Predicting response to non-selective beta-blockers with liver –spleen stiffness and heart rate in patients with liver cirrhosis and high-risk varices
This study aims to define a noninvasive machine-learning based approach to determine response to NSBB in patients with liver cirrhosis and HRVs.MethodsWe conducted a prospective study on a cohort of cirrhotic patients with documented HRVs receiving NSBB treatment. Patients were followed-up with clinical and elastography appointments at 3, 6, and 12 months after NSBB treatment initiation. NSBB response was defined as stationary or downstaging variceal grading at the 12-month esophagogastroduodenoscopy (EGD). In contrast, non-response was defined as upstaging variceal grading at the 12-month EGD or at least one variceal...
Source: Hepatology International - April 25, 2024 Category: Infectious Diseases Source Type: research
The contribution of genetics and epigenetics to MAFLD susceptibility
AbstractMetabolic dysfunction-associated fatty liver disease (MAFLD) is the most common liver disease worldwide. The risk of developing MAFLD varies among individuals, due to a combination of environmental inherited and acquired genetic factors. Genome-wide association and next-generation sequencing studies are leading to the discovery of the common and rare genetic determinants of MAFLD. Thanks to the great advances in genomic technologies and bioinformatics analysis, genetic and epigenetic factors involved in the disease can be used to develop genetic risk scores specific for liver-related complications, which can improv...
Source: Hepatology International - April 25, 2024 Category: Infectious Diseases Source Type: research
PIVKA-II combined with alpha-fetoprotein for the diagnostic value of hepatic tumors in children: a multicenter, prospective observational study
ConclusionsThe serum level of PIVKA-II was significantly higher in children with hepatic tumors, especially those with malignant tumors. The combination of PIVKA-II with AFP further increased the diagnostic performance.Trial registrationClinical Trials, NCT03645655. Registered 20 August 2018,https://www.clinicaltrials.gov/ct2/show/NCT03645655. (Source: Hepatology International)
Source: Hepatology International - April 16, 2024 Category: Infectious Diseases Source Type: research
Efficacy and safety of precision-guided transjugular extrahepatic portosystemic shunt (TEPS) in the management of cavernous transformation of the portal vein with portal hypertension: a case series
ConclusionsPrecision-guided TEPS appears to be a safe and efficacious intervention for the management of CTPV. (Source: Hepatology International)
Source: Hepatology International - April 9, 2024 Category: Infectious Diseases Source Type: research
MAFLD as part of systemic metabolic dysregulation
AbstractNonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. In recent years, a new terminology and definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed. Compared to the NAFLD definition, MAFLD better emphasizes the pathogenic role of metabolic dysfunction in the development and progression of this highly prevalent condition. Metabolic disorders, including overweight/obesity, type 2 diabetes mellitus (T2DM), atherogenic dyslipidemia and hypertension, are often associated with systemic organ dysfunctions, thereby suggesting that multiple...
Source: Hepatology International - April 9, 2024 Category: Infectious Diseases Source Type: research
APASL clinical practice guidelines on the management of acute kidney injury in acute-on-chronic liver failure
The objective of the present position paper is to critically review and analyze the published data on AKI in ACLF, evolve a consensus, and provide recommendations for early diagnosis, pathophysiology, prevention, and management of AKI in patients with ACLF. In the absence of direct evidence, we propose expert opinions for guidance in managing AKI in this very challenging group of patients and focus on areas of future research. This consensus will be of major importance to all hepatologists, liver transplant surgeons, and intensivists across the globe. (Source: Hepatology International)
Source: Hepatology International - April 5, 2024 Category: Infectious Diseases Source Type: research
Abstracts
(Source: Hepatology International)
Source: Hepatology International - April 5, 2024 Category: Infectious Diseases Source Type: research
Liver fibrosis showed a two-phase regression rate during long-term anti-HBV therapy by three-time biopsies assessments
ConclusionDuring the 5 years of long-term antiviral treatment, liver fibrosis rapidly regresses in the first 1.5 years before slowing down in the following 3.5 years.Graphical Abstract (Source: Hepatology International)
Source: Hepatology International - April 2, 2024 Category: Infectious Diseases Source Type: research
Evaluation of the histologic and immunohistochemical (CD34, glutamine synthetase) findings in idiopathic non-cirrhotic portal hypertension (INCPH)
ConclusionIn the biopsy diagnosis of INCPH, in addition to the presence of major histologic findings and the amount of portal tracts displaying these features, the expression of endothelial CD34 in periportal areas, and irregular hepatocellular GS expression can also be considered as supporting feature. (Source: Hepatology International)
Source: Hepatology International - March 27, 2024 Category: Infectious Diseases Source Type: research
Global burden and trends of acute viral hepatitis among children and adolescents from 1990 to 2019: a systematic analysis of the Global Burden of Disease Study 2019
ConclusionEffective vaccines and treatments for hepatitis B and C offer eradication opportunities. Broadening diagnostic and therapeutic coverage is vital to address disparities in service provision for children and adolescents. (Source: Hepatology International)
Source: Hepatology International - March 26, 2024 Category: Infectious Diseases Source Type: research
Abstracts
(Source: Hepatology International)
Source: Hepatology International - March 20, 2024 Category: Infectious Diseases Source Type: research
Prophylaxis of hepatic encephalopathy: current and future drug targets
AbstractHepatic encephalopathy is described by a broad spectrum of neurological and psychiatric aberrations resulting due to advanced liver dysfunction. It is a neurological disorder due to hepatic insufficiency and/or portosystemic shunts. Its clinical presentation includes neuropsychiatric dysfunction ranging from subclinical changes to comatose state. It is a sign of poor prognosis in cirrhotics with a high 1-year mortality. Each episode of hepatic encephalopathy leads to high hospitalization rate, poor prognosis and raised burden of healthcare. Primary prophylaxis is prevention of initial occurrence and secondary proph...
Source: Hepatology International - March 16, 2024 Category: Infectious Diseases Source Type: research
Safety of right liver donation after improving steatosis through weight loss in living donors: a retrospective study
ConclusionWeight loss through diet and exercise significantly could improve hepatic steatosis in living donor candidates for liver transplantation, with the surgical outcomes in recipients and donors being equivalent to those in recipients and non-steatotic donors. (Source: Hepatology International)
Source: Hepatology International - March 15, 2024 Category: Infectious Diseases Source Type: research
Laparoscopic liver resection is superior to radiofrequency ablation for small hepatocellular carcinoma: a systematic review and meta-analysis of propensity score-matched studies
ConclusionsOur meta-analysis demonstrated that in comparison with RFA in the treatment of small HCC, LH provided superior long-term OS and DFS together with lower rates of local and intrahepatic distant recurrence after surgery. However, RFA was associated with better short-term outcomes. (Source: Hepatology International)
Source: Hepatology International - March 14, 2024 Category: Infectious Diseases Source Type: research
“Dosis sola facit venenum”—Evidence for causality in the association between ketamine and cholestatic liver injury
(Source: Hepatology International)
Source: Hepatology International - March 13, 2024 Category: Infectious Diseases Source Type: research
