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Molecular targets for liver cancer therapy: From screening of target genes to clinical trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cancer arises from the accumulation of genetic alterations, and the inactivation of oncogenes, or recovery of suppressor genes, are promising strategies for cancer treatment. Genome-based drug research starts with identification of target genes and is accomplished by exploitation of target-based drugs such as monoclonal antibodies, small molecules and antisense drugs. Recently, clinical trials for treatment of advanced hepatocellular carcinoma (HCC) have been performed, and the effectiveness of sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor and Ras kinase, has been demonstrated....
Source: Hepatology Research - September 25, 2009 Category: Internal Medicine Authors: Yutaka Midorikawa, Yasuyuki Sugiyama, Hiroyuki Aburatani Source Type: journals

Fenretinide stimulates the apoptosis of hepatic stellate cells and ameliorates hepatic fibrosis in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Further studies using malondialdehyde measurement, Western blot, antioxidant, inhibitors for p53, caspase 8 and 9 [ndash] as well as anti-Fas neutralizing antibody [ndash] have shown that in HSC-T6, fenretinide-induced apoptosis involves a reactive oxygen species (ROS)-generated, P53-independent, mitochondria-associated intrinsic pathway, whereas in hepatocytes (BRL-3A), a ROS-generated, P53-dependent, Fas-related extrinsic pathway is triggered only at high concentration. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Jin Qian, Jin Sheng Zhang, Xue Qing Wang, Ju Ling Ji, Shuang Mei Source Type: journals

Overexpression of EphA2, MMP-9, and MVD-CD34 in hepatocellular carcinoma: Implications for tumor progression and prognosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Overexpressions of EphA2 and MMP-9 relate to tumor progression, metastasis, and prognosis in HCC. The present study suggests that EphA2 is associated with key mediators of angiogenesis and invasion. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Pu Yang, Weijie Yuan, Jiantai He, Jiwei Wang, Li Yu, Xin Jin, Yu Hu, Mingmei Liao, Zihua Chen, Yangde Zhang Source Type: journals

Inhibition of hepatic stellate cells proliferation by mesenchymal stem cells and the possible mechanismsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The growth inhibition of HSCs induced by MSCs through an arrest in the G0/G1 phase of the cell cycle is partially mediated by secretion of TGF-[beta]3 and HGF. MSCs inhibit HSCs activation through decreasing phosphorylation of extracellular signal-regulated kinase (ERK) 1/2. These results further support MSCs may be used as a novel therapy for treating fibrotic diseases in human. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Jing Wang, Chunjing Bian, Lianming Liao, Yashu Zhu, Jing Li, Lifen Zeng, Robert Chunhua Zhao Source Type: journals

Correlation of YMDD mutation and breakthrough hepatitis with hepatitis B virus DNA and serum ALT during lamivudine treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Correlation of ALT and HBV DNA levels with YMDD motif mutant and BTH indicates that these measurements can be used in clinical practice for deciding early switch from lamivudine to other suitable antiviral therapies. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Mariko Kobayashi, Fumitaka Suzuki, Norio Akuta, Hiromi Yatsuji, Tetsuya Hosaka, Hitomi Sezaki, Masahiro Kobayashi, Yusuke Kawamura, Yoshiyuki Suzuki, Yasuji Arase, Kenji Ikeda, Rie Mineta, Satomi Iwasaki, Sachiyo Watahiki, Hiromitsu Kumada Source Type: journals

Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggest that A3A and A3B play little role in HBV elimination through anti-viral defense mechanisms. The significance of hypermutation induced by A3A should be investigated further. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Hiromi Abe, Hidenori Ochi, Toshiro Maekawa, Tsuyoshi Hatakeyama, Masataka Tsuge, Shosuke Kitamura, Takashi Kimura, Daiki Miki, Fukiko Mitsui, Nobuhiko Hiraga, Michio Imamura, Yoshifumi Fujimoto, Shoichi Takahashi, Yusuke Nakamura, Hiromitsu Kumada, Kazuak Source Type: journals

Prolonged treatment with pegylated interferon α 2b plus ribavirin improves sustained virological response in chronic hepatitis C genotype 1 patients with late response in a clinical real-life setting in JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Patients with CHCV genotype 1 infection should be treated with PEG-IFN plus ribavirin combination therapy as early as possible, and 72 weeks' treatment is recommended in patients with LVR regardless of age. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Sumio Watanabe, Nobuyuki Enomoto, Kazuhiko Koike, Namiki Izumi, Hajime Takikawa, Etsuko Hashimoto, Fuminori Moriyasu, Hiromitsu Kumada, Michio Imawari Source Type: journals

Altered regulation of extrinsic apoptosis pathway in HCV-infected HCC cells enhances susceptibility to mapatumumab-induced apoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Both mapatumumab and lexatumumab are excellent candidates for therapy of HCC. HCV infection of Huh7.5 cells selectively up-regulates TRAIL-R1 receptor, associated with increased susceptibility to mapatumumab-mediated TRMA. HCV infection up-regulated IAP genes, offering promise for future combination therapy using TRAIL agonists and IAP inhibitors. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Xiaozhen Zhang, Astrid C. Frank, Christine M. Gille, Marybeth Daucher, Juraj Kabat, Steven Becker, Richard A. Lempicki, Karoll J. Cortez, Michael A. Polis, G. Mani Subramanian, Shyam Kottilil Source Type: journals

Hematoporphyrin derivative-mediated photodynamic therapy inhibits tumor growth in human cholangiocarcinoma in vitro and in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HPD-PDT inhibits tumor growth of human cholangiocarcinoma, suggesting that HPD-PDT is useful in cholangiocarcinoma therapy. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Liang-qi Cao, Ping Xue, Hai-wu Lu, Qiang Zheng, Zi-long Wen, Zhi-jian Shao Source Type: journals

Compartmentalization and its implication for peripheral immunologically-competent cells to the liver in patients with HBV-related acute-on-chronic liver failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The abnormal prevalence of circulating and intrahepatic ICCs possibly acts as an important factor that may drive the progression of HBV-related ACLF. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Zhengsheng Zou, Dongping Xu, Baosen Li, Shaojie Xin, Zheng Zhang, Lei Huang, Junliang Fu, Yongping Yang, Lei Jin, Jing-Min Zhao, Ming Shi, Guangde Zhou, Yanling Sun, Fu-Sheng Wang Source Type: journals

Effects of HCV proteins in current HCV transgenic modelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatits C virus (HCV) is an enveloped virus with positive-sense single-stranded RNA genome that causes both acute and persistent infections associated with chronic hepatitis, cirrhosis and hepatocellular carcinoma, which needs fully functional human hepatocytes for its development. Due to the strict human tropism of HCV, only human and higher primates such as chimpanzees have been receptive to HCV infection and development, cognition about pathophysiololgy and host immune responses of HCV infection is limited by lacking of simple laboratory models of infection for a long time. During the past decade, gene transfer approac...
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Jian Jiao, Jiangbin Wang, Matii Sallberg Source Type: journals

Impact of amino acid substitutions in the core region of HCV on multistep hepatocarcinogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: It is possible that the substitutions in the core region are not associated with HCV-related multistep hepatocarcinogenesis. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Takasuke Fukuhara, Kazuki Takeishi, Takeo Toshima, Kazutoyo Morita, Shigeru Ueda, Tomohiro Iguchi, Shigeyuki Nagata, Keishi Sugimachi, Toru Ikegami, Tomonobu Gion, Yuji Soejima, Akinobu Taketomi, Yoshihiko Maehara Source Type: journals

Interstitial chemotherapy using thermosensitive gel-coated ricin in nude mice bearing a human hepatomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Interstitial chemotherapy by intra-tumor injection of TGR was highly efficient and safe for the treatment of nude mice bearing a human hepatoma. Interstitial chemotherapy exhibits inhibitory effects by inducing apoptosis and directly killing tumor cells. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Zhi-kui Chen, Li-wu Lin, Yinghong Yang, Zhi-qiang Zhang, Huajing Cai, Min-xian Cai Source Type: journals

Susceptibility to experimental biliary atresia linked to different hepatic gene expression profiles in two mouse strainsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The different susceptibility to experimental BA was associated with an increase of CD4 T-cells in the liver of Balb/c mice, which is linked to different gene profiles at the onset of bile duct obstruction. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Johannes Leonhardt, Joachim F. Kuebler, Carmen Turowski, Thomas Tschernig, Robert Geffers, Claus Petersen Source Type: journals

Role of Kupffer cells in the outgrowth of colorectal cancer liver metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Colorectal cancer is one of the commonest malignancies in the "developed" world. The liver constitutes the main host organ for its distant metastases which, when present, augur a bad prognosis for the disease. Kupffer cells (KCs) are macrophages that constantly reside within the liver and form an effective first line defence against multiple harmful agents which reach the hepatic sinusoids via the portal circulation. KCs remove chemical compounds and dead or damaged cells, eliminate bacteria and protect against invading tumour cells. They may play a crucial tumouricidal role, exerting cytotoxic and cytostatic functions thr...
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Konstantinos A. Paschos, Ali W. Majeed, Nigel C. Bird Source Type: journals

Antiangiogenesis gene armed tumor-targeting adenovirus yields multiple antitumor activities in human HCC xenografts in nude miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The oncolytic virus with antiangiogenesis gene driven by the chimeric promoter has an improved killing efficacy on tumor cells, and may be useful for cancer gene therapy. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Lin Fang, Ying-yan Pu, Xiao-cui Hu, Li-jun Sun, Hong-mei Luo, Shao-kun Pan, Jian-zhong Gu, Xiang-rong Cao, Chang-qing Su Source Type: journals

Development of HCC in patients receiving adefovir dipivoxil for lamivudine-resistant hepatitis B virus mutantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HCC can develop in cirrhotic patients receiving adefovir add-on lamivudine. Hence, the patients with baseline AST [ge] 70 IU/L and YIDD mutants would need to be monitored closely for HCC. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Tetsuya Hosaka, Fumitaka Suzuki, Masahiro Kobayashi, Miharu Hirakawa, Yusuke Kawamura, Hiromi Yastuji, Hitomi Sezaki, Norio Akuta, Yoshiyuki Suzuki, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Yuzo Miyakawa, Hiromitsu Kumada Source Type: journals

Role of angiotensin II in liver fibrosis-induced portal hypertension and therapeutic implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Angiotensin II (AT-II) is a peptide that plays an important role in the renin-angiotensin-aldosterone (RAA) system. Traditionally, the RAA system has been related with states of systemic hypertension and hypoperfusion as a counterbalance mechanism. Recently, AT-II has been studied for its properties in the process of fibrosis in several organs, especially in the liver. AT-II is capable to stimulate the activated hepatic stellate cells, which increase expression of profibrogenic molecules like tumor growth factor-[beta], tissue inhibitor of metalloproteinase-1 and collagen I, among others. At the same time, AT-II is implied...
Source: Hepatology Research - September 7, 2009 Category: Internal Medicine Authors: Alejandro Lugo-Baruqui, José Francisco Muñoz-Valle, Sigifredo Arévalo-Gallegos, Juan Armendáriz-Borunda Source Type: journals

Cholestasis enhances liver ischemia/reperfusion-induced coagulation activation in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cholestasis significantly enhances I/R-induced hepatic damage and inflammation that concurs with an increased activation of coagulation and fibrinolysis. (Source: Hepatology Research)
Source: Hepatology Research - September 6, 2009 Category: Internal Medicine Authors: Jaap J. Kloek, Marcel Levi, Michal Heger, Chris M. van der Loos, Dirk J. Gouma, Thomas M. van Gulik Source Type: journals

Zoonotic risk of hepatitis E virus (HEV): A study of HEV infection in animals and humans in suburbs of BeijingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Workers in pig farms and slaughterhouses were more likely to contract HEV infection than the general population because of close contact with swine with a high prevalence of anti-HEV. (Source: Hepatology Research)
Source: Hepatology Research - August 7, 2009 Category: Internal Medicine Authors: Yibin Chang, Ling Wang, Jiabao Geng, Yonghong Zhu, Hongwei Fu, Furong Ren, Lingjun Li, Xiaojuan Wang, Hui Zhuang Source Type: journals

Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggest that RACK1 may have a functional significance as a regulatory cofactor of ABCB4 and is indispensable for the plasma membrane localization and translocation function of ABCB4. (Source: Hepatology Research)
Source: Hepatology Research - August 5, 2009 Category: Internal Medicine Authors: Yuki Ikebuchi, Tappei Takada, Kousei Ito, Takashi Yoshikado, Naohiko Anzai, Yoshikatsu Kanai, Hiroshi Suzuki Source Type: journals

High expression of angiotensin-converting enzyme and angiotensin-converting enzyme 2 in preservation injury after liver transplantation in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: ACE2 was closely related to tissue hypoxia due to CP-induced PI of the transplanted liver, and ACE may aggravate the inflammation in PI. Local RAS may play an important role in PI of the transplanted liver. (Source: Hepatology Research)
Source: Hepatology Research - August 5, 2009 Category: Internal Medicine Authors: Chun-Yan Xia, Ling Li, Hui-Min Liu, Wen-Ming Cong Source Type: journals

Hepatitis C virus kinetics during the first phase of pegylated interferon-α-2b with ribavirin therapy in patients with living donor liver transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The HCV infection of a transplanted liver is more refractory to treatment than a non-transplanted liver. The low reduction HCV cAg rate on day 1 is one of the problems of the combination therapy. (Source: Hepatology Research)
Source: Hepatology Research - July 12, 2009 Category: Internal Medicine Authors: Tatsuki Ichikawa, Kazuhiko Nakao, Hisamitsu Miyaaki, Susumu Eguchi, Mitsuhisa Takatsuki, Masumi Fujimito, Motohisa Akiyama, Satoshi Miuma, Eisuke Ozawa, Hidetaka Shibata, Shigeyuki Takeshita, Takashi Kanematsu, Katsumi Eguchi Source Type: journals

Flow cytometric isolation and phenotypic characterization of two subsets of ED2+ (CD163) hepatic macrophages in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The data suggest that the ED2high/AFhigh population of the liver cells represent the conventional Kupffer cells. The ED2dim/AFdim cells, however, are small hepatic resident macrophages characteristically different from the conventional Kupffer cells. (Source: Hepatology Research)
Source: Hepatology Research - July 12, 2009 Category: Internal Medicine Authors: Yao He, Tomohito Sadahiro, Sang-Ik Noh, Hong Wang, Tsuyoshi Todo, Ning-ning Chai, Andrew S. Klein, Gordon D. Wu Source Type: journals

Predictive value of suppressor of cytokine signal 3 (SOCS3) in the outcome of interferon therapy in chronic hepatitis CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the relationship between SOCS3 and phosphorylation of STAT1 in the liver and outcome of interferon therapy were examined.Methods: Prior to interferon treatment, we immunostained for SOCS3 and phosphorylated-STAT1 (P-STAT1) in 59 liver specimens from chronic hepatitis C virus (CHC) patients and compared the expression of SOCS3 and clinicopathological factors. Fifty-one patients were receiving peg-interferon alpha-2b and ribavirin therapy and also compared interferon therapy effect and the expression of SOCS3.Results: Immunostaining for SOCS3 was mainly seen in the periportal area. The concentration of P-STAT1...
Source: Hepatology Research - July 12, 2009 Category: Internal Medicine Authors: Hisamitsu Miyaaki, Tatsuki Ichikawa, Kazuhiko Nakao, Toshihisa Matsuzaki, Toru Muraoka, Takuya Honda, Shigeyuki Takeshita, Hidetaka Shibata, Eisuke Ozawa, Motohisa Akiyama, Satoshi Miuma, Katsumi Eguchi Source Type: journals

Hepatoma-derived growth factor is induced in liver regenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings showed that HDGF expression was induced in parenchymal hepatocytes before the DNA synthesis in the regenerating liver, suggesting the possible involvement of HDGF in liver regeneration as an autocrine factor. (Source: Hepatology Research)
Source: Hepatology Research - July 12, 2009 Category: Internal Medicine Authors: Hirayuki Enomoto, Hideji Nakamura, Weidong Liu, Kenya Yoshida, Yorihide Okuda, Hiroyasu Imanishi, Masaki Saito, Soji Shimomura, Toshikazu Hada, Shuhei Nishiguchi Source Type: journals

Autoantibody IgG subclasses to recombinant antigens and the role of bacterial stimuli in primary biliary cirrhosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data cumulatively supported the hypothesis that IgG2 AMA subtypes are predominant in PBC and suggest that this might be favored by an innate immune reaction against bacterial particles, such as CpG DNA. (Source: Hepatology Research)
Source: Hepatology Research - July 12, 2009 Category: Internal Medicine Authors: Toshihiro Kawai, Naomi Hosoya, Yuki Moritoki, Yusuke Kajiyama, Masashi Watanabe, Atsuko Takai, Carlo Selmi, M. Eric Gershwin, Hiroshi Miyakawa, Kentaro Kikuchi Source Type: journals

Circulating and liver tissue levels of retinol-binding protein-4 in non-alcoholic fatty liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In NAFLD patients, serum RBP4 was significantly lower as compared with controls and did not correlate with insulin resistance. In contrast, RBP4 liver tissue expression was enhanced and correlated with NAFLD histology. (Source: Hepatology Research)
Source: Hepatology Research - July 12, 2009 Category: Internal Medicine Authors: Maria Schina, John Koskinas, Dina Tiniakos, Emilia Hadziyannis, Savvas Savvas, Basil Karamanos, Emanuel Manesis, Athanasios Archimandritis Source Type: journals

Vitamin K2 downregulates the expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings suggest that vitamin K2 may suppress the proliferation of HCC cells through the downregulation of the FGFR3 expression. The transcriptional suppression of FGFR3 may be a novel mechanism of the vitamin K2 action for HCC cells. (Source: Hepatology Research)
Source: Hepatology Research - July 12, 2009 Category: Internal Medicine Authors: Ke Cao, Weidong Liu, Hideji Nakamura, Hirayuki Enomoto, Teruhisa Yamamoto, Masaki Saito, Hiroyasu Imanishi, Soji Shimomura, Peiguo Cao, Shuhei Nishiguchi Source Type: journals

Usefulness of the hyperechoic rim for assessing the therapeutic efficacy of radiofrequency ablation in hepatocellular carcinoma patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study shows that the hyperechoic rim is related to the presence of dead and necrotic tissues. Thus, assessment of the hyperechoic rim's characteristics allows one to evaluate the efficacy of RFA. (Source: Hepatology Research)
Source: Hepatology Research - July 12, 2009 Category: Internal Medicine Authors: Takahide Uehara, Masashi Hirooka, Yoshiyasu Kisaka, Masanori Abe, Yoichi Hiasa, Morikazu Onji Source Type: journals

Clinical application of an enzyme-linked immunosorbent assay detecting hepatoma-specific γ-glutamyltransferaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The sandwich ELISA system showed good reliability and reproducibility, and using the measurement, we found that serum DSA-GGT was a valuable marker of HCC, as a usable complementary to AFP. The sensitivity for identifying HCC could be significantly improved by combining DSA-GGT and AFP, and the combination could be used in large-scale screening for HCC in susceptible individuals. (Source: Hepatology Research)
Source: Hepatology Research - July 12, 2009 Category: Internal Medicine Authors: Nian-Yue Wang, Dai Zhang, Wei Zhao, Guo-Xiang Fang, Yu-Ling Shi, Mu-Hao Duan Source Type: journals

Influence of inducible nitric oxide synthase polymorphisms in Japanese patients with non-alcoholic fatty liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This is the first study to identify genetic variations in iNOS that may influence the risk of NAFLD and liver fibrosis in NAFLD. (Source: Hepatology Research)
Source: Hepatology Research - July 12, 2009 Category: Internal Medicine Authors: Masato Yoneda, Kikuko Hotta, Yuichi Nozaki, Hiroki Endo, Wataru Tomeno, Seitaro Watanabe, Kunihiro Hosono, Hironori Mawatari, Hiroshi Iida, Koji Fujita, Hirokazu Takahashi, Hiroyuki Kirikoshi, Noritoshi Kobayashi, Masahiko Inamori, Kensuke Kubota, Takeshi Source Type: journals

Plumbagin inhibits invasion and migration of liver cancer HepG2 cells by decreasing productions of matrix metalloproteinase-2 and urokinase- plasminogen activatorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We demonstrated the inhibitory effects of plumbagin on the invasion, migration and adhesion of HepG2 cells, while plumbagin treatment may decrease the expressions of MMP-2 and u-PA and enhance the expressions of TIMP-2 and PAI-1. (Source: Hepatology Research)
Source: Hepatology Research - July 12, 2009 Category: Internal Medicine Authors: Yuan-Wei Shih, Yi-Chieh Lee, Pei-Fen Wu, Yuan-Bing Lee, Tai-An Chiang Source Type: journals

Matrix metalloproteinase inhibitor, CTS-1027, attenuates liver injury and fibrosis in the bile duct-ligated mouseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The BDL mouse, liver injury and hepatic fibrosis are attenuated by treatment with the MMP inhibitor CTS-1027. This drug warrants further evaluation as an anti-fibrogenic drug in hepatic injury. (Source: Hepatology Research)
Source: Hepatology Research - July 12, 2009 Category: Internal Medicine Authors: Alisan Kahraman, Steven F. Bronk, Sophie Cazanave, Nathan W. Werneburg, Justin L. Mott, Patricia C. Contreras, Gregory J. Gores Source Type: journals

Translational research to identify clinical applications of hepatocyte growth factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatocyte growth factor (HGF), originally purified from the plasma of patients with fulminant hepatic failure, has been shown to carry out various physiological functions. HGF not only stimulates liver regeneration, but also acts as an antiapoptotic factor in in vivo experimental models. Therefore, HGF is a promising therapeutic agent for the treatment of fatal liver diseases, including fulminant hepatic failure. After performing a number of preclinical tests, our group began an investigator-initiated registered phase I/II clinical trial of patients with fulminant hepatic failure to examine the safety and clinical efficac...
Source: Hepatology Research - July 12, 2009 Category: Internal Medicine Authors: Akio Ido, Hirohito Tsubouchi Source Type: journals

An insight into the protection of rat liver against ischemia/reperfusion injury by 2-selenium-bridged β-cyclodextrinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: 2-selenium-bridged [beta]-cyclodextrin playes an important role in the protection of liver against I/R injury and this treatment may be a novel pharmacological agent for liver surgery. (Source: Hepatology Research)
Source: Hepatology Research - July 12, 2009 Category: Internal Medicine Authors: Ting-ting Lin, Bing-mei Wang, Xin-yang Li, Yu Pan, Wei Wang, Ying Mu, Jun-qiu Liu, Jia-cong Shen, Gui-min Luo Source Type: journals

New scoring system for predicting relapse after lamivudine-induced hepatitis B e-antigen loss in chronic hepatitis B patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our new scoring system may be useful for predicting relapses in patients with lamivudine-induced HBeAg loss. Treatment strategies should be individualized according to risk score. (Source: Hepatology Research)
Source: Hepatology Research - July 10, 2009 Category: Internal Medicine Authors: Byung-Cheol Song, Xiu Ji Cui, Yoo-Kyung Cho, Eun Kwang Choi, Soyoung Hyun, Hyun Joo Song, Heung Up Kim Source Type: journals

Value of the extracellular water ratio for assessment of cirrhotic patients with and without ascitesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Liver cirrhosis was characterized by a redistribution of body water. The ECW ratio is a reliable tool for quantification of redistribution of body water and can predict the development of ascites. (Source: Hepatology Research)
Source: Hepatology Research - July 9, 2009 Category: Internal Medicine Authors: Nagisa Hara, Motoh Iwasa, Kazuko Iwata, Hirohide Miyachi, Hideaki Tanaka, Masaki Takeo, Naoki Fujita, Yoshinao Kobayashi, Yoshiyuki Takei Source Type: journals

Rapid loss of hepatitis C virus genotype 1b from serum in patients receiving a triple treatment with telaprevir (MP-424), pegylated interferon and ribavirin for 12 weeksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HCV RNA was lost from serum rapidly and universally in patients infected with HCV-1b in high viral loads by the triple treatment. Because an early loss of HCV RNA correlates with high rates of sustained virological response (SVR), it would increase SVR substantially, and merit the patients who have not responded to previous therapies. (Source: Hepatology Research)
Source: Hepatology Research - July 9, 2009 Category: Internal Medicine Authors: Fumitaka Suzuki, Norio Akuta, Yoshiyuki Suzuki, Hitomi Sezaki, Hiromi Yatsuji, Yusuke Kawamura, Tetsuya Hosaka, Masahiro Kobayashi, Yasuji Arase, Kenji Ikeda, Rie Mineta, Satomi Iwasaki, Sachiyo Watahiki, Mariko Kobayashi, Yuzo Miyakawa, Hiromitsu Kumada Source Type: journals

Efficacy and limitation of bone marrow transplantation in the treatment of acute and subacute liver failure in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: BMC transplantation may have limitations in the treatment of fulminant or acute liver failure because they do not have sufficient time to develop into functional hepatocytes. Preparative HIR may be beneficial in help to convert the transplanted BMC into host hepatocytes, and provide a survival benefit. Although, However, the precise mechanism warrants further studies. (Source: Hepatology Research)
Source: Hepatology Research - July 9, 2009 Category: Internal Medicine Authors: Hirotaka Tokai, Yujo Kawashita, Yuichiro Ito, Kosho Yamanouchi, Mitsuhisa Takatsuki, Susumu Eguchi, Yoshitsugu Tajima, Takashi Kanematsu Source Type: journals

Matrine improves 17α-ethinyl estradiol-induced acute cholestasis in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: MT exhibited potential protection against EE-induced acute intrahepatic cholestasis. (Source: Hepatology Research)
Source: Hepatology Research - July 9, 2009 Category: Internal Medicine Authors: Ying Zhao, Desheng Zhai, Hui He, Junhua Liu, Tingting Li, Xijing Chen, Hui Ji Source Type: journals

Clinicopathological analysis of CD133+ and NCAM+ human hepatic stem/progenitor cells in damaged livers and hepatocellular carcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggest that CD133 and NCAM can be employed to enrich for hepatic stem/progenitor cells and that DR can be distinguished in greater detail using these markers. NCAM+ HCC were detected, but their function remains unresolved. Expression of CD133, a potent stem cell marker, may be extremely rare in the common human HCC examined. (Source: Hepatology Research)
Source: Hepatology Research - July 9, 2009 Category: Internal Medicine Authors: Atsunori Tsuchiya, Hiroteru Kamimura, Masaaki Takamura, Satoshi Yamagiwa, Yasunobu Matsuda, Yoshinobu Sato, Minoru Nomoto, Takafumi Ichida, Yutaka Aoyagi Source Type: journals

Correlation of routinely used coagulation parameters and presence of portal vein thrombosis in patients with liver cirrhosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Patients with advanced liver cirrhosis and PVT displayed lower apTT and INR compared with those without PVT. Therefore, patients with advanced liver cirrhosis and almost normal coagulation parameters might be at particular risk of developing PVT. The results suggest that regular monitoring using Doppler-ultrasound should be carried out in these patients, especially when liver transplantation is intended. (Source: Hepatology Research)
Source: Hepatology Research - July 8, 2009 Category: Internal Medicine Authors: Andreas Weber, Stephanie Krebs, Cosima Lenhardt, Stefan Wagenpfeil, Roland M. Schmid, Ewert Schulte-Frohlinde Source Type: journals

Adult to pediatric living donor liver transplantation for portal cavernomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present study is the first report of the successful use of LDLT to treat pediatric PC patients. We conclude that LDLT is effective for the majority of pediatric patients with PC. (Source: Hepatology Research)
Source: Hepatology Research - June 26, 2009 Category: Internal Medicine Authors: Mingman Zhang, Chunbao Guo, Conglun Pu, Zhimei Ren, Yingcun Li, Quan Kang, Xianqing Jin, Lvnan Yan Source Type: journals

Short-term prolongation of pegylated interferon and ribavirin therapy for genotype 1b chronic hepatitis C patients with early viral responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results indicate that short-treatment extension of PEG IFN plus RBV treatment protocols in EVR patients can improve overall SVR rates. (Source: Hepatology Research)
Source: Hepatology Research - May 6, 2009 Category: Internal Medicine Authors: Hiroki Ikeda, Michihiro Suzuki, Chiaki Okuse, Norie Yamada, Masaru Okamoto, Minoru Kobayashi, Yoshihiko Nagase, Hideaki Takahashi, Koutarou Matsunaga, Nobuyuki Matsumoto, Fumio Itoh, Hiroshi Yotsuyanagi, Yu Koitabashi, Kiyomi Yasuda, Shiro Iino Source Type: journals

Development of a hepatitis C virus relapse model using genome-length hepatitis C virus ribonucleic acid-harboring cells possessing the interferon-α-resistance phenotypeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We developed a HCV relapse model in cell culture using IFN-[alpha]-resistant HCV RNA-harboring cells. Thus anti-HCV reagents, which have a mechanism different from IFN-[alpha], were shown to be useful for preventing a relapse of IFN-[alpha]-resistant HCV. (Source: Hepatology Research)
Source: Hepatology Research - May 6, 2009 Category: Internal Medicine Authors: Yoshinari Kawai, Masanori Ikeda, Ken-ichi Abe, Masahiko Yano, Yasuo Ariumi, Hiromichi Dansako, Kazuhide Yamamoto, Nobuyuki Kato Source Type: journals

Ursodeoxycholic acid in primary sclerosing cholangitis: meta-analysis of randomized controlled trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The meta-analysis found that UDCA can improve liver biochemistry and there is a trend towards improvement in liver histology and cholangiography, but has no effect on survival free of transplantation. (Source: Hepatology Research)
Source: Hepatology Research - May 6, 2009 Category: Internal Medicine Authors: Jian Shi, Zhi Li, Xin Zeng, Yong Lin, Wei-Fen Xie Source Type: journals

Protective effects of trichostatin A on liver injury in septic miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data indicate that HDAC inhibitor TSA effectively attenuates liver injury during sepsis and these effects seem to rely on reduced inflammatory mediator production. These findings suggest that novel anti-inflammatory drugs targeting HDAC might offer promising therapeutic intervention for controlling the dysregulated inflammation. (Source: Hepatology Research)
Source: Hepatology Research - April 22, 2009 Category: Internal Medicine Authors: Li Zhang, Jingyuan Wan, Rong Jiang, Weiwei Wang, Huayu Deng, Yi Shen, Weiping Zheng, Yaping Wang Source Type: journals

Lipoxin A4 inhibited hepatocyte growth factor-induced invasion of human hepatoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: LXA4 inhibited HGF-induced invasion of HepG2 cells through NF-[kappa]B/COX-2 signaling pathway partially. (Source: Hepatology Research)
Source: Hepatology Research - April 22, 2009 Category: Internal Medicine Authors: Xiao-Yan Zhou, Yong-Sheng Li, Ping Wu, Hong-Mei Wang, Zhen-Yu Cai, Fang-Yun Xu, Du-Yun Ye Source Type: journals

Influence of angiotensin-converting enzyme I/D gene polymorphism on clinical and histological correlates of chronic hepatitis CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Female ACE I/I homozygotes have higher liver fibrosis scores in comparison to D/* women and to men; moreover, they are leaner and have a lower LDL/HDL cholesterol ratio. These observations suggest a possible mutual influence between ACE polymorphism, serum lipid concentrations and outcome of chronic HCV infection. (Source: Hepatology Research)
Source: Hepatology Research - April 22, 2009 Category: Internal Medicine Authors: Carlo Fabris, Carlo Smirne, Stefano Fangazio, Pierluigi Toniutto, Michela Burlone, Rosalba Minisini, Davide Bitetto, Edmondo Falleti, Andrea Cerutti, Mario Pirisi Source Type: journals