Probiotics ameliorate endocrine disorders via modulating inflammatory pathways: a systematic review
AbstractProbiotics has offered a new prospect to treat and manage a variety of endocrine disorders such as obesity, diabetes, non- alcoholic fatty liver disease and metabolic syndrome. The precise mechanisms by which probiotics exert their beneficial effects on endocrine disorders and its associated problems are still indecisive. It seems that regulating the immune system and suppressing pro-inflammatory pathways like tumor necrosis factor- α and interleukin-6 or triggering anti-inflammatory pathways like interleukin-4 and 10 may be one of the potential mechanisms in the managing of endocrine disorders. In this systematic...
Source: Genes and Nutrition - March 19, 2024 Category: Nutrition Source Type: research
Causal relationship between dietary salt intake and dementia risk: Mendelian randomization study
ConclusionThe results of this research present strong evidence that established a significant association between dietary salt intake and the likelihood of developing dementia. These findings reinforce the notion that the amount of dietary salt intake plays a crucial role in determining the risk of acquiring this cognitive condition. By establishing a definitive correlation, this study highlights the importance of reducing salt consumption as a preventive measure against dementia. (Source: Genes and Nutrition)
Source: Genes and Nutrition - March 15, 2024 Category: Nutrition Source Type: research
Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs
AbstractA major revelation of genome-scale biological studies in the post-genomic era has been that two-thirds of human genes do not encode proteins. The majority of non-coding RNA transcripts in humans are long non-coding RNA (lncRNA) molecules, non-protein-coding regulatory transcripts with sizes greater than 500 nucleotides. LncRNAs are involved in nearly every aspect of cellular physiology, playing fundamental regulatory roles both in normal cells and in disease. As result, they are functionally linked to multiple human diseases, from cancer to autoimmune, inflammatory, and neurological disorders. Numerous human condit...
Source: Genes and Nutrition - March 12, 2024 Category: Nutrition Source Type: research
The impact of vitamin D on type 2 diabetes management: boosting PTP1B gene expression and physical activity benefits in rats
ConclusionThe present study shows that the combined AT and Vit D supplementation positively impacts the expression of PTP1B in adipose tissue and serum irisin in rats with T2D. These findings suggest that combining AT with Vit D supplementation can provide a new and effective strategy to improve glucose tolerance and diabetes-related factors in individuals with T2D by regulating the expression of PTP1B in adipose tissue and promoting the synthesis of beneficial irisin protein. (Source: Genes and Nutrition)
Source: Genes and Nutrition - March 2, 2024 Category: Nutrition Source Type: research
Palm-based tocotrienol-rich fraction (TRF) supplementation modulates cardiac sod1 expression, fxr target gene expression, and tauro-conjugated bile acid levels in aleptinemic mice fed a high-fat diet
In conclusion, TRF supplementation in HFD-fed mice affects antioxidant activities, and more interestingly, TRF also acts as a signaling molecule that is possibly involved in several bile acid-related biochemical pathways accompanied by an increase in cardiacfxr shp expression. This study provides new insight into TRF in deregulating bile acid receptors and metabolites in high-fat diet-fed mice. (Source: Genes and Nutrition)
Source: Genes and Nutrition - February 27, 2024 Category: Nutrition Source Type: research
Genome-wide association study of serum magnesium in type 2 diabetes
In conclusion, serum magnesium concentrations are associated with genetic variability around the regions ofTAF3, MUC1/TRIM46, SHROOM3, andSLC22A7 in type 2 diabetes. (Source: Genes and Nutrition)
Source: Genes and Nutrition - January 26, 2024 Category: Nutrition Source Type: research
Dysfunction of DMT1 and miR-135b in the gut-testis axis in high-fat diet male mice
ConclusionsIn obese mice, we observed downregulation of DMT1 in the duodenum and upregulation of miR-135b in the spermatozoa. (Source: Genes and Nutrition)
Source: Genes and Nutrition - January 19, 2024 Category: Nutrition Source Type: research
Effects of dietary PUFA patterns and FADS genotype on breast milk PUFAs in Chinese lactating mothers
ConclusionsOur study suggests that different genotypes and dietary PUFA patterns affect PUFA levels in breast milk. We recommend that lactating mothers consume enough essential fatty acids to ensure that their infants ingest sufficient PUFAs. (Source: Genes and Nutrition)
Source: Genes and Nutrition - October 25, 2023 Category: Nutrition Source Type: research
From common to rare: repurposing of bempedoic acid for the treatment of glycogen storage disease type 1
AbstractHypoketotic hypoglycaemia is a biochemical hallmark of glycogen storage disease type 1 (GSD1). This is due to inhibition of carnitine-palmitoyl transferase 1 by malonyl-CoA. This inhibits the influx of long-chain fatty acids into the mitochondrial matrix for fatty acid oxidation. This leads to reduced hepatic ketogenesis and impaired energy production in the liver and kidney. Hypoketotic hypoglycaemia may result in CNS symptoms due to energy depletion.Recently, it was reported that enzymes involved in mitochondrial long-chain fatty acid oxidation are upregulated in PBMC from patients suffering from GSD1.I suggest t...
Source: Genes and Nutrition - September 18, 2023 Category: Nutrition Source Type: research
Causal associations of 25-hydroxyvitamin D with functional gastrointestinal disorders: a two-sample Mendelian randomization study
ConclusionsOur Mendelian randomization analyses suggest a negative causal relationship between 25-hydroxyvitamin D and IBS. For each additional SD increase of genetically determined 25-hydroxyvitamin D levels, the risk of IBS decreased by 16.8%. (Source: Genes and Nutrition)
Source: Genes and Nutrition - September 11, 2023 Category: Nutrition Source Type: research
Coffee consumption and periodontitis: a Mendelian Randomization study
ConclusionsThe study indicated the causality of continuous coffee consumption to the risk of periodontitis with a relatively small scale of effect estimate and no strong evidence for an effect of binary coffee-consuming behavior on periodontitis. There was also no intensive evidence suggesting reverse causality. (Source: Genes and Nutrition)
Source: Genes and Nutrition - September 9, 2023 Category: Nutrition Source Type: research
Paternal high-fat diet altered SETD2 gene methylation in sperm of F0 and F1 mice
In conclusion, we found that paternal exposure to an HFD disrupted the methylation pattern of SETD2 in the sperm of F0 mice and resulted in perturbed SETD2 expression. Furthermore, the paternal high-fat diet influenced embryo apoptosis and development, possibly through the SETD2 pathway. The altered methylation of SETD2 in sperm induced by paternal HFD partially persisted in the sperm of the F1 generation, highlighting the role of SETD2 as an epigenetic carrier for paternal intergenerational and transgenerational inheritance. (Source: Genes and Nutrition)
Source: Genes and Nutrition - August 19, 2023 Category: Nutrition Source Type: research
Causal effects of serum lipid biomarkers on early age-related macular degeneration using Mendelian randomization
ConclusionThis study identifies causal relationships between elevated circulating HDL-C/ApoA levels and increased risk of early AMD, in addition to finding that TG specifically reduces the risk of early AMD. These findings contribute to a better understanding of the role of lipid metabolism in drusen formation, particularly in early AMD development. (Source: Genes and Nutrition)
Source: Genes and Nutrition - July 21, 2023 Category: Nutrition Source Type: research
Mitochondrial reprogramming in peripheral blood mononuclear cells of patients with glycogen storage disease type Ia
ConclusionMitochondrial reprogramming is detectable in PBMC of GSDIa patients. This feature may develop as an adaptation to the liver enzyme defect and may be triggered by dietary (over)treatment in the frame of G6Pase- α deficiency. PBMC can represent an adequate mean to assess (diet-induced) metabolic disturbances in GSDIa. (Source: Genes and Nutrition)
Source: Genes and Nutrition - June 6, 2023 Category: Nutrition Source Type: research
Correction: Biomarkers of moderate alcohol intake and alcoholic beverages: a systematic literature review
(Source: Genes and Nutrition)
Source: Genes and Nutrition - May 15, 2023 Category: Nutrition Source Type: research
