Surface electrical stimulation of the auditory cortex preserves efferent medial olivocochlear neurons and reduces cochlear traits of age-related hearing loss
Hear Res. 2024 Apr 12;447:109008. doi: 10.1016/j.heares.2024.109008. Online ahead of print.ABSTRACTThe auditory cortex is the source of descending connections providing contextual feedback for auditory signal processing at almost all levels of the lemniscal auditory pathway. Such feedback is essential for cognitive processing. It is likely that corticofugal pathways are degraded with aging, becoming important players in age-related hearing loss and, by extension, in cognitive decline. We are testing the hypothesis that surface, epidural stimulation of the auditory cortex during aging may regulate the activity of corticofug...
Source: Hearing Research - April 18, 2024 Category: Audiology Authors: V Fuentes-Santamar ía Z Ben ítez-Maicán J C Alvarado I S Fern ández Del Campo M C Gabald ón-Ull M A Merch án J M Juiz Source Type: research
Surface electrical stimulation of the auditory cortex preserves efferent medial olivocochlear neurons and reduces cochlear traits of age-related hearing loss
Hear Res. 2024 Apr 12;447:109008. doi: 10.1016/j.heares.2024.109008. Online ahead of print.ABSTRACTThe auditory cortex is the source of descending connections providing contextual feedback for auditory signal processing at almost all levels of the lemniscal auditory pathway. Such feedback is essential for cognitive processing. It is likely that corticofugal pathways are degraded with aging, becoming important players in age-related hearing loss and, by extension, in cognitive decline. We are testing the hypothesis that surface, epidural stimulation of the auditory cortex during aging may regulate the activity of corticofug...
Source: Hearing Research - April 18, 2024 Category: Audiology Authors: V Fuentes-Santamar ía Z Ben ítez-Maicán J C Alvarado I S Fern ández Del Campo M C Gabald ón-Ull M A Merch án J M Juiz Source Type: research
Two are better than one: Differences in cortical EEG patterns during auditory and visual verbal working memory processing between Unilateral and Bilateral Cochlear Implanted children
The objective of this pioneering study was to identify electroencephalographic (EEG) marker pattern differences in visual and auditory VWM performances in CIs compared to NH peers and possible differences between unilateral cochlear implant (UCI) and bilateral cochlear implant (BCI) users. The main results revealed differences in theta and gamma EEG bands. Compared with hearing controls and BCIs, UCIs showed hypoactivation of theta in the frontal area during the most complex condition of the auditory task and a correlation of the same activation with VWM performance. Hypoactivation in theta was also observed, again for UCI...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Bianca Maria Serena Inguscio Giulia Cartocci Nicolina Sciaraffa Maria Nicastri Ilaria Giallini Pietro Aric ò Antonio Greco Fabio Babiloni Patrizia Mancini Source Type: research
L-Ergothioneine slows the progression of age-related hearing loss in CBA/CaJ mice
Hear Res. 2024 Apr 2;446:109004. doi: 10.1016/j.heares.2024.109004. Online ahead of print.ABSTRACTThe naturally occurring amino acid, l-ergothioneine (EGT), has immense potential as a therapeutic, having shown promise in the treatment of other disease models, including neurological disorders. EGT is naturally uptaken into cells via its specific receptor, OCTN1, to be utilized by cells as an antioxidant and anti-inflammatory. In our current study, EGT was administered over a period of 6 months to 25-26-month-old CBA/CaJ mice as a possible treatment for age-related hearing loss (ARHL), since presbycusis has been linked to hi...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Mark A Bauer Parveen Bazard Alejandro A Acosta Nidhi Bangalore Lina Elessaway Mark Thivierge Moksheta Chellani Xiaoxia Zhu Bo Ding Joseph P Walton Robert D Frisina Source Type: research
Two are better than one: Differences in cortical EEG patterns during auditory and visual verbal working memory processing between Unilateral and Bilateral Cochlear Implanted children
The objective of this pioneering study was to identify electroencephalographic (EEG) marker pattern differences in visual and auditory VWM performances in CIs compared to NH peers and possible differences between unilateral cochlear implant (UCI) and bilateral cochlear implant (BCI) users. The main results revealed differences in theta and gamma EEG bands. Compared with hearing controls and BCIs, UCIs showed hypoactivation of theta in the frontal area during the most complex condition of the auditory task and a correlation of the same activation with VWM performance. Hypoactivation in theta was also observed, again for UCI...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Bianca Maria Serena Inguscio Giulia Cartocci Nicolina Sciaraffa Maria Nicastri Ilaria Giallini Pietro Aric ò Antonio Greco Fabio Babiloni Patrizia Mancini Source Type: research
L-Ergothioneine slows the progression of age-related hearing loss in CBA/CaJ mice
Hear Res. 2024 Apr 2;446:109004. doi: 10.1016/j.heares.2024.109004. Online ahead of print.ABSTRACTThe naturally occurring amino acid, l-ergothioneine (EGT), has immense potential as a therapeutic, having shown promise in the treatment of other disease models, including neurological disorders. EGT is naturally uptaken into cells via its specific receptor, OCTN1, to be utilized by cells as an antioxidant and anti-inflammatory. In our current study, EGT was administered over a period of 6 months to 25-26-month-old CBA/CaJ mice as a possible treatment for age-related hearing loss (ARHL), since presbycusis has been linked to hi...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Mark A Bauer Parveen Bazard Alejandro A Acosta Nidhi Bangalore Lina Elessaway Mark Thivierge Moksheta Chellani Xiaoxia Zhu Bo Ding Joseph P Walton Robert D Frisina Source Type: research
Two are better than one: Differences in cortical EEG patterns during auditory and visual verbal working memory processing between Unilateral and Bilateral Cochlear Implanted children
The objective of this pioneering study was to identify electroencephalographic (EEG) marker pattern differences in visual and auditory VWM performances in CIs compared to NH peers and possible differences between unilateral cochlear implant (UCI) and bilateral cochlear implant (BCI) users. The main results revealed differences in theta and gamma EEG bands. Compared with hearing controls and BCIs, UCIs showed hypoactivation of theta in the frontal area during the most complex condition of the auditory task and a correlation of the same activation with VWM performance. Hypoactivation in theta was also observed, again for UCI...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Bianca Maria Serena Inguscio Giulia Cartocci Nicolina Sciaraffa Maria Nicastri Ilaria Giallini Pietro Aric ò Antonio Greco Fabio Babiloni Patrizia Mancini Source Type: research
L-Ergothioneine slows the progression of age-related hearing loss in CBA/CaJ mice
Hear Res. 2024 Apr 2;446:109004. doi: 10.1016/j.heares.2024.109004. Online ahead of print.ABSTRACTThe naturally occurring amino acid, l-ergothioneine (EGT), has immense potential as a therapeutic, having shown promise in the treatment of other disease models, including neurological disorders. EGT is naturally uptaken into cells via its specific receptor, OCTN1, to be utilized by cells as an antioxidant and anti-inflammatory. In our current study, EGT was administered over a period of 6 months to 25-26-month-old CBA/CaJ mice as a possible treatment for age-related hearing loss (ARHL), since presbycusis has been linked to hi...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Mark A Bauer Parveen Bazard Alejandro A Acosta Nidhi Bangalore Lina Elessaway Mark Thivierge Moksheta Chellani Xiaoxia Zhu Bo Ding Joseph P Walton Robert D Frisina Source Type: research
Two are better than one: Differences in cortical EEG patterns during auditory and visual verbal working memory processing between Unilateral and Bilateral Cochlear Implanted children
The objective of this pioneering study was to identify electroencephalographic (EEG) marker pattern differences in visual and auditory VWM performances in CIs compared to NH peers and possible differences between unilateral cochlear implant (UCI) and bilateral cochlear implant (BCI) users. The main results revealed differences in theta and gamma EEG bands. Compared with hearing controls and BCIs, UCIs showed hypoactivation of theta in the frontal area during the most complex condition of the auditory task and a correlation of the same activation with VWM performance. Hypoactivation in theta was also observed, again for UCI...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Bianca Maria Serena Inguscio Giulia Cartocci Nicolina Sciaraffa Maria Nicastri Ilaria Giallini Pietro Aric ò Antonio Greco Fabio Babiloni Patrizia Mancini Source Type: research
L-Ergothioneine slows the progression of age-related hearing loss in CBA/CaJ mice
Hear Res. 2024 Apr 2;446:109004. doi: 10.1016/j.heares.2024.109004. Online ahead of print.ABSTRACTThe naturally occurring amino acid, l-ergothioneine (EGT), has immense potential as a therapeutic, having shown promise in the treatment of other disease models, including neurological disorders. EGT is naturally uptaken into cells via its specific receptor, OCTN1, to be utilized by cells as an antioxidant and anti-inflammatory. In our current study, EGT was administered over a period of 6 months to 25-26-month-old CBA/CaJ mice as a possible treatment for age-related hearing loss (ARHL), since presbycusis has been linked to hi...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Mark A Bauer Parveen Bazard Alejandro A Acosta Nidhi Bangalore Lina Elessaway Mark Thivierge Moksheta Chellani Xiaoxia Zhu Bo Ding Joseph P Walton Robert D Frisina Source Type: research
Electrocochleographic frequency-following responses as a potential marker of age-related cochlear neural degeneration
In this study, we employed electrocochleography (ECochG) to investigate the effects of age on frequency-following neurophonic potentials, i.e., neural responses phase-locked to the carrier frequency of the tone stimulus. We compared these findings to the brainstem-generated FFRs obtained simultaneously using the same stimulation. We conducted recordings in young and older individuals with normal hearing. Responses to pure tones (250 ms, 516 and 1086 Hz, 85 dB SPL) and clicks were recorded using both ECochG at the tympanic membrane and traditional scalp electroencephalographic (EEG) recordings of the FFR. Distortion product...
Source: Hearing Research - April 10, 2024 Category: Audiology Authors: Miguel Temboury-Gutierrez Jonatan M ärcher-Rørsted Michael Bille Jesper Yde Gerard Encina-Llamas Jens Hjortkj ær Torsten Dau Source Type: research
Electrocochleographic frequency-following responses as a potential marker of age-related cochlear neural degeneration
In this study, we employed electrocochleography (ECochG) to investigate the effects of age on frequency-following neurophonic potentials, i.e., neural responses phase-locked to the carrier frequency of the tone stimulus. We compared these findings to the brainstem-generated FFRs obtained simultaneously using the same stimulation. We conducted recordings in young and older individuals with normal hearing. Responses to pure tones (250 ms, 516 and 1086 Hz, 85 dB SPL) and clicks were recorded using both ECochG at the tympanic membrane and traditional scalp electroencephalographic (EEG) recordings of the FFR. Distortion product...
Source: Hearing Research - April 10, 2024 Category: Audiology Authors: Miguel Temboury-Gutierrez Jonatan M ärcher-Rørsted Michael Bille Jesper Yde Gerard Encina-Llamas Jens Hjortkj ær Torsten Dau Source Type: research
Characteristics of spatial protein expression in the mouse cochlear sensory epithelia: Implications for age-related hearing loss
In this study, we employed a microscale proteomics approach to examine and compare protein expression in different regions of the cochlear sensory epithelia (upper half and lower half) in 1.5-month-old (normal hearing) and 6-month-old (severe high-frequency hearing loss without hair cell loss) C57BL/6J mice. A total of 2,386 proteins were detected, and no significant differences in protein expression were detected in the upper half of the cochlear sensory epithelia between the two age groups. The expression of 20 proteins in the lower half of the cochlear sensory epithelia significantly differed between the two age groups ...
Source: Hearing Research - April 7, 2024 Category: Audiology Authors: Huilin Lao Yafeng Zhu Mei Yang Lingshuo Wang Jie Tang Hao Xiong Source Type: research
Characteristics of spatial protein expression in the mouse cochlear sensory epithelia: Implications for age-related hearing loss
In this study, we employed a microscale proteomics approach to examine and compare protein expression in different regions of the cochlear sensory epithelia (upper half and lower half) in 1.5-month-old (normal hearing) and 6-month-old (severe high-frequency hearing loss without hair cell loss) C57BL/6J mice. A total of 2,386 proteins were detected, and no significant differences in protein expression were detected in the upper half of the cochlear sensory epithelia between the two age groups. The expression of 20 proteins in the lower half of the cochlear sensory epithelia significantly differed between the two age groups ...
Source: Hearing Research - April 7, 2024 Category: Audiology Authors: Huilin Lao Yafeng Zhu Mei Yang Lingshuo Wang Jie Tang Hao Xiong Source Type: research
Characteristics of spatial protein expression in the mouse cochlear sensory epithelia: Implications for age-related hearing loss
In this study, we employed a microscale proteomics approach to examine and compare protein expression in different regions of the cochlear sensory epithelia (upper half and lower half) in 1.5-month-old (normal hearing) and 6-month-old (severe high-frequency hearing loss without hair cell loss) C57BL/6J mice. A total of 2,386 proteins were detected, and no significant differences in protein expression were detected in the upper half of the cochlear sensory epithelia between the two age groups. The expression of 20 proteins in the lower half of the cochlear sensory epithelia significantly differed between the two age groups ...
Source: Hearing Research - April 7, 2024 Category: Audiology Authors: Huilin Lao Yafeng Zhu Mei Yang Lingshuo Wang Jie Tang Hao Xiong Source Type: research
