Effect of 3D printing technology-assisted TKA on cartilage tissue in rabbit with knee osteoarthritis
CONCLUSION: 3D printing technology-assisted TKA exhibits a good treatment effect in rabbit KOA. This study provides an important basis for the clinical application of 3D printing technology-assisted TKA in KOA treatment.PMID:38639204 | DOI:10.14670/HH-18-740 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 19, 2024 Category: Cytology Authors: Guoliang Wang Feng Cheng Jianxun Cui Nan Chen Qing Li Source Type: research
Establishment of human acute monocytic leukemia model with systemic infiltration in NPG mice
In conclusion, the current study demonstrated the normal growth of SHI-1 cells in the NPG mice without immunosuppression, which caused systemic leukemia similar to that observed in acute leukemia patients. We developed an efficient and reproducible model to study leukemia pathogenesis and progression.PMID:38634557 | DOI:10.14670/HH-18-742 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 18, 2024 Category: Cytology Authors: Jing Xu Qiong Wu Yanfei Rao Zhenjiang Li Wenfeng He Wanlei Sun Jifu Zheng Qingming Wang Aiping Tang Source Type: research
Moringa isothiocyanate-1 mitigates the damage of oxidative stress and apoptosis in diabetic nephropathy mice
CONCLUSIONS: MIC-1 ameliorated the kidney injury in DN mice, and its mechanism may be associated with the suppression of renal cell apoptosis, oxidative stress, and inflammatory responses.PMID:38623789 | DOI:10.14670/HH-18-741 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 16, 2024 Category: Cytology Authors: Zhou Hua Jiuhong Deng Guiying Wang Source Type: research
Blood-brain barrier disruption following brain injury: Implications for clinical practice
Histol Histopathol. 2024 Apr 1:18740. doi: 10.14670/HH-18-740. Online ahead of print.ABSTRACTThe blood-brain barrier (BBB) plays a critical role in regulating the exchange of substances between peripheral blood and the central nervous system and in maintaining the stability of the neurovascular unit in neurological diseases. To guide clinical treatment and basic research on BBB protection following brain injury, this manuscript reviews how BBB disruption develops and influences neural recovery after stroke and traumatic brain injury (TBI). By summarizing the pathological mechanisms of BBB damage, we underscore the critical...
Source: Histology and Histopathology - April 15, 2024 Category: Cytology Authors: Ruojing Bai Xintong Ge Source Type: research
Polydatin protects against articular cartilage degeneration by regulating autophagy mediated by the AMPK/mTOR signaling pathway
CONCLUSION: Our research showed that polydatin reduced apoptosis and activated autophagy both in vivo and in vitro by the AMPK/mTOR signaling pathway to protect against KOA, which provided the basis for further investigation into the potential therapeutic impact of polydatin on KOA.PMID:38606875 | DOI:10.14670/HH-18-739 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 12, 2024 Category: Cytology Authors: Zhengcong Ye Jian Lin Chun He Pengzheng Yu Guoping Cao Qinrong Shen Canfeng Wang Source Type: research
Chondroitin polymerizing factor (CHPF) promotes the progression of colorectal cancer through ASB2-mediated ubiquitylation of SMAD9
Histol Histopathol. 2024 Mar 26:18738. doi: 10.14670/HH-18-738. Online ahead of print.ABSTRACTChondroitin polymerizing factor (CHPF) has been reported to play a pivotal role in the progression of multiple cancers, however, the relationship between CHPF and colorectal cancer (CRC) progression has not been fully understood. The current study revealed that CHPF expression was upregulated in patients with CRC and correlated with an unfavorable prognosis. Also, CHPF knockdown effectively suppressed the viability and mobility of CRC cells and the growth of xenograft tumors. Additionally, SMAD9 was identified as a downstream targ...
Source: Histology and Histopathology - April 9, 2024 Category: Cytology Authors: Jiang Zhao Xiaolong Tang Huijun Zhu Source Type: research
Urolithin A attenuates bupivacaine-induced neurotoxicity in SH-SY5Y cells by regulating the SIRT1-activated PI3K/AKT pathway
In conclusion, UroA protected SH-SY5Y cells against BUP-induced injuries through PI3K/AKT signaling in a SIRT1-dependent manner.PMID:38587058 | DOI:10.14670/HH-18-737 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 8, 2024 Category: Cytology Authors: Bin Liu Yuan Wei Source Type: research
