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CD98 expression is decreased in papillary carcinoma of the thyroid and Hashimoto's thyroiditisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CD98 expression is down-regulated in thyroid papillary carcinoma; this may relate to the better prognosis associated with many of these tumours. (Source: Histopathology)
Source: Histopathology - November 18, 2009 Category: Pathology Authors: Catriona E Anderson, Catriona Graham, Michael M Herriot, Hassan M Kamel, Donald M Salter Source Type: journals

Chromogenic in situ hybridization for Her-2/neu-oncogene in breast cancer: comparison of a new dual-colour chromogenic in situ hybridization with immunohistochemistry and fluorescence in situ hybridizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CISH, using dual-colour probes (ZytoVision®) is as good as FISH for Her-2/neu analysis. The few discrepant results are likely to be caused by polysomy or tumour heterogeneity. (Source: Histopathology)
Source: Histopathology - November 17, 2009 Category: Pathology Authors: Doris Mayr, Sibylle Heim, Kerstin Weyrauch, Evelyn Zeindl-Eberhart, Anne Kunz, Jutta Engel, Thomas Kirchner Source Type: journals

Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Similar to adenomas, MGA is, at least in some cases, a clonal lesion and may be a non-obligate precursor of a subgroup of high-grade triple-negative and basal-like breast carcinomas. (Source: Histopathology)
Source: Histopathology - November 17, 2009 Category: Pathology Authors: Felipe C Geyer, Yael B Kushner, Maryou B Lambros, Rachael Natrajan, Alan Mackay, Narinder Tamber, Kerry Fenwick, Dave Purnell, Alan Ashworth, Rosemary A Walker, Jorge S Reis-Filho Source Type: journals

Activation of ERK, AKT and JNK signalling pathways in human schwannomas in situEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings provide further direct evidence for activation of the JNK/JUN, PI3K/AKT and MEK/ERK signalling pathways in schwannomas and support the development of therapeutic agents directed against these pathways for the treatment of this group of tumours. (Source: Histopathology)
Source: Histopathology - November 17, 2009 Category: Pathology Authors: David A Hilton, Natalia Ristic, Clemens O Hanemann Source Type: journals

Expression of cyclin D1 and retinoblastoma protein in Paget's disease of the vulva and breast: an immunohistochemical study of 108 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The differences in the expression of cyclin D1 and retinoblastoma may indicate the differences in the pathogenesis of PDV and PDB. (Source: Histopathology)
Source: Histopathology - November 16, 2009 Category: Pathology Authors: Patricia E Ellis, Allan B MacLean, Julie C Crow, L F Wong Te Fong, Kerstin J Rolfe, Christopher W Perrett Source Type: journals

Ketamine cystitis as a mimic of carcinoma in situEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Ketamine can lead to reactive urothelial changes that can mimic carcinoma in situ, but the long-term cancer risk remains unknown. (Source: Histopathology)
Source: Histopathology - November 16, 2009 Category: Pathology Authors: Jon D Oxley, Angela M Cottrell, Susan Adams, David Gillatt Source Type: journals

The search for lymph nodes; does a second search influence the staging and/or management in mesorectal cancer excisions?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Histopathology)
Source: Histopathology - November 12, 2009 Category: Pathology Authors: Paul Mansour, Martin W Shaw Source Type: journals

Making the most of bone marrow trephine biopsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Wilkins B S & Clark D M (2009) HistopathologyMaking the most of bone marrow trephine biopsy Bone marrow trephine biopsy is an integral component of the diagnosis, staging and follow-up of many haematological diseases. Adequate size and integrity of the initial specimen are crucial, although data defining what constitutes an adequate sample in different clinical contexts are limited. The requirement for decalcification or plastic embedding during tissue processing poses additional challenges for histological quality and successful application of essential techniques, including immunohistochemistry, DNA/RNA in situ hybridiza...
Source: Histopathology - October 30, 2009 Category: Pathology Authors: Bridget S Wilkins, David M Clark Source Type: journals

Histological grading of invasive breast carcinoma – a simplification of existing methods in a large conservation series with long-term follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Existing grading methodology is fully applicable in the narrower context of a conservation series but can be simplified. Subdivision of EE grade 2 into a true intermediate prognosis group and a second group with a worse prognosis also adds benefit. (Source: Histopathology)
Source: Histopathology - October 21, 2009 Category: Pathology Authors: Jeremy St J Thomas, Gillian R Kerr, Wilma J L Jack, Fiona Campbell, Laura McKay, Hans-Christian Pedersen, Ian H Kunkler, David A Cameron, Udi Chetty, John M S Bartlett Source Type: journals

Quantitative measurement of venous invasion of colorectal cancer with metachronous liver metastasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The average number of foci of venous invasion by colorectal cancer with metachronous liver metastasis did not differ significantly from that with synchronous ones. Furthermore, invasion into extramural large veins appeared to be associated with liver metastasis. (Source: Histopathology)
Source: Histopathology - October 20, 2009 Category: Pathology Authors: Daisuke Mori, Masami Shibaki, Masanori Masuda, Fumio Yamasaki Source Type: journals

Does cyclin D1 discriminate between BRCA2 and BRCAX breast cancers?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Histopathology)
Source: Histopathology - September 23, 2009 Category: Pathology Authors: Max Yan, Stephen B Fox Source Type: journals

Molecular assessment of sentinel lymph node in breast cancer managementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Douglas-Jones A G & Woods V(2009) HistopathologyMolecular assessment of sentinel lymph node in breast cancer management Sentinel lymph node biopsy (SLNB) is becoming accepted as standard of care for axillary staging in breast cancer. World Health Organization (WHO) re-classification of axillary metastases into macrometastases, micrometastases and individual tumour cells has highlighted the issues of sampling and further histological examination of the initially negative SLNB. Molecular detection of metastatic breast cancer cells in lymph nodes is now available as a commercial kit for intraoperative use and can resolve the ...
Source: Histopathology - June 17, 2009 Category: Pathology Authors: Anthony G Douglas-Jones, Victoria Woods Source Type: journals

Recent advances in molecular gynaecological pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Herrington C S (2009) HistopathologyRecent advances in molecular gynaecological pathology This review gives an overview of recent advances in our understanding of the molecular basis of gynaecological malignancy, including cervical, vulval, endometrial and ovarian tumours. These advances are beginning to influence clinical practice, perhaps most notably with the introduction of human papillomavirus vaccination for the prevention of anogenital neoplasia, but are likely to have broader clinical implications as further details emerge. (Source: Histopathology)
Source: Histopathology - May 11, 2009 Category: Pathology Authors: C Simon Herrington Source Type: journals

Overexpression of chromatin assembly factor-1 (CAF-1) p60 is predictive of adverse behaviour of prostatic cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In our series of cases, overexpression of CAF-1/p60 characterized prostatic cancers with a worse prognosis. CAF-1/p60 has a potential role as a new reliable prognostic biomarker for prostatic cancer. PMID: 19309489 [PubMed - as supplied by publisher] (Source: Histopathology)
Source: Histopathology - March 20, 2009 Category: Pathology Authors: Staibano S, Mascolo M, Mancini FP, Kisslinger A, Salvatore G, Di Benedetto M, Chieffi P, Altieri V, Prezioso D, Ilardi G, De Rosa G, Tramontano D Tags: Histopathology Source Type: journals

Nuclear, compared with combined nuclear and cytoplasmic expression of maspin, is linked in lung adenocarcinoma to reduced VEGF-A levels and in Stage I, improved survival.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: (N) maspin selects lung adenocarcinomas with distinct molecular and clinical features, supporting the hypothesis that its tumour inhibitor properties may be linked to its nuclear localization. PMID: 19309490 [PubMed - as supplied by publisher] (Source: Histopathology)
Source: Histopathology - March 20, 2009 Category: Pathology Authors: Frey A, Soubani AO, Adam AK, Sheng S, Pass HI, Lonardo F Tags: Histopathology Source Type: journals

Expression of c-MET, low-molecular-weight cytokeratin, matrix metalloproteinases-1 and -2 in spinal chordoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: c-MET expression was observed in most spinal chordomas and correlated with the expression of CAM5.2, suggesting a relationship to an epithelial phenotype. PMID: 19302530 [PubMed - as supplied by publisher] (Source: Histopathology)
Source: Histopathology - March 19, 2009 Category: Pathology Authors: Naka T, Boltze C, Samii A, Samii M, Herold C, Ostertag H, Iwamoto Y, Oda Y, Tsuneyoshi M, Kuester D, Roessner A Tags: Histopathology Source Type: journals

A persistent scalp nodule caused by the human botfly: exoskeletal larval spines are a key diagnostic feature of myiasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19302531 [PubMed - as supplied by publisher] (Source: Histopathology)
Source: Histopathology - March 19, 2009 Category: Pathology Authors: Shelton DA, Wright PK, Chaudhry I, Curry A Tags: Histopathology Source Type: journals

Adenocarcinoma arising in a background of chronic atrophic pouchitis in an ileoanal pouch for ulcerative colitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19302532 [PubMed - as supplied by publisher] (Source: Histopathology)
Source: Histopathology - March 19, 2009 Category: Pathology Authors: Bell AJ Tags: Histopathology Source Type: journals

Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19302533 [PubMed - as supplied by publisher] (Source: Histopathology)
Source: Histopathology - March 19, 2009 Category: Pathology Authors: Kim SS, Choi YD, Jin XM, Cho YM, Jang JJ, Juhng SW, Choi C Tags: Histopathology Source Type: journals

Expression and molecular analysis of c-kit and PDGFRs in Kaposi's sarcoma of different stages and epidemiological settings.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19302534 [PubMed - as supplied by publisher] (Source: Histopathology)
Source: Histopathology - March 19, 2009 Category: Pathology Authors: Rossi G, Sartori G, Rusev BC, Sgambato A Tags: Histopathology Source Type: journals

Interobserver agreement in grading of colorectal cancer - findings from a nationwide web-based survey of histopathologists.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19302535 [PubMed - as supplied by publisher] (Source: Histopathology)
Source: Histopathology - March 19, 2009 Category: Pathology Authors: Smeeton NC Tags: Histopathology Source Type: journals

Sacrococcygeal teratoma with extensive nephrogenic differentiation: a rare finding not to be misdiagnosed as yolk sac tumour.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19302536 [PubMed - as supplied by publisher] (Source: Histopathology)
Source: Histopathology - March 19, 2009 Category: Pathology Authors: Al-Adnani M, Walker J, Cohen M Tags: Histopathology Source Type: journals

Interstitial pneumonitis caused by Pneumocystis jirovecii pneumonia (PCP) during bortezomib treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19302537 [PubMed - as supplied by publisher] (Source: Histopathology)
Source: Histopathology - March 19, 2009 Category: Pathology Authors: Wondergem MJ, Grünberg K, Wittgen BP, Sonneveld P, Zweegman S Tags: Histopathology Source Type: journals

Emerin immunohistochemistry reveals diagnostic features of nuclear membrane arrangement in thyroid lesions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Decoration of the NM represents an original approach to identify PTC nuclear shape, highlights new structural features and might be helpful in the differential diagnosis between so-called nuclear pseudoinclusions and artefactual 'bubbles'. PMID: 19302538 [PubMed - as supplied by publisher] (Source: Histopathology)
Source: Histopathology - March 19, 2009 Category: Pathology Authors: Asioli S, Bussolati G Tags: Histopathology Source Type: journals

Gallbladder cancer: a morphological and molecular updateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Goldin R D & Roa J C(2009) HistopathologyGallbladder cancer: a morphological and molecular update Gallbladder cancer (GBC) shows a marked geographical variation in its incidence, with the highest figures being seen in India and Chile and relatively low levels in many Western countries. Risk factors for its development include the presence of gallstones, infection and the presence of an anomalous pancreatobiliary ductal junction. It can arise from either a pathway involving metaplasia or dysplasia or one in which there is a pre-existing adenoma. The former is the more common and, because it is often not associated with a ma...
Source: Histopathology - March 12, 2009 Category: Pathology Authors: Robert David Goldin, Juan Carlos Roa Source Type: journals

The expression of ERalpha, ERbeta and PR in lobular carcinoma in situ of the breast determined using laser microdissection and real-time PCR.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Increased expression of steroid receptors in LCIS suggests their possible role in the biology of LCIS and, for PR, could influence the predisposition of women diagnosed with LCIS to develop invasive breast carcinoma. PMID: 19309393 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Green AR, Young P, Krivinskas S, Rakha EA, Claire Paish E, Powe DG, Ellis IO Tags: Histopathology Source Type: journals

Rapid screening of tissue microarrays for Her-2 fluorescence in situ hybridization testing is an accurate, efficient and economic method of providing an entirely in situ hybridization-based Her-2 testing service.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Rapid screening of TMAs for routine Her-2 FISH testing is safe, economical and time efficient. The technique ensures that all patients receive 'gold standard' testing. PMID: 19309394 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Faratian D, Graham A, Rae F, Thomas J Tags: Histopathology Source Type: journals

Methylene blue-assisted lymph node dissection in combination with ex vivo sentinel lymph node mapping in gastric cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Both techniques have the potential to improve the accuracy of histopathological LN staging and can be combined successfully. PMID: 19309395 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Märkl B, Wünsch K, Hebick KU, Anthuber M, Probst A, Arnholdt HM, Spatz H Tags: Histopathology Source Type: journals

Prognostic importance of epithelial-mesenchymal transition-related protein expression in gastric carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Loss of epithelial proteins and/or the acquisition of mesenchymal proteins are associated with poorly differentiated histology, advanced stage and poor outcome in GC. The awareness and inhibition of EMT offer a promising target for prevention of metastatic progression and invasion. PMID: 19309396 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Kim MA, Lee HS, Lee HE, Kim JH, Yang HK, Kim WH Tags: Histopathology Source Type: journals

Decreased intratumoral arteries reflect portal tract destruction and aggressive characteristics in intrahepatic cholangiocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study demonstrates that intratumoral arterial vessels reflect engulfed portal tracts in ICC and decreased arterial vessels indicate aggressive tumour behaviour. Our results could contribute to clinical tumour staging and more effective therapy. PMID: 19309397 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Aishima S, Iguchi T, Nishihara Y, Fujita N, Taguchi K, Taketomi A, Maehara Y, Tsuneyoshi M Tags: Histopathology Source Type: journals

Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: GRP78 expression appears to correlate with known correlates of melanoma progression and survival and requires further evaluation as a prognostic biomarker in melanoma. PMID: 19309398 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Zhuang L, Scolyer RA, Lee CS, McCarthy SW, Cooper WA, Zhang XD, Thompson JF, Hersey P Tags: Histopathology Source Type: journals

Retiform uterine tumours resembling ovarian sex cord tumours. A comparative immunohistochemical study with retiform structures of the female genital tract.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: RUTROSCTs have benign behaviour but may be confused with various uterine adenocarcinomas or metastases. Correct diagnosis should avoid overtreatment. The immunophenotype of retiform areas is similar to that of adult rete ovarii and RWAT with minor divergence from ORSLCT. PMID: 19309399 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Nogales FF, Stolnicu S, Harilal KR, Mooney E, García-Galvis OF Tags: Histopathology Source Type: journals

Bcl-10 protein highly correlates with the expression of phosphorylated p65 NF-kappaB in peripheral T-cell lymphomas and is associated with clinical outcome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Bcl-10 is expressed in PTCLs, correlates with PKC theta and Pp65(Ser536) expression and seems to be associated with better survival. PMID: 19309400 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Briones J, Moga E, Espinosa I, Vergara C, Alvarez E, Villa J, Bordes R, Delgado J, Prat J, Sierra J Tags: Histopathology Source Type: journals

Bone marrow necrosis related to paracoccidioidomycosis: the first eight cases identified at autopsy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: All eight patients had acute PCM. Six had histological only (biopsies) and two cytological only (smears) specimens. Five biopsy specimens revealed severe and one mild coagulation patterned necrotic areas. Five had osteonecrosis. The cytological specimens also showed typical BMN patterns. Paracoccidioides brasiliensis yeast forms were visible within necrotic areas in all cases. PMID: 19309401 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Resende LS, Mendes RP, Bacchi MM, Marques SA, Barraviera B, Souza LR, Meira DA, Niéro-Melo L Tags: Histopathology Source Type: journals

Inflammatory myofibroblastic tumour of the urinary bladder mimicking recurrent uterine carcinosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19309402 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Pristauz G, Moinfar F, Chromecki T, Bader AA, Winter R, Tamussino K Tags: Histopathology Source Type: journals

Is sclerosing angiomatoid nodular transformation (SANT) of the splenic red pulp identical to inflammatory pseudotumor? Report of 16 cases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19309404 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Rosai J Tags: Histopathology Source Type: journals

Tubal and ovarian pathways to pelvic epithelial cancer: a pathological perspective.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19309405 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Piek JM, Verheijen RH, van Diest PJ Tags: Histopathology Source Type: journals

Interpretation of diffuse Cdx2 expression in endometrioid adenocarcinoma in the absence of morules.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19309406 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Wani Y Tags: Histopathology Source Type: journals

Uterine and extrauterine plexiform tumourlets are sex-cord-like tumours with myoid features.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19309407 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Nogales FF, Nicolae A, García-Galvis OF, Aneiros-Fernández J, Salas-Molina J, Stolnicu S Tags: Histopathology Source Type: journals

Metastasizing anaplastic ependymoma in an adult. Chromosomal imbalances, metabolic and gene expression profiles.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19309408 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Lopez-Gines C, Gil-Benso R, Faus C, Monleon D, Mata M, Morales JM, Cigudosa JC, Gonzalez-Darder J, Celda B, Cerda-Nicolas M Tags: Histopathology Source Type: journals

MAP-2 immunoexpression in gliomatosis cerebri.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19309409 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Romeike BF, Mawrin C Tags: Histopathology Source Type: journals

Atypical organizing haematoma/seroma following treatment for soft tissue sarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19309410 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Palomba A, Beltrami G, Campanacci D, Capanna R, Franchi A Tags: Histopathology Source Type: journals

Activation of NF-kappaB transcription factor in asthma death.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19309411 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Caramori G, Oates T, Nicholson AG, Casolari P, Ito K, Barnes PJ, Papi A, Adcock IM, Chung KF Tags: Histopathology Source Type: journals

The expression of activation induced cytidine deaminase in follicular lymphoma is independent of prognosis and stage.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19309412 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Willenbrock K, Renné C, Rottenkolber M, Klapper W, Dreyling M, Engelhard M, Küppers R, Hansmann ML, Jungnickel B Tags: Histopathology Source Type: journals

Diagnostic challenges of motility disorders: optimal detection of CD117+ interstitial cells of Cajal.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The optimized protocol presented improved CD117 detection in FFPE tissues and showed good concordance with overall localization of CD117-immunoreactive ICC as detected by IF. As such, this protocol may be more useful than current diagnostic procedures in motility disorders. PMID: 19236504 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - February 1, 2009 Category: Pathology Authors: Garrity MM, Gibbons SJ, Smyrk TC, Vanderwinden JM, Gomez-Pinilla PJ, Nehra A, Borg M, Farrugia G Tags: Histopathology Source Type: journals

Distinct biphasic histomorphological pattern in gastrointestinal stromal tumours (GISTs) with common primary mutations but divergent molecular cytogenetic progression.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results indicate that the intratumoral phenotypic diversity in GIST reflects histomorphological progression, which is associated with higher chromosomal instability, irrespective of the primary mutation. PMID: 19236505 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - February 1, 2009 Category: Pathology Authors: Agaimy A, Haller F, Gunawan B, Wünsch PH, Füzesi L Tags: Histopathology Source Type: journals

Haeme oxygenase-1 promoter polymorphism is an independent prognostic marker of gastrointestinal stromal tumour.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: HMOX-1 promoter GTn polymorphism is a potential prognostic marker and may help to allocate patients to different risk groups, customized therapy and follow-up. Haeme oxygenase-1 could represent an important candidate gene in the pathogenesis and growth of GIST. PMID: 19236506 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - February 1, 2009 Category: Pathology Authors: Vashist YK, Uzunoglu G, Cataldegirmen G, Kalinin V, Schurr P, Koenig AM, Thieltges S, Zehler O, Schneider C, Izbicki JR, Yekebas EF Tags: Histopathology Source Type: journals

Prognostic value of PRL-3 overexpression in early stages of colonic cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PRL-3 may predict poor survival and act as a promising biomarker for individualized therapy for patients with colonic cancer, especially for those diagnosed at an early stage. PMID: 19236507 [PubMed - as supplied by publisher] (Source: Histopathology)
Source: Histopathology - February 1, 2009 Category: Pathology Authors: Xing X, Peng L, Qu L, Ren T, Dong B, Su X, Shou C Tags: Histopathology Source Type: journals

Down-regulated expression of the TSAP6 protein in liver is associated with a transition from cirrhosis to hepatocellular carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: With biopsies periodically performed for surveillance purposes, the decreased expression of TSAP6 in cirrhotic tissue could reflect a decrease in the apoptotic process and could be interpreted as a warning sign. This evaluation of the TSAP6 level in cirrhotic liver conveys predictive information for the development of HCC. PMID: 19236508 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - February 1, 2009 Category: Pathology Authors: Caillot F, Daveau R, Daveau M, Lubrano J, Saint-Auret G, Hiron M, Goria O, Scotte M, Francois A, Salier JP Tags: Histopathology Source Type: journals

Computerized analyses of morphology and proliferative activity differentiate hepatoblastoma from paediatric hepatocellular carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results indicate that computerized morphometric analysis can yield useful criteria to distinguish HB from pHCC in small biopsy specimens, and, compared with FHB, the poorer prognosis of EHB may result from its more undifferentiated (immature) and proliferative phenotype. PMID: 19236509 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - February 1, 2009 Category: Pathology Authors: Tsai HW, Tsai HH, Kuo FY, Chang KC Tags: Histopathology Source Type: journals