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Evaluation of peri-operative chemotherapy using a prognostic nomogram for survival after resection of colorectal liver metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The CRLM nomogram was validated by an external cohort and more accurately predicted post-resection survival than the commonly used CRS. Differences in observed and nomogram-predicted survival may reflect the effect of treatment factors, such as peri-operative chemotherapy. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 14, 2009 Category: Gastroenterology Authors: Srinevas K. Reddy, Michael W. Kattan, Changhong Yu, Eugene P. Ceppa, Sebastian G. de la Fuente, Yuman Fong, Bryan M. Clary, Rebekah R. White Source Type: journals

Radical resection for T1b gallbladder cancer: a decision analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Decision analysis demonstrates that radical resection is associated with increased survival for most patients with T1b gallbladder cancer. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 14, 2009 Category: Gastroenterology Authors: Michael A. Abramson, Pari Pandharipande, Daniel Ruan, Jason S. Gold, Edward E. Whang Source Type: journals

Clinical factors predictive of malignant and premalignant cystic neoplasms of the pancreas: a single institution experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Based upon our single institution experience with resection of cystic neoplasms of the pancreas, we advocate an aggressive surgical approach to any patient with a cystic neoplasm of the pancreas and associated elevated CA19-9. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 13, 2009 Category: Gastroenterology Authors: Natalie B. Jones, Ioannis Hatzaras, Nathaniel George, Peter Muscarella, E. Christopher Ellison, W. Scott Melvin, Mark Bloomston Source Type: journals

Peri-operative outcomes for pancreatoduodenectomy in India: a multi-centric studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This is the first multi-centric report of peri-operative outcomes of PD from India. The results from these specialist centers are very acceptable, and appear to support the thrust towards centralization. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 12, 2009 Category: Gastroenterology Authors: Parul J. Shukla, Savio G. Barreto, M.M.S. Bedi, N. Bheerappa, Adarsh Chaudhary, M.D. Gandhi, M. Jacob, S. Jesvanth, D.G. Kannan, Vinay K. Kapoor, A. Kumar, K.K. Maudar, Hariharan Ramesh, R.A. Sastry, Rajan Saxena, Ajit Sewkani, S. Sharma, Shailesh V. Shri Source Type: journals

Proteasome inhibition enhances antitumour effects of gemcitabine in experimental pancreatic cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Bortezomib and gemcitabine demonstrate additive antitumour activity in vitro and in an experimental PaCa model, indicating the potential for clinical PaCa benefits of additional multiagent therapies that will be based upon the bortezomib and gemcitabine combination. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 12, 2009 Category: Gastroenterology Authors: Niranjan Awasthi, Margaret A. Schwarz, Roderich E. Schwarz Source Type: journals

Incidence and characteristics of chronic and lymphoplasmacytic sclerosing pancreatitis in patients scheduled to undergo a pancreatoduodenectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The incidence of pancreatitis is 9.9% for patients scheduled to undergo a pancreatoduodenectomy. Of these patients, 38% had LPSP, 13% had a intermediate form and 49% had focal chronic pancreatitis. The determination of the exact nature of a pancreatic head mass remains difficult. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 12, 2009 Category: Gastroenterology Authors: Steve M.M. de Castro, Lindsey C.F. de Nes, C. Yung Nio, Daan C. Velseboer, Fiebo J.W. Ten Kate, Olivier R.C. Busch, Thomas M. van Gulik, Dirk Jan Gouma Source Type: journals

Total pancreatectomy with islet autotransplantation: an overviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pain control is one of the most challenging aspects in the management of chronic pancreatitis. Total pancreatectomy can successfully relieve the intractable abdominal pain in these patients but will inevitably result in insulin-dependent diabetes. Islet autotransplantation aims to preserve, as far as possible, the insulin secretory function of the islet cell mass thereby reducing (or even removing) the requirement for exogenous insulin administration after a total pancreactomy. Despite the relatively small number of centres able to perform these procedures, there are important technical variations in the details of their a...
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 12, 2009 Category: Gastroenterology Authors: Seok L. Ong, Gianpiero Gravante, Cristina A. Pollard, M'Balu A. Webb, Severine Illouz, Ashley R. Dennison Source Type: journals

Long-term outcome after sequential resections of liver and lung metastases from colorectal carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Sequential liver and lung resection for CLM is associated with good long-term survival in selected patients, except in those presenting with synchronous lung and liver metastases. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 11, 2009 Category: Gastroenterology Authors: Ravi Marudanayagam, Krishnamoorthy Ramkumar, Vivekanandan Shanmugam, Gerald Langman, Pala Rajesh, Chris Coldham, Simon R. Bramhall, David Mayer, John Buckels, Darius F. Mirza Source Type: journals

Comparison of liver regeneration after a splenectomy and splenic artery ligation in a dimethylnitrosamine-induced cirrhotic rat modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: A Splenectomy significantly improved liver regeneration with reduction of plasma TGF-[beta]1 levels compared with splenic artery ligation in DMN-treated cirrhotic rats. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 11, 2009 Category: Gastroenterology Authors: Akio Morinaga, Toshiro Ogata, Masayosi Kage, Hisafumi Kinoshita, Sigeaki Aoyagi Source Type: journals

Surgical downstaging and neo-adjuvant therapy in metastatic colorectal carcinoma with irinotecan drug-eluting beads: a multi-institutional studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Hepatic arterial infusion irinotecan drug-eluting beads is safe and effective in pre-surgical therapy and helpful in evaluating the biology of metastatic colorectal cancer to the liver prior to planned hepatic resection. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 11, 2009 Category: Gastroenterology Authors: Matthew Bower, Tiffany Metzger, Ken Robbins, Dana Tomalty, Vlatimil Válek, Jean Boudný, Tomas Andrasina, Cliff Tatum, Robert C.G. Martin Source Type: journals

A comparison of pancreaticoduodenectomy and duodenum-preserving head resection for the treatment of chronic pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Duodenum-preserving head resection is equally as effective as PD in relieving pain and improving QoL in chronic pancreatitis patients, and involves a shorter hospital stay and less blood loss. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 11, 2009 Category: Gastroenterology Authors: Rebecca J. McClaine, Andrew M. Lowy, Jeffrey B. Matthews, Nathan Schmulewitz, Jeffrey J. Sussman, Angela M. Ingraham, Syed A. Ahmad Source Type: journals

Perioperative chemotherapy with bevacizumab and liver resection for colorectal cancer liver metastasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data confirm the safety of chemotherapy regimens which include Bev in the perioperative setting and demonstrate that such perioperative chemotherapy in patients with CRLM does not adversely affect patient outcome. There was no increase in perioperative morbidity compared with published rates. The addition of Bev to standard chemotherapy may improve response rates, which may, in turn, impact favourably on patient survival. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 11, 2009 Category: Gastroenterology Authors: Prosanto Chaudhury, Mazen Hassanain, Nathaniel Bouganim, Ayat Salman, Petr Kavan, Peter Metrakos Source Type: journals

Hepatic resection for colorectal metastases: the impact of surgical margin status on outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An R0 margin width of 1 cm has traditionally been considered a prerequisite to minimize local recurrence and optimize survival following hepatic resection for metastatic colorectal cancer. However, recent data have called into question the prognostic importance of the '1-cm rule'. Specifically, several studies have noted that, although an R0 resection is important, the actual margin width may not be as critical. We provide a brief overview of the impact of an R1 vs. an R0 resection on local recurrence and overall survival. In addition, we specifically review the impact of margin width in patients who have undergone an R0 r...
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 11, 2009 Category: Gastroenterology Authors: George A. Poultsides, Richard D. Schulick, Timothy M. Pawlik Source Type: journals

The effect of hyperbaric oxygen on apoptosis and proliferation in severe acute pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: During SAP, acini apoptosis and proliferation were increased. Hyperbaric oxygen therapy may improve the condition of SAP by promoting apoptosis and proliferation. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 10, 2009 Category: Gastroenterology Authors: Shir Lin Koh, Joon Win Tan, Vijayaragavan Muralidharan, Christopher Christophi Source Type: journals

Photodynamic therapy is associated with an improvement in survival in patients with irresectable hilar cholangiocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This prospective clinical cohort study has demonstrated that radical surgery and palliative Photofrin-PDT are associated with an increased survival in patients with hilar cholangiocarcinoma. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 9, 2009 Category: Gastroenterology Authors: Aaron J. Quyn, Dorin Ziyaie, Francesco M. Polignano, Iain S. Tait Source Type: journals

The role of PET-CT in patients with incidental gallbladder cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: For patients presenting with stage T1b or greater IGC, the use of 18FDG PET-CT will help reduce the number of patients undergoing non-therapeutic re-exploration and may help to determine the likely prognosis. 18FDG PET-CT might be a useful tool for the selection of patients for potentially curative treatment. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 9, 2009 Category: Gastroenterology Authors: Jean M. Butte, Francisca Redondo, Enrique Waugh, Manuel Meneses, Rossana Pruzzo, Hugo Parada, Horacio Amaral, Hernán A. De La Fuente Source Type: journals

Hepatic resection for large hepatocellular carcinoma in the era of UCSF criteriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Surgical resection, if feasible, is suggested in patients with large HCC and can be performed with acceptable overall and disease-free survival and morbidity rates. In patients eligible for transplantation, resection may also have a place in the management strategy when waiting list time is prolonged for reasons of organ shortage or when the candidate has low priority as a result of a low MELD (model for end-stage liver disease) score. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 9, 2009 Category: Gastroenterology Authors: Spiros G. Delis, Andreas Bakoyiannis, Nikos Tassopoulos, Kostas Athanassiou, Aristotelis Kechagias, Dimitrios Kelekis, Juan Madariaga, Christos Dervenis Source Type: journals

Combined pancreaticoduodenectomy and extended right hemicolectomy: outcomes and indicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This series suggests that PD combined with an en bloc extended right hemicolectomy is feasible and can achieve complete tumour clearance with acceptable morbidity. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 9, 2009 Category: Gastroenterology Authors: Eric T. Kimchi, Mehrdad Nikfarjam, Niraj J. Gusani, Diego M. Avella, Kevin F. Staveley-O'Carroll Source Type: journals

Cumulative sum (Cusum) analysis provides an objective measure of competency during training in endoscopic retrograde cholangio-pancreatography (ERCP)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Cusum analysis enables sensitive and continuous monitoring of a trainee's performance to objectively determine competency. Wider and systematic use may enable appropriate benchmarks to be identified and more objective assessment of a trainee's experience. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 9, 2009 Category: Gastroenterology Authors: Hayley M. Waller, Saxon J. Connor Source Type: journals

The impact of pre-operative serum creatinine on short-term outcomes after liver resectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: After liver resection, renal failure is rare but patients with an elevated creatinine pre-operatively are at an increased risk of both renal and non-renal complications. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 9, 2009 Category: Gastroenterology Authors: Thomas Armstrong, Fenella K.S. Welsh, John Wells, Kandiah Chandrakumaran, Timothy G. John, Myrddin Rees Source Type: journals

Systematic review of randomized controlled trials of pharmacological interventions to reduce ischaemia-reperfusion injury in elective liver resection with vascular occlusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: Methylprednisolone, trimetazidine, dextrose and ulinastatin may have protective roles against IR injury in liver resection. However, based on the current evidence, they cannot be recommended for routine use and their application should be restricted to RCTs. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 4, 2009 Category: Gastroenterology Authors: Mahmoud Abu-Amara, Kurinchi Gurusamy, Satoshi Hori, George Glantzounis, Barry Fuller, Brian R. Davidson Source Type: journals

Drug-eluting bead therapy in primary and metastatic disease of the liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Drug-eluting bead TACE is becoming more widely utilized in primary and liver-dominant metastatic disease of the liver. Outcomes of success must be expanded beyond response rates because these are not a reliable surrogate for progression-free survival or overall survival. Ongoing clinical trials will further clarify the optimal timing and strategy of this technology. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 4, 2009 Category: Gastroenterology Authors: Stewart Carter, Robert C. G. Martin II Source Type: journals

How to minimize blood loss during liver surgery in patients with cirrhosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with liver disease frequently have substantial changes in their haemostatic system. This is reflected in abnormal test results on routine coagulation screening assays such as the prothrombin time (PT), activated thromboplastin time (APTT) and platelet count. Traditionally, attempts were made to correct abnormalities in the haemostatic system as measured by routine coagulation assays prior to invasive procedures by infusion of platelets or fresh frozen plasma (FFP). Recent laboratory and clinical data have indicated that the haemostatic reserve in cirrhotic patients is relatively well maintained although the coagul...
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - August 28, 2009 Category: Gastroenterology Authors: Andrie C. Westerkamp, Ton Lisman, Robert J. Porte Tags: Review Articles Source Type: journals

Conference CalendarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - August 27, 2009 Category: Gastroenterology Tags: Conference Calendar Source Type: journals

Double liver hanging manoeuvre for central hepatectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a modification of Belghiti's liver hanging manoeuvre (LHM) using two small tubes placed in the cut planes, the first between the left lateral and medial sections, and the second along the right hepatic vein, to achieve complete anatomic central hepatectomy for a large tumour compressing surrounding vessels. Using this technique, a large central hepatocellular carcinoma compressing hilar vessels and the right hepatic vein was easily and safely resected in a 57-year-old man. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - August 27, 2009 Category: Gastroenterology Authors: Atsushi Nanashima, Syuuichi Tobinaga, Masato Araki, Takashi Nonaka, Takafumi Abo, Shigekazu Hidaka, Hiroaki Takeshita, Terumitsu Sawai, Takeshi Nagayasu Tags: Technical Reports Source Type: journals

Interpreting three-dimensional structures from two-dimensional images: a web-based interactive 3D teaching model of surgical liver anatomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: Although the intended audience for VIRTUAL Liver consists of residents in various medical and surgical specialties, the website will also be useful for other health care professionals (i.e. radiologists, nurses, hepatologists, radiation oncologists, family doctors) and educators because it provides a comprehensive resource for teaching liver anatomy. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - August 27, 2009 Category: Gastroenterology Authors: Jodi L. Crossingham, Jodie Jenkinson, Nick Woolridge, Steven Gallinger, Gordon A. Tait, Carol-Anne E. Moulton Tags: Technical Reports Source Type: journals

Laparoscopic bile duct injuries: timing of surgical repair does not influence success rate. A multivariate analysis of factors influencing surgical outcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The success of biliary reconstruction for iatrogenic bile duct injuries depended on complete eradication of abdominal infection, complete cholangiography, use of correct surgical technique, and repair by an experienced biliary surgeon. If these objectives were achieved, the repair could be performed at any point with the expectation of an excellent outcome. We see no reason to delay the repair for some arbitrary period. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - August 27, 2009 Category: Gastroenterology Authors: Lygia Stewart, Lawrence W. Way Tags: Original Articles Source Type: journals

Predicting poor outcome following hepatectomy: analysis of 2313 hepatectomies in the NSQIP databaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Analysis of the NSQIP experience with hepatectomy indicates that the current mortality and major morbidity rate benchmarks are 2.5% and 19.6%, respectively. Poor outcomes were associated with nutritional status, liver function and the extent of hepatectomy. The NSQIP general surgery morbprob and mortprob values were relatively poor predictors of post-hepatectomy observed morbidity, indicating the need for specialty-specific NSQIP modelling. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - August 27, 2009 Category: Gastroenterology Authors: Thomas A. Aloia, Bridget N. Fahy, Craig P. Fischer, Stephen L. Jones, Andrea Duchini, Joseph Galati, A. Osama Gaber, R. Mark Ghobrial, Barbara L. Bass Tags: Original Articles Source Type: journals

Biliary reconstruction and complications after living-donor liver transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although there was a higher rate of biliary stricture formation in the DDCC group, we feel that because of physiological bilioenteric continuity, comparable incidence of leakage and easy endoscopic access, DD reconstruction is the preferred approach for biliary drainage in LDLT. After LDLT, the endoscopic approach has been shown to provide effective treatment of most biliary complications. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - August 27, 2009 Category: Gastroenterology Authors: Reza F. Saidi, Nahel Elias, Dicken Sc Ko, Tatsou Kawai, James Markmann, A. Benedict Cosimi, Martin Hertl Tags: Original Articles Source Type: journals

Influence of resection margin on survival in hepatic resections for colorectal liver metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this cohort of patients, we have demonstrated that a resection margin of greater than 1 mm is associated with significantly improved 5-year overall survival, compared with involved margins or margins less than or equal to 1 mm. The possible beneficial effect of greater margins beyond 1 mm could not be demonstrated. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - August 27, 2009 Category: Gastroenterology Authors: Dries Vandeweyer, Eu Ling Neo, John W.C. Chen, Guy J. Maddern, Thomas G. Wilson, Robert T.A. Padbury Tags: Original Articles Source Type: journals

Evaluation of intrahepatic, extra-Glissonian stapling of the right porta hepatis vs. classical extrahepatic dissection during right hepatectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In selected patients, intrahepatic, extra-Glissonian stapled right hepatectomy is feasible, safe and avoids the need for EHD. The anterior approach to right hepatectomy may achieve outcomes at least as good as those associated with the classical extrahepatic approach. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - August 27, 2009 Category: Gastroenterology Authors: Adrain B. Cresswell, Fenella K. S. Welsh, Timothy G. John, Myrddin Rees Tags: Original Articles Source Type: journals

Patient outcomes after total pancreatectomy: a single centre contemporary experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: TP results in significant metabolic derangements and exocrine insufficiency, diabetic control and weight maintenance remain a challenge and readmission rates are high. Survival in those with malignant disease remains poor. However, the mortality appears to be decreasing and the morbidities associated with TP appear acceptable compared with the benefits of resection in selected patients. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - August 27, 2009 Category: Gastroenterology Authors: John A. Stauffer, Justin H. Nguyen, Michael G. Heckman, Manpreet S. Grewal, Marjorie Dougherty, Kanwar R. S. Gill, Laith H. Jamil, Daniela Scimeca, Massimo Raimondo, C. Daniel Smith, J. Kirk Martin, Horacio J. Asbun Tags: Original Articles Source Type: journals

Total pancreatectomy: a national studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Total pancreatectomy (TP) is performed for various indications. Historically, morbidity and mortality have been high. Recent series reporting improved peri-operative mortality have renewed interest in TP. We performed a national review of TP including indication, patient/hospital characteristics, complications and peri-operative mortality.Methods: The Nationwide Inpatient Sample (NIS) was queried to identify TPs performed during 1998 to 2006. Univariate analyses were used to compare patient/hospital characteristics. Multivariable logistic regression was performed to identify predictors of in-hospital mortality....
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - August 27, 2009 Category: Gastroenterology Authors: Melissa M. Murphy, William J. Knaus II, Sing Chau Ng, Joshua S. Hill, James T. McPhee, Shimul A. Shah, Jennifer F. Tseng Tags: Original Articles Source Type: journals

Total pancreatectomy for pancreatic cancer: indications and operative techniqueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Total pancreatectomy (TP) was abandoned by many surgeons because of its lack of benefits and other major drawbacks. The potential benefits of TP, including its oncological as well as its technical advantages, did not prove to be valid. Problems associated with insulin-deprived diabetes mellitus and high perioperative morbidity and mortality rates were not easily manageable. However, in the new era of pancreatic surgery, new indications for TP have been defined. These have been paralleled by improvements in surgical technique, multidisciplinary management and postoperative intensive care. These factors have transformed TP i...
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - August 27, 2009 Category: Gastroenterology Authors: Yakup Kulu, Bruno M. Schmied, Jens Werner, Pietro Muselli, Markus W. Büchler, Jan Schmidt Tags: Review Articles Source Type: journals

Open versus laparoscopic resection for liver tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: The challenge for the near future is to test the oncological integrity of laparoscopic liver resection in controlled trials in the same way that we have learned from the RCTs carried out in laparoscopic resection for colorectal cancer. It is likely that laparoscopic liver resection will then have to compete with fast-track, open liver resection. Already, concerns have been raised regarding the learning curve required to master the techniques of laparoscopic liver resection. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - August 27, 2009 Category: Gastroenterology Authors: Thomas van Gulik Tags: Review Articles Source Type: journals

Should we give thromboprophylaxis to patients with liver cirrhosis and coagulopathy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with liver cirrhosis are characterized by decreased synthesis of both pro- and anticoagulant factors, and recently there has been evidence of normal generation of thrombin resulting in a near normal haemostatic balance. Although it is generally recognized that bleeding is the most common clinical manifestation as a result of decreased platelet function and number, diminished clotting factors and excessive fibrinolysis, hypercoagulability may play an under recognized but important role in many aspects of chronic liver disease. In fact, they can encounter thrombotic complications such as portal vein thrombosis, occl...
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - August 27, 2009 Category: Gastroenterology Authors: Marco Senzolo, Maria Teresa Sartori, Ton Lisman Tags: Review Articles Source Type: journals

Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data demonstrate previously undescribed anti-inflammatory activities of Tq in PDA cells, which are paralleled by inhibition of NF-[kappa]B. Tq as a novel inhibitor of proinflammatory pathways provides a promising strategy that combines anti-inflammatory and proapoptotic modes of action. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 22, 2009 Category: Gastroenterology Authors: Navdeep Chehl, Galina Chipitsyna, Qiaoke Gong, Charles J. Yeo, Hwyda A. Arafat Tags: Original Articles Source Type: journals

Conference CalendarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 21, 2009 Category: Gastroenterology Tags: Conference Calendar Source Type: journals

Role of preoperative biliary drainage of liver remnant prior to extended liver resection for hilar cholangiocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In patients undergoing liver resection for hilar cholangiocarcinoma, FLR volume of < 30% of total liver volume is associated with increased risk for hepatic insufficiency and death. Preoperative biliary drainage of the FLR appears to improve outcome if the predicted volume is < 30%. However, in patients with FLR [ge] 30%, preoperative biliary drainage does not appear to improve perioperative outcome and, as many of these patients have hypertrophy of the FLR, PVE is likely to offer little benefit. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 21, 2009 Category: Gastroenterology Authors: Timothy J. Kennedy, Adam Yopp, Yilin Qin, Binsheng Zhao, Pingzhen Guo, Fan Liu, Larry H. Schwartz, Peter Allen, Michael D'Angelica, Yuman Fong, Ronald P. DeMatteo, Leslie H. Blumgart, William R. Jarnagin Tags: Original Articles Source Type: journals

Single nucleotide polymorphism in RECQL and survival in resectable pancreatic adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: The RECQL 3'UTR A159C SNP is not linked with other functional SNPs within RECQL but may function as a site for regulatory molecules. The mechanism of action needs to be clarified further. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 21, 2009 Category: Gastroenterology Authors: Ronald T. Cotton, Donghui Li, Steven E. Scherer, Donna M. Muzny, Sally E. Hodges, Robbi L. Catania, Agnieszka K. Witkiewicz, Jonathan R. Brody, Eugene P. Kennedy, Charles J. Yeo, F. Charles Brunicardi, Richard A. Gibbs, Marie-Claude Gingras, William E. Fi Tags: Original Articles Source Type: journals

Aetiology and outcome of acute liver failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Paracetamol overdose was the most common cause of acute liver failure. Liver transplantation, when performed for acute liver failure, has good long-term survival. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 21, 2009 Category: Gastroenterology Authors: Ravi Marudanayagam, Vivekanandan Shanmugam, Bridget Gunson, Darius F. Mirza, David Mayer, John Buckels, Simon R. Bramhall Tags: Original Articles Source Type: journals

A simplified prognostic system for resected pancreatic neuroendocrine neoplasmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A simple scoring system utilizing tumour size, histological grade, nodal metastases and resection margin status can be used to stratify outcomes in patients undergoing resection of primary pancreatic neuroendocrine neoplasms. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 21, 2009 Category: Gastroenterology Authors: Nikiforos Ballian, Agnes G. Loeffler, Victoria Rajamanickam, Peter A. Norstedt, Sharon M. Weber, Clifford S. Cho Tags: Original Articles Source Type: journals

Temporal trends in liver transplant centre volume in the USAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The relationship between centre volume and patient outcomes for liver transplantation in the USA has become less pronounced over time, suggesting that the use of procedure volume as a marker of liver transplant centre quality cannot be justified. The performance-based review process currently utilized in the USA may have contributed to this diminishing influence of centre volume on liver transplant recipient outcomes. This type of review process should be considered as a potential alternative to the volume-based referral initiatives that have been developed for other non-transplant, complex surgical procedures...
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 21, 2009 Category: Gastroenterology Authors: Elisabeth T. Tracy, Kyla M. Bennett, Emeline M. Aviki, Theodore N. Pappas, Bradley H. Collins, Janet E. Tuttle-Newhall, Carlos E. Marroquin, Paul C. Kuo, John E. Scarborough Tags: Original Articles Source Type: journals

ACS-NSQIP has the potential to create an HPB-NSQIP optionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) was started in 2004. Presently, 58% of the 198 hospitals participating in ACS-NSQIP are academic or teaching hospitals. In 2008, ACS-NSQIP initiated a number of changes and made risk-adjusted data available for use by participating hospitals. This analysis explores the ACS-NSQIP database for utility in developing hepato-pancreato-biliary (HPB) surgery-specific outcomes (HPB-NSQIP).Methods: The ACS-NSQIP Participant Use File was queried for patient demographics and outcomes for 49 HPB operations from 1 January 2005 through...
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 21, 2009 Category: Gastroenterology Authors: Henry A. Pitt, Molly Kilbane, Steven M. Strasberg, Timothy M. Pawlik, Elijah Dixon, Nicholas J. Zyromski, Thomas A. Aloia, J. Michael Henderson, Sean J. Mulvihill Tags: Original Articles Source Type: journals

Surgical dilemma: liver resection or liver transplantation for hepatocellular carcinoma and cirrhosis. Intention-to-treat analysis in patients within and outwith Milan criteriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Survival rates for patients with HCC are similar in LR and OLT. Liver resection can potentially decrease the dropout rate and serve as a bridge for future salvage LT, particularly in patients with tumours >3 cm. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 21, 2009 Category: Gastroenterology Authors: Marcelo E. Facciuto, Caroline Rochon, Mahima Pandey, Manuel Rodriguez-Davalos, Susana Samaniego, David C. Wolf, Leona Kim-Schluger, Grigory Rozenblit, Patricia A. Sheiner Tags: Original Articles Source Type: journals

National hospital volume in acute pancreatitis: analysis of the Nationwide Inpatient Sample 1998–2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Rates of admissions for acute pancreatitis in the USA are increasing. High annual hospital volume of acute pancreatitis cases confers a shorter LOS, lower adjusted mortality and a lower likelihood of pancreatic procedure for patients admitted with acute pancreatitis. Although HV hospitals were less likely than MV or LV centres to perform pancreatic procedures, the role of surgery remains unclear. Further studies should examine other possible reasons for this mortality benefit, such as the availability of specialists, the quality of critical care facilities and the timing of operative intervention. (Source: HPB...
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 21, 2009 Category: Gastroenterology Authors: Anand Singla, Nicholas G. Csikesz, Jessica P. Simons, You Fu Li, Sing Chau Ng, Jennifer F. Tseng, Shimul A. Shah Tags: Original Articles Source Type: journals

Comparative performances of staging systems for early hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: The early HCC prognostic score is superior to the AJCC/UICC staging system (6th edition) for predicting the survival of patients with early HCC after liver resection or liver transplantation. Other major HCC staging systems perform poorly in patients with early HCC. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 21, 2009 Category: Gastroenterology Authors: Hari Nathan, Gilles Mentha, Hugo P. Marques, Lorenzo Capussotti, Pietro Majno, Luca Aldrighetti, Carlo Pulitano, Laura Rubbia-Brandt, Nadia Russolillo, Benjamin Philosophe, Eduardo Barroso, Alessandro Ferrero, Richard D. Schulick, Michael A. Choti, Timoth Tags: Original Articles Source Type: journals

Conference CalendarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - June 11, 2009 Category: Gastroenterology Tags: Conference Calendar Source Type: journals

Monolobar Caroli's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - June 11, 2009 Category: Gastroenterology Authors: Julien Jarry, Jean Saric Tags: Image of the Issue Source Type: journals

Excluded segmental bile duct leakage- a complication for all hepatic surgeons to recognizeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - June 11, 2009 Category: Gastroenterology Tags: Commentary Source Type: journals