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Haemoglobin and non-alcoholic fatty liver disease: further evidence from a population-based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Xu, L, Xu, C-f, Yu, C-h, Miao, M, Li, Y-m Tags: PostScript Source Type: journals

Interleukin 2 targeted therapy in inflammatory bowel diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Yarkoni, S, Sagiv, Y, Kaminitz, A, Askenasy, N Tags: PostScript Source Type: journals

Discordant practice and limited histopathological assessment in gastrointestinal neuromuscular diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Martin, J E, Hester, T W, Aslam, H, Sinha, S, Knowles, C H Tags: PostScript Source Type: journals

Long-term safety of Infliximab for the treatment of inflammatory bowel disease: does blocking TNF{alpha} reduce colitis-associated colorectal carcinogenesis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Biancone, L, Petruzziello, C, Calabrese, E, Zorzi, F, Naccarato, P, Onali, S, Pallone, F Tags: PostScript Source Type: journals

Artificial and bioartificial liver devices: present and futureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Liver failure is associated with high morbidity and mortality without transplantation. There are two types of device for temporary support: artificial and bioartificial livers. Artificial livers essentially use non-living components to remove the toxins accumulated during liver failure. Bioartificial livers have bioreactors containing hepatocytes to provide both biotransformation and synthetic liver functions. We review here the operating principles, chemical effects, clinical effects and complications of both types, with specific attention paid to bioartificial systems. Several artificial support systems have FDA marketin...
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Carpentier, B, Gautier, A, Legallais, C Tags: GUT Recent advances in clinical practice Source Type: journals

Recent advances in autoimmune pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Autoimmune pancreatitis (AIP) is distinct from calcifying and obstructive forms of chronic pancreatitis. Clinically and histologically it has two distinct subsets: (i) lymphoplasmacytic sclerosing pancreatitis or type 1 AIP which appears to be a systemic disease characterised by abundant infiltration of affected organs with immunoglobulin G4 (IgG4)-positive plasma cells and (2) duct-centric or type 2 AIP characterised by granulocyte epithelial lesions in the pancreas without systemic involvement. In AIP a marked lymphoplasmacytic infiltrate that responds dramatically to steroid therapy suggests an autoimmune aetiology. How...
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Park, D H, Kim, M-H, Chari, S T Tags: GUT Recent advances in basic science, Pancreas and biliary tract, Pancreatitis Source Type: journals

JournalScanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Aithal, G. Tags: JournalScan Source Type: journals

A novel technique for selective NF-{kappa}B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: NF-B inhibiting decoy oligodeoxynucleotide-loaded gelatin nanoparticles is a novel tool to selectively inhibit NF-B activation in Kupffer cells in vivo. Thus, liver injury can be reduced in experimental fulminant hepatitis, but increased at ischaemia–reperfusion. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Hoffmann, F, Sass, G, Zillies, J, Zahler, S, Tiegs, G, Hartkorn, A, Fuchs, S, Wagner, J, Winter, G, Coester, C, Gerbes, A L, Vollmar, A M Tags: Hepatology Source Type: journals

An unusual case of gastric erosionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Jothimani, D K, Zanetto, U, Owen, R J, Lawson, A J, Wilson, P G Tags: GUT Snapshot Editor's quiz Source Type: journals

Insulin resistance and geographical origin: major predictors of liver fibrosis and response to peginterferon and ribavirin in HCV-4Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Insulin resistance and geographical origin are major predictors of liver fibrosis and response to peginterferon and ribavirin in HCV-4 patients. Insulin resistance is frequently encountered in these patients, and correlated independently with serum HCV-RNA. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Moucari, R, Ripault, M-P, Martinot-Peignoux, M, Voitot, H, Cardoso, A-C, Stern, C, Boyer, N, Maylin, S, Nicolas-Chanoine, M-H, Vidaud, M, Valla, D, Bedossa, P, Marcellin, P Tags: Cirrhosis Hepatology Source Type: journals

Insulin resistance is associated with liver stiffness in HIV/HCV co-infected patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: IR is associated with LS in patients co-infected with HIV/HCV. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Merchante, N, Rivero, A, de los Santos-Gil, I, Merino, D, Marquez, M, Lopez-Ruz, M A, Rodriguez-Bano, J, del Valle, J, Camacho, A, Sanz-Sanz, J, Macias, J, Perez-Camacho, I, Gomez-Mateos, J, Moro, A, Pineda, J A Tags: Hepatology Source Type: journals

A patient with new onset of thoracic pain, dyspnoea and weight lossEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Lohr, G, Luft, C, Lenz, K Tags: GUT Snapshot Editor's quiz Source Type: journals

New aspects of an anti-tumour drug: sorafenib efficiently inhibits HCV replicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data demonstrate that the well-characterised anti-tumour drug sorafenib efficiently blocks HCV replication in vitro. This novel effect of sorafenib should be further explored as an antiviral strategy for patients with chronic HCV infection. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Himmelsbach, K, Sauter, D, Baumert, T F, Ludwig, L, Blum, H E, Hildt, E Tags: Hepatology Source Type: journals

Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Colonic cell proliferation was promoted via the JNK pathway in the presence of a HFD but not in the presence of a ND. This novel mechanism may explain the involvement of the JNK pathway in the effect of dietary fat intake on colon carcinogenesis. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Endo, H, Hosono, K, Fujisawa, T, Takahashi, H, Sugiyama, M, Yoneda, K, Nozaki, Y, Fujita, K, Yoneda, M, Inamori, M, Wada, K, Nakagama, H, Nakajima, A Tags: Colon cancer Colorectal cancer Source Type: journals

Differential regulation of interleukin 17 and interferon {gamma} production in inflammatory bowel diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings support a role for IL12, TGFβ and IL21 in modulating IL17/IFN production in IBD. The abundant IL17 in inflamed IBD mucosa may help explain the relative lack of efficacy of anti-IFN antibodies in clinical trials of Crohn’s disease. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Rovedatti, L, Kudo, T, Biancheri, P, Sarra, M, Knowles, C H, Rampton, D S, Corazza, G R, Monteleone, G, Di Sabatino, A, MacDonald, T T Tags: Ulcerative colitis Inflammatory bowel disease Source Type: journals

Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Anti-GP2 autoantibodies constitute novel Crohn’s disease-specific markers, the quantification of which could significantly improve the serological diagnosis of IBD. The expression of GP2 in human enterocytes suggests an important role for anti-GP2 response in the pathogenesis of Crohn’s disease. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Roggenbuck, D, Hausdorf, G, Martinez-Gamboa, L, Reinhold, D, Buttner, T, Jungblut, P R, Porstmann, T, Laass, M W, Henker, J, Buning, C, Feist, E, Conrad, K Tags: Ulcerative colitis, Pancreas and biliary tract Inflammatory bowel disease Source Type: journals

Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Gene array studies of ulcerative colitis mucosal biopsies identified predictive panels of genes for (non-)response to infliximab. Further study of the pathways involved should allow a better understanding of the mechanisms of resistance to infliximab therapy in ulcerative colitis. ClinicalTrials.gov number, NCT00639821. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Arijs, I, Li, K, Toedter, G, Quintens, R, Van Lommel, L, Van Steen, K, Leemans, P, De Hertogh, G, Lemaire, K, Ferrante, M, Schnitzler, F, Thorrez, L, Ma, K, Song, X-Y R, Marano, C, Van Assche, G, Vermeire, S, Geboes, K, Schuit, F, Baribaud, F, Rutgeerts, Tags: Ulcerative colitis, Editor's choice Inflammatory bowel disease Source Type: journals

Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case-control study within a European prospective cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The data support a role for dietary linoleic acid in the aetiology of ulcerative colitis. An estimated 30% of cases could be attributed to having dietary intakes higher than the lowest quartile of linoleic acid intake. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: The IBD in EPIC Study Investigators Tags: Ulcerative colitis Inflammatory bowel disease Source Type: journals

An unusual cause of obscure gastrointestinal bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Tai, C-M, Wang, H-P, Hwang, J-C, Lee, T-C, Lee, C-T, Lin, J-T Tags: GUT Snapshot Editor's quiz Source Type: journals

Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CD4+ T cell immunity to gluten leads to a breach of oral gluten tolerance and small intestinal pathology in lymphopenic mice, similar to human coeliac disease. This model will be useful for the study of coeliac disease pathogenesis, and also for testing novel non-dietary therapies for coeliac disease. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Freitag, T L, Rietdijk, S, Junker, Y, Popov, Y, Bhan, A K, Kelly, C P, Terhorst, C, Schuppan, D Tags: Coeliac disease, Stomach and duodenum Small intestine Source Type: journals

Role of dietary fibres, intestinal hypermotility and leukotrienes in the pathogenesis of NSAID-induced small intestinal ulcers in catsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Insoluble DF, intestinal hypermotility, leukotrienes and cholinergic pathways are implicated in the pathogenesis of small intestinal ulcers induced by NSAIDs. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Satoh, H, Shiotani, S, Otsuka, N, Hatao, K, Nishimura, S Tags: Small intestine Source Type: journals

Association of adiponectin multimers with Barrett's oesophagusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: High levels of LMW adiponectin are associated with a decreased risk of Barrett’s oesophagus among patients with GORD. Further human studies are required to confirm these findings, and in vitro studies are needed to understand if there is a mechanism whereby adiponectin may affect Barrett’s metaplasia. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Rubenstein, J H, Kao, J Y, Madanick, R D, Zhang, M, Wang, M, Spacek, M B, Donovan, J L, Bright, S D, Shaheen, N J Tags: Gastro-oesophageal reflux Oesophagus Source Type: journals

Selective inhibition of NF-{kappa}B in Kupffer cells: good, but not for everythingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Marra, F. Tags: Commentaries Source Type: journals

HIV/hepatitis C co-infection and hepatic fibrosis: looking beyond HIV-associated immune suppression; the contribution of hepatic steatosis and insulin resistanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Bhagani, S. Tags: Commentaries Source Type: journals

Ulcerative colitis: is it in the diet?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Carbonnel, F., Boutron, M. C. Tags: Commentaries Source Type: journals

Adiponectin and JNK: metabolic/inflammatory pathways affecting gastrointestinal carcinogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Tilg, H., Kaser, A. Tags: Commentaries Source Type: journals

"Too much, too soon"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Husein, B, Iqbal, J, Mohammed, A, Shorrock, C Tags: GUT Snapshot Editor's quiz Source Type: journals

Biomarkers in IBS: when will they replace symptoms for diagnosis and management?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Barbara, G., Stanghellini, V. Tags: Constipation, Diarrhoea, Irritable bowel syndrome, Coeliac disease Leader Source Type: journals

The year in Gut 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Spiller, R. Tags: Pancreas and biliary tract, Pancreatic cancer Editorials Source Type: journals

DigestEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Tags: Digest Source Type: journals

Gastrointestinal manifestations among Chilean patients infected with novel influenza A (H1N1) 2009 virusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Riquelme, A, Alvarez-Lobos, M, Pavez, C, Hasbun, P, Dabanch, J, Cofre, C, Jimenez, J, Calvo, M Tags: PostScript Source Type: journals

Authors' replyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Harrison, S A, Neuschwander-Tetri, B A Tags: PostScript Source Type: journals

Applicability of BARD score to Japanese patients with NAFLDEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Fujii, H, Enomoto, M, Fukushima, W, Tamori, A, Sakaguchi, H, Kawada, N Tags: PostScript Source Type: journals

Letter in response to 'Coagulation and fibrosis in chronic liver disease'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Borensztajn, K, Peppelenbosch, M P, Spek, C A Tags: PostScript Source Type: journals

The contribution of megakaryocytes to liver fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Thachil, J Tags: PostScript Source Type: journals

Diagnosis, management and prevention of drug-induced liver injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Drug-induced liver injury (DILI) is increasingly being recognised as a significant cause of both acute and chronic liver disease. The most commonly implicated agents are paracetamol, antimicrobials, non-steroidal anti-inflammatory drugs, statins, isoniazid and herbal remedies. Drug-induced hepatotoxicity is generally idiosyncratic in nature. The pathogenesis of DILI remains enigmatic, but involves exposure to the toxic agent, mitochondrial injury, failure of adaptation, and innate and adaptive immune responses. Diagnosis of drug-induced liver diseases can be difficult, but the key to causality is to diligently exclude othe...
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Verma, S, Kaplowitz, N Tags: GUT Recent advances in clinical practice Source Type: journals

MicroRNAs: tools for cancer diagnosticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recently, a novel class of global gene regulators called microRNAs (miRNAs), were identified in both plants and animals. MiRNAs can reduce protein levels of their target genes with a minor impact on the target genes’ mRNAs. Accumulating evidence demonstrates the importance of miRNAs in cancer. MiRNAs that are overexpressed in cancer may function as oncogenes, and miRNAs with tumour suppressor activity in normal tissue may be downregulated in cancer. Although major advances have been achieved in our understanding of cancer biology, as well as in the development of new targeted therapies, the progress in developing imp...
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Paranjape, T, Slack, F J, Weidhaas, J B Tags: GUT Recent advances in basic science Source Type: journals

JournalScanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Tags: JournalScan Source Type: journals

The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 yearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Children with NAFLD may develop end-stage liver disease with the consequent need for liver transplantation. NAFLD in children seen in a tertiary care centre may be associated with a significantly shorter survival as compared to the general population. (Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Feldstein, A E, Charatcharoenwitthaya, P, Treeprasertsuk, S, Benson, J T, Enders, F B, Angulo, P Tags: Nonalcoholic steatosis, Editor's choice Hepatology Source Type: journals

A Crohn's disease patient with pustules and feverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Bouma, G, Neve, S, van Grieken, N C T, Mulder, C J, Stoof, T J Tags: GUT Snapshot Editor's quiz Source Type: journals

Hepatitis B virus protein preS2 potentially promotes HCC development via its transcriptional activation of hTERTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: HBV protein preS2 upregulates hTERT via the PRR element in promoting HCC development. (Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Luan, F, Liu, H, Gao, L, Liu, J, Sun, Z, Ju, Y, Hou, N, Guo, C, Liang, X, Zhang, L, Sun, W, Ma, C Tags: Hepatic cancer Hepatology Source Type: journals

Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Celecoxib shows a proapoptotic effect on HSCs through Akt inactivation and shows antifibrogenic effects in BDL- and TAA-treated rats, suggesting celecoxib as a novel antifibrotic agent of hepatic fibrosis. (Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Paik, Y-H, Kim, J K, Lee, J I, Kang, S H, Kim, D Y, An, S H, Lee, S J, Lee, D K, Han, K-H, Chon, C Y, Lee, S I, Lee, K S, Brenner, D A Tags: Cirrhosis, Pancreas and biliary tract Hepatology Source Type: journals

Intracapillary leucocyte accumulation as a novel antihaemorrhagic mechanism in acute pancreatitis in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: ILA represents a novel protective and potentially lifesaving mechanism of haemostasis in acute pancreatitis. This process depends on expression of LFA-1 and ICAM-1 and precedes the classical steps of the leucocyte recruitment cascade. (Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Ryschich, E, Kerkadze, V, Deduchovas, O, Salnikova, O, Parseliunas, A, Marten, A, Hartwig, W, Sperandio, M, Schmidt, J Tags: Pancreas and biliary tract, Pancreatitis Source Type: journals

Standard steroid treatment for autoimmune pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The major indication for steroid treatment in AIP is the presence of symptoms. An initial prednisolone dose of 0.6 mg/kg/day, is recommend, which is then reduced to a maintenance dose over a period of 3–6 months. Maintenance treatment with low-dose steroid reduces but dose not eliminate relapses. (Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Kamisawa, T, Shimosegawa, T, Okazaki, K, Nishino, T, Watanabe, H, Kanno, A, Okumura, F, Nishikawa, T, Kobayashi, K, Ichiya, T, Takatori, H, Yamakita, K, Kubota, K, Hamano, H, Okamura, K, Hirano, K, Ito, T, Ko, S B H, Omata, M Tags: Pancreas and biliary tract, Pancreatitis Source Type: journals

Modelling dysplasia detection in ulcerative colitis: clinical implications of surveillance intensityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Random biopsy surveillance is sufficiently sensitive to detect large dysplastic fields with significant colorectal cancer risk. Enhanced endoscopy can detect much smaller dysplastic fields, but these have unknown (perhaps much lower) colorectal cancer risk. Small dysplastic fields should not be assumed to indicate a high colorectal cancer risk that warrants colectomy. Prospective studies are needed to define the colorectal cancer risk and optimal management of small dysplastic lesions. (Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Awais, D, Siegel, C A, Higgins, P D R Tags: Ulcerative colitis, Colon cancer Colorectal cancer Source Type: journals

Increasing incidence of paediatric inflammatory bowel disease in Ontario, Canada: evidence from health administrative dataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Ontario has one of the highest rates of childhood-onset IBD in the world, and there is an accelerated increase in incidence in younger children. (Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Benchimol, E I, Guttmann, A, Griffiths, A M, Rabeneck, L, Mack, D R, Brill, H, Howard, J, Guan, J, To, T Tags: Endoscopy, Colon cancer Inflammatory bowel disease Source Type: journals

Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A population of tolerogenic CD103+ DCs was identified in the human gut that probably differentiate in response to IEC-derived factors and drive Treg cell development. (Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Iliev, I D, Spadoni, I, Mileti, E, Matteoli, G, Sonzogni, A, Sampietro, G M, Foschi, D, Caprioli, F, Viale, G, Rescigno, M Tags: Inflammation Source Type: journals

Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Eosinophils express CRH in the jejunum in response to psychological stress. SP and its receptors mediate the effect of stress in the CRH expression in eosinophils. Eosinophil-derived CRH activates mast cells to induce the jejunum epithelial barrier dysfunction. (Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Zheng, P-Y, Feng, B-S, Oluwole, C, Struiksma, S, Chen, X, Li, P, Tang, S-G, Yang, P-C Tags: Gastrointestinal hormones Neurogastroenterology Source Type: journals

The feasibility of wireless capsule endoscopy in detecting small intestinal pathology in children under the age of 8 years: a multicentre European studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: WCE is feasible and safe down to the age of 1.5 years. 20 children >4 years swallowed the capsule. The Advance introducer proved superior for endoscopic placement. The pathologies encountered showed age specificity and, unlike in adolescents, obscure gastrointestinal bleeding was the commonest indication. (Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Fritscher-Ravens, A, Scherbakov, P, Bufler, P, Torroni, F, Ruuska, T, Nuutinen, H, Thomson, M, Tabbers, M, Milla, P Tags: Endoscopy, Angiodysplasia, Stomach and duodenum Small intestine Source Type: journals

Gynaecological cause for bowel obstructionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - October 15, 2009 Category: Gastroenterology Authors: Sivakumar, R, Bhatti, I, Bali, A, Tierney, G Tags: GUT Snapshot Editor's quiz Source Type: journals