Immunogenicity and safety of live attenuated and recombinant/inactivated varicella zoster vaccines in people living with HIV: A systematic review
Hum Vaccin Immunother. 2024 Dec 31;20(1):2341456. doi: 10.1080/21645515.2024.2341456. Epub 2024 Apr 22.ABSTRACTFew papers focus their attention on VZV vaccination effectiveness among people living with HIV (PLWH). Flanking the live attenuated vaccine (VZL) available, a newly recombinant vaccine (RZV) was recently introduced and approved for HZ prevention among adults. PLWH represents a population on which a particular attention should be applied, in order to guarantee the vaccine efficacy and safety. We performed a literature search in USNLM, PubMed, PubMed Central, PMC and Cochrane Library. From all the publications found...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Valentina Carta Lucia Mangeri Giorgio Tiecco Emanuele Foc à Eugenia Quiros-Roldan Maria Antonia De Francesco Source Type: research
Efficacy and Safety of Gabapentinoids for Acute Herpes Zoster Neuralgia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
CONCLUSION: Gabapentin can effectively reduce acute herpes zoster neuralgia in patients. Pregabalin requires additional randomized controlled trials to supplement the analysis.PROSPERO REGISTRATION: CRD42023446643.PMID:38651606 | DOI:10.1097/AJP.0000000000001218 (Source: Herpes)
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Yinluo Li Xingzhen Long Fengrong Luo Jiarui Zhang Shaoqin Sun Pengqiang Du Hongtao Yang Qi Chen Changcheng Sheng Xue Bai Source Type: research
A dual fluorescent herpes simplex virus type 1 recombinant reveals divergent outcomes of neuronal infection
We report that the transcriptional state of neuronal HSV-1 infection is variable in response to changes in the intracellular neuronal environment.IMPORTANCEHerpes simplex virus type 1 (HSV-1) is a prevalent human pathogen that infects approximately 67% of the global human population. HSV-1 invades the peripheral nervous system, where latent HSV-1 infection persists within the host for life. Immunological evasion, viral persistence, and herpetic pathologies are determined by the regulation of HSV-1 gene expression. Studying HSV-1 gene expression during neuronal infection is challenging but essential for the development of a...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Luke F Domanico Gary P Dunn Oren Kobiler Matthew P Taylor Source Type: research
HSV-1 employs UL56 to antagonize expression and function of cGAMP channels
We report that infection with multiple human viruses depletes some of these cGAMP conduits. This includes herpes simplex virus 1 (HSV-1) that targets SLC46A2, P2X7, and the VRAC subunits LRRC8A and LRRC8C for degradation. The HSV-1 protein UL56 is necessary and sufficient for these effects that are mediated at least partially by proteasomal turnover. UL56 thereby inhibits cGAMP uptake via VRAC, SLC46A2, and P2X7. Taken together, HSV-1 antagonizes intercellular cGAMP transfer. We propose that this limits innate immunity by reducing cell-to-cell communication via the immunotransmitter cGAMP.PMID:38652659 | DOI:10.1016/j.celr...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Henry T W Blest Alexander Redmond Jed Avissar Jake Barker Anne Bridgeman Gerissa Fowler Lise Chauveau Jonny Hertzog Iolanda Vendrell Roman Fischer Marie B Iversen Lichen Jing David M Koelle S øren R Paludan Benedikt M Kessler Colin M Crump Jan Rehwinkel Source Type: research
ISGylation by HERCs facilitates STING activation
Cell Rep. 2024 Apr 21;43(5):114135. doi: 10.1016/j.celrep.2024.114135. Online ahead of print.ABSTRACTOptimal activation of stimulator of interferon genes (STING) protein is crucial for host defenses against pathogens and avoiding detrimental effects. Various post-translational modifications control STING activity. However, the function of interferon (IFN)-stimulated gene (ISG) 15 modification (ISGylation) in controlling STING stability and activation is unclear. Here, we show that the E3 ISGylation ligases HECT domain- and RCC1-like domain-containing proteins (HERCs; HERC5 in humans and HERC6 in mice) facilitate STING acti...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Ying Qin Min Wang Xintong Meng Mengge Wang Haojia Jiang Yanjie Gao Jingxin Li Chunyuan Zhao Chaofeng Han Wei Zhao Xuexing Zheng Source Type: research
Microbial keratitis in Southern Malawi: a microbiological pilot study
CONCLUSIONS: In a resource-poor setting, a CIM can be used to safely sample the cornea in patients presenting with suspected MK, enabling identification of causative microorganisms by culture and PCR. Although the microbiological spectrum found was limited to the dry season, these preliminary results could be used to guide empirical treatment.PMID:38653537 | DOI:10.1136/bmjophth-2024-001682 (Source: Herpes)
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Tobi F Somerville Shaffi Mdala Thokozani Zungu Moira Gandiwa Rose Herbert Dean Everett Caroline E Corless Nicholas A V Beare Timothy Neal Malcolm J Horsburgh Alistair Darby Stephen B Kaye Petros C Kayange Source Type: research
Long-term effectiveness and safety of upadacitinib for Japanese patients with moderate-to-severe atopic dermatitis: a real-world clinical study
CONCLUSIONS: Upadacitinib was therapeutically effective and tolerable for moderate-to-severe AD through 48 weeks in real-world clinical practice.PMID:38653561 | DOI:10.1080/09546634.2024.2344591 (Source: Herpes)
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Teppei Hagino Hidehisa Saeki Eita Fujimoto Naoko Kanda Source Type: research
Analysis of weighted gene co-expression networks and clinical validation identify hub genes and immune cell infiltration in the endometrial cells of patients with recurrent implantation failure
CONCLUSION: We first utilized WGCNA to identify the most potential nine hub genes which might be associated with RIF. Meanwhile, this study offers insights into the landscape of immune infiltration status to reveal the underlying immune pathogenesis of RIF. This may be a direction for the next study of RIF etiology. Further studies would be required to investigate the involved mechanisms.PMID:38645487 | PMC:PMC11026622 | DOI:10.3389/fgene.2024.1292757 (Source: Herpes)
Source: Herpes - April 22, 2024 Category: Infectious Diseases Authors: Zhenteng Liu Shoucui Lai Qinglan Qu Xuemei Liu Wei Zhang Dongmei Zhao Shunzhi He Yuxia Sun Hongchu Bao Source Type: research
Herpes Zoster Ophthalmicus Initially Diagnosed As Cluster Headache, Complicated by Delayed Eruption
This report elucidates the case of a 61-year-old Japanese male with painful trigeminal neuropathy attributed to VZV that was initially diagnosed as cluster headache, mainly due to the delayed cutaneous eruption. Contrary to the expected pattern of cluster headache presentations, there was no discernible fluctuation in headache severity. The transient improvement of symptoms following interventions tailored for cluster headache management, including pure oxygen inhalation and subcutaneous sumatriptan injection, inadvertently contributed to a delay in accurate diagnosis. The importance of distinguishing HZO from cluster head...
Source: Herpes - April 22, 2024 Category: Infectious Diseases Authors: Hidenori Sanayama Michito Namekawa Yoshio Sakiyama Hitoshi Sugawara Source Type: research
Cerebral Venous Sinus Thrombosis Complicating Herpes Zoster Ophthalmicus Ophthalmoplegia
We report the case of a 68-year-old lady with herpes zoster ophthalmicus ophthalmoplegia who developed cerebral venous thrombosis (CVT).PMID:38646240 | PMC:PMC11026991 | DOI:10.7759/cureus.56520 (Source: Herpes)
Source: Herpes - April 22, 2024 Category: Infectious Diseases Authors: Meithem Ali Nonyelum Obiechina Kay Teck Ling Angela Nandi Bhaskar Mukherjee Source Type: research
Shared genetic aetiology of Alzheimer's disease and age-related macular degeneration by APOC1 and APOE genes
CONCLUSION: In this study, we confirmed the genetic pleiotropy between AD and AMD and identified APOC1 and APOE as pleiotropic genes. Further, the integration of multiomics data identified ZNF131, ADNP2 and HINFP as novel diagnostic biomarkers for AD and AMD.PMID:38646507 | PMC:PMC11029327 | DOI:10.1136/bmjno-2023-000570 (Source: Herpes)
Source: Herpes - April 22, 2024 Category: Infectious Diseases Authors: Xueli Zhang Zhuoting Zhu Yu Huang Xianwen Shang Terence J O'Brien Patrick Kwan Jason Ha Wei Wang Shunming Liu Xiayin Zhang Katerina Kiburg Yining Bao Jing Wang Honghua Yu Mingguang He Lei Zhang Source Type: research
Epstein-Barr virus, Cytomegalovirus, and Herpes Simplex-1/2 reactivations in critically ill patients with COVID-19
CONCLUSIONS: Human Herpesviruses reactivations in critically ill patients with COVID-19 severe Pneumonia are associated with mortality and with a higher risk to develop both VAP and ICU-BSI.PMID:38649512 | DOI:10.1186/s40635-024-00624-9 (Source: Herpes)
Source: Herpes - April 22, 2024 Category: Infectious Diseases Authors: Alessia Mattei Lorenzo Schiavoni Elisabetta Riva Massimo Ciccozzi Roberta Veralli Angela Urselli Vincenzo Citriniti Antonio Nenna Giuseppe Pascarella Fabio Costa Rita Cataldo Felice Eugenio Agr ò Massimiliano Carassiti Source Type: research
Association of Herpes simplex infection with significantly increased risk of head and neck cancer: real-world evidence of about 500,000 patients
CONCLUSION: The surprisingly strong correlation with lip, oral cavity, and pharynx neoplasms sheds new light on supposedly harmless herpes simplex infections, suggesting them as a possible new factor for risk stratification.PMID:38643367 | DOI:10.1111/ijd.17196 (Source: Herpes)
Source: Herpes - April 21, 2024 Category: Infectious Diseases Authors: Jennifer von Stebut Max Heiland Robert Preissner Carsten Rendenbach Saskia Preissner Source Type: research
Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with pronounced antiviral activity against DNA viruses
Eur J Med Chem. 2024 Apr 15;271:116412. doi: 10.1016/j.ejmech.2024.116412. Online ahead of print.ABSTRACTNew acyclic pyrimidine nucleoside phosphonate prodrugs with a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid skeleton (O-DAPy nucleobase) were prepared through a convergent synthesis by olefin cross-metathesis as the key step. Several acyclic nucleoside 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug exhibited in vitro antiviral activity in submicromolar or nanomolar range against varicella zoster virus (VZV), human cytomegalovirus (HCMV), human herpes virus type 1 (HSV-1) and type 2 (HS...
Source: Herpes - April 21, 2024 Category: Infectious Diseases Authors: Maximes Bessi ères Vincent Roy Tuniyazi Abuduani Patrick Favetta Robert Snoeck Graciela Andrei Jennifer Moffat Franck Gallardo Luigi A Agrofoglio Source Type: research
Characterization and optimization of exopolysaccharide extracted from a newly isolated halotolerant cyanobacterium, Acaryochloris Al-Azhar MNE ON864448.1 with antiviral activity
This study aimed to identify and optimize the conditions for exopolysaccharide (EPS) production from a newly isolated cyanobacterium, Acaryochloris Al-Azhar MNE ON864448.1, besides exploring its antiviral activity. The cyanobacterial EPS was purified through DEAE-52 cellulose column with a final yield of 83.75%. Different analysis instruments were applied for EPS identification, including Fourier-transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA), and gas chromatographic-mass spectrometry (GC-MS). Plackett-Burman's design demonstrated that working volume (X1), EDTA (X2), inoculum size (X3), CaCl2 (X4...
Source: Herpes - April 21, 2024 Category: Infectious Diseases Authors: Mabroka H Saad Nagwa M Sidkey Esmail M El-Fakharany Source Type: research
