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Serum α-fetoprotein levels in liver steatosisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Patients with NAFLD have higher AFP levels than those without fatty liver changes. AFP levels rise as grade of liver steatosis increases. NAFLD should be among the differential diagnosis of elevated serum AFP levels. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9156-8Authors Ayşegül Babalı, Ankara Education and Research Hospital Department of Gastroenterology Ankara TurkeyErman Çakal, Dışkapı Education and Research Hospital Department of Endocrinology Ankara TurkeyTuğrul Purnak, Ankara Numune Education and Research Hospital Department of Gastroenterolog...
Source: Hepatology International - November 4, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Efficacy of ursodeoxycholic acid for Japanese patients with autoimmune hepatitisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  UDCA monotherapy is effective for some Japanese AIH patients; however, UDCA monotherapy for patients with either high-grade inflammatory activity or poor residual capacity of liver function is not recommended because they may reach liver failure before achievement of remission. Meanwhile, additional use of UDCA during the taper of corticosteroids may be effective for the prevention of early relapse. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9155-9Authors Yasuhiro Miyake, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences...
Source: Hepatology International - October 21, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

CME informationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CME InformationDOI 10.1007/s12072-009-9152-z Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - September 22, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

CME post testemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CME Post TestDOI 10.1007/s12072-009-9153-y Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - September 22, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

The role of quantitative hepatitis B serology in the natural history and management of chronic hepatitis Bemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Chronic hepatitis B (CHB) remains a serious clinical problem worldwide. Advances in molecular technology have enabled the development of sensitive assays for the detection and quantification of hepatitis B virus (HBV) nucleic acid and demonstrated a positive correlation between serum HBV DNA levels and disease progression. Assessment of specific serologic and virologic factors also plays a pivotal role in the diagnosis and effective management of individuals with CHB. Recent development of quantitative assays for intrahepatic HBV replicative intermediates, as well as hepatitis B e antigen and hepati...
Source: Hepatology International - September 18, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Introductionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory Supplement ArticleDOI 10.1007/s12072-009-9154-xAuthors Yun-Fan Liaw, Chang Gung Memorial Hospital and University Liver Research Unit 199 Tung Hwa North Road Taipei 105 Taiwan Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - September 18, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Combined hepatocellular and cholangiocarcinoma with sarcomatoid transformation: radiologic–pathologic correlation of a caseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  A 71-year-old man presented to our hospital with 3-week history of fever in the background of loss of both weight and appetite over the past 3 months. He was found to have a large 10-cm mass in the right lobe of the liver on a triple-phase computed tomographic scan. The tumor showed a distinct fatty component, with areas of arterial enhancement and venous washout suggestive of hepatocellular carcinoma (HCC), another component showing progressive and late enhancement suggestive of cholangiocarcinoma (CC), and a third component showing persistent hypoenhancement relative to the liver parenchyma. ...
Source: Hepatology International - September 17, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Role of N-acetylcysteine in adults with non-acetaminophen-induced acute liver failure in a center without the facility of liver transplantationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  The use of NAC causes reduction in NAI-ALF mortality and its use was safe. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9151-0Authors Khalid Mumtaz, Aga Khan University Hospital Department of Medicine Karachi PakistanZahid Azam, Aga Khan University Hospital Department of Medicine Karachi PakistanSaeed Hamid, Aga Khan University Hospital Department of Medicine Karachi PakistanShahab Abid, Aga Khan University Hospital Department of Medicine Karachi PakistanSadik Memon, Isra University Hospital Hyderabad PakistanHasnain Ali Shah, Aga Khan University Hospital Depar...
Source: Hepatology International - September 3, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Liver transplantation for acute-on-chronic liver failureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Liver transplantation for acute-on-chronic liver failure is life-saving, and the survival rates it attains are similar to those attained by transplantation for other liver conditions. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9148-8Authors Albert C. Chan, The University of Hong Kong Department of Surgery, Queen Mary Hospital 102 Pok Fu Lam Road Hong Kong ChinaSheung Tat Fan, The University of Hong Kong Department of Surgery, Queen Mary Hospital 102 Pok Fu Lam Road Hong Kong ChinaChung Mau Lo, The University of Hong Kong Department of Surgery, Queen Mary Hos...
Source: Hepatology International - August 18, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Outcomes of patients with chest tube insertion for hepatic hydrothoraxemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Chest tube insertion for hepatic hydrothorax carries significant morbidity and mortality, with questionable benefit. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9136-zAuthors Eric S. Orman, University of Michigan Department of Internal Medicine Ann Arbor MI USAAnna S. F. Lok, University of Michigan Health System Division of Gastroenterology 3912 Taubman Center, SPC 5362 Ann Arbor MI USA Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - August 11, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Dual chronic hepatitis B virus and hepatitis C virus infectionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Dual hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are common in HBV or HCV endemic areas. However, several clinical and pathogenetic issues remain unresolved. First, clinical and in vitro studies suggest the interactions between two viruses. The dynamics of the interaction in untreated setting versus treated setting and its influence on the long-term outcomes await further studies. A key issue regarding viral interactions is whether modulation of infection occurs in the same dually infected individual hepatocyte of the liver. Clarifying this issue may help to understand the reciproc...
Source: Hepatology International - August 9, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Geographic variations of predominantly hepatitis C virus associated male hepatocellular carcinoma townships in Taiwan: identification of potential high HCV endemic areasemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  We successfully highlighted some potential high HCV endemic townships in Taiwan. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9146-xAuthors Wei-Wen Su, Changhua Christian Hospital Department of Internal Medicine No. 135 Nanxiao Changhua TaiwanChien-Hung Chen, National Taiwan University Hospital and National Taiwan University College of Medicine Department of Internal Medicine No. 7 Chung San South Rd Taipei TaiwanHans Hsienhong Lin, Buddhist Tzu Chi General Hospital Department of Gastroenterology No. 707, Sec. 3, Chung Yang Rd Hualien TaiwanSheng-Shun Yang, Taic...
Source: Hepatology International - August 7, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Ultrasound surveillance for early detection of hepatocellular carcinoma among patients with chronic hepatitis Cemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Ultrasound surveillance at 6-month intervals was appropriate in general for the detection of HCC at a size smaller than 30 mm. However, in patient with established cirrhosis, more frequent screening would be needed to detect tumors of the same size. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9145-yAuthors Takahisa Sato, University of Tokyo Department of Gastroenterology 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanRyosuke Tateishi, University of Tokyo Department of Gastroenterology 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanHaruhiko Yoshida, University of...
Source: Hepatology International - August 6, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

On-treatment monitoring of HBV DNA levels: predicting response and resistance to oral antiviral therapy at week 24 versus week 48email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  The suppression of hepatitis B viral (HBV) load correlates with favorable histologic, biochemical, and serologic responses in clinical trials of patients with chronic hepatitis B (CHB). The ability to identify patients who will not experience durable viral suppression in response to a specific antiviral regimen affords the opportunity for early treatment modification to optimize outcomes and avoid the development of antiviral resistance. Substantial evidence demonstrates that on-treatment serum HBV DNA levels are predictive of virologic response and risk of resistance. Regional clinical practice gui...
Source: Hepatology International - July 30, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

The global burden of iron overloademail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  There have been major developments in the field of iron metabolism in the past decade following the identification of the HFE gene and the mutation responsible for the C282Y substitution in the HFE protein. While HFE-associated hemochromatosis occurs predominantly in people of northern European extraction, other less-common mutations can lead to the same clinical syndrome and these may occur in other populations in the Asian-Pacific region. The most common of these is the mutation that leads to changes in the ferroportin molecule, the protein responsible for the transport of iron across the basolate...
Source: Hepatology International - July 29, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Prevalence of hepatitis B virus genotype B in Vietnamese patients with chronic hepatitis Bemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Chinese patients with CHB often carry either B or C genotype. Vietnamese patients with CHB mostly have HBV genotype B. Additional studies are needed to further characterize the clinical significance of HBV genotype in the natural history and treatment outcomes of CHB in Vietnamese patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9141-2Authors Long H. Nguyen, Stanford University School of Medicine Stanford CA USANghiem B. Ha, Pacific Health Foundation San Jose CA USAPhilip Vutien, Pacific Health Foundation San Jose CA USANghi B. Ha, Pacific Health Founda...
Source: Hepatology International - July 10, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Chronic hepatitis B in Asian women of childbearing ageemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This article reviews these issues and highlights areas in which their engagement with public health efforts serves to improve quality of life and society as a whole. Content Type Journal ArticleCategory Supplement ArticleDOI 10.1007/s12072-009-9142-1Authors Nancy Leung, Chinese University of Hong Kong Department of Medicine, Alice Ho Miu Ling Nethersole Hospital Room 65, J6, 11 Chuen On Road, Tai Po, NT Hong Kong SAR China Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - July 9, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Patterns of managing chronic hepatitis B treatment-related drug resistance: a survey of physicians in Mainland China, South Korea, Taiwan, and Thailandemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Limited access to HBV resistance tests causes physicians in Asia to manage suspected resistance by various HBV DNA assays and ALT tests. This raises concerns that resistance may not be detected early enough to be rescued efficiently. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9139-9Authors Siwaporn Chainuvati, Mahidol University Department of Medicine, Siriraj Hospital 2 Prannok Road, Bangkok-noi Bangkok 10700 ThailandJun Cheng, Beijing Ditan Hospital No 8, Shundong Jie, Chaoyang District Beijing 100015 ChinaJin Lin Hou, Southern Medical University Hepatolog...
Source: Hepatology International - June 24, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

HBeAg seroconversion as an important end point in the treatment of chronic hepatitis Bemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  During the natural history of chronic hepatitis B virus (HBV) infection, the loss of serum hepatitis B e antigen (HBeAg) and the development of anti-HBe antibodies (HBeAg seroconversion) mark a transition from the immune-active phase of disease to the inactive carrier state. This review examines the evidence from natural history and cohort studies on the relationship between HBeAg seroconversion and disease progression. The role of HBeAg seroconversion as an important milestone in the management of HBeAg-positive patients with chronic hepatitis B (CHB), as well as the advantages and disadvantages of...
Source: Hepatology International - June 24, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

The state of cholesterol metabolism in the liver of patients with primary biliary cirrhosis: the role of MDR3 expressionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Hepatocellular cholesterol metabolism was at least partially disturbed, even in the early stage of PBC. The most characteristic finding was a distinct elevation of MDR3 expression, and the MDR3 levels were negatively correlated with GGT and IgM levels. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9137-yAuthors Munechika Enjoji, Fukuoka University Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences 8-19-1 Nanakuma, Jonan-ku Fukuoka 814-0180 JapanRyoko Yada, National Hospital Organization Clinical Research Center, Kyushu Medical Center Fukuok...
Source: Hepatology International - June 17, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

The saga of entecaviremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s12072-009-9138-xAuthors Ching-Lung Lai, The University of Hong Kong Department of Medicine Queen Mary Hospital, Pokfulam Hong Kong ChinaMan-Fung Yuen, The University of Hong Kong Department of Medicine Queen Mary Hospital, Pokfulam Hong Kong China Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - June 17, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Antiviral activity, dose–response relationship, and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B: a randomized, double-blind, phase II clinical trialemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Entecavir 0.01–0.5 mg is well tolerated and produces a dose-dependent reduction in viral load in nucleoside-naive Japanese patients with CHB. Compared with lamivudine 100 mg, entecavir 0.1 mg demonstrated noninferiority and entecavir 0.5 mg was superior in this population. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9135-0Authors Michiko Shindo, Akashi Municipal Hospital Division of Liver Disease, Department of Internal Medicine 1-33 Takasyo-machi, Akashi-shi Hyogo JapanKazuaki Chayama, Hiroshima University Department of Medicine and Mol...
Source: Hepatology International - May 24, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

A randomized trial of 24 versus 48 weeks of peginterferon α-2a in patients infected with chronic hepatitis C virus genotype 2 or low viral load genotype 1: a multicenter national study in Japanemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In conclusion, in patients infected with HCV genotype 2 and pretreatment viral load below 1000 kIU/ml who achieve RVR, 24-week treatment with peginterferon α-2a alone is clinically sufficient. Those who show no RVR or have higher baseline viral load, require alternative therapies. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9134-1Authors Yoshiaki Iwasaki, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Department of Gastroenterology and Hepatology 2-5-1, Shikata-cho Okayama 700-8558 JapanYasushi Shiratori, Okayama University Graduate School...
Source: Hepatology International - May 22, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Natural history of hepatic vena cava disease, the liver disease due to obstruction of the hepatic portion of inferior vena cavaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Natural history and management of HVD was different from hepatic vein thrombosis caused by hypercoagulable condition, a disease with which it is commonly grouped together under Budd-Chiari syndrome. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9133-2Authors Santosh Man Shrestha, Liver Foundation Nepal Sitapaela Height P.O. Box No. 3439 Kathmandu Nepal Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - May 8, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

A randomized controlled trial of thymalfasin plus transarterial chemoembolization for unresectable hepatocellular carcinomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  In patients with unresectable HCC, TACE + thymalfasin resulted in numerically higher rates of survival and tumor response, including transplant candidacy, with fewer bacterial infections, than TACE alone. Treatment regimens for HCC including thymalfasin as an immunomodulator should be evaluated in larger trials. Content Type Journal ArticleCategory Original articleDOI 10.1007/s12072-009-9132-3Authors Robert G. Gish, California Pacific Medical Center Department of Hepatology and Complex Gastroenterology 2340 Clay St. #233 San Francisco CA 94115 USAStuart C. Gordon, Henry Ford Heal...
Source: Hepatology International - May 8, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Cerebral embolism following N-butyl-2-cyanoacrylate injection for esophageal postbanding ulcer bleed: a case reportemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report a case of cerebral embolism a few hours after an injection of Histoacryl into a bleeding esophageal post-banding ulcer. Echocardiogram revealed patent foramen ovale. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12072-009-9130-5Authors Asmarani Abdullah, Selayang Hospital Hepatology Unit Lebohraya Selayang-Kepong 68100 Batu Caves Selangor MalaysiaSharmila Sachithanandan, Selayang Hospital Hepatology Unit Lebohraya Selayang-Kepong 68100 Batu Caves Selangor MalaysiaOoi Keat Tan, Selayang Hospital Hepatology Unit Lebohraya Selayang-Kepong 68100 Batu Caves Selangor MalaysiaYee Ming Chan, Selayan...
Source: Hepatology International - May 6, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Diffuse intrahepatic recurrence after percutaneous radiofrequency ablation for solitary and small hepatocellular carcinomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Two patients developed segmental, diffuse intrahepatic recurrence after percutaneous radiofrequency ablation (RFA) to treat a primary, solitary, and small (2.5 cm) hepatocellular carcinoma (HCC). Despite the size of the HCC, levels of the tumor markers (α-fetoprotein, α-fetoprotein-L3%, and des-γ-carboxyprothrombin) were all elevated before RFA, and tumors in both patients were contiguous with a major branch of the portal vein. Tumor biopsies of both patients revealed moderately differentiated HCC but diagnostic imaging showed an area of reduced tumor blood flow, suggesting a poorly differen...
Source: Hepatology International - April 30, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Effect of natural interferon α on proliferation and apoptosis of hepatic stellate cellsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Inhibition of the proliferation of hepatic stellate cells (HSC) is clinically important for the control of liver fibrosis and cirrhosis. Interferons are now frequently used for chronic viral hepatitis because of their anti-viral activity. However, patients treated with interferons exhibit a regression of liver fibrosis even if viral eradication is not achieved, indicating that interferon itself has anti-fibrotic activity. Herein, we show the anti-proliferation and pro-apoptotic activity of natural interferon α against HSC. We found that interferon α inhibited serum-stimulated [3H]thymidine incorpo...
Source: Hepatology International - April 21, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Well-differentiated hepatocellular carcinoma smaller than 15 mm in diameter totally eradicated with percutaneous ethanol injection instead of radiofrequency ablationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We describe three cases of well-differentiated hepatocellular carcinoma (HCC) smaller than 15 mm in diameter completely eradicated with percutaneous ethanol injection (PEI) instead of using radiofrequency ablation (RFA). Ultrasound (US) examination revealed one nodule each in segment 2 (hypoechoic, near bile ducts, 10 mm), in segment 5 (hyperechoic, near the gall bladder, 15 mm), and in segment 7 (hypoechoic, near the diaphragm, 15 mm). Although imaging studies revealed isovascular (case 1) and hypervascular (cases 2 and 3) nodules, histological analysis of US-guided biopsy tissue revealed well-diff...
Source: Hepatology International - March 21, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Association of IL-18 promoter polymorphism with liver disease severity in HCV-infected patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  IL-18 promoter polymorphism at −607 position with A/A allele is a potential protective marker, as it is associated with milder liver disease in patients with chronic HCV infection. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9127-0Authors K. Manohar, G.B. Pant Hospital Department of Gastroenterology New Delhi IndiaP. V. Suneetha, G.B. Pant Hospital Department of Gastroenterology New Delhi IndiaSukriti, G.B. Pant Hospital Department of Gastroenterology New Delhi IndiaNirupama Trehan Pati, G.B. Pant Hospital Department of Gastroenterology New Delhi IndiaAbhis...
Source: Hepatology International - March 17, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Two cases of hepatocellular adenomatosis treated with transcatheter arterial embolizationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Hepatocellular adenoma is a rare benign tumor of the liver. However, some complications, such as hemorrhage, rupture, and malignant transformation, have been reported previously. Surgical resection is considered to be the best choice of treatment, when adenomas are increasing in size, while resection is difficult to perform when multiple adenomas develop throughout the liver. Here, we report two cases of multiple hepatocellular adenomatosis. One patient had a history of aplastic anemia and the other had glycogen storage disease. We treated them with transcatheter arterial embolization (TAE) to preve...
Source: Hepatology International - March 5, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Usjmscp-Nih-Apaslemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s12072-009-9124-3 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - January 31, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Author Indexemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s12072-009-9125-2 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - January 31, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Poster Exhibitionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s12072-009-9123-4 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - January 31, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Liver cirrhosis and hepatocellular carcinoma in hepatic vena cava disease, a liver disease caused by obstruction of inferior vena cavaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  HVD is independent risk factors for LC and HCC. Severe and/or recurrent loss of hepatocytes caused by hepatic venous outflow obstruction and/or thrombotic obstruction of small radicals of hepatic and portal veins that occurred during acute exacerbations was considered important in the pathogenesis of LC and HCC in HVD. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-009-9122-5Authors Santosh Man Shrestha, Liver Foundation Nepal Sitapaela Height P.O. Box 3439 Kathmandu Nepal Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepa...
Source: Hepatology International - January 23, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Free Paper Presentationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s12072-008-9121-y Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - January 23, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Plenary Presentationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s12072-008-9118-6 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - January 22, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Invited Abstract: 19th Conference of the Asian Pacific Association for the Study of the Liveremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s12072-008-9119-5 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - January 22, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Young Investigator Presentationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s12072-008-9117-7 Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - January 22, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Poster Presentationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s12072-008-9120-z Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (Source: Hepatology International)
Source: Hepatology International - January 22, 2009 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Hepatitis A outbreaks in China during 2006: application of molecular epidemiologyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Contaminated water and suspected ice cream were associated with outbreaks of hepatitis A. Viral genetic analysis may advance field investigations in complex situations. Content Type Journal ArticleCategory ORIGINAL ARTICLEDOI 10.1007/s12072-008-9116-8Authors Jingyuan Cao, Chinese Center for Disease Control and Prevention Division of Hepatitis, National Institute for Viral Disease Control and Prevention Yingxin Street 100, Xuanwu District Beijing 100052 People’s Republic of ChinaYue Wang, Chinese Center for Disease Control and Prevention Division of Hepatitis, National Institute for Viral D...
Source: Hepatology International - December 19, 2008 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

A low steady HBsAg seroprevalence is associated with a low incidence of HBV-related liver cirrhosis and hepatocellular carcinoma in Mexico: a systematic reviewemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  To address the relationship between hepatitis B virus (HBV) endemicity and HBV-related liver diseases in Mexico. Research literature reporting on HBsAg and antibody to hepatitis B core antigen (anti-HBc) prevalence in Mexican study groups were searched in NLM Gateway, PubMed, IMBIOMED, and others. Weighted mean prevalence (WMP) was calculated from the results of each study group. A total of 50 studies were analyzed. Three nationwide surveys revealed an HBsAg seroprevalence of less than 0.3%. Horizontal transmission of HBV infection occurred mainly by sexual activity and exposure to both contaminated...
Source: Hepatology International - December 19, 2008 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Induction of tropomyosin during hepatic stellate cell activation and the progression of liver fibrosisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  The activation of hepatic stellate cells (HSCs) is a cue to initiate liver fibrosis. Activated stellate cells acquire contractile activity similar to pericytes and myofibroblasts in other organs by inducing the contractile machinery of cytoskeletons such as smooth muscle α-actin (α-SMA), a well-known marker of activated stellate cells, and actin-binding proteins. We further show herein the expression of tropomyosin in rat HSCs in the course of their activation during primary culture and liver tissue damaged by thioacetamide intoxication. In immunoblot analysis, tropomyosin became detectable in an ...
Source: Hepatology International - December 11, 2008 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Systemic and pulmonary hemodynamics in patients with extrahepatic portal vein obstruction is similar to compensated cirrhotic patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  EHPVO patients have hyperdynamic circulation manifested by high cardiac index and low systemic and pulmonary vascular resistance indices. These hemodynamic changes are comparable with compensated cirrhotic patients who have similar grade of portal hypertension. This suggests a predominant role of portal hypertension per se in the genesis of systemic and pulmonary hemodynamic alterations. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9110-1Authors Sanjeev Kumar Jha, Affiliated to University of Delhi Department of Gastroenterology, G B Pant Hospital Room 201, Ac...
Source: Hepatology International - December 10, 2008 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Two cases of development of entecavir resistance during entecavir treatment for nucleoside-naive chronic hepatitis Bemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  ETVr emerged in two Japanese nucleoside-naive CHB patients after prolonged therapy and incomplete suppression and in one patient after <0.5 mg of dosing. ETV patients with detectable HBV DNA or breakthrough after extended therapy should be evaluated for compliance to therapy and potential emergence of resistance. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12072-008-9108-8Authors Haruhiko Kobashi, Okayama University Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama JapanShin-ichi Fujioka, Okay...
Source: Hepatology International - December 10, 2008 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Liver fibrosis is a common pathway leading to cirrhosis, which is the final result of injury to the liver. Accurate assessment of the degree of fibrosis is important clinically, especially when treatments aimed at reversing fibrosis are being evolved. Liver biopsy has been considered to be the “gold standard” to assess fibrosis. However, liver biopsy being invasive and, in many instances, not favored by patients or physicians, alternative approaches to assess liver fibrosis have assumed great importance. Moreover, therapies aimed at reversing the liver fibrosis have also been tried lately with v...
Source: Hepatology International - December 4, 2008 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infectionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Our findings suggest that HBV infection itself does not affect adiponectin levels. Serum adiponectin level correlates with the progression of HBV-related liver diseases but not with the development of HBeAg SC. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12072-008-9111-0Authors Chun-Jen Liu, National Taiwan University College of Medicine, National Taiwan University Hospital Graduate Institute of Clinical Medicine No. 7, Chung-Shan South Road Taipei 10002 TaiwanPei-Jer Chen, National Taiwan University College of Medicine, National Taiwan University Hospital Graduate Ins...
Source: Hepatology International - December 2, 2008 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

The influence of hepatitis B virus genotype and subgenotype on the natural history of chronic hepatitis Bemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Studies to date suggest that HBV genotypes/subgenotypes have important influences on the outcome of chronic HBV infection, but more population-based prospective studies examining multiple genotypes are needed. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s12072-008-9112-zAuthors Brian J. McMahon, Alaska Native Tribal Health Consortium; and Arctic Investigations Program, Centers for Disease Control and Prevention Liver Disease and Hepatitis Program 4315 Diplomacy Drive Anchorage AK 99508 USA Journal Hepatology InternationalOnline ISSN 1936-0541Print ISSN 1936-0533 (S...
Source: Hepatology International - November 26, 2008 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  The Asian Pacific Association for the Study of the Liver (APASL) set up a working party on acute-on-chronic liver failure (ACLF) in 2004, with a mandate to develop consensus guidelines on various aspects of ACLF relevant to disease patterns and clinical practice in the Asia-Pacific region. Experts predominantly from the Asia–Pacific region constituted this working party and were requested to identify different issues of ACLF and develop the consensus guidelines. A 2-day meeting of the working party was held on January 22–23, 2008, at New Delhi, India, to discuss and finalize the consensus statem...
Source: Hepatology International - November 20, 2008 Category: Infectious Diseases Tags: Hepatology International Source Type: journals

Histological features of early hepatocellular carcinomas and their developmental process: for daily practical clinical applicationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Based on clinical and pathological experience, indistinct margin-type hepatocellular carcinomas (HCCs) were considered to be typical early-stage HCCs with good prognosis. For histological diagnosis, the assessment of stromal invasion (tumor invasion into portal tracts and fibrous septa) is very important. In differentiating stromal invasion from pseudoinvasion (benign hepatic tissue in the fibrous stroma), the following 5 items are useful: (1) macroscopic or panoramic views of the histological specimen, (2) amount of fibrous components of the stroma, (3) destruction of the structure of portal tracts...
Source: Hepatology International - November 14, 2008 Category: Infectious Diseases Tags: Hepatology International Source Type: journals