Unraveling the Heterogeneity of CD8+ T-Cell Subsets in Liver Cirrhosis: Implications for Disease Progression
CONCLUSIONS: : In summary, this comprehensive study defines specialized CD8+ T-cell subpopulations in cirrhosis, with CXCL13+ Tex cells displaying an exhausted phenotype associated with immune dysregulation and advanced disease. Key genes and pathways regulating these cells present potential therapeutic targets.PMID:38623058 | DOI:10.5009/gnl230345 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Kepu Zheng Leiyang Dai Shengning Zhang Yingpeng Zhao Wang Li Yang Gao Yuanyi Mang Lingfeng Jiao Yu Tang Jianghua Ran Source Type: research
A New Risk Prediction Model for Detecting Endoscopic Activity of Ulcerative Colitis
CONCLUSIONS: : The nomogram, which incorporated activated partial thromboplastin time, fecal occult blood test, β2-globulin level, and fibrinogen degradation products, served as a prospective tool for evaluating UC activity in clinical practices.PMID:38623059 | DOI:10.5009/gnl230370 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Guoyu Guan Sangdan Zhuoga Songbai Zheng Kangqiao Xu Tingwen Weng Wensi Qian Danian Ji Xiaofeng Yu Source Type: research
Long-term Outcome of Asymptomatic Esophageal Eosinophilia
CONCLUSIONS: : Some patients with aEE had improved findings without treatment, whereas others developed symptoms, emphasizing the importance of long-term monitoring and individualized treatment decisions.PMID:38623060 | DOI:10.5009/gnl230398 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yugo Suzuki Yorinari Ochiai Daisuke Kikuchi Mako Koseki Kenichi Ohashi Shu Hoteya Source Type: research
Precirrhotic Primary Biliary Cholangitis with Portal Hypertension: Bile Duct Injury Correlate
CONCLUSIONS: : Approximately 24.2% of precirrhotic PBC patients have PH, which is histologically related to the injury of bile ducts. High alkaline phosphatase levels, low white blood cell counts, high Mayo scores, and high FIB-4 index values are associated with increased risk of precirrhotic PBC with PH.PMID:38623061 | DOI:10.5009/gnl230468 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yi-Fan Hu Shun-Xin Li Hong-Li Liu Zhi-Xiang Du Shuang-Shuang Wang Miao-Yang Chen Li Wang Qing-Fang Xiong Yan-Dan Zhong Du-Xian Liu Yong-Feng Yang Source Type: research
Unraveling the Heterogeneity of CD8+ T-Cell Subsets in Liver Cirrhosis: Implications for Disease Progression
CONCLUSIONS: : In summary, this comprehensive study defines specialized CD8+ T-cell subpopulations in cirrhosis, with CXCL13+ Tex cells displaying an exhausted phenotype associated with immune dysregulation and advanced disease. Key genes and pathways regulating these cells present potential therapeutic targets.PMID:38623058 | DOI:10.5009/gnl230345 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Kepu Zheng Leiyang Dai Shengning Zhang Yingpeng Zhao Wang Li Yang Gao Yuanyi Mang Lingfeng Jiao Yu Tang Jianghua Ran Source Type: research
A New Risk Prediction Model for Detecting Endoscopic Activity of Ulcerative Colitis
CONCLUSIONS: : The nomogram, which incorporated activated partial thromboplastin time, fecal occult blood test, β2-globulin level, and fibrinogen degradation products, served as a prospective tool for evaluating UC activity in clinical practices.PMID:38623059 | DOI:10.5009/gnl230370 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Guoyu Guan Sangdan Zhuoga Songbai Zheng Kangqiao Xu Tingwen Weng Wensi Qian Danian Ji Xiaofeng Yu Source Type: research
Long-term Outcome of Asymptomatic Esophageal Eosinophilia
CONCLUSIONS: : Some patients with aEE had improved findings without treatment, whereas others developed symptoms, emphasizing the importance of long-term monitoring and individualized treatment decisions.PMID:38623060 | DOI:10.5009/gnl230398 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yugo Suzuki Yorinari Ochiai Daisuke Kikuchi Mako Koseki Kenichi Ohashi Shu Hoteya Source Type: research
Precirrhotic Primary Biliary Cholangitis with Portal Hypertension: Bile Duct Injury Correlate
CONCLUSIONS: : Approximately 24.2% of precirrhotic PBC patients have PH, which is histologically related to the injury of bile ducts. High alkaline phosphatase levels, low white blood cell counts, high Mayo scores, and high FIB-4 index values are associated with increased risk of precirrhotic PBC with PH.PMID:38623061 | DOI:10.5009/gnl230468 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yi-Fan Hu Shun-Xin Li Hong-Li Liu Zhi-Xiang Du Shuang-Shuang Wang Miao-Yang Chen Li Wang Qing-Fang Xiong Yan-Dan Zhong Du-Xian Liu Yong-Feng Yang Source Type: research
Toward a Functional Cure for Hepatitis B
Gut Liver. 2024 Mar 27. doi: 10.5009/gnl240023. Online ahead of print.ABSTRACTCurrent treatment of chronic hepatitis B virus (HBV) infection, pegylated interferon-α (pegIFN-α) and nucleos(t)ide analogue (NA), can suppress HBV replication, reverse liver inflammation and fibrosis, and decrease risks of cirrhosis and hepatocellular carcinoma, but hepatitis B surface antigen (HBsAg) loss is rare. Functional HBV cure is defined as undetectable HBsAg and unquantifiable serum HBV DNA for at least 24 weeks after a finite course of therapy. This requires suppression of HBV replication and viral protein production as well as resto...
Source: Gut and Liver - March 27, 2024 Category: Gastroenterology Authors: Anna S F Lok Source Type: research
