Reply: Endometrial scratching: the light at the end of the tunnel
Sir, (Source: Human Reproduction Update)
Source: Human Reproduction Update - January 27, 2024 Category: OBGYN Source Type: research
Endometrial scratching: the light at the end of the tunnel
Sir, (Source: Human Reproduction Update)
Source: Human Reproduction Update - January 27, 2024 Category: OBGYN Source Type: research
Declining global fertility rates and the implications for family planning and family building: an IFFS consensus document based on a narrative review of the literature
AbstractBACKGROUNDFamily-planning policies have focused on contraceptive approaches to avoid unintended pregnancies, postpone, or terminate pregnancies and mitigate population growth. These policies have contributed to significantly slowing world population growth. Presently, half the countries worldwide exhibit a fertility rate below replacement level. Not including the effects of migration, many countries are predicted to have a population decline of>50% from 2017 to 2100, causing demographic changes with profound societal implications. Policies that optimize chances to have a child when desired increase fertility rat...
Source: Human Reproduction Update - January 10, 2024 Category: OBGYN Source Type: research
The complicated ART of finding consensus on family-building health policy: a comment on the IFFS consensus document
The world has witnessed a substantial decline in fertility rates for the last five decades: from 4.8 children per woman in 1970 to 3.3 in 1990 and to 2.3 in 2022. These declines have been the focus of much research. In high-income countries (HICs), where fertility rates currently average 1.6 children per woman, the reductions below the magical 2.1 replacement level have been ascribed to a range of ideational factors, described in the rich literature on the ‘Second Demographic Transition’ (Lesthaeghe, 2010;Zaidi and Morgan, 2017). In low-income countries (LICs), the reduction is largely the product of longstanding popul...
Source: Human Reproduction Update - January 10, 2024 Category: OBGYN Source Type: research
IVF versus IUI with ovarian stimulation for unexplained infertility: a collaborative individual participant data meta-analysis
AbstractBACKGROUNDIVF and IUI with ovarian stimulation (IUI-OS) are widely used in managing unexplained infertility. IUI-OS is generally considered first-line therapy, followed by IVF only if IUI-OS is unsuccessful after several attempts. However, there is a growing interest in using IVF for immediate treatment because it is believed to lead to higher live birth rates and shorter time to pregnancy.OBJECTIVE AND RATIONALERandomized controlled trials (RCTs) comparing IVF versus IUI-OS had varied study designs and findings. Some RCTs used complex algorithms to combine IVF and IUI-OS, while others had unequal follow-up time be...
Source: Human Reproduction Update - December 26, 2023 Category: OBGYN Source Type: research
Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy
AbstractBACKGROUNDDuring the human menstrual cycle and pregnancy, the endometrium undergoes a series of dynamic remodeling processes to adapt to physiological changes. Insufficient endometrial remodeling, characterized by inadequate endometrial proliferation, decidualization and spiral artery remodeling, is associated with infertility, endometriosis, dysfunctional uterine bleeding, and pregnancy-related complications such as preeclampsia and miscarriage. Bone morphogenetic proteins (BMPs), a subset of the transforming growth factor- β (TGF-β) superfamily, are multifunctional cytokines that regulate diverse cellular activ...
Source: Human Reproduction Update - November 30, 2023 Category: OBGYN Source Type: research
COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss
AbstractBACKGROUNDPregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to experience preterm birth and their neonates are more likely to be stillborn or admitted to a neonatal unit. The World Health Organization declared in May 2023 an end to the coronavirus disease 2019 (COVID-19) pandemic as a global health emergency. However, pregnant women are still becoming infected with SARS-CoV-2 and there is limited information available regarding the effect of SARS-CoV-2 infection in early pregnancy on pregnancy outcomes.OBJECTIVE AND RATIONALEWe conducted this systematic review...
Source: Human Reproduction Update - November 28, 2023 Category: OBGYN Source Type: research
A systematic review to determine use of the Endometriosis Health Profiles to measure quality of life outcomes in women with endometriosis
AbstractBACKGROUNDThe Endometriosis Health Profiles (EHPs), the EHP-30 and EHP-5, are patient-reported outcome measures that were developed to measure the health-related quality of life (HRQoL) of women living with endometriosis. Prior to their development, a systematic review was undertaken which identified that the HRQoL of women living with endometriosis was poorly understood, with only three medical and one surgical study identified.OBJECTIVE AND RATIONALEThe 20-year anniversary of the EHP-30 provided a timely opportunity to assess how the tools have been used and explore what the findings tell us about the impact of e...
Source: Human Reproduction Update - November 25, 2023 Category: OBGYN Source Type: research
Is it new, is it true and do we care —the role of prospective review registration
AtHuman Reproduction Update, we love reviews. They can be educational, provide an in-depth overview, or contribute to clinical decision-making. But at ESHRE 2023 in Copenhagen, several people complained about the abundance of reviews, particularly systematic reviews and meta-analyses. In some areas, it is indeed hilarious with more systematic reviews than clinical trials. (Source: Human Reproduction Update)
Source: Human Reproduction Update - September 5, 2023 Category: OBGYN Source Type: research
Reply: Artificial cycle frozen embryo transfer and obstetric adverse outcomes: association or causation?
Dutch Organisation for Health Research and DevelopmentZonMw 843002807 (Source: Human Reproduction Update)
Source: Human Reproduction Update - July 28, 2023 Category: OBGYN Source Type: research
Artificial cycle frozen embryo transfer and obstetric adverse outcomes: association or causation?
Dear Sir, (Source: Human Reproduction Update)
Source: Human Reproduction Update - July 28, 2023 Category: OBGYN Source Type: research
Uterus transplantation: from research, through human trials and into the future
AbstractWomen suffering from absolute uterine factor infertility (AUFI) had no hope of childbearing until clinical feasibility of uterus transplantation (UTx) was documented in 2014 with the birth of a healthy baby. This landmark accomplishment followed extensive foundational work with a wide range of animal species including higher primates. In the present review, we provide a summary of the animal research and describe the results of cases and clinical trials on UTx. Surgical advances for graft removal from live donors and transplantation to recipients are improving, with a recent trend away from laparotomy to robotic ap...
Source: Human Reproduction Update - June 16, 2023 Category: OBGYN Source Type: research
Endometrial responses to bacterial and viral infection: a scoping review
AbstractBACKGROUNDThe endometrium is a highly dynamic tissue that undergoes dramatic proliferation and differentiation monthly in order to prepare the uterus for implantation and pregnancy. Intrauterine infection and inflammation are being increasingly recognized as potential causes of implantation failure and miscarriage, as well as obstetric complications later in gestation. However, the mechanisms by which the cells of the endometrium respond to infection remain understudied and recent progress is slowed in part owing to similar overlapping studies being performed in different species.OBJECTIVE AND RATIONALEThe aim of t...
Source: Human Reproduction Update - June 8, 2023 Category: OBGYN Source Type: research
Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis
AbstractBACKGROUNDA normal chromosomal constitution defined through PGT-A assessing all chromosomes on trophectoderm (TE) biopsies represents the strongest predictor of embryo implantation. Yet, its positive predictive value is not higher than 50 –60%. This gap of knowledge on the causes of euploid blastocysts’ reproductive failure is known as ‘the black box of implantation’.OBJECTIVE AND RATIONALESeveral embryonic, maternal, paternal, clinical, and IVF laboratory features were scrutinized for their putative association with reproductive success or implantation failure of euploid blastocysts.SEARCH METHODSA systema...
Source: Human Reproduction Update - May 16, 2023 Category: OBGYN Source Type: research
Obstetric and neonatal outcomes after natural versus artificial cycle frozen embryo transfer and the role of luteal phase support: a systematic review and meta-analysis
This study confirms that NC-FET decreases the risk of adverse obstetric and neonatal outcomes compared with AC-FET. We estimate that for each adverse outcome, use of NC-FET may prevent 4 to 22 cases per 1000 women. Consequently, NC-FET should be the preferred treatment in women with ovulatory cycles undergoing FET. Based on very low quality of evidence, the risk of preterm birth be decreased when LPS is used in NC-FET compared to AC-FET. However, because of many uncertainties —the major being the debate about efficacy of the use of LPS—future research is needed on efficacy and safety of LPS and no recommendation can be...
Source: Human Reproduction Update - May 12, 2023 Category: OBGYN Source Type: research
