Deregulated expression of autophagy genes; PIK3C3 and RAB7A in COVID-19 patients
CONCLUSIONS: The study showed reduction of PIK3C3 and RAB7A expressions in COVID-19 patients. However, further studies are recommended to clarify their roles in the disease pathogenies as autophagy genes.PMID:38609772 | DOI:10.1016/j.humimm.2024.110801 (Source: Human Immunology)
Source: Human Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Mona Tahoun Ahmed S Sadaka Source Type: research
Deregulated expression of autophagy genes; PIK3C3 and RAB7A in COVID-19 patients
CONCLUSIONS: The study showed reduction of PIK3C3 and RAB7A expressions in COVID-19 patients. However, further studies are recommended to clarify their roles in the disease pathogenies as autophagy genes.PMID:38609772 | DOI:10.1016/j.humimm.2024.110801 (Source: Human Immunology)
Source: Human Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Mona Tahoun Ahmed S Sadaka Source Type: research
Deregulated expression of autophagy genes; PIK3C3 and RAB7A in COVID-19 patients
CONCLUSIONS: The study showed reduction of PIK3C3 and RAB7A expressions in COVID-19 patients. However, further studies are recommended to clarify their roles in the disease pathogenies as autophagy genes.PMID:38609772 | DOI:10.1016/j.humimm.2024.110801 (Source: Human Immunology)
Source: Human Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Mona Tahoun Ahmed S Sadaka Source Type: research
Updates in induction immunosuppression regimens for intestinal transplantation
Hum Immunol. 2024 Apr 9:110800. doi: 10.1016/j.humimm.2024.110800. Online ahead of print.ABSTRACTIntestinal allografts are the most immunologically complex and carry the highest risk of rejection among solid organ transplantation, necessitating complex immunosuppressive management. We evaluated the latest information regarding induction immunosuppression, with an emphasis on established, novel, and emergent therapies. We also reviewed classic and novel induction immunosuppression strategies for highly sensitized recipients. Comparable progress has been made in intestinal transplantation clinical outcomes since the implemen...
Source: Human Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Johann Paulo Guzman Mohamed Maklad Mohammed Osman Ayat Elsherif Masato Fujiki Source Type: research
Updates in induction immunosuppression regimens for intestinal transplantation
Hum Immunol. 2024 Apr 9:110800. doi: 10.1016/j.humimm.2024.110800. Online ahead of print.ABSTRACTIntestinal allografts are the most immunologically complex and carry the highest risk of rejection among solid organ transplantation, necessitating complex immunosuppressive management. We evaluated the latest information regarding induction immunosuppression, with an emphasis on established, novel, and emergent therapies. We also reviewed classic and novel induction immunosuppression strategies for highly sensitized recipients. Comparable progress has been made in intestinal transplantation clinical outcomes since the implemen...
Source: Human Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Johann Paulo Guzman Mohamed Maklad Mohammed Osman Ayat Elsherif Masato Fujiki Source Type: research
Updates in induction immunosuppression regimens for intestinal transplantation
Hum Immunol. 2024 Apr 9:110800. doi: 10.1016/j.humimm.2024.110800. Online ahead of print.ABSTRACTIntestinal allografts are the most immunologically complex and carry the highest risk of rejection among solid organ transplantation, necessitating complex immunosuppressive management. We evaluated the latest information regarding induction immunosuppression, with an emphasis on established, novel, and emergent therapies. We also reviewed classic and novel induction immunosuppression strategies for highly sensitized recipients. Comparable progress has been made in intestinal transplantation clinical outcomes since the implemen...
Source: Human Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Johann Paulo Guzman Mohamed Maklad Mohammed Osman Ayat Elsherif Masato Fujiki Source Type: research
A comparative analysis of TCR immune repertoire in COVID-19 patients
Hum Immunol. 2024 Apr 5:110795. doi: 10.1016/j.humimm.2024.110795. Online ahead of print.ABSTRACTThe coronavirus disease 2019 (COVID-19) has merged as a global health threat since its outbreak in December 2019. Despite widespread recognition, there has been a paucity of studies focusing on the T cell receptor (TCR) bias in adaptive immunity induced by SARS-CoV-2. This research conducted a comparative analysis of the TCR immune repertoire to identify notable αβ TCR bias sequences associated with the SARS-CoV-2 virus antigen. The present study encompassed 73 symptomatic COVID-19 patients, categorized as moderate/mild or se...
Source: Human Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Xiao Zhu Enze Ma Ke Ning Xiangyan Feng Wei Quan Fei Wang Chaoqun Zhu Yuanjun Ma Yucui Dong Qinghua Jiang Source Type: research
A comparative analysis of TCR immune repertoire in COVID-19 patients
Hum Immunol. 2024 Apr 5:110795. doi: 10.1016/j.humimm.2024.110795. Online ahead of print.ABSTRACTThe coronavirus disease 2019 (COVID-19) has merged as a global health threat since its outbreak in December 2019. Despite widespread recognition, there has been a paucity of studies focusing on the T cell receptor (TCR) bias in adaptive immunity induced by SARS-CoV-2. This research conducted a comparative analysis of the TCR immune repertoire to identify notable αβ TCR bias sequences associated with the SARS-CoV-2 virus antigen. The present study encompassed 73 symptomatic COVID-19 patients, categorized as moderate/mild or se...
Source: Human Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Xiao Zhu Enze Ma Ke Ning Xiangyan Feng Wei Quan Fei Wang Chaoqun Zhu Yuanjun Ma Yucui Dong Qinghua Jiang Source Type: research
A comparative analysis of TCR immune repertoire in COVID-19 patients
Hum Immunol. 2024 Apr 5:110795. doi: 10.1016/j.humimm.2024.110795. Online ahead of print.ABSTRACTThe coronavirus disease 2019 (COVID-19) has merged as a global health threat since its outbreak in December 2019. Despite widespread recognition, there has been a paucity of studies focusing on the T cell receptor (TCR) bias in adaptive immunity induced by SARS-CoV-2. This research conducted a comparative analysis of the TCR immune repertoire to identify notable αβ TCR bias sequences associated with the SARS-CoV-2 virus antigen. The present study encompassed 73 symptomatic COVID-19 patients, categorized as moderate/mild or se...
Source: Human Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Xiao Zhu Enze Ma Ke Ning Xiangyan Feng Wei Quan Fei Wang Chaoqun Zhu Yuanjun Ma Yucui Dong Qinghua Jiang Source Type: research
HLA alleles associated with susceptibility and severity of the COVID-19 in Vietnamese
This study exploited the association between HLA frequencies and SARS-CoV-2 susceptibility and disease severity among the Vietnamese cohort (159 patients and 52 controls). A significant difference in frequency of both HLA class I and II in mild, moderate, and severe/fatal COVID-19 patients and negative exposure individuals - the controls were observed. Regarding SARS-CoV-2 sensitivity, HLA-A*03:01, 30:01, HLA-DQA1*01:02, DRB1*15:01, and DRB5*02:02 presented higher frequency in the control group compared with infected patients but DRB1 09:01 frequency was higher in infected patients. Regarding COVID-19 severity, HLA-F*01:01...
Source: Human Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Nguyen Thi Thanh Hai Vu Phuong Nhung Nguyen Thi Thanh Tam Tran Thi Bich Ngoc Ma Thi Huyen Thuong Ha Van Dai Nguyen Thuy Duong Nong Van Hai Nguyen Dang Ton Pham Ngoc Thach Nguyen Hai Ha Source Type: research
Polymorphisms in the CD6-ALCAM axis may modulate psoriasis risk and outcomes
Hum Immunol. 2024 Apr 5:110797. doi: 10.1016/j.humimm.2024.110797. Online ahead of print.ABSTRACTThe fact that CD6, along with its ligand - ALCAM, plays a role in regulating T cell activation makes the genes encoding these molecules promising candidates for research in T cell-mediated diseases such as psoriasis vulgaris (PsV). Our study aimed to determine whether CD6 (rs17824933C>G, rs11230563C>T and rs12360861G>A) and ALCAM (rs6437585C>T, rs11559013G>A) polymorphisms may affect psoriasis susceptibility and severity (assessed by Psoriasis Area and Severity Index (PASI)). Moreover, the presence of HLA-C*06:02...
Source: Human Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Marta Wagner Maciej Sobczy ński Andrzej Wi śniewski Łukasz Matusiak Piotr Ku śnierczyk Monika Jasek Source Type: research
Tolerance in intestinal transplantation
Hum Immunol. 2024 Apr 5:110793. doi: 10.1016/j.humimm.2024.110793. Online ahead of print.ABSTRACTIntestinal transplantation (ITx) is highly immunogenic, resulting in the need for high levels of immunosuppression, with frequent complications along with high rejection rates. Tolerance induction would provide a solution to these limitations. Detailed studies of alloreactive T cell clones as well as multiparameter flow cytometry in the graft and peripheral tissues have provided evidence for several tolerance mechanisms that occur spontaneously following ITx, which might provide targets for further interventions. These include ...
Source: Human Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Megan Sykes Source Type: research
HLA alleles associated with susceptibility and severity of the COVID-19 in Vietnamese
This study exploited the association between HLA frequencies and SARS-CoV-2 susceptibility and disease severity among the Vietnamese cohort (159 patients and 52 controls). A significant difference in frequency of both HLA class I and II in mild, moderate, and severe/fatal COVID-19 patients and negative exposure individuals - the controls were observed. Regarding SARS-CoV-2 sensitivity, HLA-A*03:01, 30:01, HLA-DQA1*01:02, DRB1*15:01, and DRB5*02:02 presented higher frequency in the control group compared with infected patients but DRB1 09:01 frequency was higher in infected patients. Regarding COVID-19 severity, HLA-F*01:01...
Source: Human Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Nguyen Thi Thanh Hai Vu Phuong Nhung Nguyen Thi Thanh Tam Tran Thi Bich Ngoc Ma Thi Huyen Thuong Ha Van Dai Nguyen Thuy Duong Nong Van Hai Nguyen Dang Ton Pham Ngoc Thach Nguyen Hai Ha Source Type: research
Polymorphisms in the CD6-ALCAM axis may modulate psoriasis risk and outcomes
Hum Immunol. 2024 Apr 5:110797. doi: 10.1016/j.humimm.2024.110797. Online ahead of print.ABSTRACTThe fact that CD6, along with its ligand - ALCAM, plays a role in regulating T cell activation makes the genes encoding these molecules promising candidates for research in T cell-mediated diseases such as psoriasis vulgaris (PsV). Our study aimed to determine whether CD6 (rs17824933C>G, rs11230563C>T and rs12360861G>A) and ALCAM (rs6437585C>T, rs11559013G>A) polymorphisms may affect psoriasis susceptibility and severity (assessed by Psoriasis Area and Severity Index (PASI)). Moreover, the presence of HLA-C*06:02...
Source: Human Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Marta Wagner Maciej Sobczy ński Andrzej Wi śniewski Łukasz Matusiak Piotr Ku śnierczyk Monika Jasek Source Type: research
Tolerance in intestinal transplantation
Hum Immunol. 2024 Apr 5:110793. doi: 10.1016/j.humimm.2024.110793. Online ahead of print.ABSTRACTIntestinal transplantation (ITx) is highly immunogenic, resulting in the need for high levels of immunosuppression, with frequent complications along with high rejection rates. Tolerance induction would provide a solution to these limitations. Detailed studies of alloreactive T cell clones as well as multiparameter flow cytometry in the graft and peripheral tissues have provided evidence for several tolerance mechanisms that occur spontaneously following ITx, which might provide targets for further interventions. These include ...
Source: Human Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Megan Sykes Source Type: research
