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1392 records returned

The utility of a prognostic index for predicting time to first treatment (TFT) in early chronic lymphocytic leukemia (CLL): the GIMEMA (Gruppo Italiano Malattie Ematologiche dell' Adulto) experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The results of this study extend the utility of a new prognostic index for predicting TFT in a large sample series of community-based patients with early CLL stage at presentation. Finally, our effort to develop a revised scoring method meets the need to dissect Binet stage A patients into different prognostic groups suitable for devising individualized and tailored follow-up during the treatment-free period. PMID: 19903673 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - November 10, 2009 Category: Hematology Authors: Molica S, Mauro FR, Callea V, Giannarelli D, Lauria F, Rotoli B, Cortelezzi A, Liso V, Foà R Tags: Haematologica Source Type: journals

Additional chromosome abnormalities in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions However, neither ACA overall nor any specific abnormality were identified as independent risk factor for relapse in multivariate analysis. The lack of independent prognostic value of ACA in APL does not support the use of alternative therapeutic strategies based on this cytogenetic finding. PMID: 19903674 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - November 10, 2009 Category: Hematology Authors: Cervera J, Montesinos P, Hernández-Rivas JM, Calasanz MJ, Aventín A, Ferro MT, Luño E, Sánchez J, Vellenga E, Rayón C, Milone G, de la Serna J, Rivas C, González JD, Tormo M, Amutio E, González M, Brunet S, Lowenberg B, Tags: Haematologica Source Type: journals

CLIP down-modulation enhances the immunogenicity of myeloid leukemic blasts resulting in increased CD4+ T cell responses.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These data emphasize the relevance of CLIP expression on leukemic blasts and the potential of CLIP as a target for immunomodulatory strategies to enhance HLA class II antigen presentation and CD4(+) T cell reactivity in AML. PMID: 19903675 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - November 10, 2009 Category: Hematology Authors: van Luijn MM, Chamuleau ME, Thompson JA, Ostrand-Rosenberg S, Westers TM, Souwer Y, Ossenkoppele GJ, van Ham SM, van de Loosdrecht AA Tags: Haematologica Source Type: journals

Pregnancy and {beta}-thalassemia: an Italian multicenter experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Provided that a multidisciplinary team is available, pregnancy is possible, safe and usually has a favorable outcome in patients with thalassemia. In women with hypogonadotropic hypogonadism, gonadal function is usually intact and fertility is usually retrievable. PMID: 19903676 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - November 10, 2009 Category: Hematology Authors: Origa R, Piga A, Quarta G, Forni GL, Longo F, Melpignano A, Galanello R Tags: Haematologica Source Type: journals

IgA and IgG hypogammaglobulinemia in Waldenstrom's macroglobulinemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions IgA and IgG hypogammaglobulinemia is common in WM which persists despite therapeutic intervention and response. IgA and IgG hypogammaglobulinemia do not predict for recurrent infection risk in WM patients, though lower levels of serum IgA and IgG are associated with disease progression in WM patients on watch and wait. PMID: 19903677 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - November 10, 2009 Category: Hematology Authors: Hunter ZR, Manning RJ, Hanzis C, Ciccarelli BT, Ioakimidis L, Patterson CJ, Lewicki MC, Tseng H, Gong P, Liu X, Zhou Y, Yang G, Sun J, Xu L, Sheehy P, Morra M, Treon SP Tags: Haematologica Source Type: journals

Prognostic impact of pre-transplantation transfusion history and secondary iron overload in patients with myelodysplastic syndrome undergoing allogeneic stem cell transplantation: a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Pre-transplantation transfusion history and serum ferritin have a significant prognostic value in MDS patients undergoing myeloablative allo-SCT, inducing a significant increase of NRM. These results indicate that transfusion history should be considered in transplantation decision-making in MDS. PMID: 19903678 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - November 10, 2009 Category: Hematology Authors: Alessandrino EP, Della Porta MG, Bacigalupo A, Malcovati L, Angelucci E, Van Lint MT, Falda M, Onida F, Bernardi M, Guidi S, Lucarelli B, Rambaldi A, Cerretti R, Marenco P, Pioltelli P, Pascutto C, Oneto R, Pirolini L, Fanin R, Bosi A Tags: Haematologica Source Type: journals

Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis (RARS-T).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19903679 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - November 10, 2009 Category: Hematology Authors: Flach J, Dicker F, Schnittger S, Kohlmann A, Haferlach T, Haferlach C Tags: Haematologica Source Type: journals

Successful eradication of acquired factor-VIII inhibitor using single low-dose rituximab.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19903680 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - November 10, 2009 Category: Hematology Authors: Wermke M, von Bonin M, Gehrisch S, Siegert G, Ehninger G, Platzbecker U Tags: Haematologica Source Type: journals

Amyloidosis relapsing after autologous stem cell transplantation treated with Bortezomib: normalization of detectable serum-free light chains and reversal of tissue damage with improved suitability for transplant.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19903681 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - November 10, 2009 Category: Hematology Authors: Brunvand MW, Bitter M Tags: Haematologica Source Type: journals

Parsing the niche code: the molecular mechanisms governing hematopoietic stem cell adhesion and differentiation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19880773 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Forsberg EC, Smith-Berdan S Tags: Haematologica Source Type: journals

Hypercoagulability and thrombotic complications in hemolytic anemias.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19880774 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Ataga KI Tags: Haematologica Source Type: journals

Blood cell activation in myeloproliferative neoplasms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19880775 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Cervantes F, Arellano-Rodrigo E, Alvarez-Larrán A Tags: Haematologica Source Type: journals

Mantle cell lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19880776 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Pileri SA, Falini B Tags: Haematologica Source Type: journals

ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The intracellular ABC transporter A3 is expressed in chronic myeloid leukemia progenitor cells and may contribute to intrinsic imatinib resistance by facilitating lysosomal sequestration in chronic myeloid leukemia cells. PMID: 19880777 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Chapuy B, Panse M, Radunski U, Koch R, Wenzel D, Inagaki N, Haase D, Truemper L, Wulf GG Tags: Haematologica Source Type: journals

SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions SOX11 mRNA and nuclear protein expression is a highly specific marker for both cyclin D1-positive and negative mantle cell lymphoma. PMID: 19880778 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Mozos A, Royo C, Hartmann E, De Jong D, Baró C, Valera A, Fu K, Weisenburger DD, Delabie J, Chuang SS, Jaffe ES, Ruiz-Marcellan C, Dave S, Rimsza L, Braziel R, Gascoyne RD, Solé F, López-Guillermo A, Colomer D, Staudt LM, Rosenwald A, Ott G Tags: Haematologica Source Type: journals

Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia. PMID: 19880779 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Dictor M, Ek S, Sundberg M, Warenholt J, György C, Sernbo S, Gustavsson E, Abu-Alsoud W, Wadström T, Borrebaeck C Tags: Haematologica Source Type: journals

Loss of HLA-DR expression and immunoblastic morphology predict adverse outcome in diffuse large B-cell lymphoma - analyses of cases from two prospective randomized clinical trials.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The previously reported International Prognostic Index-independent prognostic value of stratification into germinal center/non-germinal center B-cell lymphoma using the expression pattern of CD10, BCL6, and IRF4 was not reproducible in our series. However, other markers and the morphological subtype appear to be of prognostic value. PMID: 19880780 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Bernd HW, Ziepert M, Thorns C, Klapper W, Wacker HH, Hummel M, Stein H, Hansmann ML, Ott G, Rosenwald A, Müller-Hermelink HK, Barth TF, Möller P, Cogliatti SB, Pfreundschuh M, Schmitz N, Trümper L, Höller S, Löffler M, Feller AC, Tags: Haematologica Source Type: journals

Multiparameter flow cytometry quantification of bone marrow plasma cells at diagnosis provides more prognostic information than morphological assessment in myeloma patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Quantification of bone marrow plasma cells in multiple myeloma patients using conventional morphology is of limited prognostic value, while the merit of multiparameter flow cytometry immunophenotyping is still considered unproven. Here we compare the bone marrow plasma cell counts obtained by morphology and multiparameter flow cytometry and explore the potential prognostic impact of both techniques in 765 newly diagnosed, uniformly treated multiple myeloma patients. Although multiparameter flow cytometry generally yields lower plasma cell counts (median percentage of 11% vs. 40%, respectively; p<0.001), there is a s...
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Paiva B, Vidriales MB, Pérez JJ, Mateo G, Montalbán MA, Mateos MV, Bladé J, Lahuerta JJ, Orfao A, San Miguel JF Tags: Haematologica Source Type: journals

Use of high intensity adjusted dose low molecular weight heparin in women with mechanical heart valves during pregnancy: a single-center experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of standard dose low molecular weight heparin (LMWH) to anticoagulate women with mechanical valves in pregnancy is associated with morbidity and mortality. We conducted a prospective audit of the use of adjusted dose high intensity LMWH in 12 pregnancies in 11 women with prosthetic heart valves. LMWH +/- low-dose aspirin was started at therapeutic-dose with monitoring of anti-Xa levels to achieve a target level of 1.0-1.2 IU/mL (0.8-1.2 in the first 3/12 pregnancies). This necessitated a mean increase in the dose of LMWH of 54.4% (SD+/-33.2) over initial dose. Eleven of 12 pregnancies resulted in live births, w...
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Quinn J, Von Klemperer K, Brooks R, Peebles D, Walker F, Cohen H Tags: Haematologica Source Type: journals

Monitoring of donor chimerism in sorted CD34+ peripheral blood cells allows the sensitive detection of imminent relapse after allogeneic stem cell transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Analysis of donor chimerism is an important diagnostic tool to assess the risk of relapse after allogeneic stem cell transplantation, especially in patients lacking a specific marker suitable for monitoring of minimal residual disease. We prospectively investigated the predictive value of donor chimerism analyses in sorted CD34(+) peripheral blood cells in 90 patients with acute leukemia and myelodysplastic syndrome. The cumulative incidence of relapse after four years was significantly increased in cases with decreasing or incomplete CD34(+) donor chimerism (57% vs. 18%, p=0.0001). Multivariate analysis confirmed decr...
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Bornhäuser M, Oelschlaegel U, Platzbecker U, Bug G, Lutterbeck K, Kiehl MG, Schetelig J, Kiani A, Illmer T, Schaich M, Theuser C, Mohr B, Brendel C, Fauser AA, Klein S, Martin H, Ehninger G, Thiede C Tags: Haematologica Source Type: journals

Morphological evaluation of monocytes and monocyte precursors in bone marrow trephine biopsies - need for establishing diagnostic criteria.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19880784 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Naresh KN Tags: Haematologica Source Type: journals

Megakaryocyte-erythroid lineage promiscuity in EKLF null mouse blood.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Commitment towards megakaryocyte versus erythroid blood cell lineages occurs in the megakaryocyte-erythroid progenitor, where mutually exclusive expression of either EKLF (Klf1) or Fli1 defines alternative outcomes. Here we show there is a marked increase in the number of circulating platelets in mice lacking the erythroid transcription factor EKLF. In addition, committed erythroid cells retain key signatures of megakaryocytes both on the cell surface and at the mRNA level. We also show that the effect of EKLF on megakaryocyte-erythroid progenitor lineage decision and commitment is cell autonomous in bone marrow recons...
Source: Haematologica - October 22, 2009 Category: Hematology Authors: Tallack MR, Perkins AC Tags: Haematologica Source Type: journals

Development of an ELISA strip for the detection of {alpha} thalassemias.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19850900 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 22, 2009 Category: Hematology Authors: Makonkawkeyoon L, Pharephan S, Sirivatanapa P, Tuntiwechapikul W, Makonkawkeyoon S Tags: Haematologica Source Type: journals

Sperm quality before treatment in patients with early stage Hodgkin lymphoma enrolled in EORTC-GELA Lymphoma Group trials.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Ninety percent of males with Hodgkin lymphoma have good or intermediate sperm quality. Three percent are azoospermic. There is an association between sperm quality and the presence or absence of B-symptoms, in particular fever and night sweats. With modern fertilization techniques, sperm quality before treatment is good enough for future fatherhood in most early-stage Hodgkin lymphoma patients. PMID: 19850901 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 22, 2009 Category: Hematology Authors: van der Kaaij MA, Heutte N, van Echten-Arends J, Raemaekers JM, Carde P, Noordijk EM, Fermé C, Thomas J, Eghbali H, Brice P, Bonmati C, Henry-Amar M, Kluin-Nelemans HC Tags: Haematologica Source Type: journals

Decitabine versus 5-azacitidine for the treatment of myelodysplastic syndrome: adjusted indirect meta-analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19850902 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 22, 2009 Category: Hematology Authors: Kumar A, List AF, Hozo I, Komrokji R, Djulbegovic B Tags: Haematologica Source Type: journals

invasive aspergillosis in patients with acute myeloid leukemia: SEIFEM-2008 registry study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our series confirms the downward trend in mortality rates reported in previous series, with all new drugs providing similar survival and response rates. Recovery from neutropenia and disease stage are crucial prognostic factors. Efficacious antifungal drugs bridge the gap due to poor hematological and immunological reconstitution. PMID: 19850903 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 22, 2009 Category: Hematology Authors: Pagano L, Caira M, Candoni A, Offidani M, Martino B, Specchia G, Pastore D, Stanzani M, Cattaneo C, Fanci R, Caramatti C, Rossini F, Luppi M, Potenza L, Ferrara F, Mitra ME, Fadda RM, Invernizzi R, Aloisi T, Picardi M, Bonini A, Vacca A, Chierichini A, Me Tags: Haematologica Source Type: journals

Hematocrit and risk of venous thromboembolism in a general population. The Tromso Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our findings suggest that hematocrit and related hematological variables such as hemoglobin and RBC-c represent risk factors of VTE in a general population. PMID: 19833630 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 13, 2009 Category: Hematology Authors: Brækkan SK, Mathiesen EB, Njølstad I, Wilsgaard T, Hansen JB Tags: Haematologica Source Type: journals

Thymosin {beta}4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our results indicate a possible tumor suppressive function of Tbeta4. PMID: 19833631 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 13, 2009 Category: Hematology Authors: Caers J, Hose D, Kuipers I, Bos TJ, Van Valckenborgh E, Menu E, De Bruyne E, Goldschmidt H, Van Camp B, Klein B, Vanderkerken K Tags: Haematologica Source Type: journals

Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Expression of hepcidin, the key hormone governing iron transport, is reduced by anemia, in a manner which appears dependent on increased bone marrow activity. The temporal associations between plasma hepcidin and other iron parameters were examined in healthy humans after erythropoietin administration and venesection. Profound hepcidin suppression appeared abruptly 24 hours after subcutaneous erythropoietin (p=0.003), and was near maximal at onset, with peak (mid-afternoon) levels reduced by 73.2%, gradually recovering over the following 2 weeks. Minor changes in circulating iron, soluble transferrin receptor and growt...
Source: Haematologica - October 13, 2009 Category: Hematology Authors: Ashby DR, Gale DP, Busbridge M, Murphy KG, Duncan ND, Cairns TD, Taube DH, Bloom SR, Tam FW, Chapman R, Maxwell PH, Choi P Tags: Haematologica Source Type: journals

Early prediction of success or failure using second generation tyrosine kinase inhibitors for chronic myeloid leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Factors measurable before starting treatment can accurately predict response to 2G-TKI. Cytogenetic responses at 3, 6 and 12 months may influence the decision to continue 2G-TKI. PMID: 19833633 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 13, 2009 Category: Hematology Authors: Milojkovic D, Nicholson E, Apperley JF, Holyoake TL, Shepherd P, Drummond MW, Szydlo R, Bua M, Foroni L, Reid A, Khorashad JS, de Lavallade H, Rezvani K, Paliompeis C, Goldman JM, Marin D Tags: Haematologica Source Type: journals

Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We conclude that the procoagulant state in SCD is partially explained by the factor XI-dependent procoagulant properties of circulating erythrocyte-derived MPs. PMID: 19815831 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 7, 2009 Category: Hematology Authors: van Beers EJ, Schaap MC, Berckmans RJ, Nieuwland R, Sturk A, van Doormaal FF, Meijers JC, Biemond BJ, Tags: Haematologica Source Type: journals

Unimpaired terminal erythroid differentiation and preserved enucleation capacity in myelodysplastic 5q(del) clones: a single cell study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The 5q- syndrome should be considered as a quantitative rather than qualitative bone marrow defect. This observation might open the way to new therapeutic concepts. PMID: 19815832 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 7, 2009 Category: Hematology Authors: Garderet L, Kobari L, Mazurier C, De Witte C, Giarratana MC, Pérot C, Gorin NC, Lapillonne H, Douay L Tags: Haematologica Source Type: journals

Chronic hemolytic anemia due to novel {alpha}-globin chain variants: critical location of the mutation within the gene sequence for a dominant effect.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19815833 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 7, 2009 Category: Hematology Authors: Préhu C, Moradkhani K, Riou J, Bahuau M, Launay P, Martin N, Wajcman H, Goossens M, Galactéros F Tags: Haematologica Source Type: journals

Improved survival in thalassemia major patients on switching from desferrioxamine to combined chelation therapy with desferrioxamine and deferiprone.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19815834 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 7, 2009 Category: Hematology Authors: Telfer PT, Warburton F, Christou S, Hadjigavriel M, Sitarou M, Kolnagou A, Angastiniotis M Tags: Haematologica Source Type: journals

Early cardiac iron overload in children with transfusion-dependent anemias.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19815835 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 7, 2009 Category: Hematology Authors: Fernandes JL, Fabron A, Verissimo M Tags: Haematologica Source Type: journals

Species specific anticoagulant and mitogenic activities of murine protein S.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Recombinant murine protein S exhibits a spectrum of bioactivities with mouse plasma and smooth muscle cells similar to those of human protein S. Thus, studies of the protein C pathway in murine disease models will benefit from in vitro and in vivo studies using mouse protein S. This study extends to mouse previous observations regarding the remarkable species specificity of protein S. PMID: 19815836 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 7, 2009 Category: Hematology Authors: Fernández JA, Heeb MJ, Xu X, Singh I, Zlokovic BV, Griffin JH Tags: Haematologica Source Type: journals

Thalidomide decreases gelatinase production by malignant B lymphoid cell lines through disruption of multiple integrin-mediated signaling pathways.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Disruption of integrin-mediated signaling may be an important mechanism through which Thd and analogs impair tumor cell interactions with the microenvironment. The unexpected Thd effects on Akt activation indicate the need of further studies to elucidate whether interfering with Akt downstream effects would synergize with Thd anti-tumor activity. PMID: 19815837 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 7, 2009 Category: Hematology Authors: Segarra M, Lozano E, Corbera-Bellalta M, Vilardell C, Cibeira MT, Esparza J, Izco N, Bladé J, Cid MC Tags: Haematologica Source Type: journals

Prevalence and pathogenesis of anemia in Inflammatory Bowel disease. Influence of anti-tumor necrosis factor-{alpha} treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In out-patients with inflammatory bowel disease anemia is a common problem whose prevalence and severity are related to disease activity. The pathogenesis of anemia changes during the course of the disease, with ACD having a major role at diagnosis and iron deficiency and multifactorial forms of anemia during follow-up. In patients requiring anti-TNF-alpha treatment, response to therapy improves erythropoiesis. PMID: 19815838 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 7, 2009 Category: Hematology Authors: Bergamaschi G, Di Sabatino A, Albertini R, Ardizzone S, Biancheri P, Bonetti E, Cassinotti A, Cazzola P, Markopoulos K, Massari A, Rosti V, Bianchi Porro G, Corazza GR Tags: Haematologica Source Type: journals

Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These results demonstrate that Akt inhibitors induce apoptosis of CLL cells and might be a new therapeutic option for the treatment of CLL. PMID: 19815839 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 7, 2009 Category: Hematology Authors: de Frias M, Iglesias-Serret D, Cosialls AM, Coll-Mulet L, Santidrián AF, González-Gironès DM, de la Banda E, Pons G, Gil J Tags: Haematologica Source Type: journals

Mobilization of PML/RAR{alpha} negative peripheral blood stem cells with a combination of G-CSF and CXCR4 blockade in relapsed acute promyelocytic leukemia pretreated with arsenic trioxide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19815840 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - October 7, 2009 Category: Hematology Authors: Stölzel F, Wermke M, Röllig C, Thiede C, Platzbecker U, Bornhäuser M Tags: Haematologica Source Type: journals

Molecular basis of congenital neutropenia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19794077 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - September 30, 2009 Category: Hematology Authors: Klein C Tags: Haematologica Source Type: journals

Defective ribosome biogenesis in myelodysplastic syndromes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19794078 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - September 30, 2009 Category: Hematology Authors: Galili N, Qasim SA, Raza A Tags: Haematologica Source Type: journals

Mutations of NOTCH1, FBXW7, and prognosis in T-lineage acute lymphoblastic leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19794079 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - September 30, 2009 Category: Hematology Authors: Mullighan CG Tags: Haematologica Source Type: journals

Large granular lymphocyte disorders: new etiopathogenetic clues as a rationale for innovative therapeutic approaches.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19794080 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - September 30, 2009 Category: Hematology Authors: Zambello R, Semenzato G Tags: Haematologica Source Type: journals

4.1R-deficient human red blood cells have altered phosphatidylserine exposure pathways and are deficient in CD44 and CD47 glycoproteins.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Glycophorin C is known to bind 4.1R, and we have defined previously that it also binds CD47. From our evidence, we suggest that 4.1R plays a role in the phosphatidylserine exposure signaling pathway that is of fundamental importance in red cell turnover. The linkage of CD44 to 4.1R may be relevant to this process. PMID: 19794081 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - September 30, 2009 Category: Hematology Authors: Jeremy KP, Plummer ZE, Head DJ, Madgett TE, Sanders KL, Wallington A, Storry JR, Gilsanz F, Delaunay J, Avent ND Tags: Haematologica Source Type: journals

A phase 2 study of vorinostat in acute myeloid leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Vorinostat monotherapy demonstrated minimal activity in this group of patients with acute myeloid leukemia. Therapy was discontinued in many patients before the planned four cycles had been administered, either because of failure of vorinostat to control the leukocyte count or patients' and physicians' preference. Future studies of vorinostat in acute myeloid leukemia should focus on combinations with other drugs with which it might interact pharmacodynamically. ClinicalTrials.gov Identifier: NCT00305773. PMID: 19794082 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - September 30, 2009 Category: Hematology Authors: Schaefer EW, Loaiza-Bonilla A, Juckett M, DiPersio JF, Roy V, Slack J, Wu W, Laumann K, Espinoza-Delgado I, Gore SD, Tags: Haematologica Source Type: journals

Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: NOTCH1 and FBXW7 mutations were not predictive of outcome in the overall cohort of adult patients with T-lymphoblastic leukemia, but there was a trend towards a favorable prognostic impact of NOTCH1-FBXW7 mutations in the small subgroup of patients with low-risk ERG/BAALC expression status. Our findings further confirm the high frequency of NOTCH1 mutations in adult T-lymphoblastic leukemia. PMID: 19794083 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - September 30, 2009 Category: Hematology Authors: Baldus CD, Thibaut J, Goekbuget N, Stroux A, Schlee C, Mossner M, Burmeister T, Schwartz S, Bloomfield CD, Hoelzer D, Thiel E, Hofmann WK Tags: Haematologica Source Type: journals

Therapeutic implications of variable expression of CD52 on clonal cytotoxic T cells in CD8+ large granular lymphocyte leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: While alemtuzumab may be highly effective in large granular lymphocytic leukemia, prospective serial monitoring for the presence of CD52-deficient clonal cytotoxic T-lymphocytes should be a component of clinical trials investigating the efficacy of this drug. CD52 deficiency may explain lack of response to alemtuzumab, and such therapy may confer a survival advantage to glycophosphatidylinositol-negative clonal cytotoxic T-lymphocytes. PMID: 19794084 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - September 30, 2009 Category: Hematology Authors: Mohan SR, Clemente MJ, Afable M, Cazzolli HN, Bejanyan N, Wlodarski MW, Lichtin AE, Maciejewski JP Tags: Haematologica Source Type: journals

NKG2D gene polymorphism has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These data suggest an association between the donor HNK1 haplotype and better clinical outcome among recipients, with standard-risk disease, of bone marrow transplants from HLA-matched unrelated donors. PMID: 19794085 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - September 30, 2009 Category: Hematology Authors: Espinoza JL, Takami A, Onizuka M, Sao H, Akiyama H, Miyamura K, Okamoto S, Inoue M, Kanda Y, Ohtake S, Fukuda T, Morishima Y, Kodera Y, Nakao S, Tags: Haematologica Source Type: journals

Do commonly used clinical trial designs reflect clinical reality?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This paper contends that commonly used clinical trial designs do not reflect clinical reality as viewed by patients or physicians. Specifically, randomized phase III designs focus on improvements that are more significant statistically than medically and put an emphasis on avoiding a false positive result that is more appropriate for diseases that are curable, in contrast to acute leukemias. The resultant large sample sizes needed for each treatment restrict the trial to one or two new treatments, although historical reality suggests the difficulty in knowing, without clinical data, whether these are the best of severa...
Source: Haematologica - September 30, 2009 Category: Hematology Authors: Estey E Tags: Haematologica Source Type: journals