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Hormone therapy and cognitive functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Future studies should include measures of executive function and should address pressing clinical questions; including what formulation of combination hormone therapy is cognitively neutral/beneficial, yet effective in treating hot flashes in the early post-menopause. (Source: Human Reproduction Update)
Source: Human Reproduction Update - October 8, 2009 Category: OBGYN Authors: Maki, P. M., Sundermann, E. Tags: Reviews Source Type: journals

Orthotopic and heterotopic ovarian tissue transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION Additional evidence is required to define optimal conditions for ovarian tissue transplantation. Alternatives such as whole ovary or isolated follicles transplantations require further investigation but are likely to be successful in humans in the future. (Source: Human Reproduction Update)
Source: Human Reproduction Update - October 8, 2009 Category: OBGYN Authors: Demeestere, I., Simon, P., Emiliani, S., Delbaere, A., Englert, Y. Tags: Reviews Source Type: journals

Monozygotic twinning, cerebral palsy and congenital anomaliesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS CP and congenital anomalies share a common pathogenic mechanism attributable to MZ twinning. These abnormalities in singletons are coincident with very early loss of one conceptus. The quantitative contribution of monozygosity and monochorionicity to the genesis of CP and congenital anomalies needs to be made. (Source: Human Reproduction Update)
Source: Human Reproduction Update - October 8, 2009 Category: OBGYN Authors: Pharoah, P.O.D., Dundar, Y. Tags: Reviews Source Type: journals

Male infertility and the involvement of the X chromosomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS It can be concluded that, so far, the mutation analysis of X-linked genes in humans, presumed to be crucial for spermatogenesis or sperm quality, has been disappointing. Other approaches to learn more about male infertility are necessary. (Source: Human Reproduction Update)
Source: Human Reproduction Update - October 8, 2009 Category: OBGYN Authors: Stouffs, K., Tournaye, H., Liebaers, I., Lissens, W. Tags: Reviews Source Type: journals

Addition of growth hormone to gonadotrophins in ovarian stimulation of poor responders treated by in-vitro fertilization: a systematic review and meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS The present meta-analysis provides evidence that GH addition increases the probability of clinical pregnancy and live birth in poor responders undergoing ovarian stimulation with GnRH analogues and gonadotrophins for IVF. However, the total number of patients analyzed is small and thus further RCTs are warranted to prove or disprove this finding. (Source: Human Reproduction Update)
Source: Human Reproduction Update - October 8, 2009 Category: OBGYN Authors: Kolibianakis, E.M., Venetis, C.A., Diedrich, K., Tarlatzis, B.C., Griesinger, G. Tags: Reviews Source Type: journals

Female contraception over 40Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Women should be advised to continue with a contraceptive method until they have reached the menopause with its natural state of sterility. (Source: Human Reproduction Update)
Source: Human Reproduction Update - October 8, 2009 Category: OBGYN Authors: The ESHRE Capri Workshop Group Tags: Reviews Source Type: journals

Psychological aspects of fertility preservation in men and women affected by cancer and other life-threatening diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS The existing literature demonstrates the need for and the limits of current counselling. Future research should target the means to facilitate the decision-making process for patients and health professionals. (Source: Human Reproduction Update)
Source: Human Reproduction Update - August 11, 2009 Category: OBGYN Authors: Tschudin, S., Bitzer, J. Tags: Reviews Source Type: journals

Oocyte aging: cellular and molecular changes, developmental potential and reversal possibilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Aging of oocytes is characterized by a sequence of molecular processes that deteriorate during aging and negatively impact fertilization and development. However, oocyte aging can be delayed or reversed by various treatments to increase success rates and produce increased numbers of healthy embryos, preventing failures or abnormalities that are frequently associated with ART using aged oocytes. (Source: Human Reproduction Update)
Source: Human Reproduction Update - August 11, 2009 Category: OBGYN Authors: Miao, Y.-L., Kikuchi, K., Sun, Q.-Y., Schatten, H. Tags: Reviews Source Type: journals

Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Mitochondria-based events regulate different aspects of reproductive function, but these are not uniform throughout the several systems reviewed. Low mitochondrial activity seems a feature of ‘stemness’, being described in spermatogonia, early embryo, inner cell mass cells and embryonic stem cells. (Source: Human Reproduction Update)
Source: Human Reproduction Update - August 11, 2009 Category: OBGYN Authors: Ramalho-Santos, J., Varum, S., Amaral, S., Mota, P. C., Sousa, A. P., Amaral, A. Tags: Reviews Source Type: journals

Prediction models in reproductive medicine: a critical appraisalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Currently, there are three models with good predictive performance. These models can be used reliably as a guide for making decisions about fertility treatment, in patients similar to the development population. The effects of using these models in patient care have to be further investigated. (Source: Human Reproduction Update)
Source: Human Reproduction Update - August 11, 2009 Category: OBGYN Authors: Leushuis, E., van der Steeg, J. W., Steures, P., Bossuyt, P. M.M., Eijkemans, M. J.C., van der Veen, F., Mol, B. W.J., Hompes, P. G.A. Tags: Reviews Source Type: journals

Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS The potency and wide-ranging involvement of Treg cells in immune homeostasis and disease pathology indicates the considerable potential of these cells as therapeutic agents, raising the prospect of their utility in novel treatments for reproductive pathologies. (Source: Human Reproduction Update)
Source: Human Reproduction Update - August 11, 2009 Category: OBGYN Authors: Guerin, L. R., Prins, J. R., Robertson, S. A. Tags: Reviews Source Type: journals

Systematic review of oocyte donation: investigating attitudes, motivations and experiencesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION Differences between donor groups on a range of factors highlight the need for tailored psychosocial evaluation and counselling. The review has demonstrated that it is not useful to generalize across donor groups on various factors relating to oocyte donation. (Source: Human Reproduction Update)
Source: Human Reproduction Update - August 11, 2009 Category: OBGYN Authors: Purewal, S., van den Akker, O.B.A. Tags: Reviews Source Type: journals

Oral contraceptives and colorectal cancer risk: a systematic review and meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION Epidemiological data consistently indicate that OC users have a reduced risk of colorectal cancer, and that the protection is greater for recent use in the absence, however, of a duration–risk relation. (Source: Human Reproduction Update)
Source: Human Reproduction Update - August 11, 2009 Category: OBGYN Authors: Bosetti, C., Bravi, F., Negri, E., La Vecchia, C. Tags: Reviews Source Type: journals

Metabolic features of the reproductive phenotypes of polycystic ovary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Current metabolic evidence appears to justify the inclusion of both non-NIH PCOS groups (ovulatory and non-hyperandrogenic) as PCOS subgroups. NIH PCOS is associated with a more adverse metabolic profile including greater total and abdominal obesity, IR and risk factors for CVD and DM2 than non-NIH phenotypes. (Source: Human Reproduction Update)
Source: Human Reproduction Update - June 5, 2009 Category: OBGYN Authors: Moran, L., Teede, H. Tags: Reviews Source Type: journals

Biology of insulin-like factor 3 in human reproductionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS INSL3 promises to become an important new diagnostic tool to characterize those men with late-onset hypogonadism and to add clinical diagnostic value at amniocentesis. (Source: Human Reproduction Update)
Source: Human Reproduction Update - June 5, 2009 Category: OBGYN Authors: Ivell, R., Anand-Ivell, R. Tags: Reviews Source Type: journals

Recurrence of endometriosis and its controlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Much research is needed to better understand the patterns of recurrence and risk factors, and to develop biomarkers. One top priority is to develop biomarkers for recurrence, which may provide much needed clues to the possible mechanisms underlying recurrence and would allow the identification of patients with high recurrence risk, and permit for targeted intervention. (Source: Human Reproduction Update)
Source: Human Reproduction Update - June 5, 2009 Category: OBGYN Authors: Guo, S.-W. Tags: Reviews Source Type: journals

Effects of soy protein and isoflavones on circulating hormone concentrations in pre- and post-menopausal women: a systematic review and meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Isoflavone-rich soy products decrease FSH and LH in premenopausal women and may increase estradiol in post-menopausal women. The clinical implications of these modest hormonal changes remain to be determined. (Source: Human Reproduction Update)
Source: Human Reproduction Update - June 5, 2009 Category: OBGYN Authors: Hooper, L., Ryder, J.J., Kurzer, M.S., Lampe, J.W., Messina, M.J., Phipps, W.R., Cassidy, A. Tags: Reviews Source Type: journals

Predicting adverse obstetric outcome after early pregnancy events and complications: a reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Data from our literature review indicate, by finding significant associations, that specific early pregnancy events and complications are predictors for subsequent adverse obstetric and perinatal outcome. Though, some of these associations are based on limited or small uncontrolled studies. Larger population-based controlled studies are needed to confirm these findings. Nevertheless, identification of these risks will improve obstetric care. (Source: Human Reproduction Update)
Source: Human Reproduction Update - June 5, 2009 Category: OBGYN Authors: van Oppenraaij, R.H.F., Jauniaux, E., Christiansen, O.B., Horcajadas, J.A., Farquharson, R.G., Exalto, N., on behalf of the ESHRE Special Interest Group for Early Pregnancy (SIGEP) Tags: Reviews Source Type: journals

Approaches to improve the diagnosis and management of infertilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Greater quality control and standardization of clinical and laboratory evaluations are required to optimize ART practices and improve individual patient outcomes. Well-designed, good-quality studies are required to drive improvements to the diagnosis and management of ART processes. (Source: Human Reproduction Update)
Source: Human Reproduction Update - June 5, 2009 Category: OBGYN Authors: Devroey, P., Fauser, B.C.J.M., Diedrich, K., on behalf of the Evian Annual Reproduction (EVAR) Workshop Group 2008 Tags: Reviews Source Type: journals

Differentiation of germ cells and gametes from stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Differentiation of germ cells from SCs has the potential of becoming a future source of gametes for research use, although further investigation is needed to understand and develop the appropriate niches and culture conditions. Additionally, if genetic and epigenetic methodological limitations could be solved, therapeutic opportunities could be also considered. (Source: Human Reproduction Update)
Source: Human Reproduction Update - April 8, 2009 Category: OBGYN Authors: Marques-Mari, A.I., Lacham-Kaplan, O., Medrano, J.V., Pellicer, A., Simon, C. Tags: Reviews Source Type: journals

The current knowledge on radiosensitivity of ovarian follicle development stagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS The fact that genetic effects were observed in irradiated animals suggests that these could also occur in humans. The probability of such events remains low compared with the ‘spontaneous’ risks of genetic effects. (Source: Human Reproduction Update)
Source: Human Reproduction Update - April 8, 2009 Category: OBGYN Authors: Adriaens, I., Smitz, J., Jacquet, P. Tags: Reviews Source Type: journals

Growth hormone, menopause and ageing: no definite evidence for 'rejuvenation' with growth hormoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS There is no definite evidence that elderly subjects really benefit from treatment with GH or GH secretagogues. Strategies aimed at enhancing spontaneous GH secretion such as sleep and exercise are safer and certainly less expensive than GH supplementation regimen. (Source: Human Reproduction Update)
Source: Human Reproduction Update - April 8, 2009 Category: OBGYN Authors: Fanciulli, G., Delitala, A., Delitala, G. Tags: Reviews Source Type: journals

Breast cancer in young women and its impact on reproductive functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION This paper provides an update on the management of breast cancer in young women and is targeted at reproductive medicine specialists and gynaecologists. (Source: Human Reproduction Update)
Source: Human Reproduction Update - April 8, 2009 Category: OBGYN Authors: Hickey, M., Peate, M., Saunders, C.M., Friedlander, M. Tags: Reviews Source Type: journals

Advances in recombinant DNA technology: corifollitropin alfa, a hybrid molecule with sustained follicle-stimulating activity and reduced injection frequencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Corifollitropin alfa is the first long-acting hybrid molecule with sustained follicle-stimulating activity developed for the induction of multi-follicular growth along with GnRH antagonist co-treatment for IVF. This new treatment option may be simpler and more convenient for patients compared with conventional long protocols of daily FSH injections in combination with GnRH agonist co-treatment. The safety and efficacy of such regimens is currently being evaluated in large comparative phase III clinical trials. The development of corifollitropin alfa is the first step towards a new generation of recombinant gona...
Source: Human Reproduction Update - April 8, 2009 Category: OBGYN Authors: Fauser, B.C.J.M., Mannaerts, B.M.J.L., Devroey, P., Leader, A., Boime, I., Baird, D.T. Tags: Reviews Source Type: journals

Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS After controlling for BMI-related effects, adiponectin levels seem to be lower in women with PCOS compared with non-PCOS controls. Low levels of adiponectin in PCOS are probably related to IR but not to testosterone. Total adiponectin should not be used as a biomarker of PCOS severity. Further investigation is needed for HMW adiponectin levels in PCOS. (Source: Human Reproduction Update)
Source: Human Reproduction Update - April 8, 2009 Category: OBGYN Authors: Toulis, K.A., Goulis, D.G., Farmakiotis, D., Georgopoulos, N.A., Katsikis, I., Tarlatzis, B.C., Papadimas, I., Panidis, D. Tags: Reviews Source Type: journals

The efficacy of psychological interventions for infertile patients: a meta-analysis examining mental health and pregnancy rateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Despite the absence of clinical effects on mental health measures, psychological interventions were found to improve some patients’ chances of becoming pregnant. Psychological interventions represent an attractive treatment option, in particular, for infertile patients who are not receiving medical treatment. (Source: Human Reproduction Update)
Source: Human Reproduction Update - April 8, 2009 Category: OBGYN Authors: Hammerli, K., Znoj, H., Barth, J. Tags: Reviews Source Type: journals

Intrauterine inseminationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS IUI treatment requires ovarian stimulation to achieve modest results, but the high multiple pregnancy rates mean that it is no more than a poor substitute for IVF treatment. More trials are needed on IUI treatment with mild stimulation and on the order of IUI and other treatments. (Source: Human Reproduction Update)
Source: Human Reproduction Update - April 8, 2009 Category: OBGYN Authors: The ESHRE Capri Workshop Group Tags: Reviews Source Type: journals

Letrozole in ovulation induction: time to make decisionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Human Reproduction Update)
Source: Human Reproduction Update - February 4, 2009 Category: OBGYN Authors: Polyzos, N.P., Mauri, D., Tzioras, S. Tags: Letters to the editor Source Type: journals

Low dose aspirin and IVF: 'Is it time for a meta-analysis'? Continued: the consequences of the choices madeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Human Reproduction Update)
Source: Human Reproduction Update - February 4, 2009 Category: OBGYN Authors: Lambers, M. J., Mijatovic,, V., Hompes, P. G.A. Tags: Letters to the editor Source Type: journals

Current evidence about treatments for ectopic pregnancy: need for a rethink on RCTsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Human Reproduction Update)
Source: Human Reproduction Update - February 4, 2009 Category: OBGYN Authors: Bignardi, T., Condous, G. Tags: Letters to the editor Source Type: journals

Monoamine transporters in human endometrium and deciduaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS New knowledge about monoamine metabolism in the endometrium during menstruation and pregnancy will increase understanding of infertility problems and may offer new pharmacological approaches to optimize assisted reproduction. (Source: Human Reproduction Update)
Source: Human Reproduction Update - February 4, 2009 Category: OBGYN Authors: Hansson, S. R., Bottalico, B., Noskova, V., Casslen, B. Tags: Reviews Source Type: journals

Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS PCSK4 appears to be a crucial enzyme for reproduction. Alterations of PCSK4 expression or activity could be the underlying cause of some unexplained cases of human infertility. Conversely, inactivation of this protease represents a potential strategy for non-hormonal contraception. (Source: Human Reproduction Update)
Source: Human Reproduction Update - February 4, 2009 Category: OBGYN Authors: Gyamera-Acheampong, C., Mbikay, M. Tags: Reviews Source Type: journals

Pinopodes: a questionable role in endometrial receptivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS While there are many publications arising from one group supporting the use of pinopodes as a reliable marker of human endometrial receptivity, few independent groups have been able to confirm these results. The clinical usefulness of pinopodes to delineate a period of endometrial receptivity seems unlikely following recent findings that pinopodes are present throughout the luteal phase of the menstrual cycle. (Source: Human Reproduction Update)
Source: Human Reproduction Update - February 4, 2009 Category: OBGYN Authors: Quinn, C.E., Casper, R.F. Tags: Reviews Source Type: journals

New insights into epididymal biology and functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Significant progress has been made in our understanding of epididymal function providing new insights that ultimately could improve human health. The data also indicate that the human epididymis plays an important role in sperm maturation but has unique properties compared with animal models. (Source: Human Reproduction Update)
Source: Human Reproduction Update - February 4, 2009 Category: OBGYN Authors: Cornwall, G. A. Tags: Reviews Source Type: journals

The role of kisspeptin in the control of gonadotrophin secretionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Kisspeptins are pivotal regulators of the HPG axis and reproduction, with the ability to integrate signals from both internal and external sources. Knowledge about the signalling mechanisms involved in kisspeptin stimulation of GnRH would help improve the understanding of the importance of this critical pathway in reproduction. (Source: Human Reproduction Update)
Source: Human Reproduction Update - February 4, 2009 Category: OBGYN Authors: Roseweir, A.K., Millar, R.P. Tags: Reviews Source Type: journals

Reproductive outcome after bariatric surgery: a critical reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Close supervision before, during and after pregnancy following bariatric surgery and nutrient supplementation adapted to the patient’s individual requirements can help to prevent nutrition-related complications and improve maternal and fetal health, in this high-risk obstetric population. (Source: Human Reproduction Update)
Source: Human Reproduction Update - February 4, 2009 Category: OBGYN Authors: Guelinckx, I., Devlieger, R., Vansant, G. Tags: Reviews Source Type: journals

The effect of surgery for symptomatic endometriosis: the other side of the storyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Pain recurrence and re-operation rates after conservative surgery for symptomatic endometriosis are high and probably underestimated. Clinicians and patients should be aware that the expected benefit is operator-dependent. (Source: Human Reproduction Update)
Source: Human Reproduction Update - February 4, 2009 Category: OBGYN Authors: Vercellini, P., Crosignani, P.G., Abbiati, A., Somigliana, E., Vigano, P., Fedele, L. Tags: Reviews Source Type: journals

Contraception and HIV infection in womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS All the available reversible contraceptive methods can generally be used by women at risk of HIV infection and by HIV-infected women. Further studies are needed to investigate the safety and efficiency of hormonal contraception in women living with HIV/AIDS. (Source: Human Reproduction Update)
Source: Human Reproduction Update - February 4, 2009 Category: OBGYN Authors: Heikinheimo, O., Lahteenmaki, P. Tags: Reviews Source Type: journals

Techniques for cryopreservation of individual or small numbers of human spermatozoa: a systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Cryopreservation of individual or small numbers of human spermatozoa may replace the need for repeated surgical sperm retrieval. A controlled multicenter trial with sufficient follow-up would provide valid evidence of the potential benefit of this approach. (Source: Human Reproduction Update)
Source: Human Reproduction Update - February 4, 2009 Category: OBGYN Authors: AbdelHafez, F., Bedaiwy, M., El-Nashar, S. A., Sabanegh, E., Desai, N. Tags: Reviews Source Type: journals

The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS The analysis of cffNA may allow NIPD for a variety of genetic conditions and may in future form part of national antenatal screening programmes for DS and other common genetic disorders. (Source: Human Reproduction Update)
Source: Human Reproduction Update - December 17, 2008 Category: OBGYN Authors: Wright, C. F., Burton, H. Tags: Reviews Source Type: journals

Non-genomic progesterone actions in female reproductionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Identification of the mechanisms and receptors that relay rapid progesterone signalling is an area of research fraught with difficulties and controversy. More in-depth characterization of the putative receptors is required before the non-genomic progesterone pathway in normal and pathological reproductive function can be targeted for pharmacological intervention. (Source: Human Reproduction Update)
Source: Human Reproduction Update - December 17, 2008 Category: OBGYN Authors: Gellersen, B., Fernandes, M.S., Brosens, J.J. Tags: Reviews Source Type: journals

Functional genetic polymorphisms and female reproductive disorders: Part II--endometriosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS The evidence of an association between genetic polymorphisms and endometriosis is weak. Carriage of the GSTT1 null deletion may moderately increase the risk of this disease. We suggest that the methodology of association studies should be improved in order to identify and validate associations in endometriosis. (Source: Human Reproduction Update)
Source: Human Reproduction Update - December 17, 2008 Category: OBGYN Authors: Tempfer, C.B., Simoni, M., Destenaves, B., Fauser, B.C.J.M. Tags: Reviews Source Type: journals

Human choriogonadotrophin protein core and sugar branches heterogeneity: basic and clinical insightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Measurement of hCG and/or its related molecules is useful in clinical practice, but greater awareness is needed worldwide regarding the use of new sensitive and specific assays tailored for different clinical applications. (Source: Human Reproduction Update)
Source: Human Reproduction Update - December 17, 2008 Category: OBGYN Authors: de Medeiros, S.F., Norman, R.J. Tags: Reviews Source Type: journals

Insulin sensitizing drugs for weight loss in women of reproductive age who are overweight or obese: systematic review and meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION A structured lifestyle modification programme to achieve weight loss should still be the first line treatment in obese women with or without PCOS. Adequately powered RCTs are required to confirm the findings of this review and to assess whether the addition of high-dose metformin therapy to a structured lifestyle modification programme might contribute to more weight loss. (Source: Human Reproduction Update)
Source: Human Reproduction Update - December 17, 2008 Category: OBGYN Authors: Nieuwenhuis-Ruifrok, A.E., Kuchenbecker, W.K.H., Hoek, A., Middleton, P., Norman, R.J. Tags: Reviews Source Type: journals

The risk of monozygotic twins after assisted reproductive technology: a systematic review and meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS The risk of monozygotic twins in assisted conception is 2.25 times higher than the natural conceptions. Larger studies reporting on monozygotic twinning following single-embryo transfer or after post-natal confirmation of zygosity with DNA analysis are warranted before definitive conclusions can be drawn and guidelines produced. In order to provide adequate pre-conceptional counselling, it is important to monitor the incidence of monozygotic twins in both natural and assisted conceptions. We suggest building a national multiple pregnancy database based on accurate diagnosis of zygosity. (Source: Human Reproduction Update)
Source: Human Reproduction Update - December 17, 2008 Category: OBGYN Authors: Vitthala, S., Gelbaya, T.A., Brison, D.R., Fitzgerald, C.T., Nardo, L.G. Tags: Reviews Source Type: journals

Effects of cigarette smoking upon clinical outcomes of assisted reproduction: a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS This meta-analysis provides compelling evidence for a significant negative effect of cigarette smoking upon clinical outcomes of ART and should be presented to infertility patients who smoke cigarettes in order to optimize success rates. (Source: Human Reproduction Update)
Source: Human Reproduction Update - December 17, 2008 Category: OBGYN Authors: Waylen, A.L., Metwally, M., Jones, G.L., Wilkinson, A.J., Ledger, W.L. Tags: Reviews Source Type: journals

Mild ovarian stimulation for IVFEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Evidence in favour of mild ovarian stimulation for IVF is accumulating in recent literature. However, further, sufficiently powered prospective studies applying novel mild treatment regimens are required and structured reporting of the incidence and severity of complications, the number of treatment days, medication used, cost, patient discomfort and number of patient drop-outs in studies on IVF is encouraged. (Source: Human Reproduction Update)
Source: Human Reproduction Update - December 17, 2008 Category: OBGYN Authors: Verberg, M.F.G., Macklon, N.S., Nargund, G., Frydman, R., Devroey, P., Broekmans, F.J., Fauser, B.C.J.M. Tags: Reviews Source Type: journals

The clinical significance of the retrieval of a low number of oocytes following mild ovarian stimulation for IVF: a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS The optimal number of retrieved oocytes depends on the ovarian stimulation regimen. After mild ovarian stimulation, a modest number of oocytes is associated with optimal implantation rates and does not reflect a poor ovarian response. Therefore, the fear of reducing the number of oocytes retrieved following mild ovarian stimulation appears to be unjustified. (Source: Human Reproduction Update)
Source: Human Reproduction Update - December 17, 2008 Category: OBGYN Authors: Verberg, M.F.G., Eijkemans, M.J.C., Macklon, N.S., Heijnen, E.M.E.W., Baart, E.B., Hohmann, F.P., Fauser, B.C.J.M., Broekmans, F.J. Tags: Reviews Source Type: journals

Mild stimulation for in vitro fertilization: making progress downwardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Human Reproduction Update)
Source: Human Reproduction Update - December 17, 2008 Category: OBGYN Authors: Collins, J. Tags: Editorial Source Type: journals

Ooplasmic and nuclear transfer to prevent mitochondrial DNA disorders: conceptual and normative issuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Further interdisciplinary debate and research is needed to determine whether a clinical application of OT and NT can be morally justified, and if so, under which conditions. (Source: Human Reproduction Update)
Source: Human Reproduction Update - October 17, 2008 Category: OBGYN Authors: Bredenoord, A.L., Pennings, G., de Wert, G. Tags: Reviews Source Type: journals