The clinical significance and oncogenic function of LRRFIP1 in pancreatic cancer
ConclusionTaken together, LRRFIP1 is associated with tumorigenesis, immune cell infiltration, and prognosis in pancreatic cancer, which suggests that LRRFIP1 may be a potential biomarker and therapeutic target for pancreatic cancer. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 18, 2024 Category: Cancer & Oncology Source Type: research
Prediction of prostate cancer aggressiveness using magnetic resonance imaging radiomics: a dual-center study
ConclusionsMRI radiomics models are suitable for predicting GS and positive needles of systematic biopsy in PCa. The models can be used to identify aggressive PCa using a noninvasive, repeatable, and accurate diagnostic method. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 16, 2024 Category: Cancer & Oncology Source Type: research
Circular RNA COL1A1 promotes Warburg effect and tumor growth in nasopharyngeal carcinoma
ConclusionTo conclude, our findings delineate that circCOL1A1 exerts its oncogenic influence in NPC through the modulation of the miR-370-5p/PTMA signaling axis. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 15, 2024 Category: Cancer & Oncology Source Type: research
T cell-mediated tumor killing sensitivity gene signature-based prognostic score for acute myeloid leukemia
ConclusionA T-cell mediated killing sensitivity gene-based prognostic score TTKPI showed good accuracy in predicting survival in AML. TTKPI corresponded to functional and immunological features of the tumor microenvironment including checkpoint expression patterns and should be investigated for precision medicine approaches. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 15, 2024 Category: Cancer & Oncology Source Type: research
Immune-related LncRNAs scores predicts chemotherapeutic responses and prognosis in cervical cancer patients
ConclusionsAn eight-IRlncRs-based prediction model was identified that has the potential to be an important tool to predict chemotherapeutic responses and prognosis for CC patients. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 14, 2024 Category: Cancer & Oncology Source Type: research
Application value of intraoperative electrophysiological monitoring in cerebral eloquent area glioma surgery: a retrospective cohort study
ConclusionsThe application of IONM could improve long-term neurological function, which is closely related to prognosis and can be used as an independent prognostic factor. IONM is practical and widely available for predicting postoperative functional deficits in patients with eloquent area glioma. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 13, 2024 Category: Cancer & Oncology Source Type: research
Identification of hub genes and diagnostic efficacy for triple-negative breast cancer through WGCNA and Mendelian randomization
ConclusionWe established a co-expression network using the WGCNA methodology to detect pivotal genes associated with TNBC. This finding holds promise for advancing the creation of pre-symptomatic diagnostic tools and deepening our comprehension of the pathogenic mechanisms involved in TNBC risk genes. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 12, 2024 Category: Cancer & Oncology Source Type: research
A combination of cuproptosis and lncRNAs predicts the prognosis and tumor immune microenvironment in cervical cancer
ConclusionIn conclusion, we constructed five cuprotosis-related lncRNA prognostic models, which may be new tumor therapeutic targets for the prevention and treatment of cervical cancer. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 12, 2024 Category: Cancer & Oncology Source Type: research
Diagnostic value of circulating tumor cells in patients with thyroid cancer: a retrospective study of 1478 patients
ConclusionsAs an emerging and noninvasive testing tool, the efficacy of CTCs in diagnosing thyroid cancer is limited. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 12, 2024 Category: Cancer & Oncology Source Type: research
Bilateral adrenal neuroblastoma: peculiar pattern of a rare pediatric presentation
ConclusionBSN treatment is similar to unilateral disease. A more conservative surgical approach with adrenal tissue preservation on less extensive side should be considered. Biological variables and extent of disease are amongst the most important prognostic determinants. Future studies are warranted to further address the biologic profiling of BSN and highlight prognostic significance of size difference between both adrenal sides. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 12, 2024 Category: Cancer & Oncology Source Type: research
DSCAM-AS1 promotes the development of prostate cancer
ConclusionDSCAM-AS1 is up-regulated in prostate cancer and regulates the progression of prostate cancer cells by targeting miR-338-3p. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 11, 2024 Category: Cancer & Oncology Source Type: research
Integrating iron metabolism-related gene signature to evaluate prognosis and immune infiltration in nasopharyngeal carcinoma
ConclusionThis study presents a prognostic model utilizing IMRGs in NPC, which could assist in assessing patient prognosis and provide insights into new therapeutic targets for NPC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 11, 2024 Category: Cancer & Oncology Source Type: research
Advances in tumor microenvironment and underlying molecular mechanisms of bladder cancer: a systematic review
AbstractBladder cancer is one of the most frequent malignant tumors of the urinary system. The prevalence of bladder cancer among men and women is roughly 5:2, and both its incidence and death have been rising steadily over the past few years. At the moment, metastasis and recurrence of advanced bladder cancer —which are believed to be connected to the malfunction of multigene and multilevel cell signaling network—remain the leading causes of bladder cancer-related death. The therapeutic treatment of bladder cancer will be greatly aided by the elucidation of these mechanisms. New concepts for the trea tment of bladder ...
Source: Hormones and Cancer - April 11, 2024 Category: Cancer & Oncology Source Type: research
Hypoxic microenvironment-induced exosomes confer temozolomide resistance in glioma through transfer of pyruvate kinase M2
ConclusionIn the hypoxic microenvironment, glioma cells become resistant to TMZ due to the delivery of PKM2 by exosomes. Targeted modulation of exosomal PKM2 may be a promising strategy for overcoming TMZ resistance in glioma. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 10, 2024 Category: Cancer & Oncology Source Type: research
Significance and implications of FHIT gene expression and promoter hypermethylation in acute lymphoblastic leukemia (ALL)
ConclusionThe present study conclude thatFHIT gene hypermethylation and its altered expression may be linked in the pathogenesis of ALL and provide an evidence for the role ofFHIT in the development of ALL. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 8, 2024 Category: Cancer & Oncology Source Type: research
