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Therapeutic RNA manipulation in liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Posttranscriptional regulation of gene expression is increasingly recognized as a model for inherited and acquired disease. Recent work has expanded understanding of the range of mechanisms that regulate several of these distinct steps, including messenger RNA (mRNA) splicing, trafficking, and/or stability. Each of these pathways is implicated in disease pathogenesis, and each represents important avenues for therapeutic intervention. This review summarizes important mechanisms controlling mRNA processing and the regulation of mRNA degradation, including the role of microRNAs and RNA binding proteins. These pathways provid...
Source: Hepatology - November 17, 2009 Category: Internal Medicine Authors: Thomas A. Kerr, Nicholas O. Davidson Source Type: journals

Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Apparent mutational escape can occur in MHC class II-restricted epitopes, but this is uncommon when compared with class I-restricted epitopes in the same individual. This indicates that other mechanisms for silencing CD4 T cells are dominant in persistent HCV infections. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - November 16, 2009 Category: Internal Medicine Authors: Michael J. Fuller, Naglaa H. Shoukry, Toshifumi Gushima, David G. Bowen, Benoit Callendret, Katherine J. Campbell, Dana L. Hasselschwert, Austin L. Hughes, Christopher M. Walker Source Type: journals

Lack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:During CDE treatment mice lacking IL-6 and gp130-STAT signaling in hepatocytes are prone to hepatic metabolic changes and inflammation. This ultimately leads to progressive steatohepatitis with signs of liver remodeling. Thus, the presented model allows one to further dissect the role of IL-6/gp130-type signaling in hepatocytes during fatty liver degeneration to define new therapeutic targets in metabolic liver diseases. (HEPATOLOGY 2010.) (Source: Hepatology)
Source: Hepatology - November 16, 2009 Category: Internal Medicine Authors: Daniela C. Kroy, Naiara Beraza, Darjus F. Tschaharganeh, Leif E. Sander, Stephanie Erschfeld, Arne Giebeler, Christian Liedtke, Hermann E. Wasmuth, Christian Trautwein, Konrad L. Streetz Source Type: journals

CX3CL1 (fractalkine): A signpost for biliary inflammation in primary biliary cirrhosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: There are common properties of ECs, LSECs, and BECs, whether derived from PBC or viral hepatitis, but there are also significant differences, particularly in the potential in PBC for LMCs to adhere to ECs and BECs and to produce TNF-[alpha]; such properties were associated with augmented CX3CL1 production by BEC from PBC liver. The processes defined herein suggest potential novel biotherapies for biliary specific inflammation. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - November 11, 2009 Category: Internal Medicine Authors: Shinji Shimoda, Kenichi Harada, Hiroaki Niiro, Akinobu Taketomi, Yoshihiko Maehara, Koichi Tsuneyama, Kentaro Kikuchi, Yasuni Nakanuma, Ian R. Mackay, M. Eric Gershwin, Koichi Akashi Source Type: journals

Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: TLR9 serves as an endogenous sensor of tissue necrosis that exacerbates the innate immune response during liver I/R. Combined blockade of TLR9 and HMGB1 represents a clinically relevant, novel approach to limiting I/R injury. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - November 11, 2009 Category: Internal Medicine Authors: Zubin M. Bamboat, Vinod P. Balachandran, Lee M. Ocuin, Hebroon Obaid, George Plitas, Ronald P. DeMatteo Source Type: journals

Lamivudine maintenance beyond one year after HBeAg seroconversion is a major factor for sustained virologic response in HBeAg-positive chronic hepatitis BEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The lamivudine-induced virologic response was durable in patients under 40 years old and those receiving lamivudine for more than 12 months after HBeAg clearance or seroconversion. Age and additional treatment were major predictive factors for SVR. (HEPATOLOGY 2010.) (Source: Hepatology)
Source: Hepatology - November 9, 2009 Category: Internal Medicine Authors: Hyun Woong Lee, Heon Ju Lee, Jae Seok Hwang, Joo Hyun Sohn, Jae Young Jang, Ki Jun Han, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Yong Han Paik, Chun Kyon Lee, Kwan Sik Lee, Chae Yoon Chon, Kwang-Hyub Han Source Type: journals

Toxicant-associated steatohepatitis in vinyl chloride workersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: TASH occurred frequently in these nonobese VC workers with high cumulative exposures and normal liver enzymes. Elevated total cytokeratin 18 suggested the presence of necrotic cell death in TASH and may be a useful serologic biomarker. TASH was further characterized by insulin resistance, elevated proinflammatory cytokines, and impaired antioxidant defenses. The threshold VC exposure and the role of other chemical agents in TASH are as yet unknown. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - November 9, 2009 Category: Internal Medicine Authors: Matt Cave, Keith Cameron Falkner, Mukunda Ray, Swati Joshi-Barve, Guy Brock, Rehan Khan, Marjorie Bon Homme, Craig J. McClain Source Type: journals

The role of transjugular intrahepatic portosystemic shunt (TIPS) in the management of portal hypertension: Update 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Hepatology)
Source: Hepatology - November 9, 2009 Category: Internal Medicine Authors: Thomas D. Boyer, Ziv J. Haskal Source Type: journals

Ammonia and the neutrophil in the pathogenesis of hepatic encephalopathy in cirrhosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatic encephalopathy (HE) constitutes a neuropsychiatric syndrome which remains a major clinical problem in patients with cirrhosis. In the severest form of HE, cirrhotic patients may develop varying degrees of confusion and coma. Ammonia has been regarded as the key precipitating factor in HE, and astrocytes have been the most commonly affected cells neuropathologically. Although the evidence base supporting a pivotal role of ammonia is robust, in everyday clinical practice a consistent correlation between the concentration of ammonia in the blood and the manifest symptoms of HE is not observed. More recently the synerg...
Source: Hepatology - November 5, 2009 Category: Internal Medicine Authors: Debbie L. Shawcross, Shabnam S. Shabbir, Nicholas J. Taylor, Robin D. Hughes Source Type: journals

Systematic review of randomized trials on vasoconstrictor drugs for hepatorenal syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Terlipressin plus albumin may prolong short-term survival in type 1 HRS. The duration of the response should be considered when making treatment decisions and in the timing of potential liver transplantations. Considering the small number of patients included, the evidence does not allow for treatment recommendations regarding type 2 HRS or any of the remaining treatment comparisons assessed. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - November 4, 2009 Category: Internal Medicine Authors: Lise L. Gluud, Kurt Christensen, Erik Christensen, Aleksander Krag Source Type: journals

Generation of functional human hepatic endoderm from human induced pluripotent stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This work is first to demonstrate the efficient generation of hepatic endodermal lineage from human iPSCs that exhibits key attributes of hepatocytes, and the potential application of iPSC-derived HE in studying human liver biology. In particular, iPSCs from individuals representing highly polymorphic variants in metabolic genes and different ethnic groups will provide pharmaceutical development and toxicology studies a unique opportunity to revolutionize predictive drug toxicology assays and allow the creation of in vitro hepatic disease models. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - October 30, 2009 Category: Internal Medicine Authors: Gareth J. Sullivan, David C. Hay, In-Hyun Park, Judy Fletcher, Zara Hannoun, Catherine M. Payne, Donna Dalgetty, James R. Black, James A. Ross, Kay Samuel, Gang Wang, George Q. Daley, Je-Hyuk Lee, George M. Church, Stuart J. Forbes, John P. Iredale, Ian W Source Type: journals

Predictors of response to therapy with terlipressin and albumin in patients with cirrhosis and type 1 hepatorenal syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Terlipressin plus albumin is an effective treatment for type 1 hepatorenal syndrome (HRS), but approximately only half of the patients respond to this therapy. The aim of this study was to assess predictive factors of response to treatment with terlipressin and albumin in patients with type 1 HRS. Thirty-nine patients with cirrhosis and type 1 HRS were treated prospectively with terlipressin and albumin. Demographic, clinical, and laboratory variables obtained before the initiation of treatment as well as changes in arterial pressure during treatment were analyzed for their predictive value. Response to therapy (reduction ...
Source: Hepatology - October 29, 2009 Category: Internal Medicine Authors: André Nazar, Gustavo Henrique Pereira, Mónica Guevara, Marta Martín-Llahi, Marie-Noëlle Pepin, Marcella Marinelli, Elsa Solá, María Eugenia Baccaro, Carlos Terra, Vicente Arroyo, Pere Ginès Source Type: journals

Merimepodib, pegylated interferon, and ribavirin in genotype 1 chronic hepatitis C pegylated interferon and ribavirin nonrespondersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The addition of MMPD to Peg-IFN-alfa-2a and RBV combination therapy did not increase the proportion of nonresponder patients with genotype 1 CHC achieving an SVR. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - October 22, 2009 Category: Internal Medicine Authors: Vinod K. Rustgi, William M. Lee, Eric Lawitz, Stuart C. Gordon, Nezam Afdhal, Fred Poordad, Herbert L. Bonkovsky, Leif Bengtsson, Gurudatt Chandorkar, Matthew Harding, Lindsay McNair, Molly Aalyson, John Alam, Robert Kauffman, Shahin Gharakhanian, John G. Source Type: journals

Treatment of insulin resistance with metformin in naïve genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Adding metformin to peginterferon and ribavirin was safe and improved insulin sensitivity. Although the study failed to show a statistically significant difference between arms, it did show an improved SVR in females. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - October 20, 2009 Category: Internal Medicine Authors: Manuel Romero-Gómez, Moisés Diago, Raúl J. Andrade, José L. Calleja, Javier Salmerón, Conrado M. Fernández-Rodríguez, Ricard Solà, Javier García-Samaniego, Juan M. Herrerías, Manuel De la Mata, Ricardo Moreno-Otero, Óscar Nuñez, Antonio Olveir Source Type: journals

Interleukin-17-producing CD4+ T cells increase with severity of liver damage in patients with chronic hepatitis BEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Th17 cells are highly enriched in both peripheral blood and liver of CHB patients, and exhibit a potential to exacerbate liver damage during chronic HBV infection. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - October 19, 2009 Category: Internal Medicine Authors: Ji-Yuan Zhang, Zheng Zhang, Fang Lin, Zheng-Sheng Zou, Ruo-Nan Xu, Lei Jin, Jun-Liang Fu, Feng Shi, Ming Shi, Hui-Fen Wang, Fu-Sheng Wang Source Type: journals

Liver stiffness identifies two different patterns of fibrosis progression in patients with hepatitis C virus recurrence after liver transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Early and repeated LSM following hepatitis C recurrence in combination with clinical variables discriminates between rapid and slow fibrosers after LT. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - October 17, 2009 Category: Internal Medicine Authors: José A. Carrión, Ferran Torres, Gonzalo Crespo, Rosa Miquel, Juan-Carlos García-Valdecasas, Miquel Navasa, Xavier Forns Source Type: journals

Cost-effectiveness of nationwide hepatitis B catch-up vaccination among children and adolescents in ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The adoption of a nationwide free catch-up hepatitis B vaccination program for unvaccinated children and adolescents in China, in addition to ongoing efforts to improve birth dose and newborn vaccination coverage, will be cost-saving and can generate significant population-wide health benefits. The success of such a program in China could serve as a model for other endemic countries. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - October 17, 2009 Category: Internal Medicine Authors: David W. Hutton, Samuel K. So, Margaret L. Brandeau Source Type: journals

Oral medications with significant hepatic metabolism at higher risk for hepatic adverse eventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our study finds an important relationship between a compound's metabolism profile and reports of hepatic adverse events. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - October 15, 2009 Category: Internal Medicine Authors: Craig Lammert, Einar Bjornsson, Anna Niklasson, Naga Chalasani Source Type: journals

Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Weight reduction achieved through lifestyle intervention leads to improvements in liver histology in NASH. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - October 13, 2009 Category: Internal Medicine Authors: Kittichai Promrat, David E. Kleiner, Heather M. Niemeier, Elizabeth Jackvony, Marie Kearns, Jack R. Wands, Joseph L. Fava, Rena R. Wing Source Type: journals

Toll-like receptor 4: A starting point for proinflammatory signals in fatty liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Hepatology)
Source: Hepatology - October 12, 2009 Category: Internal Medicine Authors: Anna Alisi, Nadia Panera, Valerio Nobili Source Type: journals

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overloadEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These studies demonstrate that iron overload due to deletion of Tfr2 is more severe than that due to Hfe, and that loss of both molecules results in pronounced iron overload. Analysis of Hfe/Tfr2 double-null mice suggests that Hfe and Tfr2 regulate hepcidin through parallel pathways involving Erk1/2 and Smad1/5/8. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - October 11, 2009 Category: Internal Medicine Authors: Daniel F. Wallace, Lesa Summerville, Emily M. Crampton, David M. Frazer, Gregory J. Anderson, V. Nathan Subramaniam Source Type: journals

Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin AEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: CsA inhibits replication of JFH1 full-length genomes much more efficiently than subgenomic replicons by targeting cleavage at the NS2/NS3 junction and possibly other nonreplication lifecycle steps. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - October 9, 2009 Category: Internal Medicine Authors: Sandra Ciesek, Eike Steinmann, Heiner Wedemeyer, Michael P. Manns, Johann Neyts, Norbert Tautz, Vanesa Madan, Ralf Bartenschlager, Thomas von Hahn, Thomas Pietschmann Source Type: journals

Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Maternal fat intake contributes toward the NAFLD progression in adult offspring, which is mediated through impaired hepatic mitochondrial metabolism and up-regulated hepatic lipogenesis. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - October 8, 2009 Category: Internal Medicine Authors: Kimberley D. Bruce, Felino R. Cagampang, Marco Argenton, Junlong Zhang, Priya L. Ethirajan, Graham C. Burdge, Adrian C. Bateman, Geraldine F. Clough, Lucilla Poston, Mark A. Hanson, Josie M. McConnell, Christopher D. Byrne Source Type: journals

Metformin in chronic hepatitis C virus hepatitis: Caution needed with sex-based subgroup analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Hepatology)
Source: Hepatology - October 5, 2009 Category: Internal Medicine Authors: Diego Geroldi, Enzo Emanuele Source Type: journals

Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Inhibition of PI3K signaling in HSCs during active fibrogenesis inhibits extracellular matrix deposition, including synthesis of type I collagen, and reduces expression of profibrogenic factors. These data suggest that targeting PI3K signaling in HSCs may represent an effective therapeutic target for hepatic fibrosis. (Hepatology 2009.) (Source: Hepatology)
Source: Hepatology - September 29, 2009 Category: Internal Medicine Authors: Gakuhei Son, Ian N. Hines, Jeff Lindquist, Laura W. Schrum, Richard A. Rippe Source Type: journals

Efficacy and safety of peginterferon alfa-2a (40KD) plus ribavirin in hepatitis C patients with advanced fibrosis and cirrhosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Compared with patients with less severe disease, SVR rates are significantly lower in patients with advanced fibrosis. However, irrespective of genotype and degree of fibrosis, the time to become hepatitis C virus (HCV) RNA undetectable was the strongest predictor of SVR. (HEPATOLOGY 2010.) (Source: Hepatology)
Source: Hepatology - September 29, 2009 Category: Internal Medicine Authors: Savino Bruno, Mitchell L. Shiffman, Stuart K. Roberts, Edward J. Gane, Diethelm Messinger, Stephanos J. Hadziyannis, Patrick Marcellin Source Type: journals

Age-specific prognosis following spontaneous hepatitis B e antigen seroconversion in chronic hepatitis BEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B virus infection confers a favorable prognosis, but untoward outcomes may develop in some patients. The impact of the age of HBeAg seroconversion on prognosis is not clearly known. HBeAg-positive patients with biopsy-proven chronic hepatitis B were followed up long-term. Follow-up studies included liver biochemistry, alpha-fetoprotein, and ultrasonography every 3 to 6 months or more frequently if clinically indicated. Of the patients who underwent spontaneous HBeAg seroconversion, the incidences of HBeAg-negative hepatitis, cirrhosis, hepatocellular carcino...
Source: Hepatology - September 29, 2009 Category: Internal Medicine Authors: Yi-Cheng Chen, Chia-Ming Chu, Yun-Fan Liaw Source Type: journals

Prevalence of hepatitis B surface antigen among refugees entering the United States between 2006 and 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Centers for Disease Control and Prevention recommends hepatitis B surface antigen (HBsAg) testing to identify chronic hepatitis B virus infection for foreign-born persons from countries or regions with HBsAg prevalence of [ge]2%. However, limited data exist to indicate which countries meet this definition. To address this data gap, we estimated the HBsAg prevalence among refugees entering the United States between 2006 and 2008. We contacted state refugee health coordinators and asked them to report the number of refugees, country of origin, and HBsAg prevalence among refugees screened in their jurisdiction during the ...
Source: Hepatology - September 29, 2009 Category: Internal Medicine Authors: David B. Rein, Sarah B. Lesesne, Ann O'Fallon, Cindy M. Weinbaum Source Type: journals

Spectrum of neurocognitive impairment in cirrhosis: Implications for the assessment of hepatic encephalopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Hepatology)
Source: Hepatology - September 28, 2009 Category: Internal Medicine Authors: Jasmohan S. Bajaj, James B. Wade, Arun J. Sanyal Source Type: journals

Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The single 4-g APAP dose produced a transcriptome signature in PB cells characterized by down-regulation of oxidative phosphorylation genes accompanied by increased serum lactate. Similar gene expression changes were observed in rats and several patients after consuming hepatotoxic doses of APAP. The timing of the changes and the correlation with NAPQI production are consistent with mechanisms known to underlie APAP hepatoxicity. These studies support the further exploration of the blood transcriptome for biomarkers of DILI. (HEPATOLOGY 2010.) (Source: Hepatology)
Source: Hepatology - September 25, 2009 Category: Internal Medicine Authors: Rick D. Fannin, Mark Russo, Thomas M. O'Connell, Kevin Gerrish, Jason H. Winnike, Jeffrey Macdonald, Jack Newton, Shahid Malik, Stella O. Sieber, Joel Parker, Ruchir Shah, Tong Zhou, Paul B. Watkins, Richard S. Paules Source Type: journals

Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Ak/NF-kB signaling pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study revealed that EphrinA2 played an important role in the development and progression of HCC by promoting the survival of cancer cells, indicating its role as a potential therapeutic target in HCC. (HEPATOLOGY 2010.) (Source: Hepatology)
Source: Hepatology - September 14, 2009 Category: Internal Medicine Authors: Yu-Xiong Feng, Jiang-Sha Zhao, Jing-Jing Li, Tao Wang, Shu-Qun Cheng, Yunfei Yuan, Fudi Wang, Xiao-Fan Wang, Dong Xie Source Type: journals

Limitations of the algorithm for the SAFE biopsy: A noninvasive fibrosis measure in chronic hepatitis CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Hepatology)
Source: Hepatology - September 11, 2009 Category: Internal Medicine Authors: Mohammed Rashid, Jonathon D. Mitchell, Matthew E. Cramp, Timothy J. S. Cross Source Type: journals

Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The proinflammatory Th17 cells are generated and regulated by a fine-tuned collaborative action between different types of immune cells in distinct HCC microenvironments, and allows the inflammatory response of activated monocytes to be rerouted in a tumor-promoting direction. Selectively modulating the "context" of inflammatory response in tumors might provide a novel strategy for anticancer therapy. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - September 9, 2009 Category: Internal Medicine Authors: Dong-Ming Kuang, Chen Peng, Qiyi Zhao, Yan Wu, Min-Shan Chen, Limin Zheng Source Type: journals

Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nonalcoholic fatty liver disease (NAFLD), ranging from relatively benign simple steatosis to progressive nonalcoholic steatohepatitis (NASH) and fibrosis, is an increasingly common chronic liver disease. Liver biopsy is currently the only reliable tool for staging the subtypes of NAFLD; therefore, noninvasive serum biomarkers for evaluation of liver disease and fibrosis are urgently needed. We performed this study to describe changes in the serum proteome and identify biomarker candidates in serum samples from 69 patients with varying stages of NAFLD (simple steatosis, NASH, and NASH with advanced bridging [F3/F4] fibrosis...
Source: Hepatology - September 9, 2009 Category: Internal Medicine Authors: Lauren N. Bell, Janice L. Theodorakis, Raj Vuppalanchi, Romil Saxena, Kerry G. Bemis, Mu Wang, Naga Chalasani Source Type: journals

Long-term outcomes of positive fluorescence in situ hybridization tests in primary sclerosing cholangitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In PSC patients, the presence of a dominant stricture plus FISH polysomy has a specificity of 88% for CCA. Patients with FISH showing trisomy or tetrasomy have a similar outcome to patients with negative FISH. FISH testing should be used selectively in patients with other signs indicating CCA and not as a screening tool in all PSC patients undergoing endoscopic retrograde cholangiopancreatography (ERCP). (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - September 9, 2009 Category: Internal Medicine Authors: Sanjay Y. Bangarulingam, Einar Bjornsson, Felicity Enders, Emily G. Barr Fritcher, Gregory Gores, Kevin C. Halling, Keith D. Lindor Source Type: journals

Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: Results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Rosiglitazone has a substantial antisteatogenic effect in the first year of treatment without additional benefit with longer therapy despite a maintained effect on insulin sensitivity and transaminase levels. This suggests that improving insulin sensitivity might not be sufficient in NASH and that additional targets of therapy for liver injury should be explored. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - September 9, 2009 Category: Internal Medicine Authors: Vlad Ratziu, Fréderic Charlotte, Carole Bernhardt, Philippe Giral, Marine Halbron, Gilles LeNaour, Agnès Hartmann-Heurtier, Eric Bruckert, Thierry Poynard, LIDO Study Group Source Type: journals

Bone marrow transplantation demonstrates medullar origin of CD34+ fibrocytes and ameliorates hepatic fibrosis in Abcb4-/- miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present study is the first to identify that both BM-derived fibrocytes and HSC are involved in biliary fibrogenesis in Abcb4-/- mice. Our data suggest that changes in immunity subsequent to BM-Tx may alter hepatic fibrosis. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - September 8, 2009 Category: Internal Medicine Authors: Martin Roderfeld, Timo Rath, Robert Voswinckel, Christian Dierkes, Hartmut Dietrich, Daniel Zahner, Jürgen Graf, Elke Roeb Source Type: journals

Down-regulation of connective tissue growth factor by inhibition of transforming growth factor [beta] blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Taken together, our preclinical results indicate that LY2109761 targets the cross-talk between HCC and the stroma and provide a rationale for future clinical trials. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - September 8, 2009 Category: Internal Medicine Authors: Antonio Mazzocca, Emilia Fransvea, Francesco Dituri, Luigi Lupo, Salvatore Antonaci, Gianluigi Giannelli Source Type: journals

Reply:Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Hepatology)
Source: Hepatology - September 8, 2009 Category: Internal Medicine Authors: Shujuan Pan, Richard N. Sifers Source Type: journals

Chronically inflamed livers up-regulate expression of inhibitory B7 family membersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results demonstrate that expression of PD-1/PD-1 ligands links more directly with the degree of inflammation than with the underlying etiology of liver damage. The PD-1 pathway may assist the liver in protecting itself from immune-mediated destruction. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - September 7, 2009 Category: Internal Medicine Authors: Rachel Kassel, Michael W. Cruise, Julia C. Iezzoni, Nicholas A. Taylor, Timothy L. Pruett, Young S. Hahn Source Type: journals

CorrectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Hepatology)
Source: Hepatology - September 7, 2009 Category: Internal Medicine Source Type: journals

Folding defects in P-type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4-phenylbutyrateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A surprisingly large proportion of ATP8B1 mutations resulted in aberrant folding and decreased expression at the plasma membrane. These effects were partially restored by treatment with 4-phenylbutyrate. We propose that treatment with pharmacological chaperones may represent an effective therapeutic strategy to ameliorate the recurrent attacks of cholestasis in patients with intermittent (BRIC1) disease. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - September 4, 2009 Category: Internal Medicine Authors: Lieke M. van der Velden, Janneke M. Stapelbroek, Elmar Krieger, Peter V. E. van den Berghe, Ruud Berger, Patricia M. Verhulst, Joost C. M. Holthuis, Roderick H. J. Houwen, Leo W. J. Klomp, Stan F. J. van de Graaf Source Type: journals

Mouse organic solute transporter [alpha] deficiency enhances renal excretion of bile acids and attenuates cholestasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings indicate that loss of Ost[alpha] provides protection from liver injury in obstructive cholestasis through adaptive responses in both the kidney and liver that enhance clearance of bile acids into urine and through detoxification pathways most likely mediated by the nuclear receptor Car. (HEPATOLOGY 2010.) (Source: Hepatology)
Source: Hepatology - September 4, 2009 Category: Internal Medicine Authors: Carol J. Soroka, Albert Mennone, Lee R. Hagey, Nazzareno Ballatori, James L. Boyer Source Type: journals

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Delayed treatment with GSH and NAC protect against APAP overdose by dual mechanisms - that is, by enhancing hepatic and mitochondrial GSH levels (scavenging of reactive oxygen and peroxynitrite) - and by supporting the mitochondrial energy metabolism. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - September 3, 2009 Category: Internal Medicine Authors: Chieko Saito, Claudia Zwingmann, Hartmut Jaeschke Source Type: journals

Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The combination of the GG-MPO genotype (leading to high MPO expression) and at least one Ala-SOD2 allele (associated with high liver iron score) markedly increased the risks of HCC occurrence and death in patients with alcoholic cirrhosis. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - September 2, 2009 Category: Internal Medicine Authors: Pierre Nahon, Angela Sutton, Pierre Rufat, Marianne Ziol, Hassan Akouche, Christelle Laguillier, Nathalie Charnaux, Nathalie Ganne-Carrié, Véronique Grando-Lemaire, Gisèle N'Kontchou, Jean-Claude Trinchet, Liliane Gattegno, Dominique Pessayre, Michel B Source Type: journals

The niche of stellate cells within rat liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The space of Disse shows analogies to typical stem cell niches comprising of basal lamina components, sympathetic innervation, and adjacent cells that constitute a milieu by paracrine factors and direct physical interactions to retain HSCs at this site and to influence their cellular fate. The space of Disse serves as a niche of stellate cells, which is a novel function of this unique organ structure. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - September 1, 2009 Category: Internal Medicine Authors: Iris Sawitza, Claus Kordes, Sven Reister, Dieter Häussinger Source Type: journals

Severe sepsis in cirrhosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sepsis is physiologically viewed as a proinflammatory and procoagulant response to invading pathogens. There are three recognized stages in the inflammatory response with progressively increased risk of end-organ failure and death: sepsis, severe sepsis, and septic shock. Patients with cirrhosis are prone to develop sepsis, sepsis-induced organ failure, and death. There is evidence that in cirrhosis, sepsis is accompanied by a markedly imbalanced cytokine response ("cytokine storm"), which converts responses that are normally beneficial for fighting infections into excessive, damaging inflammation. Molecular mechanisms for...
Source: Hepatology - August 31, 2009 Category: Internal Medicine Authors: Thierry Gustot, François Durand, Didier Lebrec, Jean-Louis Vincent, Richard Moreau Source Type: journals

Use of sorafenib in patients with hepatocellular carcinoma before liver transplantation: A cost-benefit analysis while awaiting data on sorafenib safetyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Sorafenib neoadjuvant therapy is cost-effective by comparison with no therapy for T2-HCC patients waiting for LT, particularly for median times to LT under 6 months. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - August 31, 2009 Category: Internal Medicine Authors: Alessandro Vitale, Michael L. Volk, Davide Pastorelli, Sara Lonardi, Fabio Farinati, Patrizia Burra, Paolo Angeli, Umberto Cillo Source Type: journals

Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Kupffer cells have a protective role for hepatocyte damage and promote cell survival, liver regeneration, and fibrosis in cholestatic liver disease. Kupffer cell-derived ASMase is crucial for AKT activation of hepatocytes that is required for the survival and regenerative responses. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - August 30, 2009 Category: Internal Medicine Authors: Yosuke Osawa, Ekihiro Seki, Masayuki Adachi, Atsushi Suetsugu, Hiroyasu Ito, Hisataka Moriwaki, Mitsuru Seishima, Masahito Nagaki Source Type: journals

Acute portal vein thrombosis unrelated to cirrhosis: A prospective multicenter follow-up studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Recanalization occurs in one-third of patients receiving early anticoagulation for acute portal vein thrombosis, whereas thrombus extension, intestinal infarction, severe bleeding, and death are rare. Alternative therapy should be considered when ascites and splenic vein obstruction are present. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - August 30, 2009 Category: Internal Medicine Authors: Aurelie Plessier, Sarwa Darwish-Murad, Manuel Hernandez-Guerra, Yann Consigny, Federica Fabris, Jonel Trebicka, Jorg Heller, Isabelle Morard, Luc Lasser, Philippe Langlet, Marie-Hélène Denninger, Dominique Vidaud, Bertrand Condat, Antoine Hadengue, Mass Source Type: journals