Head and Neck PathologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Tumor-to-Tumor Metastasis: Renal Cell Carcinoma Metastatic to Papillary Carcinoma of Thyroid—Report of a Case and Review of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a 68-year-old man with history of RCC who presented with a 2.5-cm thyroid nodule. Histologic examination demonstrates a renal cell carcinoma metastatic to a papillary carcinoma of the thyroid. The clinicopathologic features of metastatic disease into a thyroid gland neoplasm are shown, and a review of the literature is presented. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12105-009-0147-9Authors Olga L. Bohn, MetroHealth Medical Center-Case Western Reserve University Department of Pathology Cleveland OH 44109 USALuis E. De las Casas, Paul L. Foster School of Medicine Department...
Source: Head and Neck Pathology - November 14, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Pyostomatitis Vegetans: Cellular Immune Profile and Expression of IL-6, IL-8 and TNF-αEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this study was to investigate the cellular immune profile and the expression of IL-6, IL-8 and TNF-α in tissue biopsies of pyostomatitis vegetans (PV). Working hypothesis was that knowledge of the cellular immune profile and role of mediators such as IL-6, IL-8 AND TNF-alpha may contribute to a better understanding of the pathogenesis of this rare entity. Archival tissues from three patients with clinically and histologically confirmed PV were studied. Analysis of the immune profile of the cellular infiltrate and expression of IL-6 and IL-8 were evaluated by immunohistochemistry. ISH was...
Source: Head and Neck Pathology - November 13, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Epstein-Barr Virus Latent Membrane Protein 1 is not Associated with Vessel Density nor with Hypoxia Inducible Factor 1 Alpha Expression in Nasopharyngeal Carcinoma TissueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Hypoxia-inducible factor-1α (HIF-1α) and the neo-angiogenic factors induced as a result of hypoxia-inducible factor transcriptional activation may contribute to tumorigenesis by inducing vessel formation that in turn provides oxygen and nutrients promoting tumor expansion. In vitro studies of nasopharyngeal carcinoma (NPC), an aggressive malignancy that is nearly always infected by Epstein–Barr virus, show HIF-1α is upregulated by viral latent membrane protein 1 (LMP1). The current study used immunohistochemistry to examine the extent to which HIF-1α and LMP1 are co-expressed in naturally infe...
Source: Head and Neck Pathology - November 11, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Keratocystic Odontogenic TumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The keratocystic odontogenic tumor is a benign developmental tumor with many distinguishing clinical and histologic features. These characteristics are reviewed in the setting of a typical presentation. The newly acknowledged neoplastic potential and its implications for treatment strategies are also discussed. Content Type Journal ArticleCategory Sine qua none Radiology-PathologyDOI 10.1007/s12105-009-0146-xAuthors Elizabeth A. Grasmuck, Naval Medical Center San Diego Department of Anatomic Pathology 34800 Bob Wilson Drive San Diego CA 92134-5000 USABrenda L. Nelson, Naval Medical Center San Die...
Source: Head and Neck Pathology - November 9, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Clinico-Pathologic Conference: Case 3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory 63rd Annual Meeting of the American Academy of Oral and Maxillofacial PathologyDOI 10.1007/s12105-009-0145-yAuthors Brian S. Shumway, Louisville KY USANadim M. Islam, Indianapolis IN USARama Kapoor, Louisville KY USAAnna K. Huang, Louisville KY USAForest W. Arnold, Louisville KY USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - October 31, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Ameloblastoma, Solid/Multicystic TypeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we present a case of a large ameloblastoma that presented with the typical radiographic features of variably sized radiolucent loculations. Microscopically the tumor showed a variety of histologic types, with plexiform and follicular predominating. The tumor was treated with a partial resection of the mandible. Content Type Journal ArticleCategory Sine qua none Radiology-PathologyDOI 10.1007/s12105-009-0144-zAuthors Angela M. Bachmann, Naval Medical Center San Diego Department of Anatomic Pathology 34800 Bob Wilson Drive San Diego CA 92134-5000 USARonald L. Linfesty, Naval Medical Center San Diego D...
Source: Head and Neck Pathology - October 24, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Clinico-Pathologic Conference: Case 4Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A 45 years old male patient presented with an asymptomatic right mandibular mass that extended from the angle to the premolar area. It had been present for 3 months at the time of the initial presentation. Panoramic radiograph revealed an ill-defined unilocular radiolucency. Previous dental treatment included molar extractions and antibiotic therapy. Considerable bleeding was encountered during incisional biopsy. Content Type Journal ArticleCategory 63rd Annual Meeting of the American Academy of Oral and Maxillofacial PathologyDOI 10.1007/s12105-009-0143-0Authors Fabian Ocampo-Acosta, ...
Source: Head and Neck Pathology - October 16, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Clinico-Pathologic Conference: Case 6Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory 63rd Annual Meeting of the American Academy of Oral and Maxillofacial PathologyDOI 10.1007/s12105-009-0140-3Authors Julien E. Ghannoum, Hôpital Notre-Dame (Centre Hospitalier de l’Université de Montréal) Attending, Département de Stomatologie 1560 Sherbrooke Est Montreal PQ H2L 4M1 CanadaNora A. Odingo, Stony Brook University School of Dental Medicine Program Director, General Practice Residency, Clinical Assistant Professor, Department of General Dentistry Stony Brook NY USANathalie Provost, Centre Hospitalier de l’Université de Montréal Attending, Département de Dermato...
Source: Head and Neck Pathology - October 16, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Osteopetrosis Complicated by Osteomyelitis of the Maxilla and Mandible: Light and Electron Microscopic FindingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report presents a case of osteopetrosis in a 25-year-old male, which was complicated by the development of osteomyelitis in the maxilla and mandible following traumatic injury and tooth extractions. The osteomyelitis in the mandible was refractory to marginal resection and antibiotic therapy. Partial resection with mandible reconstruction was then carried out. Light and backscattered electron scanning microscopy revealed sclerosis of spongy bone and variations in mineral density of the bone matrix. There was also a prominent periosteal bone formation in regions affected by osteomyelitis. An 18-month follow-up show...
Source: Head and Neck Pathology - October 15, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Clinico-Pathologic Conference: Case 1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory 63rd Annual Meeting of the American Academy of Oral and Maxillofacial PathologyDOI 10.1007/s12105-009-0141-2Authors Maria Fornatora, Temple University Kornberg School of Dentistry Department of Oral and Maxillofacial Pathology, Medicine and Surgery Philadelphia PA USAAmanda H. Yen, Harvard Medical School Division of Genetics, Department of Medicine Brigham and Women’s Hospital Boston MA USAJie Yang, Temple University Kornberg School of Dentistry Department of Oral and Maxillofacial Pathology, Medicine and Surgery Philadelphia PA USAMichael Pliskin, Temple University Kornberg Schoo...
Source: Head and Neck Pathology - October 13, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Salivary Gland Tumor: A Review of 599 Cases in a Brazilian PopulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, women and the parotid gland were the most affected and pleomorphic adenoma was the most frequent lesion, followed by adenoid cystic carcinoma and Warthin’s tumor. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12105-009-0139-9Authors Flávia Aparecida de Oliveira, Instituto de Patologia Tropical e Saúde Pública of the Universidade Federal de Goiás (UFG) Sector of General Pathology Goiânia-GO BrazilEliza Carla Barroso Duarte, Instituto de Patologia Tropical e Saúde Pública of the Universidade Federal de Goiás (UFG) Sector of General Pathology Goiânia-GO BrazilCláudia Teixeira...
Source: Head and Neck Pathology - September 17, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Malignant Cylindroma of the Scalp Arising in a Setting of Multiple Cylindromatosis: A Case ReportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract An unusual case of malignant cylindroma of the scalp arising in a 79-year-old white female with multiple cylindromatosis is presented. The tumor apparently arose from a cylindroma and had features of spiradenoma. Multiple cylindromatosis is an uncommon hereditary autosomal dominant disease, which is characterized by multiple skin adnexal tumors like cylindromas and trichoepitheliomas and occasional spiradenomas. Cylindroma is an uncommon benign tumor, which originates from skin appendages and is most commonly found on the scalp and face with a strong predilection for middle-aged and elderly females....
Source: Head and Neck Pathology - September 16, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Paraganglioma: Carotid Body TumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Sine qua none Radiology-PathologyDOI 10.1007/s12105-009-0130-5Authors Jacqueline A. Wieneke, Armed Forces Institute of Pathology Division of Otorhinolaryngic-ENT Pathology Room G066-09, 6800 16th Street, N.W. Washington DC 20306-6000 USAAlice Smith, Armed Forces Institute of Pathology Department of Radiology Washington DC USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - August 22, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Her-2 Immunohistochemical Expression in Oral Squamous Cell Carcinomas is Associated with Polysomy of Chromosome 17, Not Her-2 AmplificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Based on the prognostic role of Her-2 amplification and protein overexpression in breast cancer, various studies have been performed in oral squamous cell carcinomas (OSCC) with inconsistent results. As in invasive breast carcinomas Her-2 overexpression has been related to an increased number of chromosome 17 copies, a common chromosomal alteration in OSCC, we evaluated the association between polysomy 17 and Her-2 protein expression in a series of primary OSCC. Forty-one incisional biopsies of primary OSCC were included in the study. Protein expression was evaluated immunochistochemically with CB11...
Source: Head and Neck Pathology - August 21, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Head and Neck Sentinel Lymph Node Biopsy: Current State of the ArtEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Sentinel node biopsy is an alternative to elective neck dissection for the management of T1/T2 oral and oro-pharyngeal squamous cell carcinomas and is also finding application to head and neck cancer at other sites. The main clinical aim of sentinel node biopsy is to achieve better staging and there is now evidence that the procedure reduces morbidity. Reported detection rates for sentinel neck nodes are greater than 95% and there is also a negative predictive value of 95% for negative sentinel nodes. Current histopathological protocols have been developed for use in the research setting and are des...
Source: Head and Neck Pathology - August 20, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Head and Neck Squamous Cell Carcinoma in the Young: A Spectrum or a Distinct Group? Part 2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews changes at a molecular level in the typical HNSCC patient (the over 40 year old male smoker) and compares the profile to that of the young adult with HNSCC. Human papillomavirus infection with high risk types 16 and 18 has widely been reported as one of the prominent mechanisms behind the development of oropharyngeal cancer. A review of recent studies in relation to HPV and HNSCC is undertaken in this article, in an effort to examine the role that HPV plays in the development of HNSCC in young adults. Content Type Journal ArticleCategory Head and Neck Pre-Meeting of the 22nd European Congress of...
Source: Head and Neck Pathology - August 20, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Common Head and Neck Cases in Our Consultation Referrals: Diagnostic Dilemmas in Inverted PapillomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Papillomas of the nose and paranasal sinuses comprise three morphologically distinct variants—everted papilloma, inverted papilloma and cylindric cell papilloma in descending order of frequency. Recurrence of everted papilloma is unusual and malignant change does not occur. However, inverted papilloma is associated with multiple recurrences and malignant change. The histology of low grade squamous cell carcinoma of the nose may mimic that of inverted papilloma and low grade squamous cell carcinoma may coexist with inverted papilloma and be present in the same biopsy material. There is a high index...
Source: Head and Neck Pathology - August 19, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Head and Neck Squamous Cell Carcinoma in the Young: A Spectrum or a Distinct Group? Part 1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract While most head and neck squamous carcinoma (HNSCC) occurs in older people, an increasing number of young patients are being affected worldwide, with up to 5.5% <40. These are predominantly oral and oropharyngeal cancers. Some patients have heavy exposure to the usual risk factors, but an increasing number do not. Part of this trend appears to be due to rising numbers of HPV associated tonsil carcinoma, particularly in males (smokers and non-smokers). A subset of young patients, however, is non-smoking females usually with tongue cancers, not related to HPV, the aetiology of which is unclear. Var...
Source: Head and Neck Pathology - August 19, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Fascin Over Expression is Associated with Dysplastic Changes in Sinonasal Inverted Papillomas: A Study of 47 CasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Sinonasal inverted papilloma (IP) is a primary benign lesion with a tendency for local recurrence. Malignant transformation may develop in up to 15% of cases. Fascin (Fascin 1) is an actin cross-link binding protein required for the formation of actin-based cell-surface protrusions and cell motility. Fascin up-regulation in lung, gastric, breast and hepatobiliary carcinomas correlates with aggressiveness and decreased survival. Here we evaluate immunohistochemical expression of fascin in 47 sinonasal IPs from 34 patients. Fascin over-expression is significantly more common in sinonasal IP with high-...
Source: Head and Neck Pathology - August 14, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Current State of Neck Dissection in the United StatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The status of the cervical lymph nodes is the most important prognosticator in head and neck squamous cell carcinoma. The neck dissection is both a therapeutic and staging procedure and has evolved to include various types with standardized level designations (I–VI) for lymph node groups: the radical neck dissection, modified radical neck dissection, the selective neck dissection, and the extended neck dissection. The gross and histologic examination of a neck dissection should provide the critical information (size of metastasis, number of lymph nodes involved) for staging purposes. Additionally,...
Source: Head and Neck Pathology - August 7, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Papillomas of the External Ear Canal: Report of Ten cases in Chinese Patients with HPV In Situ HybridizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report HPV ISH analysis in ten cases of papillomas, involving the external ear canal in Chinese patients. These papilloma excrescences were less than 1 cm in diameter, and were benign morphologically. Automated HPV ISH analysis was performed for the hybridization of DNA probes, including both low-risk and high-risk HPV subtypes. HPV ISH results revealed that seven out of ten cases were positive for low-risk HPV (6, 11), three cases demonstrated no hybridization for low-risk HPV probe, and none of the cases revealed any detection of high-risk HPV (16, 18, 31, 33, 35, 39, 51, 52, 56, 58, and 66). On follow-up af...
Source: Head and Neck Pathology - August 2, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Syphilis: The Renaissance of an Old Disease with Oral ImplicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Syphilis is caused by Treponema pallidum an anaerobic filamentous spirochete. In recent years, striking outbreaks have occurred in USA, Canada, Russia, China and some areas of Central and Eastern Europe. Main epidemiology changes reflect sex industry, sexual promiscuity, decreasing use of barrier protection (i.e. condoms) due to false sense of security that nowadays sexually transmitted diseases are curable and lack of pertinent knowledge. Considering that the initial presentation of syphilis may be the oral cavity, it is of great relevance to include this disease in the differential diagnosis of un...
Source: Head and Neck Pathology - July 24, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

What’s New in the AFIP Fascicle on Salivary Gland Tumors: A Few Highlights from the 4th Series AtlasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract After a 12 year interval from the previous fascicle, a new fascicle on Tumors of the Salivary Glands in the new fourth series of the AFIP Atlas of Tumor Pathology was published in 2008. The data, presentation, illustrations, tables, and physical characteristics of the newest fascicle have been updated and improved. There have only been a few alterations and additions to the classification of tumors and tumor-like non-neoplastic conditions of salivary gland. Three of the most significant are discussed in this paper. Sialoblastoma has been reclassified as malignant; inflammatory pseudotumor has been r...
Source: Head and Neck Pathology - July 23, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Olfactory NeuroblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Few neoplasms are unique to the sinonasal tract, but sinonasal undifferentiated carcinoma and olfactory neuroblastoma are malignant tumors which require unique management. Due to the rarity of these tumors, practicing pathologists are not always aware of their distinctive clinical, radiographic, histologic, immunohistochemical, and molecular features. These cases are frequently submitted for consultation, further suggesting the diagnostic difficulties inherent to these tumors. Specifically, olfactory neuroblastoma is a neoplasm that can histologically mimic many tumors within the sinonasal tract, ma...
Source: Head and Neck Pathology - July 21, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

HPV-Related Nonkeratinizing Squamous Cell Carcinoma of the Oropharynx: Utility of Microscopic Features in Predicting Patient OutcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Human papilloma virus (HPV) is an etiologic agent in a subset of oropharyngeal squamous cell carcinomas (SCCs). The aim of this study was to sub-classify SCC of the oropharynx based upon histologic features into nonkeratinizing (NK) SCC, keratinizing (K) SCC, and hybrid SCC, and determine the frequency of HPV and patient survival in each group. Patients with oropharyngeal SCC with a minimum of 2 years of clinical follow-up were identified from radiation oncology databases from 1997 to 2004. All patients received either up front surgery with postoperative radiation or definitive radiation based ...
Source: Head and Neck Pathology - July 11, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report eight cases of HCCC identified at two academic institutions in six women and two men, ranging in age from 25 to 86 years. Histologically, all cases demonstrated cords, trabeculae, and nests of monomorphic clear cells as well as cells with eosinophilic granular cytoplasm. Mild cellular atypia was occasionally seen and mitoses were very rare. Seven cases demonstrated a hyalinized stroma, and one case, a myxoid stroma. Immunohistochemically, the tumor cells were positive for epithelial markers and negative for desmin and actin. Seven cases were negative for S-100. Cells were also positive for periodic acid...
Source: Head and Neck Pathology - July 6, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Metastases to the Head and Neck: An OverviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract This paper provides a review of the more common tumors to metastasize to 12 anatomic subsites of the head and neck, exclusive of cervical lymph nodes. Emphasis is placed on clinical rather than subclinical metastases discovered at autopsy. Content Type Journal ArticleCategory Head and Neck Pre-Meeting of the 22nd European Congress of PathologyDOI 10.1007/s12105-009-0123-4Authors Leon Barnes, University of Pittsburgh School of Medicine Pittsburgh PA USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 6, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

High Grade Transformation in Adenoid Cystic Carcinoma of the Parotid: Report of a Case with Cytologic, Histologic and Immunohistochemical StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the first case of ACC with high grade transformation involving the parotid. A 54-year-old man with a history of right parotid painful swelling from 1.5 years presented with recent increase in size of the swelling and facial paresis of 2 months duration. The locally invasive salivary neoplasm was composed predominantly of an undifferentiated carcinoma with foci of conventional ACC occupying less than 10% of tumor area. Immunohistochemical study of the undifferentiated component as compared to conventional ACC showed greater over-expression of p53 and Ki-67. Her-2/Neu was negative in both components....
Source: Head and Neck Pathology - June 20, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

A Case of Recurrent Multifocal Central Giant Cell GranulomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract One case of recurrent multifocal central giant cell granulomas (CGCG) is presented. Initially, the lesions presented concurrently in the maxilla and mandible with subsequent recurrence in the mandible. Now, two recurrences are seen in the maxillary sinus and ethmoid region. The literature regarding multifocal CGCG is reviewed. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12105-009-0119-0Authors Elizabeth Bilodeau, University of Pittsburgh School of Dental Medicine Department of Diagnostic Sciences Pittsburgh PA USAKhalid Chowdhury, University of Colorado Center for Craniofacial & ...
Source: Head and Neck Pathology - June 11, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Chondromyxoid Fibroma of Sphenoid Sinus with Unusual Calcifications: Case Report with Literature ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report one case of CMF involving the sphenoid sinus mimicking a chondrosarcoma. The tumor mass showed calcifications on images and histology. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12105-009-0121-6Authors Luc G. T. Morris, New York University School of Medicine Department of Otolaryngology 550 First Avenue, HCC-3C New York NY 10016 USAJordan Rihani, New York University School of Medicine Department of Otolaryngology 550 First Avenue, HCC-3C New York NY 10016 USARichard A. Lebowitz, New York University School of Medicine Department of Otolaryngology 550 First Avenue, HCC-3C New York NY 10016 U...
Source: Head and Neck Pathology - June 10, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Mario A. Luna, M.D. The University of Texas M.D. Anderson Cancer Center (January 21, 1935 to November 9, 2008)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ObituaryDOI 10.1007/s12105-009-0120-7Authors Adel K. El-Naggar, The University of Texas M.D. Anderson Cancer Center 1515 Holcombe Blvd., Unit 085 Houston TX 77030 USAJohn G. Batsakis, The University of Texas M.D. Anderson Cancer Center 1515 Holcombe Blvd., Unit 085 Houston TX 77030 USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - June 7, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Cellular Angiofibroma of Oral Mucosa: Report of Two CasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Cellular angiofibroma is a benign vascular neoplasm that typically arises in the vulva, perineal, and paratesticular region. Microscopically the lesions exhibit multiple small, non-dilated capillary channels, many of which contain erythrocytes. The endothelial lining cells are prominent, with monomorphic oval nuclei. Interposed among the vessels are both delicate and mature collagen fibers with fibroblastic hypercellularity that is variable in older lesions where sclerosis is prominent. The lesions usually do not recur following simple excision. Recent evidence indicates that cellular angiofibromas ...
Source: Head and Neck Pathology - May 31, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Glandular Odontogenic Cyst: Report of Two Cases and Review of LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Glandular odontogenic cyst (GOC) is an uncommon jaw bone cyst of odontogenic origin described in 1987 by Gardner et al. It is a cyst having an unpredictable and potentially aggressive behaviour. It also has the propensity to grow to a large size and tendency to recur with only 111 cases having been reported thus far. The first case occurred in a 42-year-old female and presented as a localized swelling extending from 19 to 29 regions. There was a history of traumatic injury at the site. There was evidence of bicortical expansion and radiographs revealed a multilocular radiolucency. The second case oc...
Source: Head and Neck Pathology - May 24, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Primary Extracranial Meningiomas: An Analysis of 146 CasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Primary extracranial meningiomas are rare neoplasms, frequently misdiagnosed, resulting in inappropriate clinical management. To date, a large clinicopathologic study has not been reported. One hundred and forty-six cases diagnosed between 1970 and 1999 were retrieved from the files of the Armed Forces Institute of Pathology. Histologic features were reviewed, immunohistochemistry analysis was performed (n = 85), and patient follow-up was obtained (n = 110). The patients included 74 (50.7%) females and 72 (49.3%) males. Tumors of the skin were much more common in males than femal...
Source: Head and Neck Pathology - May 20, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Non-Functional Parathyroid Carcinoma: A Review of the Literature and Report of a Case Requiring Extensive SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Parathyroid carcinoma is a rare malignancy, and only accounts for 0.5–2% of cases of primary hyperparathyroidism. Less than 10% of parathyroid carcinomas are non-functional, and as such, they have been rarely reported in the literature. Importantly, margin status at resection is related to prognosis, and only a handful of case reports of non-functional carcinoma note this important parameter. Here we report the first case of non-functional parathyroid carcinoma with negative margins, and review the literature on this rare entity. Whether functional or non-functional, parathyroid carcinoma can ofte...
Source: Head and Neck Pathology - April 28, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Solitary Fibrous Tumor of the Oral Cavity: Clinicopathologic and Immunohistochemical Study of 21 CasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe clinical, morphologic, and immunohistochemical features of 21 cases of solitary fibrous tumor presenting in the oral cavity. There were 9 male and 12 female patients with a median age of 51 years (range 37–83). The most common locations included the buccal mucosa (the most common site), lip, maxillary or mandibular vestibule and tongue. Histopathologic examination showed well-circumscribed tumors with two well-defined patterns: the classic pattern with densely cellular areas alternating with hypocellular areas in a variably collagenous, vascular stroma and a more uniformly sclerotic pattern with only...
Source: Head and Neck Pathology - April 28, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Orthokeratinized Odontogenic Cyst of the Mandible with Heterotopic CartilageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Cartilaginous metaplasia is a rare but well-documented phenomenon occurring in the wall of odontogenic keratocyst. The mural cartilage not associated with odontogenic keratocyst has been reported only once in a maxillary teratoid cyst of congenital origin to our knowledge. A case presented is a 38-year-old man with intraosseous keratinizing epidermoid cyst in the mandible, the wall of which contained a nodule of mature hyaline cartilage. The present lesion likely represents a previously undescribed, histologic hybrid consisting of orthokeratinized odontogenic cyst and cartilaginous heterotopia. C...
Source: Head and Neck Pathology - April 28, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Acinic Cell Carcinoma with Extensive Neuroendocrine Differentiation: A Diagnostic ChallengeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Primary salivary gland carcinoma with neuroendocrine differentiation is of rare occurrence, especially so in the parotid gland. Amongst the various reported primary tumors with neuroendocrine differentiation, acinic cell carcinoma (ACC) one such tumor. A 48 year old lady presented with a gradually increasing right infra-auricular swelling for a period of 1 year which enlarged suddenly in a short period. Contrast Enhanced Computed Tomography (CECT) suggested diagnosis of Pleomorphic Adenoma. Fine Needle Aspiration Cytology (FANC) yielded a cystic fluid suggesting a possibility of Warthin’...
Source: Head and Neck Pathology - March 26, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Sialadenosis in Patients with Advanced Liver DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Sialadenosis (sialosis) has been associated most often with alcoholic liver disease and alcoholic cirrhosis, but a number of nutritional deficiencies, diabetes, and bulimia have also been reported to result in sialadenosis. The aim of this study was to determine the prevalence of sialadenosis in patients with advanced liver disease. Patients in the study group consisted of 300 candidates for liver transplantation. Types of liver disease in subjects with clinical evidence of sialadenosis were compared with diagnoses in cases who had no manifestations of sialadenosis. The data were analyzed for signif...
Source: Head and Neck Pathology - March 26, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Multinucleated Giant Cells’ Incidence, Immune Markers, and Significance: A Study of 172 Cases of Papillary Thyroid CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Multinucleated giant cells (MGCs) are often detected in cases of papillary thyroid carcinoma (PTC). Their origin and significance, however, has not been established. One possibility is that they form in response to injury induced by fine needle aspiration biopsy (FNAB). Other hypotheses are that the chemically-altered colloid produced by PTC induces MGCs to act as colloidophages, or else MGCs are a non-specific immune response ingesting neoplastic follicle cells. We assigned 172 cases of PTC a semi-quantitative score for MGCs. Cases with “many” MGCs were immunohistochemically stained for AEI/AEI...
Source: Head and Neck Pathology - March 10, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Adenoid Cystic Carcinoma ex Pleomorphic Adenoma of the Parotid GlandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a new case of AdCC ex PA in the parotid gland of a 62 year-old woman. In our patient, there was a short interval of time between parotidectomy and local recurrence and rapid development of distant metastases. Although most of the reported cases are considered low-grade, evidence is presented here that AdCC can take the form of a high-grade malignancy in PA. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12105-009-0108-3Authors Fumio Ide, Tsurumi University School of Dental Medicine Department of Pathology 2-1-3 Tsurumi, Tsurumi-ku Yokohama 230-8501 JapanKenji Mishima, Tsurumi Universit...
Source: Head and Neck Pathology - February 28, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Update to the College of American Pathologists Reporting on Thyroid CarcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The new CAP protocol for reporting of thyroid carcinomas is a step toward improving the clinical value of the histopathologic reporting of TC. Large meticulous clinico-pathologic and molecular studies with long term follow up are still needed in order to increase the impact of microscopic examination on the prognosis and management of TC. Content Type Journal ArticleCategory Proceedings of the 2009 North American Society of Head and Neck Pathology Companion Meeting (Boston, MA)DOI 10.1007/s12105-009-0109-2Authors Ronald Ghossein, Memorial Sloan-Kettering Cancer Center Department of Pathology 1275 York Ave...
Source: Head and Neck Pathology - February 28, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

An Update on Grading of Salivary Gland CarcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Histologic grade is a significant predictor of outcome in salivary gland carcinomas. However, the sheer variety of tumor type and the rarity of these tumors pose challenges to devising highly predictive grading schemes. As our knowledge base has evolved, it is clear that carcinoma ex pleomorphic adenoma is not automatically a high grade tumor as is traditionally suggested. These tumors should be further qualified as to type/grade of carcinoma and extent, since intracapsular and minimally invasive carcinomas ex pleomorphic adenoma behave favorably. The two carcinoma types for which grading schemes ar...
Source: Head and Neck Pathology - February 25, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

The Changing Face of Head and Neck Cancer in the 21st Century: The Impact of HPV on the Epidemiology and Pathology of Oral CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The longstanding notion that head and neck squamous cell carcinoma (HNSCC) is a uniform disease process is changing. Divergence in epidemiologic trends among HNSCCs arising in different anatomic subsites has introduced a view that HNSCC is a heterogeneous group. Analysis of molecular genetic changes discloses not just individual tumor differences, but also consistent large-scale differences that permit the recognition of important tumor subtypes. One recently recognized subtype is the human papillomavirus (HPV)-positive oropharyngeal carcinoma. HPV-positive oropharyngeal cancer now dominates the hea...
Source: Head and Neck Pathology - February 24, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Diagnosis and Reporting of Follicular-Patterned Thyroid Lesions by Fine Needle AspirationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Over the past 3 decades, fine needle aspiration (FNA) has developed as the most accurate and cost-effective initial method for guiding the clinical management of patients with thyroid nodules. Thyroid FNA specimens containing follicular-patterned lesions are the most commonly encountered and include various forms of benign thyroid nodules, follicular carcinomas, and the follicular variant of papillary thyroid carcinoma. Based primarily upon the cytoarchitectural pattern, FNA is used as a screening test for follicular-patterned lesions to identify the majority of patients with benign nodules who can ...
Source: Head and Neck Pathology - February 22, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Dysplasia of the Upper Aerodigestive Tract Squamous EpitheliumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Dysplasia of the oral, laryngeal and oropharyngeal stratified squamous epithelia is a microscopically defined change that may occur in clinically identifiable lesions including erythroplakia, leukoplakia and erythroleukoplakia, lesions that convey a heightened risk for carcinomatous progression. Dysplastic lesions have been classified microscopically according to degree of cytologic atypia and changes in architectural patterns, usually on a three part or four part gradation scale. Vocal cord epithelial lesions are graded according to either the Ljubljana or the World Health Organization (WHO) system...
Source: Head and Neck Pathology - February 22, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Diagnostically Challenging Epithelial Odontogenic Tumors: A Selective Review of 7 Jawbone LesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Considerable variation in the clinicopathologic presentation of epithelial odontogenic tumors can sometimes be confusing and increase the chance of misdiagnosis. Seven diagnostically challenging jawbone lesions are described. There were 2 cases of mistaken identity in our ameloblastoma file. One unicystic type, initially diagnosed and treated as a lateral periodontal cyst, showed destructive recurrence 6 years postoperatively. The other globulomaxillary lesion was managed under the erroneous diagnosis of adenomatoid odontogenic tumor and recurred 4 times over an 11-year period. This tumor was f...
Source: Head and Neck Pathology - February 20, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Mucoepidermoid Carcinoma Arising in a Background of Sialadenoma Papilliferum: A Case ReportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a high grade mucoepidermoid carcinoma arising in a background of sialadenoma papilliferum, at the base of the tongue, an unusual location for minor salivary gland neoplasms. Eleven months after excision and nodal dissection, there is no evidence of recurrence or metastasis. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12105-009-0106-5Authors Wei Liu, SUNY Downstate Medical Center Departments of Pathology 450, Clarkson Avenue Brooklyn NY 11203 USADouglas R. Gnepp, Albert School of Medicine at Brown University, Rhode Island Hospital Department of Pathology 593 Eddy Street Providence RI 02903 ...
Source: Head and Neck Pathology - February 15, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Angiomatosis in the Head and Neck—3 Case ReportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article highlights three unusual cases of angiomatosis reported as benign lesions, in rare sites such as the malar region (predominantly infiltrating the adipose tissue), within the masseter (predominantly infiltrating the muscle) and in the mandible (infiltrating the bone). Histopathological differential diagnosis is also discussed. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12105-009-0105-6Authors Smitha R. Shetty, SDM College of Dental Sciences Dharwad IndiaSudeendra Prabhu, SDM College of Dental Sciences Dharwad India Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1...
Source: Head and Neck Pathology - February 15, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals