Hemodialysis InternationalThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Pages: 1 2 3 4 5

239 records returned

C.E.R.A. once every 4 weeks in patients with chronic kidney disease not on dialysis: The ARCTOS extension studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
C.E.R.A., a continuous erythropoietin receptor activator is approved for the treatment of anemia in patients with chronic kidney disease (CKD). The ARCTOS (administration of C.E.R.A. in CKD patients to treat anemia with a twice-monthly schedule) phase 3 study demonstrated the efficacy and safety of C.E.R.A. in correcting anemia when administered once every 2 weeks (Q2W) subcutaneously in patients with CKD not on dialysis. We assessed the feasibility and long-term safety of converting patients who responded to treatment with C.E.R.A. Q2W to C.E.R.A. once every 4 weeks (Q4W) during a 24-week extension period. After the core ...
Source: Hemodialysis International - November 4, 2009 Category: Hematology Authors: Michèle KESSLER, Alberto MARTÍNEZ-CASTELAO, Kostas C. SIAMOPOULOS, Giuseppe VILLA, Bruce SPINOWITZ, Frank C. DOUGHERTY, Ulrich BEYER Source Type: journals

Categorization of the hemodynamic response to hemodialysis: The importance of baroreflex sensitivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to investigate the contribution of impaired baroreflex sensitivity (BRS) to the pathophysiology of IDH. Thirty-four chronic HD (12 IDH-prone, 22 IDH-resistant) patients underwent BRS measurement during HD with relative blood volume monitoring. During analysis, patients were separated into four age-matched groups according to resting BRS[ge]4.5 ms/mmHg and hemodynamic stability. Resting BRS was extremely heterogenous (geometric mean BRS 5.78±1.41 [range 1.76[ndash]41.41] ms/mmHg). Relative blood volume reduction was well matched in all groups (mean reduction in relative blood volume for all patients [minus...
Source: Hemodialysis International - November 3, 2009 Category: Hematology Authors: Lindsay J. CHESTERTON, Nicholas M. SELBY, James O. BURTON, Jana FIALOVA, Cian CHAN, Chris W. MCINTYRE Source Type: journals

Safety and tolerability of intravenous ferric carboxymaltose in patients with iron deficiency anemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is limited safety information about ferric carboxymaltose (FCM), a new intravenous iron preparation. This randomized, crossover study compared the safety and tolerability of double-blinded intravenous doses of FCM or placebo in patients with iron deficiency anemia. Subjects (559) with iron deficiency anemia received a dose of either FCM (15 mg/kg, maximum 1000 mg) over 15 minutes or placebo on day 0. On day 7, subjects received the other agent. Safety evaluations were performed on days 7 and 14. The primary endpoint was the incidence of treatment-emergent adverse events during each 7-day study period. During the firs...
Source: Hemodialysis International - November 3, 2009 Category: Hematology Authors: George R. BAILIE, Nancy A. MASON, Thomas G. VALAORAS Source Type: journals

Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 54-year-old hemodialysis patient who presented with recurrent fever due to Streptococcus bovis bacteremia related to colonic tubulovillous adenoma. Following polypectomy and broad-spectrum antibiotic therapy, the patient totally recovered. In this paper, we discussed the relation between S. bovis bacteremia, colonic adenomas, and hemodialysis. Awareness of this association is critical for early diagnosis and management. (Source: Hemodialysis International)
Source: Hemodialysis International - September 16, 2009 Category: Hematology Authors: Arzu KAHVECI, Elif ARI, Hakki ARIKAN, Mehmet KOC, Serhan TUGLULAR, Cetin OZENER Source Type: journals

Complementary parameter for dialysis monitoring based on UV absorbanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study introduces a new parameter for dialysis monitoring that may be used as a complementary parameter, the area under UV-absorbance curve (AUCa), to reflect a total solute removal during dialysis. The aim was to investigate the relationship between this new dialysis on-line monitoring parameter, AUCa, and the total removal of a few solutes. Fifteen patients were monitored during hemodialysis using UV absorbance at the wavelength of 297 nm. All spent dialysate passed through a flow cuvette in a spectrophotometer and then further to a collection tank where solute concentrations in the entire spent dialysate were determ...
Source: Hemodialysis International - September 15, 2009 Category: Hematology Authors: Fredrik UHLIN, Jonas PETTERSSON, Anders FERNSTRÖM, Lars-Göran LINDBERG Source Type: journals

Higher arteriovenous fistulae blood flows are associated with a lower level of dialysis-induced cardiac injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Native arteriovenous fistulae (AVF) remain the vascular access of choice for hemodialysis (HD). Despite being associated with superior long-term outcomes (cf. catheter use), little is known about the systemic hemodynamic consequences of AVFs. Repetitive myocardial injury (myocardial stunning) is an under-recognized common consequence of HD. The aim of this study was to examine the impact of AVF flow (Qa) on dialysis-induced cardiac injury. We studied 50 chronic HD patients. All patients underwent echocardiography (and subsequent quantitative offline analysis) at baseline, during and post dialysis, to assess left ventricula...
Source: Hemodialysis International - September 15, 2009 Category: Hematology Authors: Shvan KORSHEED, James O. BURTON, Christopher W. McINTYRE Source Type: journals

Bioreactance: A new tool for cardiac output and thoracic fluid content monitoring during hemodialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to evaluate the changes in TFC in comparison with the traditional indices of fluid removal (FR) and to understand the trends in CO changes in HD patients. Minute-by-minute changes in TFC and CO were prospectively collected using the bioreactance system (NICOM®) in HD patients of a single unit. Changes in body weight ([Delta]W), hematocrit ([Delta]Hct), and amount of FR were also measured. Twenty-five patients (age 77 ± 11 years) were included. The TFC decreased in all patients by an average of 5.4 ± 7.9 k[Omega][minus]1, weight decreased by 1.48 ± 0.98 kg, and FR averaged 2.07 ± 1.93 L over a 3...
Source: Hemodialysis International - September 15, 2009 Category: Hematology Authors: Niloufar KOSSARI, Gilles HUFNAGEL, Pierre SQUARA Source Type: journals

Variability in calcium, phosphorus, and parathyroid hormone in patients on hemodialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Calcium, phosphorus, and parathyroid hormone (PTH) levels are routinely measured in patients undergoing chronic hemodialysis. Medications, diet, and dialytic therapies are modified based upon these lab values to achieve specific goal values in the hope of improving outcomes. However, the variability of these values in patients undergoing chronic hemodialysis has only been rarely studied. We prospectively investigated the variability of these measures in 35 patients undergoing chronic hemodialysis as well as the impact of this variability on clinical decision-making in a prospective manner over a month. There is significant...
Source: Hemodialysis International - September 15, 2009 Category: Hematology Authors: Helena LEVITT, Kenneth G. SMITH, Mitchell H. ROSNER Source Type: journals

Treating mineral metabolism disorders in patients undergoing long hemodialysis: A search for an optimal strategyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the evolution of MM parameters in a stable HD population undergoing long hemodialysis by performing an annual cross-sectional analysis for every year from 1994 to 2008. The therapeutic strategy has changed: the dialysate calcium concentration has decreased from a mean of 1.7 ± 0.1 to 1.5 ± 0.07 mmol/L and has been adapted to parathyroid hormone serum levels (from 1 to 1.75 mmol/L). The use of calcium-based and aluminum-based phosphate binders has decreased and they have been replaced by sevelamer; alfacalcidol has partly been replaced by native vitamin D. The percentage of patients with a parathyroid hormone se...
Source: Hemodialysis International - September 15, 2009 Category: Hematology Authors: Guillaume JEAN, Thierry VANEL, Jean-Claude TERRAT, Jean-Marc HUROT, Christie LORRIAUX, Brice MAYOR, Charles CHAZOT Source Type: journals

Quality of care assessment and adherence to the international guidelines considering dialysis, water treatment, and protection against transmission of infections in university hospital-based dialysis units in Cairo, EgyptEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
End-stage renal disease has emerged as a major public health problem around the world. In recent decades, several important advances have been made in the therapy of hemodialysis (HD) with the introduction of international guidelines to ensure the delivery of optimum care to HD patients. An increased mortality risk in HD patients unable to meet six targets in different areas of HD practice has been reported by the Dialysis Outcomes and Practice Patterns Study investigators. In this retrospective study, we assessed the current practice patterns of care for HD patients in the Kaser El-Aini Nephrology and Dialysis Center in c...
Source: Hemodialysis International - September 15, 2009 Category: Hematology Authors: Salwa IBRAHIM Source Type: journals

Solute kinetics with short-daily home hemodialysis using slow dialysate flow rateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the impact of the use of low dialysate volumes on the removal rates of solutes of different molecular weights and volumes of distribution was evaluated. Serum measurements before and after dialysis and total dialysate collection were performed over 30 times in 5 functionally anephric patients undergoing short-daily home hemodialysis (6 d/wk) over the course of 8 to 16 months. Measured solutes included [beta]2 microglobulin ([beta]2M), phosphorus, urea nitrogen, and potassium. The average spent dialysate volume (dialysate plus ultrafiltrate) was 25.4±4.7 L and the dialysis duration was 175±15 min. [beta]2 m...
Source: Hemodialysis International - September 15, 2009 Category: Hematology Authors: Orly F. KOHN, Fredric L. COE, Todd S. ING Source Type: journals

Sexual function in women receiving maintenance dialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
While substantial attention has been paid to the issue of sexual dysfunction in men on chronic dialysis, less is known about this problem in women with end-stage renal disease. We sought to assess sexual dysfunction in women on chronic dialysis and determine whether patients discuss this problem with their providers and receive treatment. We prospectively enrolled women receiving chronic hemodialysis or peritoneal dialysis in Pittsburgh, PA. We asked patients to complete the 19-item Female Sexual Function Index (FSFI) to assess sexual function and a 5-item survey that assessed whether patients had discussed sexual dysfunct...
Source: Hemodialysis International - September 15, 2009 Category: Hematology Authors: Srikanth SEETHALA, Rachel HESS, Maurizio BOSSOLA, Mark L. UNRUH, Steven D. WEISBORD Source Type: journals

Acquired perforating dermatoses in patients with diabetic kidney disease on hemodialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the clinicopathological features of APD in patients with diabetic kidney disease and discuss the recent advances in management. We retrospectively analyzed the data of 8 patients with APD presenting to our center. All patients were known cases of Type 2 diabetes and chronic kidney disease requiring maintenance dialysis. Acquired perforating dermatoses was diagnosed based on clinical presentation of itchy, keratotic papulonodular lesions, and characteristic histopathological features of transepithelial elimination on skin biopsy. The patients were subdivided into 4 types of APD based on the biopsy features. All o...
Source: Hemodialysis International - September 15, 2009 Category: Hematology Authors: K. V. S. Hari KUMAR, Jayaram PRAJAPATI, G. PAVAN, A. PARTHASARATHY, Ratan JHA, K. D. MODI Source Type: journals

Renal dysfunction due to leukemic infiltration of kidneys in a case of chronic lymphocytic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Renal failure due to leukemic infiltration of kidney in chronic lymphocytic leukemia is an extremely rare condition. The authors report a case of a 59-year-old white female, with a past medical history of chronic lymphocytic leukemia (CLL) with 2 years of evolution without medical therapy, admitted with nonoliguric acute renal failure needing dialysis. Renal biopsy showed extensive small lymphocytes' infiltration in the cortical interstitium by CLL cells. Cyclophosphamide and prednisolone were started and 1 month later changed to fludarabine plus cyclophosphamide with improvement of renal function. Although renal failure d...
Source: Hemodialysis International - September 15, 2009 Category: Hematology Authors: Ana Carina FERREIRA, Sandra BRUM, Dulce CARVALHO, Isabel PATACA, Fernanda CARVALHO, Maria Céu SANTOS, João Ribeiro SANTOS Source Type: journals

Hemodialysis access at initiation in the United States, 2005 to 2007: Still "Catheter First"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite the broad consensus that native arteriovenous fistula is the access of choice for hemodialysis, national-level information about vascular access at dialysis initiation has been unavailable in the United States. For incident hemodialysis patients, June 2005 to October 2007 (n=220,157), vascular access type was determined from the new Centers for Medicare & Medicaid Services Medical Evidence Report (form CMS-2728). Proportions with each type at first dialysis, demographic and clinical associations of each type, and associations between initial access type and survival were assessed. The mean patient age was 63.6 year...
Source: Hemodialysis International - September 15, 2009 Category: Hematology Authors: Robert N. FOLEY, Shu-Cheng CHEN, Allan J. COLLINS Source Type: journals

Mysterious PTH values after parathyroidectomy in a patient on maintenance dialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 25-year-old patient with end-stage renal disease on maintenance peritoneal dialysis underwent parathyroidectomy when his secondary hyperparathyroidism did not respond to medical management. However, over the subsequent months he developed extremely raised parathyroid hormone (PTH) levels. When surgical removal of the autotransplant was considered, preoperative work-up revealed a PTH level within the target range. It became apparent that the very high PTH values were due to the location of the blood draw close to the autotransplant, thus measuring a local rather than the systemic PTH value. The multiple causes of varying ...
Source: Hemodialysis International - August 27, 2009 Category: Hematology Authors: Marla THOMPSON, Brigitte SCHILLER Source Type: journals

Hemochromatosis gene mutations and treatment of anemia in patients on hemodialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined erythropoietin and intravenous (IV) iron requirements in hemodialysis (HD) patients with HFE mutations. Patients on HD for >90 days with no cause of anemia except chronic kidney disease were tested for HFE mutations (H63D and C282Y). Intravenous iron and erythropoietin doses were adjusted to achieve recommended targets. Monthly hemoglobin (Hb), ferritin, mean corpuscular volume, mean cell hemoglobin, erythropoietin, and IV iron doses for 3 consecutive months were averaged. Of 172 patients, 71 (41.3%) had [ge]1 HFE mutation: 24 (14%) C282Y heterozygotes, 40 (23.3%) H63D heterozygotes, 5 compound heterozy...
Source: Hemodialysis International - August 27, 2009 Category: Hematology Authors: Michaela C. BROWN, Dairena GAFFNEY, Clare GEMMELL, Eleanor OAKES, Scott MORRIS, Richard SPOONER, Alan G. JARDINE, Colin C. GEDDES Source Type: journals

Assessment of adherence to cinacalcet by prescription refill rates in hemodialysis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Secondary hyperparathyroidism is common among dialysis patients and leads to numerous complications including cardiovascular disease and renal osteodystrophy. Cinacalcet, an oral daily calcimimetic agent that sensitizes the calcium receptor to serum calcium, is approved for treatment of secondary hyperparathyroidism in dialysis patients. We identified 101 patients who received their first cinacalcet prescription between November 2004 and April 2005. All patients were participating in a Missouri state-funded pharmacy program providing free or low cost medications. We tracked the cinacalcet refill rate and refills for anothe...
Source: Hemodialysis International - August 27, 2009 Category: Hematology Authors: Yekaterina GINCHERMAN, Kirsten MOLONEY, Charles MCKEE, Daniel W. COYNE Source Type: journals

Antihypertensive prescription in pediatric dialysis: A practitioner survey by the Midwest Pediatric Nephrology Consortium studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous studies have indirectly suggested the prescription of antihypertensive medications may contribute to blood pressure control in dialysis patients. Before exploring this largely unknown field, it is necessary to examine if there is diversity in antihypertensive prescription for dialysis patients. The questionnaire by the Midwest Pediatric Nephrology Consortium was mailed to members of American Society of Pediatric Nephrology holding faculty positions in North America and Puerto Rico. Eighty-three (23.9%) of the mailed 357 surveys were analyzable. End-organ damage (43.2% respondents), interdialytic blood pressure lev...
Source: Hemodialysis International - July 15, 2009 Category: Hematology Authors: Jen-Jar LIN, Mark M. MITSNEFES, William E. SMOYER, Rudolph P. VALENTINI Source Type: journals

Effect of phosphate binders on oxidative stress and inflammation markers in hemodialysis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to evaluate the effect of sevelamer hydrochloride (SH) and calcium acetate (CA) on oxidative stress and inflammation markers in HD patients. Hemodialysis patients were randomly assigned to therapy with SH (n=17) or CA (n=14) for 1 year. Before the initiation of therapy (baseline) and at 12 months, we measured in vitro reactive oxygen species (ROS) production by stimulated and unstimulated polymorphonuclear neutrophils and serum levels of tumor necrosis factor [alpha], interleukin-10, C-reactive protein, and albumin. There was a significant reduction of spontaneous ROS production in both grou...
Source: Hemodialysis International - July 14, 2009 Category: Hematology Authors: ALINE T. PERES, MARIA A. DALBONI, MARIA E. CANZIANI, SILVIA R. MANFREDI, JOSE TARCISIO G. CARVALHO, MARCELO C. BATISTA, LILIAN CUPPARI, ALUISIO B. CARVALHO, ROSA M. A. MOYSES, NADIA GUIMARÃES, VANDA JORGETTI, MARIA C. ANDREOLI, SERGIO A. DRAIBE, MIGUEL C Source Type: journals

Predictors of anemia in patients on hemodialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Even though the use of erythropoietin and intravenous iron has improved the treatment of anemia in hemodialysis patients, a considerable proportion of these patients still have anemia. The aim of this study was to identify predictors of anemia in a hemodialysis population. In a single-center hemodialysis unit, all patients were studied with blood tests and their medication recorded during a period of 22 months. Correlations with hemoglobin (Hb) were performed with a simple regression or a t test. Variables that reached 5% significance were entered in a multiple regression analysis. Selected variables were presented in quar...
Source: Hemodialysis International - July 14, 2009 Category: Hematology Authors: WILLY AASEBØ, ANDERS HARTMANN, TROND JENSSEN Source Type: journals

The effect of in-stent restenosis on hemodialysis access patencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endovascular stents have recently been shown to extend access patency in thrombosed and stenotic arteriovenous grafts (AVG). Concern remains over the frequency and severity of in-stent restenosis, though this has not been rigorously defined to date. The study was a retrospective analysis of hemodialysis patients referred for access dysfunction during a 2-year period. Using a prospectively collected, vascular access database, we identified 76 patients seen for follow-up angiography due to access dysfunction after stent placement. We compared the effect of in-stent restenosis vs. de novo lesions in patients with previously p...
Source: Hemodialysis International - July 14, 2009 Category: Hematology Authors: Micah R. CHAN, Henry N. YOUNG, Alexander S. YEVZLIN Source Type: journals

Barbara Fristoe Prowant: 1953 – 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Hemodialysis International)
Source: Hemodialysis International - July 14, 2009 Category: Hematology Authors: MADHUKAR MISRA, ZBYLUT J. TWARDOWSKI, KARL D. NOLPH Source Type: journals

Cardiovascular disease on hemodialysis: Predictors of atherosclerosis and survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we attempted to elucidate the factors influencing atherosclerosis, as measured by carotid artery intima-media thickness (IMT), in HD patients and their impact on cardiovascular mortality. A cohort of 50 patients started on HD was selected for this study. At baseline, IMT and the presence of atheromatous plaques were assessed. Plasma homocysteine (Hcy), malondialdehyde, total antioxidant capacity, von Willebrand factor, vitamins C, E, B6, B12, folate, and C-reactive protein (CRP) were also measured. Patients were followed up for 2 years to determine the impact of IMT and associated markers on mortality using ...
Source: Hemodialysis International - July 14, 2009 Category: Hematology Authors: Ahmed BALSAM, Mohsen M. EL KOSSI, Robert LORD, A. Meguid EL NAHAS Source Type: journals

Right atrial thrombus due to internal jugular vein catheterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 58-year-old type 2 diabetic, hypertensive, end-stage renal disease patient, who 2 months after initiation of hemodialysis through a right internal jugular vein catheter, developed clinical features suggestive of pulmonary thromboembolism. An echocardiography revealed presence of a serpentine thrombus in right atrium. The internal jugular vein catheter was removed and unfractionated heparin was initiated. At the end of 6 weeks he was symptom free. We compared conservative treatment with surgery for RAT. Conservative management with central venous catheter removal and anticoagulation therapy is not inferior to th...
Source: Hemodialysis International - July 14, 2009 Category: Hematology Authors: Rapur RAM, Gudithi SWARNALATHA, Yarlagadda RAKESH, Maddury JYOSTNA, Neela PRASAD, Kaligotla Venkata DAKSHINAMURTY Source Type: journals

A randomized double-blind pilot study of serum phosphorus normalization in chronic kidney disease: A new paradigm for clinical outcomes studies in nephrologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Hemodialysis International)
Source: Hemodialysis International - July 7, 2009 Category: Hematology Authors: Geoffrey A. BLOCK, Martha S. PERSKY, Markus KETTELER, Bryan KESTENBAUM, Ravi THADHANI, Laura KOOIENGA, David SPIEGEL, John ASPLIN, James EHRLICH, Vincent DENNIS, Allen NISSENSON, Glenn M. CHERTOW, David C. WHEELER Source Type: journals

Increased leukocyte aggregates are associated with atherosclerosis in patients with hemodialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study sought to assess the relationship between leukocytes conjugated with platelets (leukocyte aggregates [LA]) and atherosclerosis in patients with HD. The present study included 118 patients on HD. As surrogate markers of atherosclerosis, aortic stiffness measured by brachial-ankle pulse wave velocity, and carotid intima-media thickness (IMT) were measured. As an assessment of LA, a method, microchannel array flow analyzer, which makes it possible to directly observe the flow of blood cell elements through the microchannel, was used. We measured a number of LA during 50 [mu]L flow of whole blood through microchanne...
Source: Hemodialysis International - July 4, 2009 Category: Hematology Authors: Shuzo KOBAYASHI, Mitsuko MIYAMOTO, Hajime KURUMATANI, Machiko OKA, Kyoko MAESATO, Tsutomu MANO, Ryota IKEE, Hidekazu MORIYA, Takayasu OHTAKE Source Type: journals

The relationship between laboratory-based outcome measures and mortality in end-stage renal disease: A systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite data that traditional laboratory-based outcome measures in dialysis are improving over time, population-based data indicate that mortality rates are not improving in parallel. With increased focus on performance measures based on laboratory-based outcomes (e.g., hematocrit, albumin, and parathyroid hormone), less emphasis has been placed on other markers, some of which may be stronger predictors of mortality. We performed a systematic review to interpret the predictive value of laboratory-based outcome measures in dialysis. We identified studies with data regarding the predictive value of laboratory-based outcomes ...
Source: Hemodialysis International - July 2, 2009 Category: Hematology Authors: Amar A. DESAI, Allen NISSENSON, Glenn M. CHERTOW, Mary FARID, Inder SINGH, Martijn G. H. VAN OIJEN, Eric ESRAILIAN, Matthew D. SOLOMON, Brennan M. R. SPIEGEL Source Type: journals

Effect of recombinant human erythropoietin on insulin resistance in hemodialysis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Insulin resistance is a characteristic feature of uremia. Insulin resistance and concomitant hyperinsulinemia are present irrespective of the type of renal disease. Treatment with recombinant human erythropoietin (rHuEPO) was said to be associated with improvement in insulin sensitivity in uremic patients. The aim of this study was to compare insulin resistance in adult uremic hemodialysis (HD) patients including diabetic patients treated with or without rHuEPO. A total of 59 HD patients were studied, patients were divided into 2 groups of subjects: 30 HD patients on regular rHuEPO treatment (group A), and 29 HD patients n...
Source: Hemodialysis International - June 24, 2009 Category: Hematology Authors: Essam KHEDR, Magdy EL-SHARKAWY, Saed ABDULWAHAB, Essam Nor ELDIN, Medhat ALI, Abla YOUSSIF, Bassam AHMED Source Type: journals

Primary hyperoxaluria causing ESRD and gangrene of extremities leading to amputationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 45-year-old female with end-stage renal disease secondary to nephrolithiasis, who presented with a fulminating vascular syndrome before confirming the diagnosis of primary hyperoxaluria. This case illustrates that in this infrequent clinical entity, the diagnosis is often delayed with incorrect initial management. (Source: Hemodialysis International)
Source: Hemodialysis International - June 21, 2009 Category: Hematology Authors: Nidhi M. MUNSHI, Luis CONCEPCION, Mohanram NARAYANAN Source Type: journals

Medication changes based on echocardiography in dialysis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kidney/Disease Outcome Quality Initiative (K/DOQI) guidelines recommend baseline echocardiography at the initiation of dialysis and every 3 years thereafter in patients for early detection of cardiac disease to optimize medical therapy. Because dialysis patients are at increased cardiovascular risk and thus most are already on cardioprotective medications, we hypothesize that serial screening echocardiography will not alter cardioprotective medications in dialysis patients. Retrospective analysis of medication administration of 231 dialysis patients was conducted. Patients were divided into 2 groups, those with and those w...
Source: Hemodialysis International - June 21, 2009 Category: Hematology Authors: Chun K. CHONG, Michael MUZOORA, George J. ECKERT, Masoor KAMALESH, Sharon M. MOE Source Type: journals

A simple method to create buttonhole cannulation tracks in a busy hemodialysis unitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The preference for fistulae as the hemodialysis access of choice has led to a significant number of accesses that are less than ideal for cannulation. Buttonhole cannulation is ideal for such accesses, but the technique for creation provides major challenges. In 12 patients, buttonhole tunnel tracks were created by leaving the polyurethane catheter of a Clampcath® hemodialysis needle indwelling for 10 days after the initial cannulation. After each dialysis the catheter was flushed, and dressed with an antibacterial ointment and gauze. Dialysis was carried out via the catheter during that time. After day 10, the catheter w...
Source: Hemodialysis International - June 9, 2009 Category: Hematology Authors: Rosa M. MARTICORENA, Joyce HUNTER, Ramona COOK, Mina KASHANI, Julia DELACRUZ, Elizabeth PETERSHOFER, Steve MACLEOD, Niki DACOURIS, Philip A. McFARLANE, Sandra M. DONNELLY, Marc B. GOLDSTEIN Source Type: journals

Intraoperative dialysis during liver transplantation with citrate dialysateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a 40-year-old female with acetaminophen-induced fulminant liver failure with associated AKI who underwent intraoperative dialytic support during liver transplantation anticoagulated with citrate dialysate during the entire procedure. The patient tolerated the procedure well without any signs of citrate toxicity and maintained adequate anticoagulation for patency of the dialysis circuit. Citrate dialysate is a safe alternative for intradialytic support of liver transplantation in fulminant liver failure. (Source: Hemodialysis International)
Source: Hemodialysis International - June 8, 2009 Category: Hematology Authors: Robert M. WINROW, Connie DAVIS, Jeffrey B. HALLDORSON, Suhail AHMAD Source Type: journals

Hypoparathyroidism associated with severe mineral bone disease postrenal transplantation, treated successfully with recombinant PTHEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case report of severe hypocalcemia (secondary to surgical hypoparathyroidism) and "hungry bone syndrome," treated successfully with teriparatide (Forteo®) in a patient who underwent renal transplantation following subtotal parathyroidectomy. (Source: Hemodialysis International)
Source: Hemodialysis International - May 30, 2009 Category: Hematology Authors: Ashutosh MAHAJAN, Mohanram NARAYANAN, Gregory JAFFERS, Luis CONCEPCION Source Type: journals

Antibiotic lock: In vitro stability of vancomycin and four percent sodium citrate stored in dialysis catheters at 37°CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to evaluate the chemical stability of the vancomycin in 4% sodium citrate in HD catheters as an interdialytic lock. Vancomycin was prepared and diluted with sodium citrate 4% and stored in polyvinyl chloride syringes, 2 carbothane dialysis catheters (Hemostar®) and 2 dual floating HD catheters (CardioMed®). Syringes were stored at 4 °C or 23 °C and the catheters were stored in an incubator at 37 °C for 72 hours. Samples underwent daily chromatographic analysis and the luminal concentration of vancomycn was determined on study days 0, 1, and 3. When vancomycin is reconstituted with norma...
Source: Hemodialysis International - May 28, 2009 Category: Hematology Authors: Marisa BATTISTELLA, Scott WALKER, Shirley LAW, Charmaine LOK Source Type: journals

Simple evaluation of aortic arch calcification by chest radiography in hemodialysis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vascular calcification is associated with a poor prognosis in dialysis patients. It can be assessed with computed tomography but simple inoffice techniques may provide useful information. We compared the results obtained with a simple noninvasive technique with those obtained using multidetector computed tomography for aortic arch calcification volume (AoACV) in chronic hemodialysis (HD) patients. The enrolled study subjects were 63 (32 men and 31 women) maintenance HD patients. Calcification of the aortic arch was semiquantitatively estimated with a AoAC score (AoACS) on plain chest radiology. The AoACV was increased, wit...
Source: Hemodialysis International - May 27, 2009 Category: Hematology Authors: Tetsuya OGAWA, Hideki ISHIDA, Nami MATSUDA, Ayuko FUJIU, Akiko MATSUDA, Kyoko ITO, Yoshitaka ANDO, Kosaku NITTA Source Type: journals

Initial clinical experience with a new heparin-coated chronic hemodialysis catheterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this paper we wish to report our clinical experience with a new heparin-coated dialysis catheter with a symmetric tip. Over a 16-month period, 60 heparin-coated Tal Palindrome[trade] catheters were placed in 57 patients. Catheter patency, catheter-related complications, and reasons for catheter removal were recorded. The patient's initial cause of end-stage renal disease, underlying diseases, and site of access were recorded as well. Patients were specifically followed for development of heparin-induced thrombocytopenia. Patient ages were 34[ndash]91 (average 66). Fifty-four percent of patients had a history of diabetes...
Source: Hemodialysis International - May 19, 2009 Category: Hematology Authors: Hamid MOJIBIAN, Marcelo SPECTOR, Nina NI, Donna ELISEO, Jeffrey POLLAK, Michael TAL Source Type: journals

Survival pattern of hemodialysis patients in Kumasi, Ghana: A summary of forty patients initiated on hemodialysis at a new hemodialysis unitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate the survival pattern of hemodialysis patients at a dialysis unit in Kumasi, Ghana, through a retrospective (observational) study. Patients who were placed on hemodialysis at the dialysis unit at Komfo Anokye teaching hospital from October 25, 2006 to December 2007. The patients were followed from initiation of dialysis until December 31, 2007. The overall mortality was 14 (35.9%) on the incident population for the period and that for the first 90 days was 12 (32.4%) patients. Chronic glomerulonephritis was the underlying kidney disease in 35.9%. This was followed by hypertension (19.1%) and diabetes mellitus (1...
Source: Hemodialysis International - May 15, 2009 Category: Hematology Authors: Benjamin A. EGHAN, Kwabena AMOAKO-ATTA, Charity Ama KANKAM, Anthony NSIAH-ASARE Source Type: journals

Long-term effects of magnesium carbonate on coronary artery calcification and bone mineral density in hemodialysis patients: A pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Observational data suggest that elevated magnesium levels in dialysis patients may prevent vascular calcification and in vitro magnesium can prevent hydroxyapatite crystal growth. However, the effects of magnesium on vascular calcification and bone mineral density have not been studied prospectively. Seven chronic hemodialysis patients participated in this open label, prospective pilot study to evaluate the effects of a magnesium-based phosphate binder on coronary artery calcification (CAC) scores and vertebral bone mineral density (V-BMD) in patients with baseline CAC scores >30. Magnesium carbonate/calcium carbonate (ele...
Source: Hemodialysis International - May 12, 2009 Category: Hematology Authors: David M. SPIEGEL, Beverly FARMER Source Type: journals

Myocardial contractile function and intradialytic hypotensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dialysis-induced hypotension remains a significant problem in hemodialysis (HD) patients. Numerous factors result in dysregulation of blood pressure control and impaired myocardial reserve in response to HD-induced cardiovascular stress. Episodic intradialytic hypotension may be involved in the pathogenesis of evolving myocardial injury. We performed an initial pilot investigation of cardiovascular functional response to pharmacological cardiovascular stress in hypotension-resistant (HR) and hypotension-prone (HP) HD patients. We studied 10 matched chronic HD patients (5 HP, 5 HR). Dobutamine-atropine stress (DAS) was perf...
Source: Hemodialysis International - May 12, 2009 Category: Hematology Authors: Paul J. OWEN, William S. PRIESTMAN, Mhairi K. SIGRIST, Stewart H. LAMBIE, Stephen G. JOHN, Lindsay J. CHESTERTON, Christopher W. MCINTYRE Source Type: journals

ErrataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Hemodialysis International)
Source: Hemodialysis International - April 21, 2009 Category: Hematology Tags: Erratum Source Type: journals

Causes and consequences of inflammation on anemia management in hemodialysis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inflammation is common among hemodialysis patients, and evidence is accumulating to suggest that inflammation is a major contributor to morbidity and mortality. Several factors have been suggested as potential causes of inflammation, including infections and the atherosclerosis process, as well as etiologies directly related to kidney disease such as reduced renal function and dialysis. Among several inflammatory biomarkers investigated, serum C-reactive protein (CRP) is the most widely used. In hemodialysis patients, raised CRP levels have been shown to be predictive of cardiovascular events, hospitalization, and all-caus...
Source: Hemodialysis International - April 21, 2009 Category: Hematology Authors: Lakhmir S. CHAWLA, Mahesh KRISHNAN Tags: REVIEW ARTICLE Source Type: journals

Rate of creatinine equilibration in whole bloodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The classic assumption that a large fraction of blood creatinine remains sequestered within erythrocytes when blood is dialyzed has been challenged by recent observations where approximately 60% of erythrocyte water appeared accessible to diffusive creatinine transport during a dialyzer transit. This discrepancy provided the motivation to revisit and reanalyze the equilibration of creatinine across the erythrocyte membrane in a series of in vitro studies with normal human blood under erythrocyte loading and unloading conditions at 37 °C. The time course of plasma creatinine concentrations measured by a kinetic picric acid...
Source: Hemodialysis International - April 21, 2009 Category: Hematology Authors: Daniel SCHNEDITZ, Yichien YANG, Georgios CHRISTOPOULOS, Josef KELLNER Tags: ORIGINAL ARTICLES Source Type: journals

Outcome among patients with acute renal failure needing continuous renal replacement therapy: A single center studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Outcome of acute renal failure (ARF) and use of continuous renal replacement therapy (CRRT) have shown a consistently high mortality. (1) Evaluate the short-term patient survival. (2) Evaluate dialysis-free survival. (3) Evaluate risk factors associated with overall survival and the continued need for intermittent dialysis. We identified adults ([ge]18 years) needing CRRT, treated in the critical care units of Froedtert Medical and Lutheran Hospital from January 1, 2003 till December 31, 2005. Patients were divided into two major groups needing CRRT, end stage renal disease (ESRD) (chronic dialysis) and non-ESRD with ARF. ...
Source: Hemodialysis International - April 21, 2009 Category: Hematology Authors: Syed HUSSAIN, Walter PIERING, Tayyab MOHYUDDIN, Mohammad SALEH, Yong-Ran ZHU, Mary HANAN, Eric COHEN Tags: ORIGINAL ARTICLES Source Type: journals

Low cholesterol along with inflammation predicts morbidity and mortality in hemodialysis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Low and not high cholesterol seems to predict high mortality in hemodialysis (HD) patients. The confirmation of this reverse epidemiology as well as its possible interconnection with the increased inflammatory activity observed in this population is being explored in the present study. A group of 136 HD patients was prospectively studied for 2 years, and cardiovascular disease (CVD) as well as all-cause mortality and morbidity were recorded. Baseline lipid profile, inflammatory status, and patients' characteristics were studied as potential survival and hospitalization predictors. During the 24-month follow-up, 21 deaths (...
Source: Hemodialysis International - April 21, 2009 Category: Hematology Authors: George TSIRPANLIS, Fotini BOUFIDOU, Margarita ZOGA, George TRIANTAFYLLIS, Alexandra FATOUROU, Kyriaki STAMATELOU, Aliki BLETA, Christiana PETRIHOU, Stylianos CHATZIPANAGIOTOU, Chrysoula NICOLAOU Tags: ORIGINAL ARTICLES Source Type: journals

Cool dialysate reduces asymptomatic intradialytic hypotension and increases baroreflex variabilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to investigate if the baroreflex sensitivity (BRS) response to HD differed between standard and cool-temperature dialysate. Ten patients (mean age 67±2 years) prone to IDH were recruited into a randomized, crossover study to compare BRS variation at dialysate temperatures of 37 °C (HD37) and 35 °C (HD35). Each patient underwent continuous beat-to-beat BP monitoring during a dialysis session of HD37 and HD35. During HD37 2 patients developed symptomatic IDH, as opposed to 1 with HD35. However, asymptomatic IDH occurred with a frequency of 0.4 episodes per session with HD35 and 6.2 episodes per session du...
Source: Hemodialysis International - April 21, 2009 Category: Hematology Authors: Lindsay J. CHESTERTON, Nicholas M. SELBY, James O. BURTON, Chris W. McINTYRE Tags: ORIGINAL ARTICLES Source Type: journals

Interdialytic weight gain and ultrafiltration rate in hemodialysis: Lessons about fluid adherence from a national registry of clinical practiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to estimate the prevalence of high fluid consumers, describe UFR patterns, and describe patient characteristics associated with IWG and UFR. The Swedish Dialysis DataBase and The Swedish Renal Registry of Active Treatment of Uremia were used as data sources. Data were analyzed from patients aged [ge]18 on regular treatment with hemodialysis (HD) and registered during 2002 to 2006. Interdialytic weight gain and dialytic UFR were examined in annual cohorts and the records were based on 9693 HD sessions in 4498 patients. Differences in proportions were analyzed with the chi-square test and differences in mean...
Source: Hemodialysis International - April 21, 2009 Category: Hematology Authors: Magnus LINDBERG, Karl-Göran PRÜTZ, Per LINDBERG, Björn WIKSTRÖM Tags: ORIGINAL ARTICLES Source Type: journals

Calcium-sensing receptor gene polymorphisms and cardiac valvular calcification in patients with chronic renal failure: A pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we studied the relation of calcium-sensing receptor (CaSR) gene polymorphisms to the development of VC in chronic hemodialysis patients. A total of 41 chronic hemodialysis patients (26 male, mean age 47.23 ± 11.36 years vs. 15 females, mean age 48.13 ± 14.66 years) undergoing treatment for more than 1 year were evaluated with transthoracic echocardiography. In patients with and without VC, CaSR gene polymorphisms (A990G, C1011G) were investigated by PCR, using allele-specific primers. In randomly chosen subjects, PCR analysis was verified by DNA sequencing. Cardiac valve calcification was detected in 21 p...
Source: Hemodialysis International - April 21, 2009 Category: Hematology Authors: Funda TURKMEN, Ali OZDEMİR, Can SEVİNC, P[iota]nar Ata EREN, Serdar DEMİRAL Tags: ORIGINAL ARTICLES Source Type: journals

Metformin-induced encephalopathy without lactic acidosis in a patient with contraindication for metforminEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 51-year-old Korean man with end-stage renal disease and who was on intermittent hemodialysis was admitted with progressive dysarthria, gait disturbance, and myoclonus. The liver function tests and the electrolyte and arterial gas analyses were normal. The Magnetic resonance imaging scan showed a diffuse symmetric high signal intensity in the basal ganglia on the T2-weighted image. After a thorough history taking, we knew that he had been treated with metformin for 3 months at other hospital without our hospitals staff's knowledge. After stopping the metformin, the patient's neurologic signs and symptoms disappeared and t...
Source: Hemodialysis International - April 21, 2009 Category: Hematology Authors: Eun Young JUNG, Hyun Seop CHO, Jong Woo SEO, Dong Wook KIM, Hyun-Jung KIM, Se-Ho CHANG, Dong Jun PARK Tags: CASE REPORTS Source Type: journals

Complex wounds tend to develop more rapidly in patients receiving hemodialysis because of diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The number of patients requiring dialysis because of diabetes mellitus is increasing and such patients often have complex chronic wounds, which are difficult to heal. However, there are few retrospective studies of wounds requiring surgical treatment. We evaluated 14 patients receiving hemodialysis (HD) (8 because of diabetes and 6 because of other diseases) who had extremity wounds and underwent surgical treatment in our unit from 2004 through 2007. We investigated differences in the cause of wounds, and in the interval between the start of HD and wound development. Wounds in patients undergoing HD because of diabetes ori...
Source: Hemodialysis International - April 21, 2009 Category: Hematology Authors: Masaki FUJIOKA, Kiyoshi OKA, Riko KITAMURA, Aya YAKABE Tags: CASE REPORTS Source Type: journals