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133 records returned

Effect of repeated laser microsurgical operations on laryngeal cancer prognosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to evaluate whether repeated sessions of transoral CO2 laser microsurgery (TLM) aiming to achieve clear histologic margins carry a negative effect on the prognosis of laryngeal cancer.This was a retrospective evaluation of 763 cases that underwent primary TLM treatment for laryngeal cancer. Cases were compared for overall survival and local control rates with respect to status of surgical margins and number of procedures necessary to achieve these margins.No significant differences were noted among cases with negative surgical margins regardless of the number of procedures necessary to achieve the...
Source: Head and Neck - November 19, 2009 Category: ENT & OMF Authors: Alexander D. Karatzanis, Frank Waldfahrer, Georgios Psychogios, Joachim Hornung, Johannes Zenk, George A. Velegrakis, Heinrich Iro Source Type: journals

Treatment guideline for hemangiomas and vascular malformations of the head and neckEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vascular anomalies are among the most common congenital and neonatal dysmorphogenesis, which are separated into hemangiomas and vascular malformations. They can occur in various areas throughout the body, with 60% being located in the head and neck. The true mechanism of pathogenesis of vascular anomalies is still unclear. Various treatment methods have been reported, and there are still controversies over the selection of different treatment modalities. Based on the clinical and basic research and current literature, the Chinese Division of Oral and Maxillofacial Vascular Anomalies formulated a treatment guideline for hem...
Source: Head and Neck - November 18, 2009 Category: ENT & OMF Authors: Jia Wei Zheng, Qin Zhou, Xiu Juan Yang, Yan An Wang, Xin Dong Fan, Guo Yu Zhou, Zhi Yuan Zhang, James Y. Suen Source Type: journals

Continued alcohol use in patients with head and neck cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The effect of posttreatment alcohol consumption on health-related quality of life (QOL) and factors predicting overall QOL and continued alcohol consumption were examined in patients with head and neck cancer.Self-reported alcohol use and abuse 1 year after diagnosis was analyzed.Although current drinkers (44.5% of 283 patients) had better overall QOL and fewer depressive symptoms, current social drinkers had the best scores, whereas current problem drinkers had the worst. Female sex, fewer depressive symptoms, less pain, and better eating function predicted better QOL. Oral function was the only predictor of 12-month alco...
Source: Head and Neck - November 17, 2009 Category: ENT & OMF Authors: Andrea E. Potash, Lucy Hynds Karnell, Alan J. Christensen, Mark W. Vander Weg, Gerry F. Funk Source Type: journals

Widespread expression of prostate apoptosis response-4 in nasopharyngeal carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prostate apoptosis response-4 (Par-4) augments apoptosis in various tumors, either during apoptotic insult or by ectopic overexpression. However, investigation of Par-4 expression in nasopharyngeal carcinoma (NPC) is lacking.Specimens from patients with NPC, hypopharyngeal carcinoma (HPC), or oral cavity cancer were examined for Par-4 expression using immunohistochemistry. NPC cell proliferation and apoptosis were analyzed using immunohistochemical staining for Ki67, B-cell lymphoma 2 (Bcl-2), and in situ terminal deoxyribonucleotidyl transferase (TdT)-mediated biotin-16-dUTP nick end-labeling (TUNEL) assay, respectively.P...
Source: Head and Neck - November 12, 2009 Category: ENT & OMF Authors: Jeng-Woei Lee, Wei-Ting Hsiao, Kuei-Fang Lee, Lai-Fa Sheu, Hsue-Yin Hsu, Lee-Ping Hsu, Borcherng Su, Moon-Sing Lee, Yih-Chih Hsu, Chung-Hsing Chang Source Type: journals

Toll-like receptor agonists as third signals for dendritic cell-tumor fusion vaccinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the present study was to evaluate the therapeutic efficacy of dendritic cell (DC)-tumor fusion hybrids with Toll-like receptor (TLR) agonists.DC-tumor fusion hybrids were generated by electrofusion and injected into the inguinal lymph nodes of C57BL/6 mice with 3-day established pulmonary metastases. Paired TLR agonists polyinosine:polycytadilic acid [poly(I:C)] and cytosine-phosphate-guanine (CpG) were then injected intraperitoneally. Enzyme-linked immunosorbent assay (ELISA) was used to evaluate interleukin (IL)-12 production from the DC-tumor fusion hybrids in vitro.Fusion + TLR agonists (60 metastases) had s...
Source: Head and Neck - November 11, 2009 Category: ENT & OMF Authors: Edward I. Cho, Chunrui Tan, Gary K. Koski, Peter A. Cohen, Suyu Shu, Walter T. Lee Source Type: journals

Transoral CO2 laser treatment for Tis-T3 glottic cancer: The University of Brescia experience on 595 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transoral CO2 laser surgery has been accepted as a valuable therapeutic option for glottic cancer.This was a retrospective analysis of 595 patients. Five-year overall and disease-specific survivals, local control with laser, locoregional, regional control, and organ preservation rates were calculated. The impact of different variables was calculated by univariate analysis.Overall, disease-specific and disease-free survivals, local control with laser, locoregional, regional control, and organ preservation rates were 87.5%, 99%, 81.3%, 92.7%, 98.9%, 98.2%, and 97.1%, respectively. Univariate analysis showed a significant imp...
Source: Head and Neck - November 10, 2009 Category: ENT & OMF Authors: Giorgio Peretti, Cesare Piazza, Daniela Cocco, Luigi De Benedetto, Francesca Del Bon, Luca Oscar Redaelli De Zinis, Piero Nicolai Source Type: journals

Microvascular free flap reconstruction versus palatal obturation for maxillectomy defectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Palatal obturators and microvascular free flaps are both used to treat patients with maxillectomy defects, however, the optimal technique remains controversial.A retrospective analysis of 113 patients undergoing maxillectomy for cancer was performed. Seventy-three patients received an obturator and 40 patients were reconstructed with a free flap.Speech intelligibility and postoperative diet were comparable between the obturator and free flap groups, except in cases of extensive (>50%) palatal defects, where free flap reconstruction was superior in both aspects (p = .019 and p = .043, respectively). The average time for pre...
Source: Head and Neck - November 9, 2009 Category: ENT & OMF Authors: Mauricio A. Moreno, Roman J. Skoracki, Ehab Y. Hanna, Matthew M. Hanasono Source Type: journals

Arteriovenous malformation in the pretragal region: Case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We reported a case of AVM in the pretragal region, which was successfully removed by complete excision after preoperative selective embolization in a 32-year-old man. Combined superselective and particle embolization is a useful method to decrease the blood flow in the pretragal AVM.We successfully treated the patient for the AVM in the pretragal area by complete excision within 72 hours after the preoperative combined superselective and particle embolization. Although our case is similar to auricular AVMs in point of symptoms and treatment, this is the first case reported at this unusual site. © 2009 Wiley Periodicals, I...
Source: Head and Neck - November 9, 2009 Category: ENT & OMF Authors: Kyung Soo Kim Source Type: journals

Expression of matrix metalloproteinase-1, -7, -9, -13, Ki-67, and HER-2 in epithelial-myoepithelial salivary gland cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The expression of matrix metalloproteinases (MMPs) in epithelial-myoepithelial salivary gland carcinoma has not been studied previously.Immunohistochemistry for MMP-1, -7, -9, -13, Ki-67, and HER-2, as well as HER-2 gene amplification by silver enhanced in situ hybridization was performed in a series of 12 paraffin-embedded histopathologic samples of patients from Canada and Finland.A positive MMP-13 (p = .0022), higher MMP-13 (p = .0274), and higher MMP-9 (p = .0274) index (multiplication of staining intensity by percentage of the positive cells) predicted better overall survival. In disease-specific analysis, higher MMP-...
Source: Head and Neck - November 9, 2009 Category: ENT & OMF Authors: Heikki Luukkaa, Pekka Klemi, Ilmo Leivo, Antti A. Mäkitie, Jonathan Irish, Ralph Gilbert, Bayardo Perez-Ordonez, Pirkko Hirsimäki, Tero Vahlberg, Atte Kivisaari, Veli-Matti Kähäri, Reidar Grénman Source Type: journals

Altered fractionation and adjuvant chemotherapy for head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this review was to discuss the role of altered fractionation and adjuvant chemotherapy for patients treated with definitive radiotherapy (RT) for head and neck squamous cell carcinoma (HNSCC).This review explores the pertinent literature and discusses the optimal management of previously untreated patients with stage III-stage IVA and/or -B HNSCCs.Depending on the schedule, altered fractionation improves locoregional control and survival. Both hyperfractionation and concomitant boost RT improve locoregional control and are associated with improved overall survival (OS). Adjuvant chemotherapy improves OS; the gre...
Source: Head and Neck - November 6, 2009 Category: ENT & OMF Authors: William M. Mendenhall, Charles E. Riggs, Mikhail Vaysberg, Robert J. Amdur, John W. Werning Source Type: journals

Meeting Report - The NIDCR 2nd Salivary Gland Tumor Meeting, November 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Head and Neck)
Source: Head and Neck - November 4, 2009 Category: ENT & OMF Authors: Adel K. El-Naggar, Frederic J. Kaye, Yasaman Shirazi, J. Silvio Gutkind, Arlene A. Forastiere Source Type: journals

Detection of metachronous esophageal squamous carcinoma in patients with head and neck cancer with use of transnasal esophagoscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of transnasal esophagoscopy was examined for detecting metachronous esophageal squamous carcinoma in patients with head and neck squamous cell carcinoma (HNSCC).In all, 398 transnasal esophagoscopies were performed in 293 previously treated patients with HNSCC between December 2007 and January 2009.Metachronous esophageal squamous carcinoma was detected in 15 (5.1%) patients. The prevalence rate was 15.9% (7/44) in patients with hypopharyngeal cancer, significantly higher than the 8.3% (2/24) with laryngeal, 7.1% (3/42) with oropharyngeal, and 1.6% (3/183) with oral cancer (p = .001). The stage distributions of eso...
Source: Head and Neck - November 3, 2009 Category: ENT & OMF Authors: Yan-Ye Su, Fu-Min Fang, Hui-Ching Chuang, Sheng-Dean Luo, Chih-Yen Chien Source Type: journals

Complementary and alternative medicine use in patients presenting to a head and neck oncology clinicEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to determine the prevalence of complementary and alternative medicine (CAM) use among patients presenting to a head and neck oncology clinic prior to a diagnosis.The study was conducted by administering questionnaires to 102 patients after being seen in the Head and Neck Oncology clinic for their initial consultation. The questionnaire assessed the extent of CAM use, types of CAMs used, and their reasons for use.A total of 132 CAMs were currently being used among 56 patients. The most common CAMs in use were multivitamins (26/132) and vitamin D (21/132). Meditation and yoga were associated with th...
Source: Head and Neck - November 3, 2009 Category: ENT & OMF Authors: Tarren Vyas, Robert D. Hart, Jonathan R. Trites, Timothy J. Philips, Kathleen E. M. Archibald, Judith E. Phillips, S. Mark Taylor Source Type: journals

Immunostaining patterns of CD31 and podoplanin in previously untreated advanced oral/oropharyngeal cancer: Prognostic implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to assess angiogenesis and lymphangiogenesis patterns in advanced oral/oropharyngeal cancer by immunohistochemical techniques.Forty-five patients with advanced oral/oropharyngeal cancer, treated by primary surgery between January 1996 and December 2005, were selected. All cases were followed for at least 24 months. Angiogenesis and lymphangiogenesis were evaluated with antibodies against CD31 and podoplanin, respectively. Survival outcomes were calculated by the Kaplan-Meier method, whereas univariate comparisons were obtained by log-rank, chi-square, and Mann-Whitney tests.Survival correlat...
Source: Head and Neck - November 3, 2009 Category: ENT & OMF Authors: Andrea Bolzoni Villaret, Alberto Schreiber, Fabio Facchetti, Simona Fisogni, Silvia Lonardi, Davide Lombardi, Daniela Cocco, Luca Oscar Redaelli de Zinis, Piero Nicolai Source Type: journals

Accelerated fractionation radiotherapy and late intensification with 2 intra-arterial cisplatin infusions for locally advanced head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was established to determine the maximum tolerated dose of intra-arterial cisplatin (IAC) concurrent with accelerated fractionation radiotherapy for locally advanced head and neck squamous cell carcinoma (HNSCC).We conducted a phase I study. Treatment consisted of 70 Gy/35 fractions/5.8 weeks and 2 weekly IAC infusions during the last 2 weeks.Ten patients were recruited. Two patients had stage III, 1 had stage IVa, and 7 had stage IVb disease. Three patients received IAC at 100 mg/m2, 3 at 125 mg/m2, and 4 at 150 mg/m2. Nine patients received both planned infusions. Dose-limiting toxicity occurred at 150 mg/m2 a...
Source: Head and Neck - November 3, 2009 Category: ENT & OMF Authors: Kwok Hung Yu, Simon C. H. Yu, Edwin P. Hui, Michael K. M. Kam, Alexander C. Vlantis, Edmund Yuen, Anthony T. C. Chan Source Type: journals

Kimura's disease in a white manEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on a rare case of Kimura's disease in the hard palate of a white man.A 56-year-old white man was seen with a rapidly growing mass in the upper jaw. A complete tumor resection with hemimaxillectomy was performed. The tumor, which showed signs of inflammation, was located within the bone and the soft tissue.Kimura's disease was diagnosed by histopathologic examination of the resected tumor.This case demonstrates that Kimura's disease, though rare, is not limited to the Asian population. We present a case of a tumor in a white man. This adds another possibility for uncertain differential diagnoses of rapidly growing...
Source: Head and Neck - November 2, 2009 Category: ENT & OMF Authors: Urs D. A. Müller-Richter, Antonios Moralis, Tobias Reuther, Michael Kochel, Torsten E. Reichert, Oliver Driemel Source Type: journals

Nuclear factor-[kappa]B expression as a novel marker of radioresistance in early-stage laryngeal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion.NF-[kappa]B expression may be a novel marker of radioresistance in early-stage laryngeal cancer. © 2009 Wiley Periodicals, Inc. Head Neck, 2009 (Source: Head and Neck)
Source: Head and Neck - November 2, 2009 Category: ENT & OMF Authors: Kenji Yoshida, Ryohei Sasaki, Hideki Nishimura, Yoshiaki Okamoto, Yoko Suzuki, Tetsuya Kawabe, Miki Saito, Naoki Otsuki, Yoshitake Hayashi, Toshinori Soejima, Kenichi Nibu, Kazuro Sugimura Source Type: journals

Anaplastic thyroid cancer: Clinical outcomes with conformal radiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions.Outcomes for anaplastic thyroid cancer treated with 3DRT or IMRT remain equivalent to historical results. Healthy patients with localized disease who tolerate full dose irradiation can potentially enjoy prolonged survival. Biologically targeted radiosensitization merits prioritized investigation. © 2009 Wiley Periodicals, Inc. Head Neck, 2009 (Source: Head and Neck)
Source: Head and Neck - November 2, 2009 Category: ENT & OMF Authors: Aarti Bhatia, Archana Rao, Kie-Kian Ang, Adam S. Garden, William H. Morrison, David I. Rosenthal, Douglas B. Evans, Gary Clayman, Steven I. Sherman, David L. Schwartz Source Type: journals

Comparison of biofilm formation on new Phonax and Provox 2 voice prostheses - A pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In voice rehabilitation for laryngectomized patients, voice prosthetic biofilm formation is still an unsolved problem. Design and materials of voice prostheses have been altered by manufacturers to improve function and extend the lifetime of devices. The goal of the study was to investigate biofilm formation on Provox 2 and Phonax, recently introduced voice prostheses made of thermoplastic polyurethane.Five laryngectomized patients were equipped with both Phonax and Provox 2 voice prostheses. Microbial colonization was analyzed using standard microbiological methods. Biofilm formation and material infiltration were illustr...
Source: Head and Neck - October 28, 2009 Category: ENT & OMF Authors: Matthias Leonhard, Doris Moser, Adrian Reumueller, Gudrun Mancusi, Wolfgang Bigenzahn, Berit Schneider-Stickler Source Type: journals

Role of intratumoral lymphatic vessels in the lymph node dissemination of laryngopharyngeal squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The development of new markers for lymphatic endothelium allowed the study of intratumoral lymphatic microcirculation, as well as its association with lymph node metastasis.In all, 120 patients with laryngopharyngeal squamous cell carcinoma (LPSCC) without previous treatment were retrospectively studied. The immunohistochemical determination of PA2.26 antigen/podoplanin was used to assess intratumoral lymphatic vessels (ILVs) in the primary tumor.Multivariate analysis revealed that lymph node metastasis was associated with tumor location (p = .001), differentiation grade (p = .02), and ILV (p = .013). Hypopharyngeal and su...
Source: Head and Neck - October 27, 2009 Category: ENT & OMF Authors: Adolfo Hinojar-Gutiérrez, María Encarnación Fernández-Contreras, Solssireé Álvarez-Carrillo, Miguel Quintanilla, Carlos Gamallo Source Type: journals

Three-dimensional photogrammetry for surgical planning of tissue expansion in hemifacial microsomiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We aim to illustrate the applications of 3-dimensional (3-D) photogrammetry for surgical planning and longitudinal assessment of the volumetric changes in hemifacial microsomia.A 3-D photogrammetric system was employed for planning soft tissue expansion and transplantation of a vascularized scapular flap for a patient with hemifacial microsomia. The facial deficiency was calculated by superimposing a mirror of the normal side on the preoperative image. Postsurgical volumetric changes were monitored by serial superimposition of 3-D images.A total of 31 cm3 of tissue expansion was achieved within a period of 4 weeks. A scapu...
Source: Head and Neck - October 27, 2009 Category: ENT & OMF Authors: Yasas S. N. Jayaratne, John Lo, Roger A. Zwahlen, Lim K. Cheung Source Type: journals

Carcinoma arising from pharyngeal diverticulaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report 2 patients with pharyngeal diverticulum carcinoma exhibiting an unusual presentation and good long-term, disease-free survival with normal speech and swallowing.A 70-year-old man with a carcinoma in a recurrent pharyngeal diverticulum excised 20 years previously and a 65-year-old man with a neck mass as the only presentation of pharyngeal diverticulum carcinoma.Our patients were treated with open resection, laryngeal preservation, and postoperative radiotherapy (PORT), resulting in long-term tumor control and disease-free survival of 5 and 15 years (longest reported), respectively.One-stage diverticulectomy with ...
Source: Head and Neck - October 27, 2009 Category: ENT & OMF Authors: Afroze Shah Khan, Raghav C. Dwivedi, Abbas Shah Khan, Khin Thway, Cyril Fisher, Peter H. Rhys-Evans Source Type: journals

New insights in the vascular supply of the human parotid gland - Consequences for parotid gland-sparing irradiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study describes the detailed vascular supply of the human parotid gland. These results may contribute to improve parotid sparing radiotherapy, thus reducing complications such as xerostomia in the future. © 2009 Wiley Periodicals, Inc. Head Neck, 2009 (Source: Head and Neck)
Source: Head and Neck - October 27, 2009 Category: ENT & OMF Authors: Marjolein J. van Holten, Judith M. Roesink, Chris H. J. Terhaard, Pètra M. Braam Source Type: journals

Clinical grading of oral mucosa by curve-fitting of corrected autofluorescence using diffuse reflectance spectraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Laser-induced autofluorescence (LIAF) and diffuse reflectance (DR) were collectively used in this clinical study to improve early oral cancer diagnosis and tissue grading.LIAF and DR emission from oral mucosa were recorded on a fiber-optic spectrometer by illumination with a 404-nm diode laser and tungsten halogen lamp in 36 healthy volunteers and 40 lesions of 20 patients.Absorption dips in LIAF spectra at 545 and 575 nm resulting from changes in oxygenated hemoglobin were corrected using DR spectra of the same site. These corrected spectra were curve-fitted using Gaussian spectral functions to determine constituent emiss...
Source: Head and Neck - October 13, 2009 Category: ENT & OMF Authors: Rupananda Jayachandra Mallia, Narayanan Subhash, Anitha Mathews, Rejnish Kumar, Shiny Sara Thomas, Paul Sebastian, Jayaprakash Madhavan Source Type: journals

Endoglin as a marker in cervical paragangliomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study compares the expression of endoglin with vascular endothelial growth factor (VEGF), commonly used as a marker for neoangiogenesis in cervical paragangliomas (CPG).The CPG were surgically obtained from 5 patients and compared with nontumoral lung obtained from patients subjected to pulmonary resection. Detection with specific antibodies was used to determine the expression of the proteins VEGF and endoglin. The expressions of hypoxia-inducible factor (HIF) and vascular cell adhesion molecule-1 (VCAM-1) were used to determine the degree of hypoxia and capillarization, respectively.Endoglin is located at the plasma...
Source: Head and Neck - October 12, 2009 Category: ENT & OMF Authors: Nélida Eleno, Annette Düwel, Angel Muñoz, José Paz-Bouza, Jose-Miguel López-Novoa, Francisco Lozano Source Type: journals

Inhibition of invasion and migration of salivary gland adenocarcinoma cells by 5[prime]-nitro-indirubinoxime (5[prime]-NIO)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
5[prime]-Nitro-indirubinoxime (5[prime]-NIO) is a derivative of the bis-indole indirubin that exhibits anticancer activities. The present study investigated the anti-invasive action of 5[prime]-NIO in salivary gland ductal adenocarcinoma, SGT cells.The wound-scratch, migration, and invasion assays were applied to determine the effect of 5[prime]-NIO on the migration capacity and invasiveness of SGT cells. Reverse-transcriptase-polymerase chain reaction (RT-PCR) and Western blot were performed to evaluate the impacts of 5[prime]-NIO on the expression of [beta]1 integrin and matrix metalloproteinases MMP-2 (gelatinase-A) and...
Source: Head and Neck - October 12, 2009 Category: ENT & OMF Authors: Ji-Hye Yoon, Soo-A Kim, Jae-Il Kim, Jong-Hwan Park, Sang-Gun Ahn, Jung-Hoon Yoon Source Type: journals

Targeted radionuclide therapy in head and neck cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is great potential for targeted radionuclide therapy (TRT) in the treatment of head and neck cancer. In recent years, developments in fields such as antigen screening, protein engineering, and cancer biology have facilitated the rational design of targeted pharmaceuticals, with monoclonal antibodies forming the most rapidly expanding category. TRT may be a promising way to improve targeted treatment, especially in head and neck cancer, because of the intrinsic radiosensitivity of this tumor type. TRT may also provide a good foundation on which to build rational biologic combination therapies. In the next few years th...
Source: Head and Neck - October 12, 2009 Category: ENT & OMF Authors: Marika V. Nestor Source Type: journals

Morbidity and mortality of thyroidectomy for substernal goiterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Our objective was to evaluate morbidity and mortality of thyroidectomy in substernal goiters and identify patients at risk for these events.The medical records of 127 patients with substernal goiters were retrospectively reviewed.The most common preoperative symptom was shortness of breath (48%). 13% of the 127 patients were asymptomatic. Preoperative imaging identified tracheal deviation in 69% and tracheal compression in 41% of the cases. Substernal goiters were resected via a cervical approach in 100% of the cases. Six patients (5%) had postoperative hoarseness, 1 had permanent vocal cord paralysis, and 19 (15%) had tra...
Source: Head and Neck - October 12, 2009 Category: ENT & OMF Authors: Bassam Abboud, Ghassan Sleilaty, Nadine Mallak, Hicham Abou Zeid, Bassam Tabchy Source Type: journals

Atlas of Skull Base Surgery and Neurotology, 2nd EditionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Head and Neck)
Source: Head and Neck - October 12, 2009 Category: ENT & OMF Authors: Moises A. Arriaga Source Type: journals

Practical Head and Neck OncologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Head and Neck)
Source: Head and Neck - October 12, 2009 Category: ENT & OMF Authors: Amy Anne D. Lassig Source Type: journals

Extraesophageal RefluxEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Head and Neck)
Source: Head and Neck - October 12, 2009 Category: ENT & OMF Authors: Lisa T. Galati Source Type: journals

The Larynx, 3rd Edition, Volumes 1 and 2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Head and Neck)
Source: Head and Neck - October 12, 2009 Category: ENT & OMF Authors: John M. Schweinfurth Source Type: journals

Revision Surgery in OtolaryngologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Head and Neck)
Source: Head and Neck - October 12, 2009 Category: ENT & OMF Authors: Kelly Michele Malloy Source Type: journals

Upregulation of interleukin-1 by Epstein-Barr virus latent membrane protein 1 and its possible role in nasopharyngeal carcinoma cell growthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated what EBV-encoded proteins were involved in such IL-1 production.IL-1[alpha] and IL-1[beta] messenger ribonucleic acids (mRNAs) were detected in the EBV latent membrane protein 1 (LMP1) transfectant (LMP135) only by reverse transcriptase-polymerase chain reaction (RT-PCR). LMP1-mediated IL-1[alpha] and IL-1[beta] production could be enhanced by tumor necrosis factor alpha (TNF-[alpha]), determined by enzyme-linked immunosorbent assay (ELISA). Moreover, IL-1[alpha] and IL-1[beta] mRNAs and proteins were increased in a dose-dependent manner in epithelial cells transiently transfected by an LMP1 plasmid...
Source: Head and Neck - October 12, 2009 Category: ENT & OMF Authors: Yu-Tzu Huang, Mei-Ying Liu, Ching-Hwa Tsai, Te-Huei Yeh Source Type: journals

Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 2001, we presented a Cox regression model that is able to predict survival of the newly diagnosed patient with head and neck squamous cell carcinoma (HNSCC). This model is based on the TNM classification and other important clinical variables such as age at diagnosis, sex, primary tumor site, and prior malignancies. We aim to improve this model by including comorbidity as an extra prognostic variable. Accurate prediction of the prognosis of the newly diagnosed patient with head and neck cancer can assist the physician in patient counseling, clinical decision-making, and quality maintenance.All patients with HNSCC of the...
Source: Head and Neck - October 12, 2009 Category: ENT & OMF Authors: Frank R. Datema, Marciano B. Ferrier, Marc P. van der Schroeff, Robert J. Baatenburg de Jong Source Type: journals

Extracapsular spread in oral squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Extracapsular spread (ECS) in the cervical lymph nodes represents the most significant adverse prognostic indicator in oral squamous cell carcinoma (OSCC).In a consecutive cohort of OSCC treated by primary surgery, ECS was seen in 25% (101) of 400 patients.ECS doubled the incidence of local recurrence and distant metastases, but tripled regional failure. The recurrences occurred sooner in ECS than in non-ECS cases (206 vs 334 days, p = .04). Patients with macroscopic ECS had a 5-year overall survival (OS) of 19% compared with 31% in microscopic ECS. MRI neck staging offered poor sensitivity, especially in microscopic ECS. ...
Source: Head and Neck - October 12, 2009 Category: ENT & OMF Authors: Richard J. Shaw, Derek Lowe, Julia A. Woolgar, James S. Brown, E. David Vaughan, Christopher Evans, Huw Lewis-Jones, Rebecca Hanlon, Gillian L. Hall, Simon N. Rogers Source Type: journals

Hyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Resistance to chemotherapy is a major limitation in the treatment of head and neck squamous cell carcinomas (HNSCCs), accounting for high mortality rates in patients. Here, we investigated the role of replication protein A (RPA) in cisplatin and etoposide resistance.We used 6 parental HNSCC cell lines. We also generated 1 cisplatin-resistant progeny subline from a parental cisplatin-sensitive cell line, to examine cisplatin resistance and sensitivity with respect to RPA2 hyperphosphorylation and cell-cycle response.Cisplatin-resistant HNSCC cell levels of hyperphosphorylated RPA2 in response to cisplatin were 80% to 90% gr...
Source: Head and Neck - September 28, 2009 Category: ENT & OMF Authors: Karoline C. Manthey, Jason G. Glanzer, Diana D. Dimitrova, Greg G. Oakley Source Type: journals

Role of postoperative irradiation for patients with bilateral cervical nodal metastases from cutaneous melanoma: A critical assessmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to evaluate the role of regional nodal radiation therapy (RT) for patients with bilateral cervical nodal metastases from melanoma.Between 1998 and 2008, 16 patients with bilateral cervical metastases without distant metastases were treated with postoperative RT (30 Gy in 5 fractions delivered twice weekly).Median follow-up was 5 months (range, 1-34 months). Median survival was 9 months (95% confidence interval [CI], 0-23 months). Overall survival was 68%, 50%, and 27% at 6, 12, and 24 months, respectively. Regional nodal control was 74% and 64% at 6 and 12 months, respectively. Rates of developmen...
Source: Head and Neck - September 28, 2009 Category: ENT & OMF Authors: B. Ashleigh Guadagnolo, Jeffrey N. Myers, Gunar K. Zagars Source Type: journals

Existence of MRI-negative clinical (large nerve) perineural squamous cell carcinoma spreadEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Head and Neck)
Source: Head and Neck - September 28, 2009 Category: ENT & OMF Authors: Kenneth Chung Wah Lee, Benedict Panizza Source Type: journals

Laryngeal inflammatory myofibroblastic tumors: Different clinical appearance and histomorphologic presentation of one entityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the clinical presentation, histomorphology, and new molecular findings of 2 cases.Paraffin-embedded specimens were stained immunohistochemically (eg, vimentin, AE1/3, Alk-1, smooth muscle [sm-]actin, p53, Rb1, immunoglobulin G4 [IgG4]). Epstein-Barr virus-encoded RNA (EBER) in situ hybridization and HHV8-polymerase chain reaction (PCR) were done. Comparative genomic hybridization (CGH) was performed.Case 1 was that of a 56-year-old man with an infiltrating plasma-cell-rich tumor (Alk-1-, sm-actin+). Plasma cells were strongly positive for IgG4. CGH was unsuspicious. Case 2 was that of a 34-year-old woman with an ...
Source: Head and Neck - September 28, 2009 Category: ENT & OMF Authors: Hans-Ullrich Völker, Matthias Scheich, Andreas Zettl, Rudolf Hagen, Hans Konrad Müller-Hermelink, Stefan Gattenlöhner Source Type: journals

Dendritic cells pulsed with GST-EGFR fusion protein: Effect in antitumor immunity against head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Overexpression of epidermal growth factor receptor (EGFR) is common in head and neck squamous cell carcinoma (HNSCC). Targeting EGFR is an effective approach to treat EGFR-positive HNSCC. However, the clinical benefits of the present EGFR-targeting agents are still limited in HNSCC patients.Recombinant glutathione-S-transferase (GST)-EGFR fusion protein was produced and purified. Dendritic cells (DCs) of C3H mice were pulsed with fusion protein. Mice were challenged with HNSCC cells before or after vaccination with these DCs, and the cytotoxic T-lymphocyte (CTL) response, interferon-[gamma] (IFN-[gamma]) secretion, tumor g...
Source: Head and Neck - September 28, 2009 Category: ENT & OMF Authors: Bei-Bei Yang, Hua Jiang, Jia Chen, Xing Zhang, Jing-Jia Ye, Jiang Cao Source Type: journals

Methods of monitoring buried flapsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Head and Neck)
Source: Head and Neck - September 28, 2009 Category: ENT & OMF Authors: T. W. Chiu, David S. Y. Wong, A. Burd Source Type: journals

Nonparotid parapharyngeal oncocytoma: A case report and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of a 73-year-old man with a previous history of prostate cancer that had the incidental finding of an 18F-fluorodeoxyglucose (FDG) image of a highly avid parapharyngeal space lesion noted on a follow-up positron emission tomography-computed tomography (PET/CT) scan. Excision of the mass, through a transcervical approach, demonstrated it to be an isolated oncocytoma of the parapharyngeal space, noncontiguous with the parotid gland. Based on our literature search, this may be the first such reported case. A brief review of the available literature examining the known body of knowledge regarding these neopla...
Source: Head and Neck - September 28, 2009 Category: ENT & OMF Authors: James L. Barrese, Sean Lau, Bihong T. Chen, Ellie Maghami Source Type: journals

UltraCision harmonic scalpel versus clamp-and-tie total thyroidectomy: A clinical trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, 90 patients were randomized into group A (classic technique of tying and knots) and group B (harmonic scalpel). We recorded the following: age, sex, pathology, thyroid weight, hemostatic technique, duration of operation, change in calcemia ([Delta]Ca), change in hematocrit ([Delta]Ht), change in hemoglobin ([Delta]Hgb), change in white blood cell count ([Delta]WBC), vocal motility, operative difficulty, postoperative vocal alteration, postoperative pain, complications, blood in the drains, operating time, mass of gland excised per minute, and hospitalization.Differences (p < .05) were observed concerning dur...
Source: Head and Neck - September 28, 2009 Category: ENT & OMF Authors: Theodossis S. Papavramidis, Konstantinos Sapalidis, Nick Michalopoulos, Konstantina Triantafillopoulou, George Gkoutzamanis, Isaak Kesisoglou, Spiros T. Papavramidis Source Type: journals

Biochemical and clinical responses after treatment of a catecholamine-secreting glomus jugulare tumor with gamma knife radiosurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of a 47-year-old man with a symptomatic norepinephrine-hypersecreting GJT treated with definitive single-fraction gamma knife radiosurgery and pharmacologic catecholamine blockade. At a 32-month follow-up, he has experienced significant symptomatic improvement, excellent control of local tumor growth, minimal treatment-related morbidity, and near normalization of catecholamine levels.Radiosurgery was safe and effective in significantly reducing the functional capacity of a paraganglioma. Care must be taken to avoid inducing a hypertensive crisis during and following treatment, and longer follow-up will h...
Source: Head and Neck - September 28, 2009 Category: ENT & OMF Authors: William A. Castrucci, Veronica L. S. Chiang, Ilja Hulinsky, Jonathan P. S. Knisely Source Type: journals

Head and neck squamous cell cancer and the human papillomavirus: Summary of a National Cancer Institute State of the Science Meeting, November 9-10, 2008, Washington, D.C.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Head and Neck)
Source: Head and Neck - September 28, 2009 Category: ENT & OMF Authors: David J. Adelstein, John A. Ridge, Maura L. Gillison, Anil K. Chaturvedi, Gypsyamber D'Souza, Patti E. Gravitt, William Westra, Amanda Psyrri, W. Martin Kast, Laura A. Koutsky, Anna Giuliano, Steven Krosnick, Andy Trotti, David E. Schuller, Arlene Forasti Source Type: journals

Respiratory-swallow phase patterns and their relationship to swallowing impairment in patients treated for oropharyngeal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Unstable respiratory-swallowing coordination has been associated with disorders and disease. The goals of this study were (1) to describe respiratory-swallow patterns in patients with dysphagia consequent to treatments for cancers of the oropharynx and (2) to determine the association between respiratory-swallow patterns, airway invasion, and overall severity of swallowing impairment.This prospective, cross-sectional design compared respiratory-swallow patterns in 20 patients treated for oropharyngeal cancer and 20 healthy, age-matched control participants. Nasal airflow direction was synchronously recorded with videofluor...
Source: Head and Neck - September 24, 2009 Category: ENT & OMF Authors: Martin B. Brodsky, David H. McFarland, Thomas S. Dozier, Julie Blair, Christopher Ayers, Yvonne Michel, M. Boyd Gillespie, Terry A. Day, Bonnie Martin-Harris Source Type: journals

Evidence-Based OtolaryngologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Head and Neck)
Source: Head and Neck - September 23, 2009 Category: ENT & OMF Authors: Thomas L. Eby Source Type: journals

Prediction of hypocalcemia after using 1- to 6-hour postoperative parathyroid hormone and calcium levels: An analysis of pooled individual patient data from 3 observational studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigate the usefulness of combining calcium and PTH to increase the predictive power.Individual patient data were obtained from 3 studies (152 patients) that fulfilled our criteria (using PTH assay within hours postthyroidectomy to predict symptomatic hypocalcemia).Changes in combined PTH and calcium threshold levels checked 1 to 6 hours after thyroidectomy were excellent in predicting postoperative hypocalcemia. A decrease in PTH of 60%, coupled with a simultaneous decrease in calcium of 10%, 5 to 6 hours postoperatively resulted in a sensitivity and specificity of 100%. However, combined PTH and cal...
Source: Head and Neck - September 23, 2009 Category: ENT & OMF Authors: Jeffrey Saad Jumaily, J. Pieter Noordzij, Alex G. Dukas, Stephanie L. Lee, Victor J. Bernet, Richard J. Payne, Ian K. McLeod, Michael P. Hier, Martin J. Black, Paul D. Kerr, Marco Raffaelli, Rocco Bellantone, Celestino P. Lombardi, Mary S. Dietrich Source Type: journals

Unintentional parathyroidectomy and hypoparathyroidism in secondary central compartment surgery for thyroid cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Unintentional parathyroidectomy is a complication of thyroid surgery. To our knowledge, no study has specifically examined the incidence of inadvertent parathyroidectomy exclusively in patients undergoing secondary central compartment surgery for recurrent or persistent thyroid cancer.The records of 40 patients who underwent 42 secondary central compartment surgeries for thyroid cancer were reviewed to determine the incidence of inadvertent parathyroidectomy.Parathyroid tissue was present on permanent pathology in 31% of SCCSs. Unintentional parathyroidectomy did not have an effect on hypoparathyroidism. Concomitant latera...
Source: Head and Neck - September 23, 2009 Category: ENT & OMF Authors: Michael P. Ondik, Johnathan McGinn, Francis Ruggiero, David Goldenberg Source Type: journals