Assessment of patient-reported outcomes measures in heart failure: a systematic review
AbstractHeart failure (HF) is a prevalent global disease, particularly impacting developed countries. With the world ’s aging population, HF’s impact on the quantity and quality of life is expected to grow. This review aims to ascertain the frequency, characteristics, and properties of all patient-reported outcomes measures (PROMs) studied in HF patients. We searched Ovid/Medline and Web of Science for origina l articles about PROMs performed in adults with HF. Using pre-established quality criteria for measurement properties, an overall rating was assigned to evaluate and compare different instruments. The quality of ...
Source: Heart Failure Reviews - April 17, 2024 Category: Cardiology Source Type: research
Correction to: Pediatric takotsubo cardiomyopathy: A review and insights from a National Multicentric Registry
(Source: Heart Failure Reviews)
Source: Heart Failure Reviews - April 16, 2024 Category: Cardiology Source Type: research
Resistance is not futile: a systematic review of the benefits, mechanisms and safety of resistance training in people with heart failure
AbstractExercise offers many physical and health benefits to people with heart failure (CHF), but aerobic training (AT) predominates published literature. Resistance training (RT) provides additional and complementary health benefits to AT in people with CHF; we aimed to elucidate specific health benefits accrued, the mechanism of effect and safety of RT. We conducted a systematic search for RT randomised, controlled trials in people with CHF, up until August 30, 2023. RT offers several benefits including improved physical function (peak VO2 and 6MWD), quality of life, cardiac systolic and diastolic function, endothelial b...
Source: Heart Failure Reviews - April 15, 2024 Category: Cardiology Source Type: research
Comparative analysis of treatment options for chronic heart failure and depression: a systematic review and Bayesian network meta-analysis
AbstractDifferent interventions have been evaluated for the treatment of depression in heart failure (HF) patients. However, clear and established recommendations are lacking. PubMed, Scopus, and Web of Science databases were systematically searched for randomized controlled trials (RCT) evaluating the effect of various treatment options on depression scores in heart failure patients. The primary outcome was a change in depression scores presented as standardized mean difference (SMD). A Bayesian network for meta-analysis was constructed. Twenty-five RCTs were included, randomizing 6014 patients with confirmed heart failur...
Source: Heart Failure Reviews - April 13, 2024 Category: Cardiology Source Type: research
Current status and future directions in pediatric ventricular assist device
This article reviews the clinically available devices, adverse events, and future directions of design and implementation in pediatric VADs. (Source: Heart Failure Reviews)
Source: Heart Failure Reviews - March 26, 2024 Category: Cardiology Source Type: research
Correction to: Budget impact analyses for treatment of heart failure. A systematic review
(Source: Heart Failure Reviews)
Source: Heart Failure Reviews - March 25, 2024 Category: Cardiology Source Type: research
New perspectives in the echocardiographic hemodynamics multiparametric assessment of patients with heart failure
AbstractInternational Guidelines consider left ventricular ejection fraction (LVEF) as an important parameter to categorize patients with heart failure (HF) and to define recommended treatments in clinical practice. However, LVEF has some technical and clinical limitations, being derived from geometric assumptions and is unable to evaluate intrinsic myocardial function and LV filling pressure (LVFP). Moreover, it has been shown to fail to predict clinical outcome in patients with end-stage HF. The analysis of LV antegrade flow derived from pulsed-wave Doppler (stroke volume index, stroke distance, cardiac output, and car...
Source: Heart Failure Reviews - March 20, 2024 Category: Cardiology Source Type: research
Abnormal phosphorylation / dephosphorylation and Ca2+ dysfunction in heart failure
AbstractHeart failure (HF) can be caused by a variety of causes characterized by abnormal myocardial systole and diastole. Ca2+ current through the L-type calcium channel (LTCC) on the membrane is the initial trigger signal for a cardiac cycle. Declined systole and diastole in HF are associated with dysfunction of myocardial Ca2+ function. This disorder can be correlated with unbalanced levels of phosphorylation / dephosphorylation of LTCC, endoplasmic reticulum (ER), and myofilament. Kinase and phosphatase activity changes along with HF progress, resulting in phased changes in the degree of phosphorylation / dephosphoryla...
Source: Heart Failure Reviews - March 18, 2024 Category: Cardiology Source Type: research
Budget impact analyses for treatment of heart failure. A systematic review
This study aims to systemically review the budget impact analysis of heart failure treatments on health care expenditure worldwide. Scientific databases such as PubMed, Web of Science, Scopus, and Google Scholar were searched for budget impact analysis and heart failure treatments, over January 2001 to August 2023. The quality assessment of the selected studies was evaluated through ISPOR practice guideline. Nineteen studies were included in this systematic review. Based on ISPOR recommendations, most studies were performed on a 1-year time horizon and used a government (public health) or health system perspective. Data...
Source: Heart Failure Reviews - March 16, 2024 Category: Cardiology Source Type: research
Pediatric takotsubo cardiomyopathy: A review and insights from a National Multicentric Registry
This study provides valuable insights into understanding pediatric TTS and underscores the necessity for further research in this age group.Graphical Abstract (Source: Heart Failure Reviews)
Source: Heart Failure Reviews - March 14, 2024 Category: Cardiology Source Type: research
Incremental diagnostic and prognostic utility of left atrial deformation in heart failure using speckle tracking echocardiography
AbstractLeft atrium (LA) is a very important component of cardiovascular performance. The assessment of LA function has gathered the interest with expanding research supporting the utility as a biomarker for outcomes in heart failure (HF). Echocardiography is the main imaging modality which helps in a qualitative and quantitative assessment of the LA size and function. Recent advances in probe technology and software analysis have provided a better understanding of LA anatomy, physiology, pathology, and function. A variety of parameters have been defined as markers of LA function but there is no single parameter that best ...
Source: Heart Failure Reviews - March 11, 2024 Category: Cardiology Source Type: research
The prevalence of coronary microvascular dysfunction (CMD) in heart failure with preserved ejection fraction (HFpEF): a systematic review and meta-analysis
In conclusion, this is the first systematic review and meta-analysis of all studies reporting the prevalence of CMD in patients with HFpEF. Our study demonstrates that CMD is common in patients with HFpEF and might be associated with poor clinical outcomes in these patients. Clinicians should attach importance to CMD in the diagnosis and treatment of HFpEF. The number of studies in this field is relatively small. Therefore, more high-quality studies are needed to explore the diagnostic and prognostic value of CMD and the potential role of CMD as a therapeutic target in patients with HFpEF. (Source: Heart Failure Reviews)
Source: Heart Failure Reviews - March 1, 2024 Category: Cardiology Source Type: research
Current perspectives of sudden cardiac death management in hypertrophic cardiomyopathy
In this study, we review the latest findings regarding pathogenesis, risk stratification, and prevention of SCD in HCM patients, highlighting the clinic practice of cardiovascular magnetic resonance imaging for SCD management. (Source: Heart Failure Reviews)
Source: Heart Failure Reviews - March 1, 2024 Category: Cardiology Source Type: research
Heart failure with mildly reduced and preserved ejection fraction: A review of disease burden and remaining unmet medical needs within a new treatment landscape
Abstract This review provides a comprehensive overview of heart failure with mildly reduced and preserved ejection fraction (HFmrEF/HFpEF), including its definition, diagnosis, and epidemiology; clinical, humanistic, and economic burdens; current pharmacologic landscape in key pharmaceutical markets; and unmet needs to identify key knowledge gaps. We conducted a targeted literature review in electronic databases and prioritized articles with valuable insights into HFmrEF/HFpEF. Overall, 27 randomized controlled trials (RCTs), 66 real-world evidence studies, 18 clinical practice guidelines, and 25 additional publicati...
Source: Heart Failure Reviews - February 27, 2024 Category: Cardiology Source Type: research
Cardiac contractility modulation in patients with heart failure — A review of the literature
AbstractExperimental in vivo and in vitro studies showed that electric currents applied during the absolute refractory period can modulate cardiac contractility. In preclinical studies, cardiac contractility modulation (CCM) was found to improve calcium handling, reverse the foetal myocyte gene programming associated with heart failure (HF), and facilitate reverse remodeling. Randomized control trials and observational studies have provided evidence about the safety and efficacy of CCM in patients with HF. Clinically, CCM therapy is indicated to improve the 6-min hall walk, quality of life, and functional status of HF pati...
Source: Heart Failure Reviews - February 23, 2024 Category: Cardiology Source Type: research
