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Circumcision and Risk of Sexually Transmissible Infections in a Community-Based Cohort of HIV-Negative Homosexual Men in Sydney, Australia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These are the first prospective data obtained from homosexual men to assess circumcision status as a risk factor for STIs. Circumcised men were at reduced risk of incident syphilis but no other prevalent or incident STIs. Circumcision is unlikely to have a substantial public health impact in reducing acquisition of most STIs in homosexual men. PMID: 19911990 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - November 19, 2009 Category: Infectious Diseases Authors: Templeton DJ, Jin F, Prestage GP, Donovan B, Imrie JC, Kippax SC, Cunningham PH, Kaldor JM, Mindel A, Cunningham AL, Grulich AE Tags: J Infect Dis Source Type: journals

Prevalence of Trichomonas vaginalis infection among young reproductive age women in India: implications for treatment and prevention.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The burden of T. vaginalis infection at 8.5% is relatively high among a community sample of young reproductive aged women. Because this infection increases the risk of HIV transmission and is associated with adverse pregnancy outcomes, there is a need for increased screening and treatment of this easily curable sexually transmissible infection in India. PMID: 19917204 [PubMed - in process] (Source: Herpes)
Source: Herpes - November 19, 2009 Category: Infectious Diseases Authors: Madhivanan P, Bartman MT, Pasutti L, Krupp K, Arun A, Reingold AL, Klausner JD Tags: Sex Health Source Type: journals

Detection of herpetic viruses in gingival crevicular fluid of patients suffering from periodontal diseases: prevalence and effect of treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study showed that the prevalence of HCMV and HSV viruses in GCF is higher in patients suffering from periodontitis compared to periodontally healthy subjects, and that the prevalence of HCMV is higher in deep periodontal pockets. It also brought evidences that periodontal therapy may be associated with virus elimination in diseased sites. PMID: 19832804 [PubMed - in process] (Source: Herpes)
Source: Herpes - October 18, 2009 Category: Infectious Diseases Authors: Grenier G, Gagnon G, Grenier D Tags: Oral Microbiol Immunol Source Type: journals

Bortezomib in combination with dexamethasone and subsequent thalidomide for newly-diagnosed multiple myeloma: a Chinese experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our preliminary experience in Chinese patients indicated that bortezomib-dexamethasone-thalidomide is highly effective in newly-diagnosed MM. Grade three and 4 toxicities are rare after median 2 cycles of therapy. The relative lower rates of neuropathy and DVT/PE in the Chinese patients with MM are being cautiously observed. PMID: 19773080 [PubMed - in process] (Source: Herpes)
Source: Herpes - September 24, 2009 Category: Infectious Diseases Authors: Zheng W, Wei G, Ye X, He J, Li L, Wu W, Shi J, Zhang J, Huang W, Xie W, Luo Y, Xue X, Lin M, Huang H, Cai Z Tags: Leuk Res Source Type: journals

Modulation of T Cell Proliferation through LIGHT-HVEM-BTLA Cosignaling Pathway.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The maintenance of T cell homeostasis requires balance of both positive and negative regulatory signals of T cell proliferation. The herpesvirus entry mediator (HVEM) is a TNF superfamily member, which provides a stimulatory signal when binding LIGHT on T cells. Interestingly, HVEM also engages B and T lymphocyte attenuator (BTLA), an Ig superfamily member that provides an inhibitory signal to T cells. HVEM may act as a molecular switch between positive and inhibitory cosignaling in T cells. Substantial evidence from mouse models and human diseases indicate that the dysregulation of the LIGHT-HVEM-BTLA cosignaling path...
Source: Herpes - August 28, 2009 Category: Infectious Diseases Authors: Cheung TC Tags: Recent Pat DNA Gene Seq Source Type: journals

Disseminated herpes simplex virus (HSV) hepatitis diagnosed by dermatology evaluation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19702997 [PubMed - in process] (Source: Herpes)
Source: Herpes - August 28, 2009 Category: Infectious Diseases Authors: Arkin LM, Castelo-Soccio L, Kovarik C Tags: Int J Dermatol Source Type: journals

Prevalence of oral lesions among Saudi dental patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The findings of this study provide information on the types and prevalence of oral lesions among Saudi dental patients. This provides baseline data for future studies about the prevalence of oral lesions in the general population. PMID: 19700894 [PubMed - in process] (Source: Herpes)
Source: Herpes - August 26, 2009 Category: Infectious Diseases Authors: Al-Mobeeriek A, AlDosari AM Tags: Ann Saudi Med Source Type: journals

Postherpetic neuralgia in the elderly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Postherpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ) or 'shingles' and affects a significant proportion of HZ patients with the disease, with the elderly being most frequently and seriously affected. Characterised by various types of pain (constant, intermittent and stimulus evoked) that persist between 3 months and many years after the resolution of the HZ rash, PHN can have a severe impact on the patient's quality of life and functional ability. PHN remains highly resistant to current treatments. In this review, we discuss the epidemiology, clinical features and management of PHN in the ...
Source: Herpes - August 22, 2009 Category: Infectious Diseases Authors: Johnson RW, McElhaney J Tags: Int J Clin Pract Source Type: journals

A missed point in deciphering the viral synergy between herpes simplex virus and HIV.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19695487 [PubMed - in process] (Source: Herpes)
Source: Herpes - August 22, 2009 Category: Infectious Diseases Authors: Lisco A, Vanpouille C, Margolis L Tags: Lancet Infect Dis Source Type: journals

Neurological disorders in HIV-infected children in India.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Early diagnosis of neurological disorders in HIV-infected children is important for appropriate investigation and management, especially the introduction of HAART. PMID: 19689858 [PubMed - in process] (Source: Herpes)
Source: Herpes - August 20, 2009 Category: Infectious Diseases Authors: Gupta S, Shah DM, Shah I Tags: Ann Trop Paediatr Source Type: journals

Bioluminescent imaging of MAPK function with intein-mediated reporter gene assay.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For nondestructive analysis of chemical processes in living mammalian cells, here we show a new reporter gene assay for detecting Ras-Raf-1 interactions based on protein splicing of transcription factors with DnaE inteins. The protein splicing induces connection of a DNA-binding protein (modified LexA; mLexA) with a transcription activation domain of a herpes simplex virus protein (VP16AD). Ras is connected with N-terminal DnaE and mLexA, while Raf-1 is connected with C-terminal DnaE and VP16AD. Upon stimulation with EGF, the interaction between Ras and Raf-1 triggers folding of the DnaEs, thereby inducing protein spli...
Source: Herpes - August 18, 2009 Category: Infectious Diseases Authors: Kanno A, Ozawa T, Umezawa Y Tags: Methods Mol Biol Source Type: journals

Herpes zoster ophthalmicus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19679612 [PubMed - in process] (Source: Herpes)
Source: Herpes - August 17, 2009 Category: Infectious Diseases Authors: Lam FC, Law A, Wykes W Tags: BMJ Source Type: journals

Once daily valacyclovir for reducing viral shedding in subjects newly diagnosed with genital herpes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In this study, the frequency of total and subclinical HSV-2 shedding was greater than reported in earlier studies involving subjects with a history of symptomatic genital recurrences. Our study is the first to demonstrate a significant reduction in viral shedding with valacyclovir 1 g daily compared to placebo in a population of subjects newly diagnosed with HSV-2 infection. PMID: 19680456 [PubMed - in process] (Source: Herpes)
Source: Herpes - August 17, 2009 Category: Infectious Diseases Authors: Martens MG, Fife KH, Leone PA, Dix LP, Brennan CA Tags: Infect Dis Obstet Gynecol Source Type: journals

[Effects of recurrent herpetic infection on functional activity of T-cells in patients with rheumatoid arthritis]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: IL-10 hyperproduction observed in recurrent herpetic infection may contribute to progression of rheumatoid arthritis. PMID: 19663188 [PubMed - in process] (Source: Herpes)
Source: Herpes - August 13, 2009 Category: Infectious Diseases Tags: Ter Arkh Source Type: journals

Nonparametric estimator of relative time with application to the Acyclovir Prevention Trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Similar to Cox's relative hazard estimator, the proposed RT does not assume the data are generated from a particular distribution. RTs should be more widely used as a measure of association in clinical trials. Clinical Trials 2009; 6: 320-328. http://ctj.sagepub.com. PMID: 19667028 [PubMed - in process] (Source: Herpes)
Source: Herpes - August 13, 2009 Category: Infectious Diseases Authors: Cole SR, Haitao Chu , Lei Nie Tags: Clin Trials Source Type: journals

Effect of laser phototherapy on recurring herpes labialis prevention: an in vivo study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study represents an in vivo indication that this treatment should be further considered as an effective alternative to therapeutic regimens for herpes labialis lesions. PMID: 19669856 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - August 10, 2009 Category: Infectious Diseases Authors: de Carvalho RR, de Paula Eduardo F, Ramalho KM, Antunes JL, Bezinelli LM, de Magalhães MH, Pegoretti T, de Freitas PM, de Paula Eduardo C Tags: Lasers Med Sci Source Type: journals

Meningoencephalitis-complicating herpes zoster ophthalmicus infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Herpes zoster ophthalmicus is a known complication of herpes zoster and the most common manifestation of cranial zoster, accounting for a significant number of zoster cases.1 An uncommon but serious complication of herpes zoster ophthalmicus is zoster meningoencephalitis. The exact incidence of herpes zoster meningoencephalitis is not known; in 1 series, 5.5% of patients who initially presented with ophthalmic zoster had neurological complications.2 Here we report a case of herpes zoster meningoencephalitis in a patient with herpes zoster ophthalmicus. Journal of Hospital Medicine 2009;4:E19-E22. (c) 2009 Society of Ho...
Source: Herpes - August 9, 2009 Category: Infectious Diseases Authors: Srinivasan S, Ahn G, Anderson A Tags: J Hosp Med Source Type: journals

Herpes simplex type-2 meningitis: presentation and lack of standardized therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: HSV-2 meningitis presents most often without a history of genital herpes, recurrent meningitis, or genital symptoms. Current management practices are highly variable and may lead to unnecessary hospitalization and prolonged intravenous therapy. PMID: 19559173 [PubMed - in process] (Source: Herpes)
Source: Herpes - June 30, 2009 Category: Infectious Diseases Authors: Landry ML, Greenwold J, Vikram HR Tags: Am J Med Source Type: journals

Alzheimer's disease and infection: do infectious agents contribute to progression of Alzheimer's disease?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Infection with several important pathogens could constitute risk factors for cognitive impairment, dementia, and Alzheimer's disease (AD) in particular. This review summarizes the data related to infectious agents that appear to have a relationship with AD. Infections with herpes simplex virus type 1, picornavirus, Borna disease virus, Chlamydia pneumoniae, Helicobacter pylori, and spirochete were reported to contribute to the pathophysiology of AD or to cognitive changes. Based on these reports, it may be hypothesized that central nervous system or systemic infections may contribute to the pathogenesis or pathophysiol...
Source: Herpes - June 30, 2009 Category: Infectious Diseases Authors: Honjo K, van Reekum R, Verhoeff NP Tags: Alzheimers Dement Source Type: journals

A phase i-ii study of live attenuated varicella-zoster virus vaccine to boost immunity in human immunodeficiency virus-infected children with previous varicella.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A PHASE I-II STUDY OF LIVE ATTENUATED VARICELLA-ZOSTER VIRUS VACCINE TO BOOST IMMUNITY IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED CHILDREN WITH PREVIOUS VARICELLA. Pediatr Infect Dis J. 2009 Jul;28(7):653-655 Authors: Gershon AA, Levin MJ, Weinberg A, Song LY, Larussa PS, Steinberg SP, Bartlett P, Herpes zoster, may be severe and recurrent in HIV-infected children. We determined the safety and immunogenicity of live attenuated varicella-zoster virus (VZV) vaccine in 46 HIV-infected children who had experienced varicella. There were no serious adverse events. Two years after vaccination 82% of subjects remained V...
Source: Herpes - June 30, 2009 Category: Infectious Diseases Authors: Gershon AA, Levin MJ, Weinberg A, Song LY, Larussa PS, Steinberg SP, Bartlett P, Tags: Pediatr Infect Dis J Source Type: journals

Viral infection of cells in culture detected using infrared microscopy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
FTIR microscopy has been used to collect spectra for uninfected (mock) Vero cells, and cells that have been infected with herpes simplex virus type 1 (HSV-1) and human adenovirus type 5 (Ad-5). Cells were infected at a multiplicity of infection of 10, and studied at 24 hours post exposure. The spectra for infected samples display many differences compared to the spectra for uninfected samples. To estimate how well the spectra for uninfected and infected samples could be discriminated, we used logistic and partial least squares regression methods. We show that the spectra for HSV-1 and mock infected samples are well dif...
Source: Herpes - June 30, 2009 Category: Infectious Diseases Authors: Hastings G, Krug P, Wang R, Guo J, Lamichhane HP, Tang T, Hsu YS, Ward J, Katz D, Hilliard J Tags: Analyst Source Type: journals

Epidemiology of sexually transmitted infections in suspected child victims of sexual assault.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The prevalence of each STI among sexually victimized children is <10%, even when highly sensitive detection methods are used. Most children with STIs have normal or nonspecific findings on physical examination. PMID: 19564286 [PubMed - in process] (Source: Herpes)
Source: Herpes - June 30, 2009 Category: Infectious Diseases Authors: Girardet RG, Lahoti S, Howard LA, Fajman NN, Sawyer MK, Driebe EM, Lee F, Sautter RL, Greenwald E, Beck-Sagué CM, Hammerschlag MR, Black CM Tags: Pediatrics Source Type: journals

Herpes; +346 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
346 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Herpes These pubmed results were generated on 2009/06/27PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Herpes)
Source: Herpes - June 27, 2009 Category: Infectious Diseases Tags: Report Source Type: journals

Systemic administration of radiation-potentiated anti-angiogenic gene therapy against primary and metastatic cancer based on transcriptionally controlled HSV-TK.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transcription-targeted gene delivery directed against angiogenic endothelial cells is a new approach against advanced cancer. Moreover, the herpes simplex virus-thymidine kinase (HSV-TK) gene coupled with low dose radiotherapy is an efficient and externally controlled cytotoxic system. We have previously demonstrated enhanced endothelial-specific cell expression and killing using the modified murine pre-proendothelin-1 promoter (PPE1-3x) to direct adenoviral expression of a pro-apoptotic gene. The purpose of this study was to create an externally potentiated systemic anti-antiangiogenic gene delivery system based on an...
Source: Herpes - March 15, 2009 Category: Infectious Diseases Authors: Hodish I, Tal R, Shaish A, Varda-Bloom N, Greenberger S, Rauchwerger A, Breitbart E, Bangio L, Ben-Shushan D, Pfeffer R, Feder B, Waitsman A, Barshack I, Goldberg I, Mazaki-Tovi S, Peled M, Harats D Tags: Cancer Biol Ther Source Type: journals

Isolation of a sulphated polysaccharide from a recently discovered sponge species (Celtodoryx girardae) and determination of its anti-herpetic activity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exopolysaccharides (EPS) were extracted from a sponge, Celtodoryx girardae recently discovered in the Golfe du Morbihan in 2000. Sponge samples were collected monthly from November 2007 to May 2008. SEC analysis of EPS samples showed that they exhibit a unique molecular weight of approximately 800 kDa. However, infrared analysis revealed that structural seasonal variations occur. EPS fractions also exhibit significant sulphate contents and were screened in vitro for a potential antiviral activity against Herpes simplex virus type 1 (HSV-1). The best result was obtained with a sample collected in January which exhibits ...
Source: Herpes - March 6, 2009 Category: Infectious Diseases Authors: Rashid ZM, Lahaye E, Defer D, Douzenel P, Perrin B, Bourgougnon N, Sire O Tags: Int J Biol Macromol Source Type: journals

Valacyclovir to reduce transmission of genital herpes simplex virus infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19239344 [PubMed - in process] (Source: Herpes)
Source: Herpes - February 28, 2009 Category: Infectious Diseases Authors: Drew WL Tags: J Infect Dis Source Type: journals

New Insights on Interactions Between HIV-1 and HSV-2.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Herpes simplex type 2 (HSV-2) infection is common and frequently asymptomatic. Concerns exist about the high prevalence of HSV-2, particularly in areas of high HIV prevalence, because of observations that HSV-2 is associated with an increased risk of HIV acquisition, transmission, and disease progression. Several randomized trials have tested or are testing whether HSV-2 treatment can limit the spread of HIV, with mixed results. Although treatment with acyclovir, 400 mg twice daily, does not reduce HIV incidence, suppressive acyclovir and valacyclovir reduce HIV levels in plasma and in the genital tract. Ongoing trials...
Source: Herpes - February 28, 2009 Category: Infectious Diseases Authors: Delany-Moretlwe S, Lingappa JR, Celum C Tags: Curr Infect Dis Rep Source Type: journals

Sexual behaviour and diagnosis of people over the age of 50 attending a sexual health clinic.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: High levels of unsafe sex and many important sexual health problems were identified which provide direction for public health interventions for older sexually active Australians. PMID: 19243374 [PubMed - in process] (Source: Herpes)
Source: Herpes - February 28, 2009 Category: Infectious Diseases Authors: Bourne C, Minichiello V Tags: Australas J Ageing Source Type: journals

Embryonic Stem Cell Grafting in Normal and Infarcted Myocardium: Serial Assessment with MR Imaging and PET Dual Detection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Dual-modality imaging permits complementary information in regard to cell survival and proliferation, graft formation, and effects on cardiac function. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/250/3/821/DC1 (c) RSNA, 2009. PMID: 19244049 [PubMed - in process] (Source: Herpes)
Source: Herpes - February 28, 2009 Category: Infectious Diseases Authors: Qiao H, Zhang H, Zheng Y, Ponde DE, Shen D, Gao F, Bakken AB, Schmitz A, Kung HF, Ferrari VA, Zhou R Tags: Radiology Source Type: journals

Managing genital herpes infections in pregnancy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article will examine the current recommendations for diagnosis using serologic and viral detection techniques. Treatment options for initial and recurrent genital herpes infection in pregnancy are reviewed. The use of prophylactic antivirals and cesarean delivery are discussed. The article concludes with a look to the future, including potential changes in the management of herpes simplex virus-infected pregnant women. PMID: 19245354 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - February 28, 2009 Category: Infectious Diseases Authors: Aga IE, Hollier LM Tags: Womens Health (Lond Engl) Source Type: journals

Human herpes virus 8-unrelated primary effusion lymphoma-like lymphoma: report of a rare case and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe an 89-year-old human immunodeficiency virus (HIV)-negative male patient with HHV8-unrelated PEL-like lymphoma in the pleura. No hepatosplenomegaly or lymphadenopathy was detected. Chest radiography and computed tomography revealed right pleural effusion, but no evidence of tumor mass or lymph node enlargement. Cytological analysis of the pleural effusion revealed a high-grade lymphoma with round nuclei, prominent nucleoli and abundant cytoplasm with immunophenotypes positive for CD45, CD30, CD38, CD7 and CD71. Because of the advanced age, no chemotherapy was given. Effusion resolved spontaneously. One year afte...
Source: Herpes - February 28, 2009 Category: Infectious Diseases Authors: Adiguzel C, Bozkurt SU, Kaygusuz I, Uzay A, Tecimer T, Bayik M Tags: APMIS Source Type: journals

Herpes zoster ophthalmicus or Herpes zoster maxillaris?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19237800 [PubMed - in process] (Source: Herpes)
Source: Herpes - February 26, 2009 Category: Infectious Diseases Authors: Chandravanshi SL, Rathore MK Tags: Indian J Ophthalmol Source Type: journals

Asymptomatically shed recombinant herpes simplex virus type 1 strains detected in saliva.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen infecting most individuals worldwide. The majority of HSV-1-infected individuals have no clinical symptoms but shed HSV-1 asymptomatically in saliva. Recent phylogenetic analyses of HSV-1 have defined three genetic clades (A-C) and recombinants thereof. These data have all been based on clinical HSV-1 isolates and do not cover genetic variation of asymptomatically shed HSV-1. The primary goal of this study was to investigate such variation. A total of 648 consecutive saliva samples from five HSV-1-infected volunteers was collected. Asymptomatic shedding was d...
Source: Herpes - February 18, 2009 Category: Infectious Diseases Authors: Liljeqvist JA, Tunbäck P, Norberg P Tags: J Gen Virol Source Type: journals

Can We Predict a Prolonged Course and Intractable Cases of Herpes Simplex Encephalitis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19218765 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - February 18, 2009 Category: Infectious Diseases Authors: Shoji H Tags: Intern Med Source Type: journals

Rituximab and Chemotherapy in Primary Gastric Lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The addition of rituximab to CHOP chemotherapy did not improve outcome in early-stage PGL. PMID: 19216628 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - February 13, 2009 Category: Infectious Diseases Authors: Avilés A, Castañeda C, Cleto S, Neri N, Huerta-Guzmán J, Gonzalez M, Nambo MJ Tags: Cancer Biother Radiopharm Source Type: journals

Immune Responses to Herpes Viral Vectors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Over two decades have passed since the initial technology was created to develop recombinant herpes simplex viruses (Meignier et al., 1988; Post and Roizman, 1981; Roizman and Jenkins, 1985). Since that time, herpes simplex viruses have been engineered into amenable tools for gene therapy. There are a wide range of herpes simplex virus (HSV) based vector platforms and packaging strategies, which are continually being improved to fit the needs of a particular application. In this review, we will present the biology of HSV, explore various HSV based vectors utilized in gene therapeutic approaches, and the severity of the...
Source: Herpes - February 13, 2009 Category: Infectious Diseases Authors: Ryan DA, Federoff HJ Tags: Hum Gene Ther Source Type: journals

Cytologic and immunocytochemical features of EBV negative primary effusion lymphoma: Report on seven Japanese cases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report presents seven Japanese cases of PEL. In situ hybridization revealed that the PEL cells were negative for EBV in all cases. An immunocytological analysis showed that only one case was positive for HHV-8, and PEL cells were positive for CD20 in all cases. MUM1 was positive, but CD10 and CD138 were negative in six cases. One case each was positive for CD30 and BCL-6. The phenotypic patterns of HIV-related is BCL6-/MUM1+/CD138+, thus, the phenotypic findings observed by immunocytochemistry in this study were somehow different from those reported in Western countries. However, the cytomorphological features of PEL ...
Source: Herpes - February 13, 2009 Category: Infectious Diseases Authors: Kishimoto K, Kitamura T, Hirayama Y, Tate G, Mitsuya T Tags: Diagn Cytopathol Source Type: journals

Sti prevalence and associated factors among urban men in Pakistan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: HIV prevalence in Pakistan remains low, however emergence of genital herpes is a matter of concern as it could lead to a future conduit for HIV spread. Health education messages should target less educated segments of society and specifically advocate safe sex practices and early diagnosis. PMID: 19211591 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - February 11, 2009 Category: Infectious Diseases Authors: Mir AM, Wajid A, Reichenbach L, Khan M Tags: Sex Transm Infect Source Type: journals

Intent to Accept and Acceptance of Herpes Testing in Adolescents and Young Adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study suggests that intent does not always predict behaviour even when the two are measured within close temporal proximity. There are factors that may predict intent only or behavior only, or may predict behavior, but solely through influencing intent. Understanding how these various relationships work may be important to efforts designed to maximize acceptance of HSV-2 testing. PMID: 19211592 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - February 11, 2009 Category: Infectious Diseases Authors: Kelly NC, Zimet GD, Aalsma MC, Bernstein DI, Fortenberry JD, Rosenthal SL Tags: Sex Transm Infect Source Type: journals

Use of the designation "shedder" in mucosal detection of herpes simplex virus DNA involving repeated sampling.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Most HSV-2 seropositive persons shed HSV from the genital mucosa. Dichotomization of persons into "shedders" and "nonshedders" or "high" and "low" shedders yields inferences that depend upon sampling interval length. Overall shedding rates provide consistent measures regardless of the number of swabs collected. PMID: 19211593 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - February 11, 2009 Category: Infectious Diseases Authors: Magaret A, Johnston C, Wald A Tags: Sex Transm Infect Source Type: journals

Components of Nuclear Domain 10 bodies Regulate Varicella Zoster Virus Replication.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report we show that ORF61p, the Varicella Zoster Virus (VZV) ortholog, does not degrade PML and only slightly alters Sp100 levels. Furthermore, we demonstrate that other virus proteins cannot substitute for this lack of function during infection. By use of short interfering RNAs we depleted PML, Sp100 and Daxx and studied their role in plaquing efficiency, virus protein accumulation, infectious center titer and virus spread. These studies show that components of ND10s can accelerate VZV replication but do not ultimately control cell-associated virus titers. We conclude that while both ICP0 and ORF61p activate virus...
Source: Herpes - February 11, 2009 Category: Infectious Diseases Authors: Kyratsous CA, Silverstein SJ Tags: J Virol Source Type: journals

Fewer Latent HSV-1 and Cytotoxic T-Cells Occur in the Ophthalmic Division than in the Maxillary and Mandibular Divisions of the Human Trigeminal Ganglion and Nerve.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the large accumulation of LAT and cytotoxic T-cells in the V2 and V3 but not in the V1 division of the TG reflects the sites supplied by the sensory fibers and the clinical reactivation patterns. PMID: 19211753 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - February 11, 2009 Category: Infectious Diseases Authors: Hüfner K, Horn A, Derfuss T, Glon C, Sinicina I, Arbusow V, Strupp M, Brandt T, Theil D Tags: J Virol Source Type: journals

Cytotoxicity and antiangiogenesis by fibroblast growth factor 2-targeted Ad-TK cancer gene therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS:: These data suggest that FGF2-retargeted Ad-TK produces a combination of expected direct antitumor cytotoxicity and a newly reported antiangiogenesis effect that could prove promising as a novel therapeutic approach in the treatment of FGF receptor-expressing cancers. Laryngoscope, 2009. PMID: 19213040 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - February 11, 2009 Category: Infectious Diseases Authors: Saito K, Khan K, Sosnowski B, Li D, O'Malley BW Tags: Laryngoscope Source Type: journals

Herpes zoster oticus associated with varicella zoster virus encephalitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ramsay-Hunt syndrome, herpes zoster oticus (HZO), derived its name from James Ramsay Hunt, who first described it in 1907. It is classically characterized by acute peripheral facial paralysis, herpetic eruptions on the auricle, and vestibulocochlear dysfunction due to the reactivation of varicella zoster virus (VZV). In this Case Report, the authors describe an HZO patient with simultaneous VZV encephalitis. To date, only eight cases of HZO associated with VZV encephalitis have been reported in the English literature. Therefore, the authors discuss all the aspects of this rare entity, including clinical examination, ra...
Source: Herpes - February 11, 2009 Category: Infectious Diseases Authors: Eskiizmir G, Uz U, Taşkiran E, Unlü H Tags: Laryngoscope Source Type: journals

Type I IFN response to Papiine herpesvirus 2 (Herpesvirus papio 2; HVP2) determines neuropathogenicity in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Isolates of baboon alpha-herpesvirus Papiine herpesvirus 2 (HVP2) exhibit one of two distinct phenotypes in mice: extremely neurovirulent or apathogenic. Previous studies implicated the type I interferon (IFN) response as being a major factor in controlling infection by apathogenic isolates. To further investigate the possibility that the host IFN-beta response underlies the pathogenicity of the two HVP2 subtypes, the susceptibility of mice lacking the IFN-beta receptor (IFNAR(-/-)) to infection was examined. Apathogenic isolates of HVP2 (HVP2ap) replicated in IFNAR(-/-) primary mouse dermal fibroblast (PMDF) cultures ...
Source: Herpes - February 10, 2009 Category: Infectious Diseases Authors: Rogers KM, Deatheridge M, Breshears MA, Chapman S, Black D, Ritchey JW, Payton M, Eberle R Tags: Virology Source Type: journals

SK2 potassium channel overexpression in basolateral amygdala reduces anxiety, stress-induced corticosterone secretion and dendritic arborization.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we employed a gene therapeutic approach to reduce anxiety and dendritic arborization of the amygdala neurons. Specifically, we overexpressed SK2 potassium channel in the basolateral amygdala using a herpes simplex viral system. Our choice of therapeutic cargo was guided by the indications that activation of the amygdala might underlie anxiety and that SK2 could reduce neuronal activation by exerting inhibitory influence on action potentials. We report that SK2 overexpression reduced anxiety and stress-induced corticosterone secretion at a systemic level. SK2 overexpression also reduced dendritic arborization ...
Source: Herpes - February 10, 2009 Category: Infectious Diseases Authors: Mitra R, Ferguson D, Sapolsky RM Tags: Mol Psychiatry Source Type: journals

Single-day famciclovir for the treatment of genital herpes: follow-up results of time to next recurrence and assessment of antiviral resistance *Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Treatment with single-day famciclovir for recurrent genital herpes did not shorten the time to the next recurrence. Drug resistance to penciclovir continues to be a rare event in immunocompetent patients. PMID: 19192993 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - February 8, 2009 Category: Infectious Diseases Authors: Bodsworth N, Fife K, Koltun W, Tyring S, Abudalu M, Prichard M, Hamed K Tags: Curr Med Res Opin Source Type: journals

Oncolytic herpes simplex virus vectors and taxanes synergize to promote killing of prostate cancer cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genetically engineered oncolytic herpes simplex virus-1 (HSV-1) vectors selectively replicate in tumor cells causing direct killing whereas sparing normal cells. One clinical limitation of using oncolytic HSV vectors is their attenuated growth. We hypothesized that the appropriately chosen chemotherapeutic agent combined with an oncolytic HSV could be an effective means to promote augmented prostate cancer cell killing both in vitro and in vivo. Here we have identified that G47Delta synergizes with the microtubule-stabilizing taxane agents docetaxel and paclitaxel to enhance the in vitro killing of prostate cancer cell...
Source: Herpes - February 6, 2009 Category: Infectious Diseases Authors: Passer BJ, Castelo-Branco P, Buhrman JS, Varghese S, Rabkin SD, Martuza RL Tags: Cancer Gene Ther Source Type: journals

Influence of antisense oligonucleotides targeting tumor necrosis factor-alpha on experimental herpetic-induced chorioretinitis of mouse eye.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The results suggested that TNF-alpha ASON reduced the content of TNF-alpha in mouse eyes, and this topical treatment decreased the inflammatory reaction. It may be an effective method for treating HSV-1-induced chorioretinitis in the clinic. PMID: 19188750 [PubMed - in process] (Source: Herpes)
Source: Herpes - February 5, 2009 Category: Infectious Diseases Authors: Mei H, Xing Y, Yang J, Wang A, Xu Y, Heiligenhaus A Tags: Pathobiology Source Type: journals

Association of C-terminal ubiquitin hydrolase BAP1 with cell cycle regulator HCF-1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Protein ubiquitination provides an efficient and reversible mechanism to regulate cell cycle progression and checkpoint control. Numerous regulatory proteins direct the addition of ubiquitin to lysine residues on target proteins and these are countered by an army of deubiquitinating enzymes (DUBs). BRCA1-associated protein-1 (Bap1) is a ubiquitin carboxy-terminal hydrolase and is frequently mutated in lung and sporadic breast tumors. Bap1 can suppress growth of lung cancer cells in athymic nude mice and this requires its DUB activity. Here we show that Bap1 interacts with host cell factor-1 (HCF-1), a transcriptional c...
Source: Herpes - February 2, 2009 Category: Infectious Diseases Authors: Misaghi S, Ottosen S, Izrael-Tomasevic A, Arnott D, Lamkanfi M, Lee J, Liu J, O'Rourke K, Dixit VM, Wilson AC Tags: Mol Cell Biol Source Type: journals