Proteomic profiling of tumor microenvironment and prognosis risk prediction in stage I lung adenocarcinoma
CONCLUSION: The risk score model derived from proteomic profiling of tumor microenvironment can be used to predict recurrence risk and prognosis of stage I LUAD.PMID:38621342 | DOI:10.1016/j.lungcan.2024.107791 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 15, 2024 Category: Genetics & Stem Cells Authors: Yueh-Feng Lu Ya-Hsuan Chang Yi-Ju Chen Min-Shu Hsieh Mong-Wei Lin Hsao-Hsun Hsu Chia-Li Han Yu-Ju Chen Sung-Liang Yu Jin-Shing Chen Hsuan-Yu Chen Source Type: research
Proteomic profiling of tumor microenvironment and prognosis risk prediction in stage I lung adenocarcinoma
CONCLUSION: The risk score model derived from proteomic profiling of tumor microenvironment can be used to predict recurrence risk and prognosis of stage I LUAD.PMID:38621342 | DOI:10.1016/j.lungcan.2024.107791 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 15, 2024 Category: Genetics & Stem Cells Authors: Yueh-Feng Lu Ya-Hsuan Chang Yi-Ju Chen Min-Shu Hsieh Mong-Wei Lin Hsao-Hsun Hsu Chia-Li Han Yu-Ju Chen Sung-Liang Yu Jin-Shing Chen Hsuan-Yu Chen Source Type: research
Being the Pioneer of Life Sciences in China: -Introduction to Beijing Genomics Institute
Genomics Proteomics Bioinformatics. 2004 Feb;2(1):59-63. doi: 10.1016/S1672-0229(04)02009-1. Epub 2016 Nov 28.NO ABSTRACTPMID:38620138 | PMC:PMC5172448 | DOI:10.1016/S1672-0229(04)02009-1 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 15, 2024 Category: Genetics & Stem Cells Authors: Xin Zhang Source Type: research
Systems Biology Brings Life Sciences Closer: -Report on the China-UK Systems Biology Workshop 2005
Genomics Proteomics Bioinformatics. 2005;3(3):194-196. doi: 10.1016/S1672-0229(05)03025-1. Epub 2016 Nov 28.NO ABSTRACTPMID:38620188 | PMC:PMC5172556 | DOI:10.1016/S1672-0229(05)03025-1 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 15, 2024 Category: Genetics & Stem Cells Authors: Ming Chen Source Type: research
Lectin-Based Immunophenotyping and Whole Proteomic Profiling of CT-26 Colon Carcinoma Murine Model
Int J Mol Sci. 2024 Apr 4;25(7):4022. doi: 10.3390/ijms25074022.ABSTRACTA murine colorectal carcinoma (CRC) model was established. CT26 colon carcinoma cells were injected into BALB/c mice's spleen to study the primary tumor and the mechanisms of cell spread of colon cancer to the liver. The CRC was verified by the immunohistochemistry of Pan Cytokeratin and Vimentin expression. Immunophenotyping of leukocytes isolated from CRC-bearing BALB/c mice or healthy controls, such as CD19+ B cells, CD11+ myeloid cells, and CD3+ T cells, was carried out using fluorochrome-labeled lectins. The binding of six lectins to white blood c...
Source: Genomics Proteomics ... - April 13, 2024 Category: Genetics & Stem Cells Authors: Anna Farag ó Ágnes Zvara L ászló Tiszlavicz Éva Hunyadi-Gulyás Zsuzsanna Darula Zolt án Hegedűs Enik ő Szabó S ára Eszter Surguta J ózsef Tóvári L ászló G Puskás G ábor J Szebeni Source Type: research
Perspective: The complex relationship between charge, mobility, and gas-phase protein structure
J Mass Spectrom. 2024 May;59(5):e5013. doi: 10.1002/jms.5013.ABSTRACTIon mobility spectrometry coupled to mass spectrometry (IMS/MS) is a widely used tool for biomolecular separations and structural elucidation. The application of IMS/MS has resulted in exciting developments in structural proteomics and genomics. This perspective gives a brief background of the field, addresses some of the important issues in making structural measurements, and introduces complementary techniques.PMID:38605450 | DOI:10.1002/jms.5013 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 12, 2024 Category: Genetics & Stem Cells Authors: Ian K Webb Source Type: research
Perspective: The complex relationship between charge, mobility, and gas-phase protein structure
J Mass Spectrom. 2024 May;59(5):e5013. doi: 10.1002/jms.5013.ABSTRACTIon mobility spectrometry coupled to mass spectrometry (IMS/MS) is a widely used tool for biomolecular separations and structural elucidation. The application of IMS/MS has resulted in exciting developments in structural proteomics and genomics. This perspective gives a brief background of the field, addresses some of the important issues in making structural measurements, and introduces complementary techniques.PMID:38605450 | DOI:10.1002/jms.5013 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 12, 2024 Category: Genetics & Stem Cells Authors: Ian K Webb Source Type: research
Unraveling the role of cloud computing in health care system and biomedical sciences
Heliyon. 2024 Apr 2;10(7):e29044. doi: 10.1016/j.heliyon.2024.e29044. eCollection 2024 Apr 15.ABSTRACTCloud computing has emerged as a transformative force in healthcare and biomedical sciences, offering scalable, on-demand resources for managing vast amounts of data. This review explores the integration of cloud computing within these fields, highlighting its pivotal role in enhancing data management, security, and accessibility. We examine the application of cloud computing in various healthcare domains, including electronic medical records, telemedicine, and personalized patient care, as well as its impact on bioinforma...
Source: Genomics Proteomics ... - April 11, 2024 Category: Genetics & Stem Cells Authors: Sonali Sachdeva Saurabh Bhatia Ahmed Al Harrasi Yasir Abbas Shah Khalid Anwer Anil K Philip Syed Faisal Abbas Shah Ajmal Khan Sobia Ahsan Halim Source Type: research
Unraveling the role of cloud computing in health care system and biomedical sciences
Heliyon. 2024 Apr 2;10(7):e29044. doi: 10.1016/j.heliyon.2024.e29044. eCollection 2024 Apr 15.ABSTRACTCloud computing has emerged as a transformative force in healthcare and biomedical sciences, offering scalable, on-demand resources for managing vast amounts of data. This review explores the integration of cloud computing within these fields, highlighting its pivotal role in enhancing data management, security, and accessibility. We examine the application of cloud computing in various healthcare domains, including electronic medical records, telemedicine, and personalized patient care, as well as its impact on bioinforma...
Source: Genomics Proteomics ... - April 11, 2024 Category: Genetics & Stem Cells Authors: Sonali Sachdeva Saurabh Bhatia Ahmed Al Harrasi Yasir Abbas Shah Khalid Anwer Anil K Philip Syed Faisal Abbas Shah Ajmal Khan Sobia Ahsan Halim Source Type: research
A complement C4-derived glycopeptide is a biomarker for PMM2-CDG
CONCLUSIONComplement C4-derived Man5GlcNAc2 glycopeptide could be a biomarker for accurate diagnosis and therapeutic monitoring of patients with PMM2-CDG and other CDGs.FUNDINGU54NS115198 (Frontiers in Congenital Disorders of Glycosylation: NINDS; NCATS; Eunice Kennedy Shriver NICHD; Rare Disorders Consortium Disease Network); K08NS118119 (NINDS); Minnesota Partnership for Biotechnology and Medical Genomics; Rocket Fund; R01DK099551 (NIDDK); Mayo Clinic DERIVE Office; Mayo Clinic Center for Biomedical Discovery; IA/CRC/20/1/600002 (Center for Rare Disease Diagnosis, Research and Training; DBT/Wellcome Trust India Alliance)...
Source: Genomics Proteomics ... - April 8, 2024 Category: Genetics & Stem Cells Authors: Kishore Garapati Rohit Budhraja Mayank Saraswat Jinyong Kim Neha Joshi Gunveen S Sachdeva Anu Jain Anna N Ligezka Silvia Radenkovic Madan Gopal Ramarajan Savita Udainiya Kimiyo Raymond Miao He Christina Lam Austin Larson Andrew C Edmondson Kyriakie Sarafo Source Type: research
A complement C4-derived glycopeptide is a biomarker for PMM2-CDG
CONCLUSIONComplement C4-derived Man5GlcNAc2 glycopeptide could be a biomarker for accurate diagnosis and therapeutic monitoring of patients with PMM2-CDG and other CDGs.FUNDINGU54NS115198 (Frontiers in Congenital Disorders of Glycosylation: NINDS; NCATS; Eunice Kennedy Shriver NICHD; Rare Disorders Consortium Disease Network); K08NS118119 (NINDS); Minnesota Partnership for Biotechnology and Medical Genomics; Rocket Fund; R01DK099551 (NIDDK); Mayo Clinic DERIVE Office; Mayo Clinic Center for Biomedical Discovery; IA/CRC/20/1/600002 (Center for Rare Disease Diagnosis, Research and Training; DBT/Wellcome Trust India Alliance)...
Source: Genomics Proteomics ... - April 8, 2024 Category: Genetics & Stem Cells Authors: Kishore Garapati Rohit Budhraja Mayank Saraswat Jinyong Kim Neha Joshi Gunveen S Sachdeva Anu Jain Anna N Ligezka Silvia Radenkovic Madan Gopal Ramarajan Savita Udainiya Kimiyo Raymond Miao He Christina Lam Austin Larson Andrew C Edmondson Kyriakie Sarafo Source Type: research
A complement C4-derived glycopeptide is a biomarker for PMM2-CDG
CONCLUSIONComplement C4-derived Man5GlcNAc2 glycopeptide could be a biomarker for accurate diagnosis and therapeutic monitoring of patients with PMM2-CDG and other CDGs.FUNDINGU54NS115198 (Frontiers in Congenital Disorders of Glycosylation: NINDS; NCATS; Eunice Kennedy Shriver NICHD; Rare Disorders Consortium Disease Network); K08NS118119 (NINDS); Minnesota Partnership for Biotechnology and Medical Genomics; Rocket Fund; R01DK099551 (NIDDK); Mayo Clinic DERIVE Office; Mayo Clinic Center for Biomedical Discovery; IA/CRC/20/1/600002 (Center for Rare Disease Diagnosis, Research and Training; DBT/Wellcome Trust India Alliance)...
Source: Genomics Proteomics ... - April 8, 2024 Category: Genetics & Stem Cells Authors: Kishore Garapati Rohit Budhraja Mayank Saraswat Jinyong Kim Neha Joshi Gunveen S Sachdeva Anu Jain Anna N Ligezka Silvia Radenkovic Madan Gopal Ramarajan Savita Udainiya Kimiyo Raymond Miao He Christina Lam Austin Larson Andrew C Edmondson Kyriakie Sarafo Source Type: research
Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis-associated adhesion of ovarian cancer cells
CONCLUSIONS: Our findings reveal a novel function for Th17 cells in the OC microenvironment, which entails the IL-17A/TNF-mediated induction of mesothelial-mesenchymal transition, disruption of mesothelial layer integrity and consequently promotion of OC cell adhesion. These effects are potentiated by a positive feedback loop between mesothelial and Th17 cells. Together with the observed clinical associations and accumulation of Th17 cells in omental micrometastases, our observations point to a potential role in early metastases formation and thus to new therapeutic options.PMID:38566518 | PMC:PMC10988119 | DOI:10.1002/ctm...
Source: Genomics Proteomics ... - April 3, 2024 Category: Genetics & Stem Cells Authors: Felix Neuhaus Sonja Lieber Veronika Shinkevich Anna Mary Steitz Hartmann Raifer Kathrin Roth Florian Finkernagel Thomas Worzfeld Andreas Burchert Corinna Keber Andrea Nist Thorsten Stiewe Silke Reinartz Vanessa M Beutgen Johannes Graumann Kim Pauck Holger Source Type: research
Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis-associated adhesion of ovarian cancer cells
CONCLUSIONS: Our findings reveal a novel function for Th17 cells in the OC microenvironment, which entails the IL-17A/TNF-mediated induction of mesothelial-mesenchymal transition, disruption of mesothelial layer integrity and consequently promotion of OC cell adhesion. These effects are potentiated by a positive feedback loop between mesothelial and Th17 cells. Together with the observed clinical associations and accumulation of Th17 cells in omental micrometastases, our observations point to a potential role in early metastases formation and thus to new therapeutic options.PMID:38566518 | PMC:PMC10988119 | DOI:10.1002/ctm...
Source: Genomics Proteomics ... - April 3, 2024 Category: Genetics & Stem Cells Authors: Felix Neuhaus Sonja Lieber Veronika Shinkevich Anna Mary Steitz Hartmann Raifer Kathrin Roth Florian Finkernagel Thomas Worzfeld Andreas Burchert Corinna Keber Andrea Nist Thorsten Stiewe Silke Reinartz Vanessa M Beutgen Johannes Graumann Kim Pauck Holger Source Type: research
Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis-associated adhesion of ovarian cancer cells
CONCLUSIONS: Our findings reveal a novel function for Th17 cells in the OC microenvironment, which entails the IL-17A/TNF-mediated induction of mesothelial-mesenchymal transition, disruption of mesothelial layer integrity and consequently promotion of OC cell adhesion. These effects are potentiated by a positive feedback loop between mesothelial and Th17 cells. Together with the observed clinical associations and accumulation of Th17 cells in omental micrometastases, our observations point to a potential role in early metastases formation and thus to new therapeutic options.PMID:38566518 | PMC:PMC10988119 | DOI:10.1002/ctm...
Source: Genomics Proteomics ... - April 3, 2024 Category: Genetics & Stem Cells Authors: Felix Neuhaus Sonja Lieber Veronika Shinkevich Anna Mary Steitz Hartmann Raifer Kathrin Roth Florian Finkernagel Thomas Worzfeld Andreas Burchert Corinna Keber Andrea Nist Thorsten Stiewe Silke Reinartz Vanessa M Beutgen Johannes Graumann Kim Pauck Holger Source Type: research
