IEE Transactions on Medical Imaging
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IEEE Transactions on Medical Imaging information for authors
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Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
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(Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
Special issue on multivariate microscopy image analysis
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(Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
Isbi 2010
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Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
Correction for Susceptibility-Induced Distortion in Echo-Planar Imaging Using Field Maps and Model-Based Point Spread Function
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In conclusion, the proposed framework gave us an overall picture of how different correction methods work. The model-based PSF method, which required fewer reference scans and less computational load, was more clinically feasible than other methods. (Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
Cardiac C-Arm CT: A Unified Framework for Motion Estimation and Dynamic CT
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Generating 3-D images of the heart during interventional procedures is a significant challenge. In addition to real time fluoroscopy, angiographic C-arm systems can also now be used to generate 3-D/4-D CT images on the same system. One protocol for cardiac CT uses ECG triggered multisweep scans. A 3-D volume of the heart at a particular cardiac phase is then reconstructed by applying Feldkamp (FDK) reconstruction to the projection images with retrospective ECG gating. In this work we introduce a unified framework for heart motion estimation and dynamic cone-beam reconstruction using motion corrections. The benefits of moti...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
Kernel Granger Causality Mapping Effective Connectivity on fMRI Data
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Although it is accepted that linear Granger causality can reveal effective connectivity in functional magnetic resonance imaging (fMRI), the issue of detecting nonlinear connectivity has hitherto not been considered. In this paper, we address kernel Granger causality (KGC) to describe effective connectivity in simulation studies and real fMRI data of a motor imagery task. Based on the theory of reproducing kernel Hilbert spaces, KGC performs linear Granger causality in the feature space of suitable kernel functions, assuming an arbitrary degree of nonlinearity. Our results demonstrate that KGC captures effective couplings ...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
Robust Initial Detection of Landmarks in Film-Screen Mammograms Using Multiple FFDM Atlases
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Automated analysis of mammograms requires robust methods for pectoralis segmentation and nipple detection. Locating the nipple is especially important in multiview computer aided detection systems, in which findings are matched across images using the nipple-to-finding distance. Segmenting the pectoralis is a key preprocessing step to avoid false positives when detecting masses due to the similarity of the texture of mammographic parenchyma and the pectoral muscle. A multiatlas algorithm capable of providing very robust initial estimates of the nipple position and pectoral region in digitized mammograms is presented here. ...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
Rapid Dynamic Image Registration of the Beating Heart for Diagnosis and Surgical Navigation
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Dynamic cardiac magnetic resonance imaging (MR) and computed tomography (CT) provide cardiologists and cardiac surgeons with high-quality 4-D images for diagnosis and therapy, yet the effective use of these high-quality anatomical models remains a challenge. Ultrasound (US) is a flexible imaging tool, but the US images produced are often difficult to interpret unless they are placed within their proper 3-D anatomical context. The ability to correlate real-time 3-D US volumes (RT3D US) with dynamic MR/CT images would offer a significant contribution to improve the quality of cardiac procedures. In this paper, we present a r...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
Distribution of Fiducial Registration Error in Rigid-Body Point-Based Registration
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Rigid-body point-based registration is frequently used in computer assisted surgery to align corresponding points, or fiducials, in preoperative and intraoperative data. This alignment is mostly achieved by assuming the same homogeneous error distribution for all the points; however, due to the properties of the medical instruments used in measuring the point coordinates, the error distribution might be inhomogeneous and different for each point. In this paper, in an effort to understand the effect of error distribution in the localized points on the performed registration, we derive a closed-form solution relating the err...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
Effects of Different Imaging Models on Least-Squares Image Reconstruction Accuracy in Photoacoustic Tomography
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In the classic formulation of photoacoustic tomography (PAT), two distinct descriptions of the imaging model have been employed for developing reconstruction algorithms. We demonstrate that the numerical and statistical properties of unweighted least-squares reconstruction algorithms associated with each imaging model are generally very different. Specifically, some PAT reconstruction algorithms, including many of the iterative algorithms previously explored, do not work directly with the raw measured pressure wavefields, but rather with an integrated data function that is obtained by temporally integrating the photoacoust...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
${K}$ -Space and Image-Space Combination for Motion-Induced Phase-Error Correction in Self-Navigated Multicoil Multishot DWI
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Motion during diffusion encodings leads to different phase errors in different shots of multishot diffusion-weighted acquisitions. Phase error incoherence among shots results in undesired signal cancellation when data from all shots are combined. Motion-induced phase error correction for multishot diffusion-weighted imaging (DWI) has been studied extensively and there exist multiple phase error correction algorithms. A commonly used correction method is the direct phase subtraction (DPS). DPS, however, can suffer from incomplete phase error correction due to the aliasing of the phase errors in the high spatial resolution p...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
Model-Based Iterative Reconstruction for Radial Fast Spin-Echo MRI
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In radial fast spin-echo magnetic resonance imaging (MRI), a set of overlapping spokes with an inconsistent T2 weighting is acquired, which results in an averaged image contrast when employing conventional image reconstruction techniques. This work demonstrates that the problem may be overcome with the use of a dedicated reconstruction method that further allows for T2 quantification by extracting the embedded relaxation information. Thus, the proposed reconstruction method directly yields a spin-density and relaxivity map from only a single radial data set. The method is based on an inverse formulation of the problem and ...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
Effect of Voxel Size and Computation Method on Tc-99m MAA SPECT/CT-Based Dose Estimation for Y-90 Microsphere Therapy
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The use of selective internal radiation therapy for treatment of hepatocellular carcinoma and liver metastases using Y-90 labeled microspheres has become an effective and widely used treatment regimen. However, dosimetric evaluations of this treatment are still primitive as uniform distribution models based only on injected activity are often used. This investigation attempts to quantify the effectiveness of several sophisticated patient-specific techniques which utilize the source distribution of Tc-99m MAA simulation studies to perform voxelized dosimetric computations. Among these techniques are complete Monte-Carlo rad...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
A New Distortion Model for Strong Inhomogeneity Problems in Echo-Planar MRI
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This paper proposes a new distortion model for strong inhomogeneity problems in echo planar imaging (EPI). Fast imaging sequences in magnetic resonance imaging (MRI), such as EPI, are very important in applications where temporal resolution or short total acquisition time is essential. Unfortunately, fast imaging sequences are very sensitive to variations in the homogeneity of the main magnetic field. The inhomogeneity leads to geometrical distortions and intensity changes in the image reconstructed via fast Fourier transform. Also, under strong inhomogeneity, the accelerated intravoxel dephase may overly attenuate signals...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
A Reconstruction Algorithm for Photoacoustic Imaging Based on the Nonuniform FFT
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Fourier reconstruction algorithms significantly outperform conventional backprojection algorithms in terms of computation time. In photoacoustic imaging, these methods require interpolation in the Fourier space domain, which creates artifacts in reconstructed images. We propose a novel reconstruction algorithm that applies the one-dimensional nonuniform fast Fourier transform to photoacoustic imaging. It is shown theoretically and numerically that our algorithm avoids artifacts while preserving the computational effectiveness of Fourier reconstruction. (Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
Generalized Algorithms for Direct Reconstruction of Parametric Images From Dynamic PET Data
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Indirect and direct methods have been developed for reconstructing parametric images from dynamic positron emission tomography (PET) data. Indirect methods are simple and easy to implement because reconstruction and kinetic modeling are performed in two separate steps. Direct methods estimate parametric images directly from dynamic PET sinograms and, in theory, can be statistically more efficient, but the algorithms are often difficult to implement and are very specific to the kinetic model being used. This paper presents a class of generalized algorithms for direct reconstruction of parametric images that are relatively e...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
A Stochastic Approach to Estimate the UncertaintyInvolved in B-Spline Image Registration
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Uncertainties in image registration may be a significant source of errors in anatomy mapping as well as dose accumulation in radiotherapy. It is, therefore, essential to validate the accuracy of image registration. Here, we propose a method to detect areas where mono modal B-spline registration performs well and to distinguish those from areas of the same image, where the registration is likely to be less accurate. It is a stochastic approach to automatically estimate the uncertainty of the resulting displacement vector field. The coefficients resulting from the B-spline registration are subject to moderate and randomly pe...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
An Image Based Auto-Focusing Algorithm forDigital Fundus Photography
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In fundus photography, the task of fine focusing the image is demanding and lack of focus is quite often the cause of suboptimal photographs. The introduction of digital cameras has provided an opportunity to automate the task of focusing. We have developed a software algorithm capable of identifying best focus. The auto-focus (AF) method is based on an algorithm we developed to assess the sharpness of an image. The AF algorithm was tested in the prototype of a semi-automated nonmydriatic fundus camera designed to screen in the primary care environment for major eye diseases. A series of images was acquired in volunteers w...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
Statistical Sinogram Restoration in Dual-Energy CT for PET Attenuation Correction
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We report simulations that compare the proposed techniques and existing approaches. (Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
In Vivo High-ResolutionConductivity Imaging of the Human Leg Using MREIT: The First Human Experiment
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We present the first in vivo cross-sectional conductivity image of the human leg with 1.7 mm pixel size using the magnetic resonance electrical impedance tomography (MREIT) technique. After a review of its experimental protocol by an Institutional Review Board (IRB), we performed MREIT imaging experiments of four human subjects using a 3 T MRI scanner. Adopting thin and flexible carbon–hydrogel electrodes with a large surface area and good contact, we could inject as much as 9 mA current in a form of 15 ms pulse into the leg without producing a painful sensation and motion artifact. Sequentially injecting two imagin...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
Approaching Artery Rigid Dynamics in IVUS
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Tissue biomechanical properties (like strain and stress) are playing an increasing role in diagnosis and long-term treatment of intravascular coronary diseases. Their assessment strongly relies on estimation of vessel wall deformation. Since intravascular ultrasound (IVUS) sequences allow visualizing vessel morphology and reflect its dynamics, this technique represents a useful tool for evaluation of tissue mechanical properties. Image misalignment introduced by vessel–catheter motion is a major artifact for a proper tracking of tissue deformation. In this work, we focus on compensating and assessing IVUS rigid in-p...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
B-Mode Ultrasound Image Simulation in Deformable 3-D Medium
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This paper presents an algorithm for fast image synthesis inside deformed volumes. Given the node displacements of a mesh and a reference 3-D image dataset of a predeformed volume, the method first maps the image pixels that need to be synthesized from the deformed configuration to the nominal predeformed configuration, where the pixel intensities are obtained easily through interpolation in the regular-grid structure of the reference voxel volume. This mapping requires the identification of the mesh element enclosing each pixel for every image frame. To accelerate this point location operation, a fast method of projecting...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
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Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
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Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals
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Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
IEEE Transactions on Medical Imaging information for authors
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Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
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(Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Special issue on multivariate microscopy image analysis
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(Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Isbi 2010
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Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Tomographic Reconstruction of Three-Dimensional Volumes Using the Distorted Born Iterative Method
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Although real imaging problems involve objects that have variations in three dimensions, a majority of work examining inverse scattering methods for ultrasonic tomography considers 2-D imaging problems. Therefore, the study of 3-D inverse scattering methods is necessary for future applications of ultrasonic tomography. In this work, 3-D reconstructions using different arrays of rectangular elements focused on elevation were studied when reconstructing spherical imaging targets by producing a series of 2-D image slices using the 2-D distorted Born iterative method (DBIM). The effects of focal number f/#, speed of sound cont...
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Motor Protein Function in Skeletal Muscle—A Multiple Scale Approach to Contractility
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We present an approach to skeletal muscle contractility and its regulation over different scales ranging from biomechanical studies in intact muscle fibers down to the motility and interaction of single motor protein molecules. At each scale, shortening velocities as a measure for weak cross-bridge cycling rates are extracted and compared. Experimental approaches include transmitted light microscopy, second harmonic generation imaging of contracting myofibrils, and fluorescence microscopy of single molecule motility. Each method yields image sequences that are analyzed with automated image processing algorithms to extract ...
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Controlling Familywise Error Rate for Matched Subspace Detection in Dynamic FDG PET
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Detection of small lesions in fluorodeoxyglucose (FDG) positron emission tomography (PET) is limited by image resolution and low signal to noise ratio. We have previously described a matched subspace detection method that uses the time activity curve to distinguish tumors from background in dynamic FDG PET. Applying this algorithm on a voxel by voxel basis throughout the dynamic image produces a test statistic image or ldquomaprdquo which on thresholding indicates the potential locations of secondary or metastatic tumors. In this paper, we describe a thresholding method that controls familywise error rate (FWER) for the ma...
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Noise Estimation in Magnitude MR Datasets
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Estimating the noise parameter in magnitude magnetic resonance (MR) images is important in a wide range of applications. We propose an automatic noise estimation method that does not rely on a substantial proportion of voxels being from the background. Specifically, we model the magnitude of the observed signal as a mixture of Rice distributions with common noise parameter. The expectation-maximization (EM) algorithm is used to estimate all parameters, including the common noise parameter. The algorithm needs initializing values for which we provide some strategies that work well. The number of components in the mixture mo...
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Reproducible Classification of Infarct Heterogeneity Using Fuzzy Clustering on Multicontrast Delayed Enhancement Magnetic Resonance Images
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Delayed enhancement MRI (DE-MRI) can be used to identify myocardial infarct (MI). Classification of MI into the infarct core and heterogeneous periphery (called the gray zone) on conventional inversion-recovery gradient echo (IR-GRE) DE-MRI images has been related to inducibility for ventricular tachycardia. However, this classification is sensitive to image noise, depends on the signal intensity characteristics in a remote region of myocardium, and requires manual contours of the endocardial border. Image analysis and fuzzy clustering techniques were developed to analyze images acquired using a multicontrast delayed enhan...
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Learning-Based Vertebra Detection and Iterative Normalized-Cut Segmentation for Spinal MRI
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Automatic extraction of vertebra regions from a spinal magnetic resonance (MR) image is normally required as the first step to an intelligent spinal MR image diagnosis system. In this work, we develop a fully automatic vertebra detection and segmentation system, which consists of three stages; namely, AdaBoost-based vertebra detection, detection refinement via robust curve fitting, and vertebra segmentation by an iterative normalized cut algorithm. In order to produce an efficient and effective vertebra detector, a statistical learning approach based on an improved AdaBoost algorithm is proposed. A robust estimation proced...
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Noise Reduction in Computed Tomography Scans Using 3-D Anisotropic Hybrid Diffusion With Continuous Switch
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Noise filtering techniques that maintain image contrast while decreasing image noise have the potential to optimize the quality of computed tomography (CT) images acquired at reduced radiation dose. In this paper, a hybrid diffusion filter with continuous switch (HDCS) is introduced, which exploits the benefits of three-dimensional edge-enhancing diffusion (EED) and coherence-enhancing diffusion (CED). Noise is filtered, while edges, tubular structures, and small spherical structures are preserved. From ten high dose thorax CT scans, acquired at clinical doses, ultra low dose ( 15 mAs ) scans were simulated and used to eva...
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Effect of Domain Shape Modeling and Measurement Errors on the 2-D D-Bar Method for EIT
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The D-bar algorithm based on Nachman's 2-D global uniqueness proof for the inverse conductivity problem (Nachman, 1996) is implemented on a chest-shaped domain. The scattering transform is computed on this chest-shaped domain using trigonometric and adjacent current patterns and the complete electrode model for the forward problem is computed with the finite element method in order to obtain simulated voltage measurements. The robustness and effectiveness of the method is demonstrated on a simulated chest with errors in input currents, output voltages, electrode placement, and domain modeling. (Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Trabecular Bone Analysis in CT and X-Ray Images of the Proximal Femur for the Assessment of Local Bone Quality
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Currently, conventional X-ray and CT images as well as invasive methods performed during the surgical intervention are used to judge the local quality of a fractured proximal femur. However, these approaches are either dependent on the surgeon's experience or cannot assist diagnostic and planning tasks preoperatively. Therefore, in this work a method for the individual analysis of local bone quality in the proximal femur based on model-based analysis of CT- and X-ray images of femur specimen will be proposed. A combined representation of shape and spatial intensity distribution of an object and different statistical approa...
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Fast Large-Tip-Angle Multidimensional and Parallel RF Pulse Design in MRI
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Large-tip-angle multidimensional radio-frequency (RF) pulse design is a difficult problem, due to the nonlinear response of magnetization to applied RF at large tip-angles. In parallel excitation, multidimensional RF pulse design is further complicated by the possibility for transmit field patterns to change between subjects, requiring pulses to be designed rapidly while a subject lies in the scanner. To accelerate pulse design, we introduce a fast version of the optimal control method for large-tip-angle parallel excitation. The new method is based on a novel approach to analytically linearizing the Bloch equation about a...
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Estimating Kinetic Parameter Maps From Dynamic Contrast-Enhanced MRI Using Spatial Prior Knowledge
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Dynamic contrast-enhanced magnetic resonance (DCE-MR) imaging can be used to study microvascular structure in vivo by monitoring the abundance of an injected diffusible contrast agent over time. The resulting spatially resolved intensity-time curves are usually interpreted in terms of kinetic parameters obtained by fitting a pharmacokinetic model to the observed data. Least squares estimates of the highly nonlinear model parameters, however, can exhibit high variance and can be severely biased. As a remedy, we bring to bear spatial prior knowledge by means of a generalized Gaussian Markov random field (GGMRF). By using inf...
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Shear Modulus Decomposition Algorithm in Magnetic Resonance Elastography
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Magnetic resonance elastography (MRE) is an imaging modality capable of visualizing the elastic properties of an object using magnetic resonance imaging (MRI) measurements of transverse acoustic strain waves induced in the object by a harmonically oscillating mechanical vibration. Various algorithms have been designed to determine the mechanical properties of the object under the assumptions of linear elasticity, isotropic and local homogeneity. One of the challenging problems in MRE is to reduce the noise effects and to maintain contrast in the reconstructed shear modulus images. In this paper, we propose a new algorithm ...
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
Comparison of Analytic and Algebraic Methods for Motion-Compensated Cone-Beam CT Reconstruction of the Thorax
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Respiratory motion is a major concern in cone-beam (CB) computed tomography (CT) of the thorax. It causes artifacts such as blur, streaks, and bands, in particular when using slow-rotating scanners mounted on the gantry of linear accelerators. In this paper, we compare two approaches for motion-compensated CBCT reconstruction of the thorax. The first one is analytic; it is heuristically adapted from the method of Feldkamp, Davis, and Kress (FDK). The second one is algebraic: the system of linear equations is generated using a new algorithm for the projection of deformable volumes and solved using the simultaneous algebraic...
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
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Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
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Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals
IEEE Transactions on Medical Imaging information for authors
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Source: IEE Transactions on Medical Imaging - July 28, 2009 Category: Biomedical Engineering Source Type: journals
Special issue on multivariate microscopy image analysis
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Source: IEE Transactions on Medical Imaging - July 28, 2009 Category: Biomedical Engineering Source Type: journals
Call for papers ISBI 2010
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Source: IEE Transactions on Medical Imaging - July 28, 2009 Category: Biomedical Engineering Source Type: journals
Young's Modulus Reconstruction for Radio-Frequency Ablation Electrode-Induced Displacement Fields: A Feasibility Study
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Radio-frequency (RF) ablation is a minimally invasive treatment for tumors in various abdominal organs. It is effective if good tumor localization and intraprocedural monitoring can be done. In this paper, we investigate the feasibility of using an ultrasound-based Young's modulus reconstruction algorithm to image an ablated region whose stiffness is elevated due to tissue coagulation. To obtain controllable tissue deformations for abdominal organs during and/or intermediately after the RF ablation, the proposed modulus imaging method is specifically designed for using tissue deformation fields induced by the RF electrode....
Source: IEE Transactions on Medical Imaging - July 28, 2009 Category: Biomedical Engineering Source Type: journals
Blind Decomposition of Transmission Light Microscopic Hyperspectral Cube Using Sparse Representation
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We present the multiplicative physical model of image formation in transmission light microscopy, justify reduction of a hyperspectral image decomposition problem to a blind source separation problem, and provide method for hyperspectral restoration of separated compounds. In our approach, dimensionality reduction using principal component analysis (PCA) is followed by a blind source separation (BSS) algorithm. The BSS method is based on sparsifying transformation of observed images and relative Newton optimization procedure. The presented method was verified on hyperspectral images of biological tissues. The method was co...
Source: IEE Transactions on Medical Imaging - July 28, 2009 Category: Biomedical Engineering Source Type: journals
