the increased incidence of early gas...
Source: Gastric Cancer - November 4, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Docetaxel: its role in current and future treatments for advanced gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A globally accepted standard chemotherapy remains undetermined in gastric cancer, but the recent introduction of active “new-generation agents” such as taxanes, irinotecan (CPT-11), oxaliplatin, S-1, and capecitabine, offers hope for markedly improving patient outcomes. Docetaxel, as well as the other new-generation agents, plays a key role in the development of the new-era chemotherapy, and the incorporation of taxanes has provided several regimens, such as docetaxel/cisplatin/5-fluorouracil (5-FU) (DCF), that could become standard treatment. The DCF regimen is now regarded as a standard treatm...
Source: Gastric Cancer - November 4, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Can an intramucosal undifferentiated-type gastric cancer become a candidate for endoscopic submucosal resection?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s10120-009-0518-7Authors Seigo Kitano, Oita University Faculty of Medicine Department of Surgery I 1-1 Idaigaoka, Yufu Oita 879-5593 Japan Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 3 / October, 2009 (Source: Gastric Cancer)
Source: Gastric Cancer - November 4, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Paclitaxel chemotherapy for the treatment of gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A comprehensive review of phase I and phase II clinical trials of paclitaxel and paclitaxel-containing chemotherapy regimens for advanced gastric cancer was performed. Response rates, median progression-free survivals, and median overall survivals were examined, together with the treatment regimens and the numbers of patients registered in each trial. Although paclitaxel monotherapy produced considerable improvement in tumor response and prognosis, combination doublet or triplet chemotherapy with fluoropyrimidines and/or platinum compounds showed better results than the paclitaxel monotherapy. With ...
Source: Gastric Cancer - June 29, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Left-sided approach for suprapancreatic lymph node dissection in laparoscopy-assisted distal gastrectomy without duodenal transectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Laparoscopy-assisted distal gastrectomy (LADG) with extended lymph node dissection has not yet been widely adopted for the treatment of gastric cancers because of the perceived complexity of the procedure. Suprapancreatic lymph node dissection is one of the most important and demanding procedures in this approach. The techniques of duodenal transection within the abdominal cavity or taping of the common hepatic or splenic artery had traditionally been adopted for suprapancreatic nodal dissection during open surgery. In 2005, we developed a new laparoscopic procedure to safely and simply perform supr...
Source: Gastric Cancer - June 29, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Duodenal stump cancer after Billroth-II distal gastrectomy for gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Duodenal cancer is an uncommon neoplasm and it mostly arises from the periampullary area. However, metachronous or even recurrent cancer at the duodenal stump following Billroth II type distal gastrec tomy for gastric cancer is extremely rare and, to our knowledge, has not yet been reported. A 68-year-old man underwent Billroth II distal gastrectomy with D2 lymph node dissection for an advanced gastric cancer. At that time the tumor stage was T2bN3M0, with 44 of 78 retrieved lymph nodes showing metastasis. He was well without recurrence for 3 years; however, he visited our hospital because of the ab...
Source: Gastric Cancer - June 29, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Cronkhite-Canada syndrome complicated with huge intramucosal gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report documents a 59-year-old Japanese man with CCS who underwent a total gastrectomy for gastric tumors. The resected specimen showed a huge gastric adenocarcinoma with numerous polyps throughout the stomach. The cancer was pathologically limited to within the mucosa and its histological structure resembled that of hyperplasia in CCS polyps, which led us to suppose that the carcinoma had arisen from hyperplastic CCS polyps. These results urged us to study the phenotypic expression of mucins, which revealed MUC2(−) and MUC5AC(+) and supported the diagnosis of the tumor as a gastric-type well-differentiate adeno...
Source: Gastric Cancer - June 29, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

New double-stapling technique for esophagojejunostomy and esophagogastrostomy in gastric cancer surgery, using a peroral intraluminal approach with a digital stapling systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a new double-stapling technique for esophagojejunostomy and esophagogastrostomy, using a peroral intraluminal approach with a digital stapling system, a flexible shaft remote-control stapler — the Surg-ASSIST and Power Circular Stapler 21 mm (PCS). The overtube of the flexible shaft of the PCS is prepared with a nylon tie and secured to a nasogastric (NG) tube. The flexible shaft is manually advanced down the esophagus with guidance by pulling the NG tube from the abdominal cavity side. The trocar of the flexible shaft is removed from the stump of the abdominal esophagus and connected to the anvil and th...
Source: Gastric Cancer - June 29, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

A clinicopathological study of gastric stump carcinoma following proximal gastrectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Gastric stump carcinoma following proximal gastrectomy occurred at a high frequency of 5.4% of initial resections. It is necessary to select a reconstruction method that facilitates postoperative endoscopic examination, as well as to follow up the patients after proximal gastrectomy in the long term for the early detection and early treatment of gastric stump carcinoma. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0502-2Authors Shigekazu Ohyama, Cancer Institute Hospital of JFCR Department of Surgery 3-10-6 Ariake, Koto-ku Tokyo 135-8550 JapanMasanori Tokunaga...
Source: Gastric Cancer - June 29, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Serum interleukin-6 and -10 levels in patients with gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These findings indicate that serum IL-6 may suggest gastric cancer progression. On the other hand, IL-10 may play an important role in host immunity and the prognosis of GC patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-009-0509-8Authors Masahide Ikeguchi, Tottori University Department of Surgery, Division of Surgical Oncology, Faculty of Medicine 36-1 Nishi-cho Yonago 683-8504 JapanTomoko Hatada, Tottori University Department of Surgery, Division of Surgical Oncology, Faculty of Medicine 36-1 Nishi-cho Yonago 683-8504 JapanManabu Yamamoto, Tottori Universi...
Source: Gastric Cancer - June 29, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Helicobacter pylori and gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Helicobacter pylori is now well known as an important pathogen related to the development of gastric cancer. However, some clinicians still doubt the causal association of H. pylori with the development of gastric cancer. To summarize the recent clinical data on the link between H. pylori and gastric cancer, we reviewed related articles published over the past 3 years, after the award of the Nobel Prize for Physiology or Medicine to Drs. J.R. Warren and B.J. Marshall for the first culture and isolation of H. pylori and the investigation of their relevance to peptic ulcer disease. This updated summar...
Source: Gastric Cancer - June 29, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

What technique is suitable for laparoscopic suprapancreatic lymph node dissection?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s10120-009-0512-0Authors Seigo Kitano, Oita University Faculty of Medicine Department of Surgery I 1-1 Idaigaoka, Yufu Oita 879-5593 Japan Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 2 / June, 2009 (Source: Gastric Cancer)
Source: Gastric Cancer - June 29, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Nishi Memorial Award in Gastric CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory AnnouncementDOI 10.1007/s10120-009-0513-z Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 2 / June, 2009 (Source: Gastric Cancer)
Source: Gastric Cancer - June 29, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Joint international efforts to combat a still-deadly disease: the next generationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory From the New Editors-in-ChiefDOI 10.1007/s10120-009-0504-0Authors Hubert J. Stein, Klinikum Nuernberg Department of Surgery Nuremberg Germany Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 1 / April, 2009 (Source: Gastric Cancer)
Source: Gastric Cancer - April 24, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

The first European Union Network of Excellence for Gastric Cancer conference, Rome, Italy, April 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Meeting ReportDOI 10.1007/s10120-009-0499-6Authors William Allum, Royal Marsden NHS Foundation Trust Department of Surgery Fulham Road London SW3 6JJ UKAlfredo Garofalo, Royal Marsden NHS Foundation Trust Department of Surgery Fulham Road London SW3 6JJ UKMaurizio Degiuli, Royal Marsden NHS Foundation Trust Department of Surgery Fulham Road London SW3 6JJ UKChristoph Schuhmacher, Royal Marsden NHS Foundation Trust Department of Surgery Fulham Road London SW3 6JJ UK Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue V...
Source: Gastric Cancer - April 24, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Toward a new level of international exchange of information about gastric cancer research: a message from a new editor-in-chiefEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory From the New Editors-in-ChiefDOI 10.1007/s10120-009-0503-1Authors Yuko Kitagawa, Keio University School of Medicine Department of Surgery 35 Shinanomachi, Shinjuku-ku Tokyo 160-8582 Japan Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 1 / April, 2009 (Source: Gastric Cancer)
Source: Gastric Cancer - April 24, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Ludwik Rydygier — contributor to modern surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s10120-009-0500-4Authors Radoslaw Pach, Jagiellonian University First Department of General and GI Surgery Krakow PolandAnita Orzel-Nowak, Jagiellonian University Institute of Nursing, Faculty of Health Care Krakow PolandThecla Scully, University Hospital North Staffordshire Stoke-on-Trent, West Midlands UK Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 1 / April, 2009 (Source: Gastric Cancer)
Source: Gastric Cancer - April 24, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Phase II trial of S-1 for neoadjuvant chemotherapy against scirrhous gastric cancer (JCOG 0002)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion S-1 neoadjuvant chemotherapy appeared feasible and showed positive effects against scirrhous gastric cancer; however, the survival rate with S-1 did not reach the expected rate required when selecting an agent for a phase III trial to confirm the effectiveness of neoadjuvant chemotherapy against scirrhous gastric cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0496-1Authors Taira Kinoshita, National Cancer Center Hospital East Department of Surgical Oncology 6-5-1 Kashiwanoha, Kashiwa Chiba 277-8577 JapanMitsuru Sasako, Hyogo College of Medicine Departmen...
Source: Gastric Cancer - April 24, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

A comparison of gastric cancer between Japan and ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10120-008-0495-2Authors Zhong-Xin Li, The University of Tokyo Department of Gastrointestinal Surgery 3-7-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanMichio Kaminishi, The University of Tokyo Department of Gastrointestinal Surgery 3-7-1 Hongo, Bunkyo-ku Tokyo 113-8655 Japan Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 1 / April, 2009 (Source: Gastric Cancer)
Source: Gastric Cancer - April 24, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Impact of plasma tissue inhibitor of metalloproteinase-1 on long-term survival in patients with gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results suggest that plasma TIMP-1 is a strong independent prognosticator for the long-term survival of patients with gastric cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0494-3Authors Takaki Yoshikawa, Kanagawa Cancer Center Department of Gastrointestinal Surgery 1-1-2 Nakao, Asahi-ku Yokohama 241-0815 JapanHaruhiko Cho, Kanagawa Cancer Center Department of Gastrointestinal Surgery 1-1-2 Nakao, Asahi-ku Yokohama 241-0815 JapanAkira Tsuburaya, Kanagawa Cancer Center Department of Gastrointestinal Surgery 1-1-2 Nakao, Asahi-ku Yokohama 241-0815 Jap...
Source: Gastric Cancer - April 24, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Improving outcome for scirrhous gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s10120-009-0501-3Authors H. H. Hartgrink, Leiden University Medical Centre Department of Surgery PO Box 9600 2300 RC Leiden The Netherlands Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Number 1 / April, 2009 (Source: Gastric Cancer)
Source: Gastric Cancer - April 24, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Study of clinicopathological factors associated with the occurrence of synchronous multiple gastric carcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion While other studies have shown risk factors for multiple gastric carcinomas, the present study is unique in showing risk assessment criteria based on a combination of risk factors for multiple gastric carcinomas. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0493-4Authors Toshikatsu Nitta, Osaka Medical College Department of Pathology Osaka JapanYutaro Egashira, Osaka Medical College Department of Pathology Osaka JapanHiroshi Akutagawa, Osaka Medical College Department of Pathology Osaka JapanGo Edagawa, Osaka Medical College Department of Pathology Osaka JapanY...
Source: Gastric Cancer - April 24, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Expression of tight-junction-associated proteins in human gastric cancer: downregulation of claudin-4 correlates with tumor aggressiveness and survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Tight-junction-associated proteins, particularly claudin-4, may play important roles in determining invasiveness, metastatic potential, and survival in gastric cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0497-0Authors Satoshi Ohtani, Fukushima Medical University Department of Surgery 1 1 Hikarigaoka Fukushima 960-1295 JapanMasanori Terashima, Shizuoka Cancer Center Hospital Department of Gastric Surgery Shizuoka JapanJun Satoh, Fukushima Medical University Department of Surgery 1 1 Hikarigaoka Fukushima 960-1295 JapanNobutoshi Soeta, Fukushima Medical ...
Source: Gastric Cancer - April 24, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Imaging in assessing lymph node status in gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion AUS, EUS, MDCT, conventional MRI, and FDG-PET cannot reliably be used to confirm or exclude the presence of LN metastasis. The performance of highresolution PET/CT fusion and functional MRI techniques still has to be determined. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s10120-008-0492-5Authors Robert Michael Kwee, Maastricht University Medical Center Department of Radiology P. Debyelaan 25 6202 AZ Maastricht The NetherlandsThomas Christian Kwee, University Medical Center Utrecht Department of Radiology Utrecht The Netherlands Journal Gastric CancerOnline ISSN 143...
Source: Gastric Cancer - April 24, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Modified Billroth-I reconstruction after distal gastrectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10120-009-0498-7Authors Yoshiyuki Hoya, The Jikei University School of Medicine Department of Surgery, Daisan Hospital 4-11-1 Izumihon-cho, Komae Tokyo 201-8601 JapanTetsuya Taki, The Jikei University School of Medicine Department of Surgery, Daisan Hospital 4-11-1 Izumihon-cho, Komae Tokyo 201-8601 JapanMasato Hoshino, The Jikei University School of Medicine Department of Surgery, Daisan Hospital 4-11-1 Izumihon-cho, Komae Tokyo 201-8601 JapanAtsuo Shida, The Jikei University School of Medicine Department of Surgery, Daisan Hospital 4-11-1 Izumihon-...
Source: Gastric Cancer - April 24, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

IntroductionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s10120-008-0491-6Authors Masaki Kitajima, International University of Health and Welfare Tokyo Japan Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 12 Journal Issue Volume 12, Supplement 1 / January, 2009 (Source: Gastric Cancer)
Source: Gastric Cancer - January 25, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Prediction of S-1-induced anemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract S-1, a novel oral fluoropyrimidine, has shown remarkably good tolerability in Korean gastric and colorectal cancer patients due to its favorable safety profile. Myelosuppression and diarrhea were the events that precluded dose escalation in Japan, whereas gastrointestinal toxicity and skin reaction were the major limiting factors in Western countries. In contrast, the major adverse event in Korean patients was anemia, which appeared early in the S-1 treatment period and varied among patients. Conventional comparative genomic hybridization (CGH) is used to screen for chromosomal copy number variation...
Source: Gastric Cancer - January 25, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

S-1 review from preclinical pharmacologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract S-1, developed by the scientific theory of both potentiating the antitumor efficacy of 5-fluorouracil (5-FU) and reducing the gastrointestinal (GI) toxicity induced by 5-FU, is a new oral formulation consisting of 1 M tegafur, 0.4 M gimeracil, and 1 M potassium oteracil. By combining gimeracil, a potent inhibitor of 5-FU degradation, and potassium oteracil, which protects against 5-FU-induced GI toxicity to tegafur, S-1, as a dihydropyrimidine dehydrogenase (DPD)-inhibitory fluoropyrimidine (DIF), showed higher antitumor activity, with low intestinal toxicity, compared to continuous infusion of 5-FU...
Source: Gastric Cancer - January 25, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Adjuvant chemotherapy with 5-FU or regimens including oral fluoropyrimidine for curable gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Since 2000, several studies have reported positive results in reasonable-size randomized controlled trials of adjuvant treatment for potentially curable gastric cancer. At present, postoperative adjuvant chemoradiotherapy and perioperative chemotherapy are the standard of care in the United States and Europe (including Great Britain), respectively, while postoperative S-1 monotherapy is the standard of care in Japan. The effect of adjuvant treatment varies according to the type of surgery, and the best results so far have been observed in the adjuvant chemotherapy of TS-1 for gastric cancer (ACTS-GC...
Source: Gastric Cancer - January 25, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Prediction of clinical outcome of S-1-based chemotherapy for gastric cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract S-1, an oral fluoropyrimidine has been considered to be a key drug in the treatment of advanced gastric cancer in Japan as a standard chemotherapy option. Individual variations in the enzyme activity of the 5-FU metabolic pathway can affect the extent of 5-FU metabolism and affect the efficacy of S-1 based chemotherapy. In this review, the role of genetic factors in affecting the therapeutic efficacy of S-1 is discussed, with special emphasis on enzymes involved in the 5-FU metabolic pathway. The gene expressions of thymidylate synthase, thymidine phosphorylase, and orotate phosphoribosyltransferase...
Source: Gastric Cancer - January 25, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Clinical development of S-1 plus cisplatin therapy as first-line treatment for advanced gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We reviewed the clinical development of S-1 and S-1 plus cisplatin (CDDP) therapy for advanced gastric cancer (AGC). S-1 is an active oral fluoropyrimidine in patients with AGC. Phase I/II clinical trials of S-1 plus CDDP for AGC have yielded high response rates and the agents were well tolerated. On the basis of these phase I/II studies, we performed a randomized phase III study comparing S-1 plus CDDP with S-1 alone in patients with AGC. In the S-1 plus CDDP group, S-1 was given orally, twice daily for 3 consecutive weeks, and 60 mg/m2 CDDP was given intravenously on day 8, followed by a 2-week re...
Source: Gastric Cancer - January 25, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

JCOG trials of systemic chemotherapy for unresectable or recurrent gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract From the late 1980s to the early 1990s, the Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group (GIOSG/JCOG) conducted several phase II studies, some of which evaluated oral fluoropyrimidines and others of which introduced Western regimens to Japanese patients. Thereafter, in the phase III study JOCG9205 comparing 5-fluorouracil (5-FU), 5-FU plus cisplatin (CDDP) (FP), and uracil and tegafur (UFT) plus mitomycin (UFTM), neither FP nor UFTM showed a survival benefit over 5-FU alone. Whereas irinotecan (CPT-11) and S-1 (new oral fluoropyrimidine) were developed with promising ac...
Source: Gastric Cancer - January 25, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Combination chemotherapy of S-1 and taxanes in KoreaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Various combination treatments incorporating S-1 are undergoing clinical trials in Korea, especially combinations with taxane, oxaliplatin, or irinotecan. In a phase I study to estimate the maximum tolerated dose of docetaxel in combination with S-1 administered at a fixed dose of 40 mg/m2 twice daily on days 1–14 of each 3-week cycle in patients with advanced gastric cancer, 60 mg/m2 docetaxel was declared to be the maximum tolerated dose. A phase I/II study of the same schedule of combination chemotherapy with S-1 plus docetaxel reported doses of S-1/docetaxel of 40/75 mg/m2 as the maximum tolera...
Source: Gastric Cancer - January 25, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Phase I/II studies of combination chemotherapy with S-1 and platinum in patients with previously untreated metastatic or recurrent gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, phase I/II studies of combination chemotherapy with S-1 and platinum in patients with metastatic or recurrent gastric cancer were reviewed. We found that the combination of S-1 plus cisplatin was highly active against advanced gastric cancer, with a favorable toxicity profile. The response rates were 53%-74% in Japan, 47.6% in Korea, and 51% in the United States and Europe. There is no internationally accepted standard care for patients with advanced gastric cancer yet, but S-1 is likely to replace infusional 5-FU, and oxaliplatin may represent an alternative to cisplatin in the near future. More innova...
Source: Gastric Cancer - January 25, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Future perspectives of chemotherapy for advanced gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract According to the results of two recent randomized studies of treatment for metastatic gastric cancer in Japan, S-1 could replace infusional 5-fluorouracil and S-1 plus cisplatin showed a significant survival advantage over S-1 monotherapy, with a favorable toxicity profile. However, no globally accepted standards have been established yet and we have to wait for the results of other ongoing international studies, including studies of S-1 and its combinations, to achieve such standards. There are two major approaches to achieve further progress in the treatment of advanced gastric cancer. The first i...
Source: Gastric Cancer - January 25, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Combination therapy with S-1 and irinotecan (CPT-11) for advanced or recurrent gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract S-1 and irinotecan (CPT-11) are active agents against gastric cancer. Some preclinical studies have demonstrated the theoretical background of combination therapy with S-1 and CPT-11 for gastric cancer. Based on these findings, several phase I/II studies of this combination therapy, which has been proposed as a candidate of standard treatment for advanced or recurrent gastric cancer in Japan, have been conducted. Although there were slight differences in the administration schedules of the combination therapy with S-1 and CPT-11 in these phase II studies, the response rates were more than 50%, and t...
Source: Gastric Cancer - January 25, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Disseminated cancer cells in the peritoneal cavity: what can we do when we detect them?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s10120-008-0490-7Authors Yasuhiro Kodera, Nagoya University Graduate School of Medicine Department of Surgery II 65 Tsurumai-cho, Showa-ku Nagoya 466-8550 Japan Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 Journal Volume Volume 11 Journal Issue Volume 11, Number 4 / December, 2008 (Source: Gastric Cancer)
Source: Gastric Cancer - January 9, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Ludwik Rydygier — contributor to modern surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Modern surgery is usually considered to have begun in nineteenth century Europe. One of the most famous contributors to gastric cancer surgery was the Polish surgeon Ludwik Rydygier, born in 1850. He initiated new methods in several fields, such as gastrointestinal surgery, orthopedics, gynecology, and urology. He was the second surgeon in the world to perform an antral resection, which he carried out on November 16, 1880. The patient, a 64-year-old man, suffered from pyloric cancer and died 12 hours after the procedure as a result of postoperative shock. The next pyloric resection was performed by ...
Source: Gastric Cancer - January 9, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Initial experience in Brazil with endoscopic submucosal dissection for early gastric cancer using insulation-tipped knife: a safety and feasibility studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion When adequately indicated, ESD is a safe and feasible technique. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0489-0Authors Daniela Medeiros Milhomem Cardoso, Araújo Jorge Cancer Hospital Endoscopic Unit, Department of Gastrointestinal Oncology Rua 239, No. 181, Setor Universitário, CEP 74605-070 Goiânia GO BrazilPaulo Moacir de Oliveira Campoli, Araújo Jorge Cancer Hospital Endoscopic Unit, Department of Gastrointestinal Oncology Rua 239, No. 181, Setor Universitário, CEP 74605-070 Goiânia GO BrazilChizu Yokoi, National Cancer Center Hospital Endoscopy Un...
Source: Gastric Cancer - January 9, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Detection of micrometastases in peritoneal washings of gastric cancer patients by the reverse transcriptase polymerase chain reactionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion RT-PCR using a panel of tumor markers, including CEA, detects (+) cytology. The clinical significance of “false-positive” overexpression of CEA, survivin, or CK20 but cytology (−) remains to be defined. RT-PCR could represent a more sensitive method than cytology for detection of subclinical peritoneal tumor dissemination; this may be useful in improving patient selection for operative management and clinical trials. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0483-6Authors Kimberly Moore Dalal, Memorial Sloan-Kettering Cancer Center Department of Surg...
Source: Gastric Cancer - January 9, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Laparoscopy-assisted esophagoenteral anastomosis using endoscopic purse-string suture instrument “Endo-PSI (II)” and circular staplerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract It is said that laparoscopic esophagoenteral anastomosis is not easy. In particular, purse-string suture of the abdominal esophagus is difficult when using a circular stapler. We have developed an endoscopic purse-string suture instrument, the “Endo-PSI (II)”, and the instrument was employed clinically during laparoscopy-assisted total gastrectomy. The device was inserted into the abdominal cavity through a 4-cm minilaparotomy of the epigastrium, and pneumoperitoneum was established by closing a Lap Disc. The Endo-PSI (II) was attached to the abdominal esophagus and a straight needle with a 2-0 ...
Source: Gastric Cancer - January 9, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Heterogeneous prognoses of patients with tumors invaded within muscularis propria according to tumor depth in the layers of the muscularis propriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Gastric cancers with muscularis propria invasion had heterogeneous prognoses according to the tumor depth in the muscularis propria layers. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0486-3Authors Yu Imamura, Kumamoto University 1 Department of Gastroenterological Surgery, Graduate School of Medical Sciences 1-1-1 Honjo Kumamoto 860-8556 JapanYoshifumi Baba, Kumamoto University 1 Department of Gastroenterological Surgery, Graduate School of Medical Sciences 1-1-1 Honjo Kumamoto 860-8556 JapanShinji Ishikawa, Kumamoto University 1 Department of Gastroenterolog...
Source: Gastric Cancer - January 9, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Combination chemotherapy with cisplatin and irinotecan in patients with adenocarcinoma of the small intestineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion IP combination chemotherapy may be an acceptable option for patients with SBA. Further studies are warranted to determine the optimal chemotherapeutic regimen for SBA. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0484-5Authors Makiko Ono, National Cancer Center Hospital Gastrointestinal Oncology Division Tokyo JapanKuniaki Shirao, Oita University Department of Medical Oncology, Faculty of Medicine 1-1 Idaigaoka, Hasama-machi, Yufu Oita 879-5593 JapanAtsuo Takashima, National Cancer Center Hospital Gastrointestinal Oncology Division Tokyo JapanChigusa Morizane, ...
Source: Gastric Cancer - January 9, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals

Recurrence in early gastric cancer with lymph node metastasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The number of nodes positive for metastasis was the only independent risk factor for recurrence after curative surgery in patients with lymph node-positive early gastric cancer. These high-risk patients may obtain additional survival benefit if targeted with adjuvant chemotherapy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10120-008-0485-4Authors Makoto Saka, National Cancer Center Hospital Gastric Surgery Division 5-1-1, Tsukiji, Chuo-ku Tokyo 104-0045 JapanHitoshi Katai, National Cancer Center Hospital Gastric Surgery Division 5-1-1, Tsukiji, Chuo-ku Tokyo 104-0045 ...
Source: Gastric Cancer - January 9, 2009 Category: Gastroenterology Tags: Gastric Cancer Source Type: journals