General and Comparative Endocrinology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Baseline and stress-induced steroid plasma levels and immune function vary annually and are associated with vocal activity in male toads (Rhinella icterica)
This study investigated annual variation in plasma corticosterone and testosterone levels, plasma bacterial killing ability (BKA), and neutrophil to lymphocyte ratio (NLR) in free-living male toads (Rhinella icterica). Toads were sampled in the field (baseline) and 1 h-post restraint over five months, and we considered the occurrence of vocal activity. Baseline corticosterone, testosterone, and BKA showed higher values during the reproductive period, specifically in calling male toads. The NLR was similar throughout the year, but higher values were observed in calling toads. Moreover, baseline NLR and BKA were positively c...
Source: General and Comparative Endocrinology - April 14, 2024 Category: Endocrinology Authors: Braz Titon Junior Adriana Maria Giorgi Barsotti Stefanny Christie Monteiro Titon Renata Ibelli Vaz Aymam Cobo de Figueiredo Ronyelle Vasconcelos-Teixeira Carlos A Navas Fernando Ribeiro Gomes Source Type: research

The role of TGF- β signaling in muscle atrophy, sarcopenia and cancer cachexia
Gen Comp Endocrinol. 2024 Apr 10;353:114513. doi: 10.1016/j.ygcen.2024.114513. Online ahead of print.ABSTRACTSkeletal muscle, comprising a significant proportion (40 to 50 percent) of total body weight in humans, plays a critical role in maintaining normal physiological conditions. Muscle atrophy occurs when the rate of protein degradation exceeds protein synthesis. Sarcopenia refers to age-related muscle atrophy, while cachexia represents a more complex form of muscle wasting associated with various diseases such as cancer, heart failure, and AIDS. Recent research has highlighted the involvement of signaling pathways, inc...
Source: General and Comparative Endocrinology - April 11, 2024 Category: Endocrinology Authors: Xin-Qiang Lan Cheng-Jie Deng Qi-Quan Wang Li-Min Zhao Bao-Wei Jiao Yang Xiang Source Type: research

The Role of TGF- β Signaling in Muscle Atrophy, Sarcopenia and Cancer Cachexia
Gen Comp Endocrinol. 2024 Apr 9:114513. doi: 10.1016/j.ygcen.2024.114513. Online ahead of print.ABSTRACTSkeletal muscle, comprising a significant proportion (40 to 50 percent) of total body weight in humans, plays a critical role in maintaining normal physiological conditions. Muscle atrophy occurs when the rate of protein degradation exceeds protein synthesis. Sarcopenia refers to age-related muscle atrophy, while cachexia represents a more complex form of muscle wasting associated with various diseases such as cancer, heart failure, and AIDS. Recent research has highlighted the involvement of signaling pathways, includin...
Source: General and Comparative Endocrinology - April 11, 2024 Category: Endocrinology Authors: Xin-Qiang Lan Cheng-Jie Deng Qi-Quan Wang Li-Min Zhao Bao-Wei Jiao Yang Xiang Source Type: research

Association of seasonal changes in circulating cortisol concentrations with the expression of cortisol biosynthetic enzymes and a glucocorticoid receptor in the blubber of common bottlenose dolphin
Gen Comp Endocrinol. 2024 Apr 7:114516. doi: 10.1016/j.ygcen.2024.114516. Online ahead of print.ABSTRACTCortisol is secreted from the adrenal cortex in response to stress, and its circulating levels are used as robust physiological indicators of stress intensity in various animals. Cortisol is also produced locally in adipose tissue by the conversion of steroid hormones such as cortisone, which is related to fat accumulation. Circulating cortisol levels, probably induced by cold stress, increase in cetaceans under cold conditions. However, whether cortisol production in subcutaneous adipose tissue is enhanced when fat accu...
Source: General and Comparative Endocrinology - April 9, 2024 Category: Endocrinology Authors: Miwa Suzuki Noriko Funasaka Yuki Sato Daiki Inamori Yurie Watanabe Miki Ozaki Masayuki Hosono Hideaki Shindo Keiko Kawamura Toshiyuki Tatsukawa Motoi Yoshioka Source Type: research

Corrigendum to "The uterus masculinus of the Eurasian beaver (Castor fiber L.) - The appraisal of fast hormone regulation by membrane androgen and estrogen receptors involvement" [Gen. Comp. Endocrinol. 345 (2024) 114389]
Gen Comp Endocrinol. 2024 Apr 6:114502. doi: 10.1016/j.ygcen.2024.114502. Online ahead of print.NO ABSTRACTPMID:38584035 | DOI:10.1016/j.ygcen.2024.114502 (Source: General and Comparative Endocrinology)
Source: General and Comparative Endocrinology - April 7, 2024 Category: Endocrinology Authors: M Kotula-Balak G Lonc M Zarzycka J Tomiyasu K Knapczyk-Stwora B J P łachno A J Korzekwa J Kaczmarczyk I Krakowska Source Type: research

Hormonal effects on glucose and ketone metabolism in a perfused liver of an elasmobranch, the North Pacific spiny dogfish, Squalus suckleyi
Gen Comp Endocrinol. 2024 Apr 4;352:114514. doi: 10.1016/j.ygcen.2024.114514. Online ahead of print.ABSTRACTHormonal influence on hepatic function is a critical aspect of whole-body energy balance in vertebrates. Catecholamines and corticosteroids both influence hepatic energy balance via metabolite mobilization through glycogenolysis and gluconeogenesis. Elasmobranchs have a metabolic organization that appears to prioritize the mobilization of hepatic lipid as ketone bodies (e.g. 3-hydroxybutyrate [3-HB]), which adds complexity in determining the hormonal impact on hepatic energy balance in this taxon. Here, a liver perfu...
Source: General and Comparative Endocrinology - April 6, 2024 Category: Endocrinology Authors: Alexandra N Schoen Alyssa M Weinrauch Ian A Bouyoucos Jason R Treberg W Gary Anderson Source Type: research

The expression profiles of cyp19a1, sf-1, esrs and gths in the brain-pituitary during gonadal sex differentiation in juvenile Japanese eels
This study aimed to investigate the sex-related gene expressions in the brain-pituitary and tried to clarify their roles in the brain and gonads during gonadal sex differentiation. Based on our previous histological study, the control eels developed as males, and estradiol-17β (E2) was used for feminization. Our results showed that during testicular differentiation, the brain cyp19a1 transcripts and aromatase proteins were increased significantly; moreover, the cyp19a1, sf-1, foxl2s, and esrs (except gperb) transcripts in the midbrain/pituitary also were increased significantly. Forebrain gnrh1 transcripts increased sligh...
Source: General and Comparative Endocrinology - April 6, 2024 Category: Endocrinology Authors: Shan-Ru Jeng Guan-Chung Wu Wen-Shiun Yueh Pei-Hua Liu Shu-Fen Kuo Sylvie Dufour Ching-Fong Chang Source Type: research

Can irisin be developed as the molecular evolutionary clock based on the origin and functions?
Gen Comp Endocrinol. 2024 Apr 4;352:114515. doi: 10.1016/j.ygcen.2024.114515. Online ahead of print.ABSTRACTIrisin, a myokine identified in 2012, has garnered research interest for its capacity to induce browning of adipocytes and improve metabolic parameters. As such, the potential therapeutic applications of this exercise-induced peptide continue to be explored. Though present across diverse animal species, sequence analysis has revealed subtle variation in the irisin protein. In this review, we consider the effects of irisin on disease states in light of its molecular evolution. We summarize current evidence for irisin'...
Source: General and Comparative Endocrinology - April 6, 2024 Category: Endocrinology Authors: Junyu Chen Lijun Guo Chenglong Wang Peng Peng Jiaming Wu Huaidong Zhang Feng Liu Qin Li Source Type: research

Dual role of pregnancy in breast cancer risk
This article summarizes the changes in hormone levels before and after pregnancy, and the roles of hormones in mammary gland development and breast cancer progression. Other factors, such as changes in breast morphology and mammary gland differentiation, changes in the proportion of mammary stem cells (MaSCs), changes in the immune and inflammatory environment, and changes in lactation before and after pregnancy, also play key roles in the occurrence and development of breast cancer. This review discusses the dual effects and the potential mechanisms of pregnancy on breast cancer risk from the above aspects, which is helpf...
Source: General and Comparative Endocrinology - March 25, 2024 Category: Endocrinology Authors: Shiting Fu Hao Ke Huozhong Yuan Huaimeng Xu Wenyan Chen Limin Zhao Source Type: research