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Misleading De Novo Detection of Serum Anti-HLA-A3 Antibodies In Kidney Recipients Having Received ATG Prior To Transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here the de novo detection by CDC and flow cytometry (Luminex) of anti-HLA-A3 Ab in the serum of kidney recipients treated with ATG Fresenius. The Ab, of rabbit origin, was detected in every assessable patient (n=16), with the exception of the HLA-A3 recipients and/or recipients receiving an HLA-A3 graft, before becoming undetectable at latest day 102 after transplantation. It is of major importance that transplantation monitoring laboratories bear in mind the possibility of therapeutic Ab detection when interpreting anti-HLA Ab results. PMID: 19914324 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - November 12, 2009 Category: Allergy & Immunology Authors: Masson E, Devillard N, Chabod J, Yannaraki M, Thevenin C, Tiberghien P, Rebibou JM Tags: Hum Immunol Source Type: journals

Blood soluble HLA-G levels are associated with HIV-1 infection in Beninese commercial sex workers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrates that low levels of plasma sHLA-G are associated with HIV-1 infection. PMID: 19913587 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Lajoie J, Loembe MM, Poudrier J, Guédou F, Pépin J, Labbé AC, Alary M, Roger M Tags: Hum Immunol Source Type: journals

Alveolar macrophages in allergic asthma; an expression signature characterized by heat shock protein pathways.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The implication of alveolar macrophages (AM) in asthma, a Th2 disease, has not been well characterized. Thus, the goal of this study is to better characterize AM phenotype of allergic asthmatic compared with normal subjects using genomic expression analyses. Microarray analyses were performed with AM isolated from bronchoalveolar lavage. Robust multi-array analysis (RMA) normalization and Smyth's moderated t test were used to select differentially expressed genes. Fifty differentially expressed genes were identified. Nineteen have been classified in categories linked to stress or immune responses and among them; nine a...
Source: Human Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Madore AM, Perron S, Turmel V, Laviolette M, Bissonnette EY, Laprise C Tags: Hum Immunol Source Type: journals

Influence of CTLA-4/CD28/ICOS gene polymorphisms on the susceptibility to cervical squamous cell carcinoma and stage of differentiation in the Polish population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was undertaken to evaluate the association between the polymorphisms CTLA-4c.49A>G, CTLA-4g.319C>T, CTLA-4g.*642AT(8_33), CTLA-4g.*6230G>A (CT60), CD28 c.17+3T>C, ICOSc.1554+4GT(8_15) and susceptibility to CSCC. The association between CTLA-4g.319C>T[T] allele and [TT+CT] genotype and susceptibility to CSCC was observed (OR=1.95, p =0.005, and OR=2.02, p =0.006, respectively). The CTLA-4g.319C>T[T] allele and [TT+CT] genotype increased the risk of well-differentiated CSCC by a factor of 3.84 and 4.44 ( p =0.0001, and p =0.0001, respectively). In patients with moderately differentiated CSCC, a t...
Source: Human Immunology - November 11, 2009 Category: Allergy & Immunology Authors: Pawlak E, Karabon L, Wlodarska-Polinska I, Jedynak A, Jonkisz A, Tomkiewicz A, Kornafel J, Stepien M, Ignatowicz A, Lebioda A, Dobosz T, Frydecka I Tags: Hum Immunol Source Type: journals

Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada Disease in Japanese.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Killer cell immunoglobulin-like receptors (KIR) control the effector function of natural killer (NK) cells and subsets of T cell and the genes encoding KIRs are substantially variable among individuals. Majority of the Japanese (58.4%) are homozygous for group A KIR haplotypes that encode only a single activating KIR2DS4. Contrarily, the majority of the Japanese patients with Vogt-Koyanagi-Harada (VKH) disease (69.2%), a panuveitis carry Bx genotypes that encode 2-5 activating KIR receptors. Particularly, individuals carrying three activating KIR genes 3DS1, 2DS1 and 2DS5 are more frequent in patient group compared to ...
Source: Human Immunology - November 5, 2009 Category: Allergy & Immunology Authors: Levinson RD, Okada AA, Ashouri E, Keino H, Rajalingam R Tags: Hum Immunol Source Type: journals

The effect of HLA homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human Leukocyte Antigen (HLA) genes play a critical role in host immunity including vaccine responses. HLA molecules present antigenic peptides to T cells and provide inhibitory signals to NK cells, and polymorphisms within HLA genes allows for binding and presentation of a diverse array of self and foreign peptides. Heterozygosity across HLA alleles has been found to play a positive role in host defense for a variety of infections. Homozygosity within one or more HLA loci may restrict this epitope repertoire and limit T cell responses to infection or vaccination. Here we report that homozygosity within the HLA DPB1 lo...
Source: Human Immunology - November 4, 2009 Category: Allergy & Immunology Authors: Kennedy RB, Ovsyannikova IG, Vierkant RA, Jacobson RM, Poland GA Tags: Hum Immunol Source Type: journals

Selection of escape mutation by Pol154-162-specific cytotoxic T cells among chronically HIV-1-infected HLA-B*5401-positive individuals.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Most escape mutations have been identified on CTL epitopes presented by Caucasian or African HLA class I alleles, whereas there is a limited number of studies identifying the escape mutations on those presented by Asian alleles. HLA-B54 is a common HLA allele in Asian countries. We recently identified 5 HLA-B*5401-restricted HIV-1-specific CTL epitopes. We here investigated escape mutations in these CTL epitopes in Japanese HIV-1-infected individuals. The frequency of substitution from Glu (E) to Asp (D) at position 7 (FV9-7D) in the Pol 154-162 (FV9) epitope was significantly higher in HLA-B*5401(+) HIV-infected indiv...
Source: Human Immunology - November 2, 2009 Category: Allergy & Immunology Authors: Hashimoto M, Kitano M, Honda K, Koizumi H, Dohki S, Oka S, Takiguchi M Tags: Hum Immunol Source Type: journals

Functional Variants of the P2RX7 Gene, Aseptic Osteolysis and Revision of the Total Hip Arthroplasty: A Preliminary Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Periprosthetic osteolysis (OL) is a major long-term complication of the total hip arthroplasty (THA) which can result in aseptic loosening and revision surgery. Purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7) is an important regulator of inflammation and bone turnover. We were, therefore, interested whether functional variants of the P2RX7 gene may be associated with OL and risk for THA failure. 205 unrelated Czech patients with cementless type THA were stratified according to the severity of OL and revision of THA. Four "loss-of-function" P2RX7 single nucleotide polymorphisms (SNPs), namely Glu496Ala, Ile...
Source: Human Immunology - November 2, 2009 Category: Allergy & Immunology Authors: Mrazek F, Gallo J, Stahelova A, Petrek M Tags: Hum Immunol Source Type: journals

Inverse association of peripheral blood CD4+ invariant natural killer T cells with atopy in human asthma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Invariant natural killer T (iNKT) cells have been reported to play a role in the pathogenesis of murine asthma. However, the role for iNKT cells in the pathogenesis of human asthma is not defined. We determined how blood iNKT cells are associated with atopy in asthmatics. Peripheral blood mononuclear cells were isolated from 45 asthmatics. iNKT cells were stained with 6B11 mAb, anti-TCRvalpha24 mAb or alpha-GalactosylCeramide (GalCer)-loaded CD1d-tetramer, and analyzed with flowcytometric assays. Increased serum total IgE or one or more positive skin reactions to common allergens were used as atopic indexes. Asthmatics...
Source: Human Immunology - October 29, 2009 Category: Allergy & Immunology Authors: Koh YI, Shim JU, Wi JO, Han ER, Jin NC, Oh SH, Park CK, Park DJ Tags: Hum Immunol Source Type: journals

Peripheral Blood Mononuclear Cell Transcriptome Profiles Suggest T-cell Immunosuppression after Uncomplicated Mechanical Circulatory Support Device Surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion transcriptome-wide expression profiling of PBMCs suggests a response pattern to MCSD-implantation with inflammatory activation and simultaneous T-cell suppression. PMID: 19879911 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - October 29, 2009 Category: Allergy & Immunology Authors: Sinha A, Shahzad K, Latif F, Cadeiras M, von Bayern MP, Oz S, Naka Y, Deng MC Tags: Hum Immunol Source Type: journals

No association between transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A 77C>G transversion and Hashimoto's thyroiditis in a German population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No association between transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A 77C>G transversion and Hashimoto's thyroiditis in a German population. Hum Immunol. 2009 Oct 29; Authors: Thude H, Weißenborn S, Vilser C, Müller UA, Kloos C, Wolf G, Beck J, Barz D The CD45 77C>G transversion (rs17612648) in exon A of the CD45 gene has been reported to be associated with the development of various autoimmune diseases. Since Hashimoto's thyroiditis (HT) is a typical autoimmune disease we promote a study to determine the association of the 77C>G transversion with susceptibility to H...
Source: Human Immunology - October 29, 2009 Category: Allergy & Immunology Authors: Thude H, Weißenborn S, Vilser C, Müller UA, Kloos C, Wolf G, Beck J, Barz D Tags: Hum Immunol Source Type: journals

HLA-DRB1*01 allele and low plasma IgG1 concentration may predispose to herpes-associated recurrent lymphocytic meningitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recurrent lymphocytic meningitis (RLM) is a rare illness caused mostly by herpes simplex virus type 2 (HSV-2). Predisposing factors are not known. Deficiencies in immunoglobulin G subclasses 1 (IgG1) and 3 (IgG3), and complement protein C4 are associated with susceptibility to, and persistence of bacterial and viral infections. Selected HLA and mannose-binding lectin (MBL) alleles have previously been associated with recurrent genital herpes or herpetic meningitis. We assessed the frequencies of low IgG1 and IgG3, their allotypes (Gm), HLA-A*, -B*, -DRB1* and MBL2 alleles, and deficiencies in C4A and C4B genes, as pote...
Source: Human Immunology - October 29, 2009 Category: Allergy & Immunology Authors: Kallio-Laine K, Seppänen M, Aittoniemi J, Kautiainen H, Seppälä I, Valtonen V, Färkkilä M, Kalso E, Lokki ML Tags: Hum Immunol Source Type: journals

Description of two novel alleles HLA-Cw*0766 and Cw*0767 identified in a Chinese Han individual by sequence-based typing.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two novel HLA-C alleles, Cw*0766 and Cw*0767 identified in a Chinese voluntary stem cell donor. This sample was initially found by direct PCR-SBT with an inconclusive result. To clarify this unusual SBT result, the PCR product of HLA-C gene covering from exon 1 to 4 was subjected to cloning and haplotype sequencing and family study of HLA inheritance consisting of 6 members were confirmed. Novel Cw*0766 allele differs from the closest allele Cw*07020101 by single nucleotide change at genomic DNA nt 1651 C>A (codon 206 CTG>ATG) in exon 4, which results in an amino acid change Leu206Met. Another novel allele ...
Source: Human Immunology - October 24, 2009 Category: Allergy & Immunology Authors: Deng Z, Xu Y, Wang D, Jin S Tags: Hum Immunol Source Type: journals

Activating KIR receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The polymorphic killer-cell immunoglobulin-like receptors (KIR) control natural killer (NK) cell response against viral infection and tumor transformation. Here we investigated if select KIR genes are associated with recurrent respiratory papillomatosis (RRP), a rare disease of the larynx and upper airway caused by human papilloma viruses (HPV)-6/11. DNA from 66 RRP patients and 195 healthy controls were characterized for KIR and HLA gene polymorphism. Patients lacking activating KIR genes 3DS1 and 2DS1 were more common in severe RRP compared to mild-moderate RRP (78.8% vs. 48.5%, p=0.019). Further, patients carrying a...
Source: Human Immunology - October 24, 2009 Category: Allergy & Immunology Authors: Bonagura VR, Du Z, Ashouri E, Luo L, Hatam LJ, Devoti JA, Rosenthal DW, Steinberg BM, Abramson AL, Gjertson DW, Reed EF, Rajalingam R Tags: Hum Immunol Source Type: journals

Nomenclature for factors of the HLA system, update September 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19852994 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - October 20, 2009 Category: Allergy & Immunology Authors: Marsh SG Tags: Hum Immunol Source Type: journals

Nomenclature for factors of the HLA system, update August 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19836431 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - October 13, 2009 Category: Allergy & Immunology Authors: Marsh SG, Tags: Hum Immunol Source Type: journals

Nomenclature for factors of the HLA system, update July 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19835924 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - October 12, 2009 Category: Allergy & Immunology Authors: Marsh SG, Tags: Hum Immunol Source Type: journals

"Sequence variations at the HLA-linked olfactory receptor cluster do not influence female preferences for male odors"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We previously reported that paternally-inherited human leukocyte antigen (HLA) alleles are a template for women's preference for male odors (P = 0.0007). However, it has been suggested that sequence variation in a nearby olfactory receptor (OR) cluster on chromosome 6p influences smell preference. To determine if the HLA-linked OR genes contribute to previously observed HLA-mediated behaviors, we use the odor preference data from our earlier study in combination with a new resequencing study of four functional HLA-linked OR genes in the same subjects. Our results indicate that OR alleles in the genes surveyed are not i...
Source: Human Immunology - October 11, 2009 Category: Allergy & Immunology Authors: Thompson EE, Haller G, Pinto JM, Sun Y, Zelano B, Jacob S, McClintock MK, Nicolae DL, Ober C Tags: Hum Immunol Source Type: journals

Identification of a microRNA signature in dendritic cell vaccines for cancer immunotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dendritic cells (DCs) exposed to tumor antigens followed by treatment with Th1-polarizing differentiation signals have paved the way for development of DC-based cancer vaccines. Critical parameters for assessment of the optimal functional state of DCs and prediction of the vaccine potency of activated DCs have in the past been based on measurements of differentiation surface markers like HLA-DR, CD80, CD83, CD86 and CCR7 and level of secreted cytokines like IL-12p70. However, the level of these markers does not provide a complete picture of the DC-phenotype, and may be insufficient for prediction of clinical outcome fo...
Source: Human Immunology - October 7, 2009 Category: Allergy & Immunology Authors: Holmstrøm K, Pedersen AW, Claesson MH, Zocca MB, Jensen SS Tags: Hum Immunol Source Type: journals

Association of HLA class II alleles with response to immunosuppressive therapy in Korean aplastic anemia patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HLA-DR15 (DR2) is overrepresented in aplastic anemia (AA) patients, and its presence is associated with a better response to cyclosporine-based immunosuppressive therapy (IST). However, little is known about other HLA alleles affecting therapy response. We investigated 37 Korean patients with severe AA for the association of HLA class II alleles with response to IST: cyclosporine A combined with anti-thymocyte globulin or anti-lymphocyte globulin. Molecular or serologic typing of HLA-DR and HLA-DQ alleles was performed. In responders (13/37, 35.1%), the frequency of HLA-DR15 was increased (69.2% vs 8.3%, p = 0.0002) an...
Source: Human Immunology - October 7, 2009 Category: Allergy & Immunology Authors: Song EY, Kang HJ, Shin HY, Ahn HS, Kim I, Yoon SS, Park S, Kim BK, Park MH Tags: Hum Immunol Source Type: journals

Increased Percentage of B Cells in Patients with More-Advanced Hepatocellular Carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusions, our findings suggested that HCC patients might exhibit enhanced innate immunity and reduced adaptive immunity, compared to healthy volunteers. A higher percentage of B cells was found in patients with more-advanced HCC when compared to those with early HCC, and this might serve as an indicator of the severity of HCC. PMID: 19819282 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - October 7, 2009 Category: Allergy & Immunology Authors: Lin JC, Shih YL, Chien PJ, Liu CL, Lee JJ, Liu TP, Ko WC, Shih CM Tags: Hum Immunol Source Type: journals

Coengagement of alpha4beta1 integrin (VLA-4) and CD4 or CD8 is necessary to induce maximal Erk1/2 phosphorylation and cytokine production in human T cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The alpha(4)beta(1) integrin VLA-4 (very-late activation antigen-4) and the lineage-specific CD4 and CD8 receptors have been proposed as putative costimulatory receptors on T cells. To assess the relative contribution of signaling through the TCR, CD28 and these accessory molecules, we activated human T cells using soluble antibodies recognizing all four of these T cell receptor classes (CD3, CD28, CD4/CD8 and VLA-4) and assessed the degree of activation using higher-order flow cytometry detecting intracellular Erk1/2 phosphorylation and production of IL-2 and IFNgamma. We found that: 1) costimulation via CD4/CD8, in a...
Source: Human Immunology - October 4, 2009 Category: Allergy & Immunology Authors: Kim TK, Billard MJ, Wieder ED, McIntyre BW, Komanduri KV Tags: Hum Immunol Source Type: journals

Improved Luminex-based HLA-specific antibody screening using dithiothreitol treated sera.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study highlights the need to consider routine testing of sera with and without DTT for analysis of HLA-specific antibodies by SAB. PMID: 19808074 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - October 2, 2009 Category: Allergy & Immunology Authors: Kosmoliaptsis V, O'Rourke C, Bradley JA, Taylor CJ Tags: Hum Immunol Source Type: journals

A regulatory SNP in Ubiquitin D gene associated with celiac disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An aberrant immune response triggered by dietary gluten is the main driving force underlying celiac disease (CD), but other biological pathways that are dysregulated also participate in disease development. Genetic variation within these pathways might influence expression, contributing to susceptibility to CD. We have investigated the implication of ubiquitin D (UBD), a member of the ubiquitin-proteasome system that is strongly upregulated in the intestinal mucosa of active CD. RT-PCR analysis of intestinal biopsy sample pairs (at diagnosis vs. treated) from 30 CD patients confirmed overexpression of UBD in active dis...
Source: Human Immunology - October 2, 2009 Category: Allergy & Immunology Authors: Castellanos-Rubio A, Santin I, Irastorza I, Sanchez-Valverde F, Castaño L, Vitoria JC, Bilbao JR Tags: Hum Immunol Source Type: journals

MBL deficiency increases the risk of recurrent infections in children with Down syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Down syndrome (DS) is the most frequent cause of intellectual disability worldwide. DS individuals present abnormalities in the immune system which include high susceptibility to recurrent infections (RI), as well as autoimmune diseases. Respiratory tract infections remain one of the major causes of death in DS. Mannan-binding lectin (MBL) functions as an opsonina and initiates the lectin complement pathway. MBL deficiency was shown to increase the susceptibility to different infectious diseases, notably by extracellular pathogens. In the present study, MBL circulating levels were evaluated in 150 children with DS from...
Source: Human Immunology - October 1, 2009 Category: Allergy & Immunology Authors: Nisihara RM, Utiyama SR, Oliveira NP, Messias-Reason IJ Tags: Hum Immunol Source Type: journals

Aging and plasmacytoid DCs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19799954 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - September 28, 2009 Category: Allergy & Immunology Authors: Goldstein DR Tags: Hum Immunol Source Type: journals

Short-term exposure to HCMV-infected fibroblasts induces a proportional increase of active CD94/NKG2A+ NK cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Natural Killer (NK) cells are essential components of the immune response against human cytomegalovirus (HCMV). As NK cells are part of the innate immune system providing an immediate defense against pathogens, short-term exposure to HCMV infected cells may induce changes in the phenotype and function of these cells. To identify immediate reactions of NK cells to HCMV we co-cultured peripheral blood mononuclear cells (PBMCs) with HCMV-infected fibroblasts for 24- and 72 hours. A distinct HCMV mediated proportional enlargement of a subset of NK cells expressing CD94/NKG2A was sustained throughout the period of incubatio...
Source: Human Immunology - September 23, 2009 Category: Allergy & Immunology Authors: Petersen L, Petersen CC, Møller-Larsen A, Hokland ME Tags: Hum Immunol Source Type: journals

Monocyte chemoattractant protein (MCP)-1 -2518 A/G single nucleotide polymorphism in Chinese Han patients with Ocular Behcet's disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the present study suggests that the MCP-1 -2518 AA genotype seems to display a protective association with ocular BD, whereas the -2518 AG genotype might be a susceptible factor to ocular BD in Chinese Han population. PMID: 19782713 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - September 23, 2009 Category: Allergy & Immunology Authors: Hou S, Yang P, Du L, Jiang Z, Mao L, Shu Q, Zhou H, Kijlstra A Tags: Hum Immunol Source Type: journals

The suppressive activity rather than the frequency of FoxP3+ regulatory T cells is essential for CA125-specific T cell activation after abagovomab treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The results of several clinical trials have clearly demonstrated the potential of the anti-idiotype (anti-Id) vaccine abagovomab to induce CA125-specific immunity in ovarian cancer patients. Due to the central role of regulatory T cells (Tregs) in tumor immunology, we analyzed the frequency and suppressive activity of CD25+FoxP3+ Tregs in sixteen patients treated with abagovomab. During vaccination, mean frequencies of peripheral Treg with a CD4+CD25+FoxP3+CD127- phenotype were enhanced, but returned to baseline levels in the follow-up phase. Despite of increasing Treg counts, the suppressive activity of Tregs was dimi...
Source: Human Immunology - September 23, 2009 Category: Allergy & Immunology Authors: Reinartz S, Pfisterer J, du Bois A, Jackisch C, Baumann KH, Wagner U Tags: Hum Immunol Source Type: journals

+49G>A polymorphism in the CTLA-4 gene increases susceptibility to HBV-related HCC in male Chinese population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
+49G>A polymorphism in the CTLA-4 gene increases susceptibility to HBV-related HCC in male Chinese population. Hum Immunol. 2009 Sep 21; Authors: Gu X, Qi P, Zhou F, Ji Q, Wang H, Dou T, Zhao Y, Gao C Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is one of the important regulators and functions negatively in immune response. Its nonsynonymous polymorphism +49G>A (dbSNP: rs231775) has been linked to elevated risk of T-cell-mediated autoimmune diseases, infectious diseases and even carcinomas. Here we examined the genotypes at rs231775 of 1003 subjects in Han Chinese population to detect the association between...
Source: Human Immunology - September 20, 2009 Category: Allergy & Immunology Authors: Gu X, Qi P, Zhou F, Ji Q, Wang H, Dou T, Zhao Y, Gao C Tags: Hum Immunol Source Type: journals

HLA Class I Molecules Reflect an Altered Host Proteome Following Influenza Virus Infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Class I HLA sample and display peptides from thousands of endogenous proteins at the cell surface. During infection, the influenza virus modifies the host cell proteome by (i) triggering host anti-viral responses, (ii) hijacking host processes, and (iii) inhibiting host mRNA processing. In turn, the catalog of HLA class I peptides that decorate the surface of an infected cell is positioned to reflect an altered host cell proteome. To understand the host-encoded peptides presented by class I molecules following influenza infection, we compared by mass spectrometry (MS) peptides eluted from the HLA of naïve and infe...
Source: Human Immunology - September 9, 2009 Category: Allergy & Immunology Authors: Wahl A, Schafer F, Bardet W, Hildebrand WH Tags: Hum Immunol Source Type: journals

Association of a NKG2D gene variant with SLE in two populations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION:: SLE is associated with the SNP rs2255336 of NKG2D. PMID: 19735685 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - September 3, 2009 Category: Allergy & Immunology Authors: Kabalak G, Thomas R, Martin J, Ortego-Centeno N, Jimenez-Alonso J, de Ramón E, Buyny S, Hamsen S, Gross WL, Schnarr S, Zeidler H, Gromnica-Ihle E, Schmidt RE, Witte T Tags: Hum Immunol Source Type: journals

CTLA-4 promoter polymorphisms are associated with latent autoimmune diabetes in adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule is an important regulator of T cell activation and a susceptible candidate for autoimmune diseases. In order to evaluate the impact of CTLA-4 promoter allelic variants of the CTLA-4 gene in latent autoimmune diabetes in adults (LADA), the MH30 (rs231806), -1147 (rs16840252) and -318 (rs5742909) single nucleotide polymorphisms (SNPs) were studied in a population of Estonian origin, including 61 LADA patients and 230 controls. It was found that the MH30 GG genotype (p=0.0051) and the G allele (p=0.0023) were significantly associated with LADA. The frequency distribution ...
Source: Human Immunology - September 3, 2009 Category: Allergy & Immunology Authors: Douroudis K, Prans E, Uibo R Tags: Hum Immunol Source Type: journals

Serum Cytokine Elevations in Celiac Disease: Association with Disease Presentation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Celiac disease (CD) is an autoimmune disorder, which is triggered by an immune response to gluten that occurs in genetically predisposed individuals. Although considered to be a primary gastrointestinal disease, CD is now known to have widespread systemic manifestations. We attempted to define the nature and role of systemic cytokine levels in the pathophysiology of CD. Multiplex cytokine assays were performed on 4 different groups of adult patients; Patients with active CD (ACD), patients on a Gluten Free Diet (GFD) with positive TTG IgA Antibodies, patients on a GFD with negative antibodies and those with Refractory ...
Source: Human Immunology - September 3, 2009 Category: Allergy & Immunology Authors: Manavalan JS, Hernandez L, Shah JG, Konikkara J, Naiyer AJ, Roland AL, Ciaccio E, Minaya MT, Green PH, Bhagat G Tags: Hum Immunol Source Type: journals

Lack of evidence of a role of the XBP1 and PRDM1 polymorphisms in Spanish patients with IgA deficiency.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the polymorphisms studied in the PRDM1 and XBP1 genes do not seem to be involved in IgAD predisposition in the Spanish population. PMID: 19735688 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - September 3, 2009 Category: Allergy & Immunology Authors: Del Pozo N, López-Mejías R, Fernández-Arquero M, Ferreira A, García-Rodríguez MC, de la Concha EG, Fontán G, Urcelay E, Núñez C Tags: Hum Immunol Source Type: journals

From MAC to HLA: Professor Jean Dausset, the pioneer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19705528 [PubMed - in process] (Source: Human Immunology)
Source: Human Immunology - August 27, 2009 Category: Allergy & Immunology Authors: Carosella ED Tags: Hum Immunol Source Type: journals

Hereditary angioedema in Greek families due to novel and recurrent mutations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study constitutes the first molecular analysis of hereditary angioedema (HAE) in Greece, where eleven patients from 3 unrelated families with recurrent angioedema attacks and decreased C1 inhibitor antigenic levels were analyzed for SERPING1 mutations. Interestingly, one family displayed a novel SERPING1 alteration, characterized by the substitution of two consecutive nucleotides TC to AA, resulting in a termination codon (F225X). To the best of our knowledge, this is the first report of such a mutation in SERPING1, causing HAE. The second family displayed the nonsense mutation W482X, and the third the missense mutati...
Source: Human Immunology - August 21, 2009 Category: Allergy & Immunology Authors: Speletas M, Boukas K, Papadopoulou-Alataki E, Tsitsami E, Germenis AE Tags: Hum Immunol Source Type: journals

Rapid High-throughput HLA Typing by Massively-parallel Pyrosequencing for High-Resolution Allele Identification.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the development and first application in a clinical setting of a novel, human leukocyte antigen sequence-based typing method by exploring the next-generation sequencing technology as provided by the Genome Sequencer FLX system (Roche / 454 Life Sciences, Branford, CT, USA). The developed system allows for ambiguity-free, high-throughput, high-resolution HLA-A and -B typing with the potential for automation. Primers and Genome Sequencer FLX specific adaptors were lengthened with donor-identifying barcode sequences to identify each of 8 Caucasian reference donors within one single multiplex sequencing run. Result...
Source: Human Immunology - August 21, 2009 Category: Allergy & Immunology Authors: Gabriel C, Danzer M, Hackl C, Kopal G, Hufnagl P, Hofer K, Polin H, Stabentheiner S, Pröll J Tags: Hum Immunol Source Type: journals

Differential modulation of R5-tropic HIV-1 transfer from macrophages towards T cells under IL-4/IL-13 microenvironment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, secreted cytokines within mucosae may differentially influence both the HIV-1 production within the mucosal target cells reservoir and its spread thorough the mucosal tissue. PMID: 19706316 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - August 21, 2009 Category: Allergy & Immunology Authors: Saïdi H, Carbonneil C, Magri G, Eslahpazire J, Sekaly RP, Bélec L Tags: Hum Immunol Source Type: journals

Are immunoglobulin concentrations associated with body composition of adolescents?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS:: Apparently immunoglobulin concentrations are not affected by overweight, obesity, excessive or central BF in adolescents. PMID: 19698756 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - August 17, 2009 Category: Allergy & Immunology Authors: Zúñiga-Torres MG, Martínez-Carrillo BE, Pardo-Morales RV, Wärnberg J, Marcos A, Benítez-Arciniega AD, Valdés-Ramos R Tags: Hum Immunol Source Type: journals

Role of HLA, KIR and Cytokine Gene Polymorphisms in Leptospirosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Leptospirosis is an emerging zoonotic disease caused by pathogenic species of the genus Leptospira. It has a broad range of clinical presentations in humans. While progress has been obtained in the characterization of the host immune system factors that may affect disease progression and outcome, to date few reports have addressed the role of genetic polymorphisms in the susceptibility to Leptospirosis. In this work a group of patients with a history of leptospiral infection and a control group were compared for polymorphisms in the Human Leukocyte Antigen (HLA), in Killer-cell Immunoglobulin-like Receptors (KIR) and i...
Source: Human Immunology - August 12, 2009 Category: Allergy & Immunology Authors: Fialho RN, Martins L, Pinheiro JP, Bettencourt BF, Couto AR, Santos MR, Peixoto MJ, Garrett F, Leal J, Tomás AM, Bruges-Armas J Tags: Hum Immunol Source Type: journals

Lack of association of NKX2-3, IRGM and ATG16L1 inflammatory bowel diseases susceptibility variants with celiac disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, no evidence of association with CD has been found for the Crohn's disease susceptibility polymorphisms studied in the NKX2-3, ATG16L1 and IRGM genes. PMID: 19683022 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - August 11, 2009 Category: Allergy & Immunology Authors: Dema B, Fernández-Arquero M, Maluenda C, Polanco I, Figueredo MA, de la Concha EG, Urcelay E, Núñez C Tags: Hum Immunol Source Type: journals

Estimation of high-resolution HLA-A, -B, -C, -DRB1 allele and haplotype frequencies based on 8,862 German stem cell donors and implications for strategic donor registry planning.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present allele and haplotype frequencies derived from a data set of 8,862 German stem cell donors who were typed at high resolution for the HLA-A, HLA-B, HLA-C, and HLA-DRB1 genes upon registration. Calculated haplotype frequencies were used to estimate the probability p to find matching donors subject to donor registry size n. The impact of various matching standards on p(n) was analyzed. When high-resolution matching for HLA-A, HLA-B, HLA-C, and HLA-DRB1 is required, p(1,000,000) is 0.678. The corresponding value for n=7,000,000 is 0.859. In a scenario with low-resolution matching and no consideration of HLA-C, p(1,00...
Source: Human Immunology - August 11, 2009 Category: Allergy & Immunology Authors: Schmidt AH, Baier D, Solloch UV, Stahr A, Cereb N, Wassmuth R, Ehninger G, Rutt C Tags: Hum Immunol Source Type: journals

Association of Human Leukocyte Antigens (HLA) with Nasopharyngeal Carcinoma (NPC) in High-Risk Multiplex Families in Taiwan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Association between specific human leukocyte antigens (HLA) alleles and NPC have been reported for sporadic NPC but studies of familial NPC are lacking. We evaluated this association with familial NPC in a study of 301 NPC cases and 1010 family and community controls from Taiwan. Class I HLA alleles were characterized using a sequence-based typing protocol. Allele frequencies between case and control groups were compared by chi-square or exact tests. For alleles associated with NPC, odds ratios (OR) and 95% confidence intervals (CI) were calculated. Similar allelic frequency distribution and HLA associations were found...
Source: Human Immunology - August 11, 2009 Category: Allergy & Immunology Authors: Yu KJ, Gao X, Chen CJ, Yang XR, Diehl SR, Goldstein A, Hsu WL, Liang XS, Marti D, Liu MY, Chen JY, Carrington M, Hildesheim A Tags: Hum Immunol Source Type: journals

Homotypic T cell/T cell interaction induces T cell activation, proliferation, and differentiation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Activated CD4 T cells might induce T cell activation from CD4 resting T cells in the absence of antigen presenting cells through interaction of activation-induced surface molecules (e.g. CD80, CD86, CD70, MHC class II) and their ligands constitutively expressed on resting T cells. Supporting this hypothesis, CD4 memory T cells proliferated in response to contact with activated T cells and expressed activation markers, such as CD25, CD30, and CD69. Analysis of their cytokine profile revealed differentiation of interleukin (IL)-10- and interferon (IFN)-gamma -double-producing cells in response to contact with activated T...
Source: Human Immunology - August 10, 2009 Category: Allergy & Immunology Authors: Ramming A, Thümmler K, Schulze-Koops H, Skapenko A Tags: Hum Immunol Source Type: journals

Genetic association study of FOXP3 polymorphisms in allergic rhinitis in Chinese population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The FOXP3 gene encodes a transcription factor thought to be essential for the development and function of regulatory T cells which are prevailing mediators of immunological tolerance via suppression/modulation of both T helper 1 and T helper 2 mediated immune responses. Previous studies have demonstrated an association between common polymorphisms in FOXP3 and a number of immune diseases. The aim of this study was to investigate whether genetic polymorphisms at the FOXP3 locus predispose to allergic rhinitis in Chinese Han population. Six polymorphisms in promoter and intron areas were genotyped in 193 allergic rhiniti...
Source: Human Immunology - August 9, 2009 Category: Allergy & Immunology Authors: Zhang L, Zhang Y, Desrosiers M, Wang C, Zhao Y, Han D Tags: Hum Immunol Source Type: journals

High levels of molecular polymorphism at the KIR2DL4 locus in French and Congolese populations: impact for anthropology and clinical studies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To characterize KIR2DL4 molecular polymorphism, a cloning-sequencing protocol was performed in 49 French and 52 Teke Congolese individuals. These two populations exhibit high levels of genetic diversity for KIR2DL4, possibly under the influence of natural selection. The most frequent alleles in French (i.e. *00801 and *00802 with a cumulated frequency around 43%) are not the same in Congolese (i.e. *00103 at 47%). In the latter population, four new allelic variants were detected, three of them harbouring non-synonymous substitutions leading to amino-acid changes in the extra-cellular and cytoplasmic domains of the prot...
Source: Human Immunology - August 9, 2009 Category: Allergy & Immunology Authors: Buhler S, Di Cristofaro J, Frassati C, Basire A, Galicher V, Chiaroni J, Picard C Tags: Hum Immunol Source Type: journals

Modulation of glucocorticoid receptor induction properties by cofactors in peripheral blood mononuclear cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glucocorticoids are widely used for their anti-inflammatory and immunosuppressive properties. Changing concentrations of transcriptional cofactors or chemicals in transiently transfected tissue culture cells are known to modify several properties of glucocorticoid receptor-regulated gene expression including total activity (A(max)), agonist steroid potency (EC(50)), and the percent of full agonist activity for antisteroids (percent partial agonist activity). However, no reports exist for endogenous genes in primary human cells. Here we document that reduced concentrations of TIF2, a p160 coactivator, in peripheral bloo...
Source: Human Immunology - August 4, 2009 Category: Allergy & Immunology Authors: Luo M, Simons SS Tags: Hum Immunol Source Type: journals

Ionizing radiation modulates the surface expression of hla-g in a human melanoma cell line.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human leukocyte antigen G (HLA-G) is non-classical HLA class I molecule involved in fetus protection from maternal immune system, transplant tolerance, and viral and tumoral immune escape. Tumor-specific HLA-G expression has been described for a wide variety of malignancies, including melanomas. The aim of this study was to evaluate if ionizing radiations (IR) could modulate the surface expression of HLA-G1 in a human melanoma cell line that expresses endogenously membrane-bound HLA-G1. For this purpose, cells were exposed to increasing doses of gamma irradiation (0-20 Gy) and HLA-G1 levels at the plasma membrane were ...
Source: Human Immunology - August 4, 2009 Category: Allergy & Immunology Authors: Michelin S, Gallegos CE, Dubner D, Favier B, Carosella ED Tags: Hum Immunol Source Type: journals

Introduction/Editorial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19665042 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - August 4, 2009 Category: Allergy & Immunology Authors: Carosella ED Tags: Hum Immunol Source Type: journals