Homeopathy
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20 years ago: The British Homoeopathic Journal, July 1989.
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PMID: 19647214 [PubMed - in process]
Source: Homeopathy - July 1, 2009 Category: Complementary Medicine Authors: Land ST Tags: Homeopathy Source Type: journals
The concept of miasm--evolution and present day perspective.
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This paper reviews the circumstances in which the concept of miasm evolved and how subsequent developments in medicine have improved our understanding of the cause of diseases. It concludes with an emphasis on the need to further refine the homeopathic concept of disease.
PMID: 19647213 [PubMed - in process]
Source: Homeopathy - July 1, 2009 Category: Complementary Medicine Authors: Mathur M Tags: Homeopathy Source Type: journals
A review of immunomodulators with reference to Canova.
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Immunomodulators are substances which modify the immunity of an individual to favour a particular immunological response. The immune response and the function of the immune response regulation process are described, with special reference to cancer and autoimmune disease. Homeopathy and its role in immune regulation are discussed with special reference to Canova. Canova is a homeopathic product produced, according to the Hahnemannian homeopathic method, in Brazil. Its role in cancer, bone marrow and haematopoiesis as well as macrophage and monocyte activation is reviewed. Canova seems to stabilize platelet morphology i...
Source: Homeopathy - July 1, 2009 Category: Complementary Medicine Authors: Smit E, Oberholzer HM, Pretorius E Tags: Homeopathy Source Type: journals
Homeopathic treatment in resistant livedoid vasculopathy: case report.
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This paper describes the successful outcome of homeopathic treatment in a case of resistant livedoid vasculopathy (LV). LV is a rare disease characterized by chronic recurrent and painful ulceration of the lower limbs, frequently associated to atrophie blanche (AB), probably due to procoagulant conditions. Most literature reports single or very few cases; response to treatment is difficult, even resistant. This patient suffered LV for 7 years before seeking homeopathic treatment; ulcers recurred frequently, at intervals less than 3 months, in spite of continual use of pentoxyfilline. Configuration of signs and symptoms...
Source: Homeopathy - July 1, 2009 Category: Complementary Medicine Authors: Waisse-Priven S, Jurj G, Lima Thomaz LC, Tierno SA, Filho WL, Sos AB Tags: Homeopathy Source Type: journals
Effect of Mercurius solubilis on the bacteriological response in the alveolitis process in rats.
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CONCLUSIONS: Merc sol. 12 cH did not reduce bacterial growth, but the microbiotica remained within the parameters of normality, obtaining the best results at 21 days after treatment.
PMID: 19647210 [PubMed - in process]
Source: Homeopathy - July 1, 2009 Category: Complementary Medicine Authors: de Araújo FR, de Castro CM, Severo MS, Diniz Mde F, Viana MT, Evêncio LB Tags: Homeopathy Source Type: journals
Immunomodulatory activity of Toxicodendron pubescens in experimental models.
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This study shows that Rhus tox possesses immunostimulatory activity in its crude form as well as in homeopathically diluted forms. These effects appeared to be concentration dependent as higher dilutions had less potent effects.
PMID: 19647209 [PubMed - in process]
Source: Homeopathy - July 1, 2009 Category: Complementary Medicine Authors: Patil CR, Salunkhe PS, Gaushal MH, Gadekar AR, Agrawal AM, Surana SJ Tags: Homeopathy Source Type: journals
Individualized homeopathic treatment of dermatological complaints in a public outpatient clinic.
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CONCLUSIONS: Outcome studies are useful to point out to the effectiveness of individualized homeopathic treatment in dermatological complaints. Outcomes suggest that actions focusing on pathological categories do not lead to homeopathic suppression.
PMID: 19647208 [PubMed - in process]
Source: Homeopathy - July 1, 2009 Category: Complementary Medicine Authors: Waisse-Priven S, Jurj G, Lima Thomaz LC, Tierno SA, Filho WL, Sos A, de Souza MF Tags: Homeopathy Source Type: journals
Homeopathy in the public health system: a seven-year observational study at Lucca Hospital (Italy).
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CONCLUSIONS: Homeopathic therapy is associated with improvement in a range of chronic and recurring pathologies. Certain characteristics of patient and pathology influence the outcome.
PMID: 19647207 [PubMed - in process]
Source: Homeopathy - July 1, 2009 Category: Complementary Medicine Authors: Rossi E, Endrizzi C, Panozzo MA, Bianchi A, Da Frè M Tags: Homeopathy Source Type: journals
Homeopathic treatment of minor aphthous ulcer: a randomized, placebo-controlled clinical trial.
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CONCLUSION: The results suggest that homeopathic treatment is an effective and safe method in the treatment of MiRAU.
PMID: 19647206 [PubMed - in process]
Source: Homeopathy - July 1, 2009 Category: Complementary Medicine Authors: Mousavi F, Mojaver YN, Asadzadeh M, Mirzazadeh M Tags: Homeopathy Source Type: journals
Thinking out of the national box: what is there to learn?
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PMID: 19647205 [PubMed - in process]
Source: Homeopathy - July 1, 2009 Category: Complementary Medicine Authors: Güthlin C Tags: Homeopathy Source Type: journals
Homeopathic treatment of weaned piglets.
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PMID: 19358970 [PubMed - in process]
Source: Homeopathy - April 1, 2009 Category: Complementary Medicine Authors: Thomas DM Tags: Homeopathy Source Type: journals
Problematic statistical analyses in Zacharias et al.
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PMID: 19358969 [PubMed - in process]
Source: Homeopathy - April 1, 2009 Category: Complementary Medicine Authors: Thomas DM Tags: Homeopathy Source Type: journals
Analysis of a re-analysis of a meta-analysis: in defence of Shang et al.
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PMID: 19358967 [PubMed - in process]
Source: Homeopathy - April 1, 2009 Category: Complementary Medicine Authors: Wilson P Tags: Homeopathy Source Type: journals
20 years ago: The British Homoeopathic Journal, April 1989.
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PMID: 19358966 [PubMed - in process]
Source: Homeopathy - April 1, 2009 Category: Complementary Medicine Authors: Land ST Tags: Homeopathy Source Type: journals
Antidepressants, suicidality and rebound effect: evidence of similitude?
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CONCLUSIONS: Rebound and withdrawal effects, including suicidality occur with antidepressant drugs. They are relatively rare but more intense than the primary action of the drug. The probability of such effects is influenced by patient factors including age and diagnosis, and drug factors including half-life.
PMID: 19358965 [PubMed - in process]
Source: Homeopathy - April 1, 2009 Category: Complementary Medicine Authors: Teixeira MZ Tags: Homeopathy Source Type: journals
"In at the deep end": an intensive foundation training in homeopathy for medical students.
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We report one in homeopathic medicine run jointly by the University of Bristol and the Bristol Homeopathic Hospital. The SSC was an intensive four week course using a variety of learning methods, grounded in the Faculty of Homeopathy's Primary Health Care Examination (PHCE) Certificate syllabus. Students were exposed to specialist clinics and the prescribing methods used in them. They received tuition from a veterinarian, a psychiatrist, a medical historian, a professional homeopath and an expert in the evidence base of complementary medicine. Educational methods included interactive lectures, out-patient clinics, recorded...
Source: Homeopathy - April 1, 2009 Category: Complementary Medicine Authors: Thompson TD, Thompson EA Tags: Homeopathy Source Type: journals
Homeopathy for the treatment of menstrual irregularities: a case series.
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OBJECTIVE: A preliminary study to evaluate the usefulness of homeopathic treatment in the care of menstrual irregularities. METHOD: Patients were diagnosed at the first appointment according to menstrual cycle over the past year: Amenorrhea (AM), Oligo-amenorrhea (OL-AM), OL, Taking hormone replacement therapy (HRT). All patients were prescribed an individualised, global homeopathic treatment. The main outcomes were: time to resumption of periods, change of clinical diagnosis at the end of follow-up or after 2 years. The secondary outcomes were: menstrual regularity at the end of follow-up, compared to pre-treatment fr...
Source: Homeopathy - April 1, 2009 Category: Complementary Medicine Authors: Cardigno P Tags: Homeopathy Source Type: journals
Homeopathic treatment for bone regeneration: experimental study.
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CONCLUSION: The study demonstrated that for repair of surgical defects in rat mandibles Plumbum met. 30c and control did not differ significantly in histomorphometric terms.
PMID: 19358962 [PubMed - in process]
Source: Homeopathy - April 1, 2009 Category: Complementary Medicine Authors: Almeida JD, Arisawa EA, Balducci I, da Rocha RF, Carvalho YR Tags: Homeopathy Source Type: journals
Dual effect of Toxicodendron pubescens on Carrageenan induced paw edema in rats.
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CONCLUSION: Rhus tox, in crude form, exerts anti-inflammatory effects after a single dose and proinflammatory effect after multiple doses in Carrageenan induced paw inflammation in rats. Further study is needed to explain this dual effect.
PMID: 19358961 [PubMed - in process]
Source: Homeopathy - April 1, 2009 Category: Complementary Medicine Authors: Patil CR, Gadekar AR, Patel PN, Rambhade A, Surana SJ, Gaushal MH Tags: Homeopathy Source Type: journals
Isopathic versus enantiomeric inhibition of U-50488 HCl toxicity--experimental studies.
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CONCLUSION: We conclude that enantiomeric potencies are superior to identically produced isopathic potencies, in inhibiting toxicity of (-)-U-50488 HCl. Homeopathic inhibition of toxicity may be stereospecific.
PMID: 19358960 [PubMed - in process]
Source: Homeopathy - April 1, 2009 Category: Complementary Medicine Authors: Kuzeff RM, Topashka-Ancheva M, Metcheva R Tags: Homeopathy Source Type: journals
Healthcare provided by a homeopath as an adjunct to usual care for Fibromyalgia (FMS): results of a pilot Randomised Controlled Trial.
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CONCLUSIONS: Given the acceptability of the treatment and the clinically relevant effect on function, there is a need for a definitive study to assess the clinical and cost effectiveness of adjunctive healthcare by a homeopath for patients with FMS.
PMID: 19358959 [PubMed - in process]
Source: Homeopathy - April 1, 2009 Category: Complementary Medicine Authors: Relton C, Smith C, Raw J, Walters C, Adebajo AO, Thomas KJ, Young TA Tags: Homeopathy Source Type: journals
The singer, the song, or both?
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PMID: 19358958 [PubMed - in process]
Source: Homeopathy - April 1, 2009 Category: Complementary Medicine Authors: Fisher P Tags: Homeopathy Source Type: journals
Response to Leslie Rose.
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PMID: 19135968 [PubMed - as supplied by publisher]
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Relton C, Thomas KJ, O'Cathain A Tags: Homeopathy Source Type: journals
Re: Land S. Social and Historical. 20 years ago: The British Homoeopathic Journal, April 1988. Homeopathy 2008; 97: 108-110.
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PMID: 19135967 [PubMed - as supplied by publisher]
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Davies AE Tags: Homeopathy Source Type: journals
Are media attacks justified? A response to Vithoulkas.
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PMID: 19135966 [PubMed - in process]
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Johnson G Tags: Homeopathy Source Type: journals
Homeopathy: the clinical picture is no clearer.
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PMID: 19135965 [PubMed - in process]
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Rose L Tags: Homeopathy Source Type: journals
Response to Geoff Johnson.
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PMID: 19135964 [PubMed - as supplied by publisher]
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Vithoulkas G Tags: Homeopathy Source Type: journals
20 years ago: The British Homoeopathic Journal, January 1989.
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PMID: 19135963 [PubMed - in process]
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Land ST Tags: Homeopathy Source Type: journals
In search of the reliable repertory.
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The development of homeopathic repertories is complex, reflecting history, the emergence of divergent views on homeopathic philosophy, and differences in opinion as to what constitutes reliable materia medica. The purpose of this paper is to critically evaluate the content of repertories examining its reliability, the quality of source material, and the evidence that it forms a reliable bridge between case and materia medica. Reliability may be improved by demanding higher standards and consistency of evidence. However, it is necessary to understand what constitutes evidence, and the importance of taking into account t...
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Gadd B Tags: Homeopathy Source Type: journals
Treatment of spasmodic dysphonia with homeopathic medicine: a clinical case report.
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Botulinum toxin (Botox) injection is the only conventional medical treatment available for patients with spasmodic dysphonia (SD). Some patients are reluctant to receive Botox treatment due to concerns about unknown long-term side effects, expense, and dependence on repeated injections. The purpose of the study was to report the perceptual and physiological changes in the vocal functions of an SD patient treated with classical homeopathy. The results were similar to a previous case report: classical homeopathy seems to be capable of amelioratiny SD symptoms beyond the short-term effects of Botox injections. Although th...
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Xue SA, de Schepper L, Hao GJ Tags: Homeopathy Source Type: journals
Polarity analysis, a new approach to increase the precision of homeopathic prescriptions.
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CONCLUSION: The use of polarity analysis as an integral part of case analysis and differential diagnosis of possible remedies together with an increased awareness for assessing the reliability of symptoms in repertorisation lead to a substantial improvement in the precision of homeopathic prescriptions.
PMID: 19135960 [PubMed - in process]
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Frei H Tags: Homeopathy Source Type: journals
Lymphocyte proliferation stimulated by activated human macrophages treated with Canova.
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In this study, the MI of lymphocyte cultured received the medium containing CA-stimulated macrophages showed a higher proliferation index (p<0.01) than the lymphocytes cultured in a medium without CA-treated macrophages. Our results suggest that CA treatment, in addition to activating macrophages, indirectly induces lymphocyte proliferation and has potential as a new adjuvant therapeutic approach.
PMID: 19135959 [PubMed - in process]
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Burbano RR, Leal MF, da Costa JB, Bahia Mde O, de Lima PD, Khayat AS, Seligman IC, de Assumpção PP, Buchi Dde F, Smith Mde A Tags: Homeopathy Source Type: journals
Ignatia in the treatment of oral lichen planus.
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CONCLUSION: Our results suggest that Ignatia has a beneficial effect in treatment of OLP in selected patients.
PMID: 19135958 [PubMed - in process]
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Mousavi F, Sherafati S, Mojaver YN Tags: Homeopathy Source Type: journals
Homeopathic drug selection using Intuitionistic fuzzy sets.
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Using intuitionistic fuzzy set theory, Sanchez's approach to medical diagnosis has been applied to the problem of selection of single remedy from homeopathic repertorization. Two types of Intuitionistic Fuzzy Relations (IFRs) and three types of selection indices are discussed. I also propose a new repertory exploiting the benefits of soft-intelligence.
PMID: 19135957 [PubMed - in process]
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Kharal A Tags: Homeopathy Source Type: journals
Statistical analysis of six repertory rubrics after prospective assessment applying Bayes' theorem.
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BACKGROUND: After prospective assessment of six homeopathic symptoms we validated some rubrics of the homeopathic repertory using Bayesian theory. In this paper we introduce statistical arguments for introducing or discarding entries from the repertory. METHODS: 4094 patients entered the prospective study and 4072 prescriptions were evaluated. After translating typeface into Likelihood Ratios (LRs), Confidence Intervals and the probability of existing repertory entries compared to our findings were calculated. OUTCOME: Our assessment yielded 121 relevant results to validate existing repertory entries. Five symptoms cou...
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Rutten AL, Stolper CF, Lugten RF, Barthels RW Tags: Homeopathy Source Type: journals
Observational study of homeopathic and conventional therapies in patients with diabetic polyneuropathy.
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CONCLUSION: Complementary homeopathic therapy of diabetic neuropathy was feasible and promising effects in symptom scores and cost savings were observed.
PMID: 19135955 [PubMed - in process]
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Pomposelli R, Piasere V, Andreoni C, Costini G, Tonini E, Spalluzzi A, Rossi D, Quarenghi C, Zanolin ME, Bellavite P Tags: Homeopathy Source Type: journals
Evaluation of the quality of life after individualized homeopathic treatment for seasonal allergic rhinitis. A prospective, open, non-comparative study.
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CONCLUSIONS: After homeopathic treatment, patients reported an alleviation of their symptoms of allergic rhinitis as reported in the RQLQ. A formal Randomized Clinical Trial (RCT) is indicated.
PMID: 19135954 [PubMed - in process]
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Goossens M, Laekeman G, Aertgeerts B, Buntinx F, Tags: Homeopathy Source Type: journals
Cost-benefit evaluation of homeopathic versus conventional therapy in respiratory diseases.
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CONCLUSIONS: Homeopathic treatment for respiratory diseases (asthma, allergic complaints, Acute Recurrent Respiratory Infections) was associated with a significant reduction in the use and costs of conventional drugs. Costs for homeopathic therapy are significantly lower than those for conventional pharmacological therapy.
PMID: 19135953 [PubMed - in process]
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Rossi E, Crudeli L, Endrizzi C, Garibaldi D Tags: Homeopathy Source Type: journals
Improving homeopathic prescribing.
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PMID: 19135952 [PubMed - in process]
Source: Homeopathy - January 1, 2009 Category: Complementary Medicine Authors: Malcolm R Tags: Homeopathy Source Type: journals
20 years ago: The British Homoeopathic Journal, July 1988.
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PMID: 18657777 [PubMed - in process]
Source: Homeopathy - July 1, 2008 Category: Complementary Medicine Authors: Land ST Tags: Homeopathy Source Type: journals
Believing in order to understand: Hahnemann's hierarchisation of values.
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During the last 200 years, the social, scientific, and religious framework in which homeopathy is taught and practiced has changed tremendously. Various different forms of homeopathy have been advocated. To avoid being misled by the prevailing pluralism as a standard of reference for assessing new concepts, Hahnemann's original ideas and attitude toward medicine, philosophy, and ethics are discussed. Hahnemann's hierarchisation of values appears to consist primarily in striving for a world view in which he could conceive of himself as a spiritual and moral being, secondly in a yearning for scientific advancement, and t...
Source: Homeopathy - July 1, 2008 Category: Complementary Medicine Authors: Schmidt JM Tags: Homeopathy Source Type: journals
'Homeopathy': untangling the debate.
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Conclusions drawn from one of these aspects are often inappropriately applied to another aspect. In interpreting the homeopathy evidence it is important to understand that the existing clinical experimental (randomised controlled trial) evidence base provides evidence as to the efficacy of homeopathic medicines, but not the effectiveness of treatment by a homeopath. The observational evidence base provides evidence as to the effectiveness of treatment by a homeopath. We make four recommendations to promote clarity in the reporting, design and interpretation of homeopathy research.
PMID: 18657775 [PubMed - in process]
Source: Homeopathy - July 1, 2008 Category: Complementary Medicine Authors: Relton C, O'Cathain A, Thomas KJ Tags: Homeopathy Source Type: journals
Effect of homeopathic medicines on helminth parasitism and resistance of Haemonchus contortus infected sheep.
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This study evaluated the effects of homeopathic treatment on control of Haemonchus contortus infection in sheep. Twenty lambs were randomized to three treatments: treated with the homeopathic medicines, Ferrum phosphoricum, Arsenicum album and Calcarea carbonica; treated with a conventional antihelminthic, doramectin, and an untreated control group. Fecal and blood samples were taken from each animal on days 18, 38 and 68 after start of treatment. A significant reduction in number of H. contortus larvae (p<0.01) was observed for animals in the homeopathic treatment group compared to the control group. Fecal egg counts s...
Source: Homeopathy - July 1, 2008 Category: Complementary Medicine Authors: Zacharias F, Guimarães JE, Araújo RR, Almeida MA, Ayres MC, Bavia ME, Mendonça-Lima FW Tags: Homeopathy Source Type: journals
An animal model for the study of Chamomilla in stress and depression: pilot study.
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The behavioral and hematological effects of treatment with Chamomilla 6cH in mice subjected to experimental stress are described. Swiss mice were randomly divided into pairs, one animal was inoculated with Ehrlich's tumor, the other was treated daily with Chamomilla 6cH or control or received no treatment. After 7 days, the animals were observed in an open-field arena and blood samples taken. Mice who cohabitated with a sick cage-mate showed a decrease in their general activity, but those treated with Chamomilla 6cH were less severely affected (p=0.0426). No hematological changes were observed. In a second experiment, ...
Source: Homeopathy - July 1, 2008 Category: Complementary Medicine Authors: Pinto SA, Bohland E, Coelho Cde P, Morgulis MS, Bonamin LV Tags: Homeopathy Source Type: journals
Delayed luminescence of high homeopathic potencies on sugar globuli.
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Delayed luminescence signals of Arg.met. CMf (100Mf), Canth. CMf, Bov. CMf absorbed onto sugar globuli was observed by exciting them at their known resonance frequency of 2.060 MHz. Arn. CMf also showed delayed luminescence when excited at 2.060 MHz and at 1.828 MHz. Alc. LMK (50MK) could not be excited by 2.060 MHz and showed properties of control globuli. Canth. LMK could not be excited at 2.006 MHz. The delayed luminescence signals were characterized by the coefficient B(2) typical of the delayed luminescence of non-living complex systems, and by the coefficient B(0) typical of living systems. Both coefficients can ...
Source: Homeopathy - July 1, 2008 Category: Complementary Medicine Authors: Lenger K, Bajpai RP, Drexel M Tags: Homeopathy Source Type: journals
Electrical impedance and HV plasma images of high dilutions of sodium chloride.
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This paper reports impedance data and high voltage plasma photographic plates of high dilutions of sodium chloride in water submitted to the homeopathic dilution and succession up to 30cH. Extremely low concentrations of the original salt, even beyond Avogadro number, clearly differ from 'pure' water and; the action of sodium chloride on the electrical properties of water is inverted at high dilution.
PMID: 18657771 [PubMed - in process]
Source: Homeopathy - July 1, 2008 Category: Complementary Medicine Authors: Assumpção R Tags: Homeopathy Source Type: journals
Homeopathy and systematics: a systematic analysis of the therapeutic effects of the plant species used in homeopathy.
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The therapeutic effects of the plant species used in homeopathy have never been subjected to systematic analysis. A survey of the various Materiae Medicae shows that over 800 plant species are the source of medicines in homeopathy. As these medicines are considered related to one another with respect to their therapeutic effects for treating similar symptoms, the aim is to classify and map them using the concept of homology. This involves placing the discipline of homeopathy into a comparative framework using these plant medicines as taxa, therapeutic effects as characters, and contemporary cladistic techniques to anal...
Source: Homeopathy - July 1, 2008 Category: Complementary Medicine Authors: Bharatan V Tags: Homeopathy Source Type: journals
Towards standard setting for patient-reported outcomes in the NHS homeopathic hospitals.
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CONCLUSIONS: We have successfully piloted a process of national clinical data collection using patient-reported outcome in homeopathic hospital outpatients, identifying a wide range and complexity of medical complaints treated in that setting. After a series of homeopathy appointments, a high proportion of patients, often representing "effectiveness gaps" for conventional medical treatment, reported improvement in health affecting their daily living. These pilot findings are informing our developing programme of standard setting for homeopathic care in the hospital outpatient context.
PMID: 18657769 [PubMed - in process]
Source: Homeopathy - July 1, 2008 Category: Complementary Medicine Authors: Thompson EA, Mathie RT, Baitson ES, Barron SJ, Berkovitz SR, Brands M, Fisher P, Kirby TM, Leckridge RW, Mercer SW, Nielsen HJ, Ratsey DH, Reilly D, Roniger H, Whitmarsh TE Tags: Homeopathy Source Type: journals
The electrical properties of high dilutions.
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PMID: 18657768 [PubMed - in process]
Source: Homeopathy - July 1, 2008 Category: Complementary Medicine Authors: Smith CW Tags: Homeopathy Source Type: journals
20 years ago: the British Homoeopathic Journal, April 1988.
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PMID: 18439974 [PubMed - in process]
Source: Homeopathy - April 1, 2008 Category: Complementary Medicine Authors: Land ST Tags: Homeopathy Source Type: journals
